J P Klein

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Modelling competing risks in cancer studies
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Stat Med 25:1015-34. 2006
  2. ncbi request reprint Survival analysis methods in cancer studies
    John P Klein
    Medical College of Wisconsin, Milwaukee, WI, USA
    Cancer Treat Res 113:37-57. 2002
  3. ncbi request reprint Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 9701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Biometrics 61:223-9. 2005
  4. ncbi request reprint Estimation of current leukaemia-free survival following donor lymphocyte infusion therapy for patients with leukaemia who relapse after allografting: application of a multistate model
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, P O Box 26509, Milwaukee, WI 53226, USA
    Stat Med 19:3005-16. 2000
  5. ncbi request reprint Analyzing survival curves at a fixed point in time
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Stat Med 26:4505-19. 2007
  6. ncbi request reprint Summary curves for patients transplanted for chronic myeloid leukaemia salvaged by a donor lymphocyte infusion: the current leukaemia-free survival curve
    J P Klein
    The Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
    Br J Haematol 109:148-52. 2000
  7. pmc SAS and R functions to compute pseudo-values for censored data regression
    John P Klein
    Division of Biostatistics, Department of Population Health, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Comput Methods Programs Biomed 89:289-300. 2008
  8. ncbi request reprint Autotransplants for Hodgkin's disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    H M Lazarus
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 17:534-45. 1999
  9. ncbi request reprint Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part 2: Regression modeling
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 28:1001-11. 2001
  10. ncbi request reprint High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America
    K H Antman
    Breast Cancer Working Committee of the Autologous Blood and Marrow Transplant Registry of North America, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 15:1870-9. 1997

