Lori A Knackstedt

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB Suite 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 322:1103-9. 2007
  2. pmc Glutamate and reinstatement
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, United States
    Curr Opin Pharmacol 9:59-64. 2009
  3. pmc Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South, Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 67:81-4. 2010
  4. pmc Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 30:7984-92. 2010
  5. pmc Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training
    Heather Trantham-Davidson
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 32:12406-10. 2012
  6. pmc Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking
    Ilan Sondheimer
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Behav Brain Res 225:252-8. 2011
  7. pmc The role of cystine-glutamate exchange in nicotine dependence in rats and humans
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 65:841-5. 2009
  8. ncbi request reprint Evidence for opponent-process actions of intravenous cocaine and cocaethylene
    Lori A Knackstedt
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Pharmacol Biochem Behav 72:931-6. 2002

Research Grants

  1. Evaluating models of cocaine self-administration
    Lori Knackstedt; Fiscal Year: 2007

Detail Information

Publications8

  1. ncbi request reprint Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB Suite 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 322:1103-9. 2007
    ..Furthermore, the differences in reinstatement are predicted more by length of cocaine access than by escalation of drug intake...
  2. pmc Glutamate and reinstatement
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, United States
    Curr Opin Pharmacol 9:59-64. 2009
    ..The similarities in the neurochemistry behind relapse to these varied drug classes indicate that drugs that target the glutamate system could be effective at treating relapse to multiple types of drugs...
  3. pmc Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South, Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 67:81-4. 2010
    ..Another regulator of extracellular glutamate is the glial glutamate transporter GLT-1. We hypothesized that cocaine self-administration reduces GLT-1 and that GLT-1 upregulation inhibits cocaine seeking...
  4. pmc Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 30:7984-92. 2010
    ..These data identify a cellular mechanism that may contribute to extinction-induced inhibition of cocaine seeking...
  5. pmc Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training
    Heather Trantham-Davidson
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 32:12406-10. 2012
    ..These data indicate that ceftriaxone normalizes multiple aspects of glutamate homeostasis following cocaine self-administration and thus holds the potential to reduce relapse in human cocaine addicts...
  6. pmc Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking
    Ilan Sondheimer
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Behav Brain Res 225:252-8. 2011
    ..Taken together, these results indicate that ceftriaxone produces enduring changes in glutamate homeostasis in the nucleus accumbens which counteract addiction-related behaviors...
  7. pmc The role of cystine-glutamate exchange in nicotine dependence in rats and humans
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 65:841-5. 2009
    ....
  8. ncbi request reprint Evidence for opponent-process actions of intravenous cocaine and cocaethylene
    Lori A Knackstedt
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Pharmacol Biochem Behav 72:931-6. 2002
    ..These data are consistent with the view that the development of CE may account for efficacy of ethanol to delay and weaken the aversive aftereffects of COC...

Research Grants2

  1. Evaluating models of cocaine self-administration
    Lori Knackstedt; Fiscal Year: 2007
    ..At the same time point that these behavioral and neurochemical changes will be monitored, we will also look for changes in known molecular markers of addiction via immunoblots. ..