Detail Information

Publications61

  1. ncbi request reprint Modelling competing risks in cancer studies
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Stat Med 25:1015-34. 2006
    ..We illustrate the use and interpretation of additive models for the hazard rate or for the cumulative incidence function using data from a study of the efficacy of two preparative regimes for hematopoietic stem cell transplantation...
  2. ncbi request reprint Survival analysis methods in cancer studies
    John P Klein
    Medical College of Wisconsin, Milwaukee, WI, USA
    Cancer Treat Res 113:37-57. 2002
  3. ncbi request reprint Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 9701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Biometrics 61:223-9. 2005
    ..We study the properties of this estimator and apply the technique to a study of the effect of alternative donors on relapse for patients given a bone marrow transplant for leukemia...
  4. ncbi request reprint Estimation of current leukaemia-free survival following donor lymphocyte infusion therapy for patients with leukaemia who relapse after allografting: application of a multistate model
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, P O Box 26509, Milwaukee, WI 53226, USA
    Stat Med 19:3005-16. 2000
    ..Here we show that this estimator does not actually estimate the probability of interest and we use a multi-stage model to develop a new and more appropriate estimator for 'current leukaemia-free survival'...
  5. ncbi request reprint Analyzing survival curves at a fixed point in time
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Stat Med 26:4505-19. 2007
    ..The methods are illustrated on a study comparing survival for autologous and allogeneic bone marrow transplants...
  6. ncbi request reprint Summary curves for patients transplanted for chronic myeloid leukaemia salvaged by a donor lymphocyte infusion: the current leukaemia-free survival curve
    J P Klein
    The Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
    Br J Haematol 109:148-52. 2000
    ..The second is based on an estimate constructed by looking at appropriate differences between Kaplan-Meier estimates. We compare these estimates using data on 189 consecutive patients who underwent SCT over a 7-year period...
  7. pmc SAS and R functions to compute pseudo-values for censored data regression
    John P Klein
    Division of Biostatistics, Department of Population Health, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Comput Methods Programs Biomed 89:289-300. 2008
    ..Here we present SAS macros and R functions to compute these pseudo-values. We illustrate the use of these routines and show how to obtain regression estimates for a study of bone marrow transplant patients...
  8. ncbi request reprint Autotransplants for Hodgkin's disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    H M Lazarus
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 17:534-45. 1999
    ..e., those with primary induction failure) have a poor prognosis. Some subjects who receive high-dose therapy with autologous hematopoietic progenitor-cell infusion experience prolonged progression-free survival...
  9. ncbi request reprint Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part 2: Regression modeling
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 28:1001-11. 2001
    ..We present methods to check the assumptions of the Cox regression. Finally, and perhaps most importantly, we provide suggestions for presenting the results in clear and thorough tables and graphs...
  10. ncbi request reprint High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America
    K H Antman
    Breast Cancer Working Committee of the Autologous Blood and Marrow Transplant Registry of North America, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 15:1870-9. 1997
    ..To identify trends in high-dose therapy with autologous hematopoietic stem-cell support (autotransplants) for breast cancer (1989 to 1995)...
  11. ncbi request reprint Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse
    Stephanie J Lee
    Graft vs Host Disease Working Committee of the International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 100:406-14. 2002
    ..Survival and disease-free survival of the most favorable cGVHD group in each scheme were similar, or better, than those of patients without cGVHD; these patients may not need aggressive or extended immune suppression...
  12. ncbi request reprint Confidence bands for the difference of two survival curves under proportional hazards model
    M J Zhang
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Lifetime Data Anal 7:243-54. 2001
    ..A simulation approach is used to generate the bands. This approach is used to compare the survival probabilities of chemotherapy and allogeneic bone marrow transplants for chronic leukemia...
  13. ncbi request reprint Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant
    M Eapen
    Statistical Center, International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226, USA
    Bone Marrow Transplant 34:721-7. 2004
    ..Although age, disease status and conditioning regimen are important, duration of remission after first transplantation appear to be the most important determinant of outcome...
  14. ncbi request reprint Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia
    Jorge Sierra
    International Bone Marrow Transplant Registry IBMTR, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Blood 100:1997-2004. 2002
    ..Best candidates are younger patients with a low percentage of blasts and preserved platelet counts...
  15. ncbi request reprint Multi-state models for bone marrow transplantation studies
    John P Klein
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Stat Methods Med Res 11:117-39. 2002
    ..Finally, we present an estimate of a new measure of treatment efficiency, the current leukemia free survival function, which is derived from a multi-state model approach...
  16. ncbi request reprint Modeling random effects for censored data by a multivariate normal regression model
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biometrics 55:497-506. 1999
    ..The estimated degree of dependence is comparable to other models, but the present approach has the advantage that the interpretation of the random effect is simpler than in the frailty model...
  17. ncbi request reprint Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program
    A H Filipovich
    Statistical Center of the International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 97:1598-603. 2001
    ..The best transplantation outcomes in Wiskott-Aldrich syndrome are achieved with HLA-identical sibling donors. Equivalent survivals are possible with unrelated donors in young children...
  18. ncbi request reprint Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part I: unadjusted analysis
    J P Klein
    Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 28:909-15. 2001
    ..We also present a simple estimate of current leukemia-free survival which is useful in summarizing post-transplant events...
  19. ncbi request reprint The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase
    S J Lee
    Chronic Leukemia Working Committee of the International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 98:3205-11. 2001
    ..In conclusion, no evidence was found for an independent adverse effect of IFN pretreatment on the outcome of subsequent unrelated donor transplantation...
  20. ncbi request reprint Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose
    C A Keever-Taylor
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 27:791-800. 2001
    ....
  21. ncbi request reprint Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: A randomized, multicenter, double-blind trial
    K J Henrickson
    Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Oncol 18:1269-78. 2000
    ..To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections...
  22. pmc Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial
    Eric P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 70:1546-51. 2008
    ..To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT)...
  23. pmc Analyzing center specific outcomes in hematopoietic cell transplantation
    Brent R Logan
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Lifetime Data Anal 14:389-404. 2008
    ..We illustrate the technique using a recent center specific analysis performed by the Center for International Blood and Marrow Transplant Research, and study the performance of this method using simulation...
  24. ncbi request reprint Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia
    Linus H Santo Tomas
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI 53226, USA
    Chest 128:153-61. 2005
    ..We sought to identify risk factors for BO using data from the International Bone Marrow Transplant Registry...
  25. ncbi request reprint Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
    Mary Eapen
    Statistical Center, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA
    Lancet 369:1947-54. 2007
    ....
  26. pmc Comparing treatments in the presence of crossing survival curves: an application to bone marrow transplantation
    Brent R Logan
    Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Biometrics 64:733-40. 2008
    ..We study these methods using simulation and illustrate them on a study comparing survival for autologous and allogeneic bone marrow transplants...
  27. ncbi request reprint Biomechanics of the double rocker sole shoe: gait kinematics and kinetics
    Jason T Long
    Orthopaedic and Rehabilitation Engineering Center OREC, Medical College of Wisconsin Marquette University, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Biomech 40:2882-90. 2007
    ....
  28. ncbi request reprint Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research
    Julie A Panepinto
    Department of Hematology Oncology Bone Marrow Transplant, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Haematol 137:479-85. 2007
    ....
  29. ncbi request reprint Incomplete chest wall decompression: a clinical evaluation of CPR performance by trained laypersons and an assessment of alternative manual chest compression-decompression techniques
    Tom P Aufderheide
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Resuscitation 71:341-51. 2006
    ..Complete chest wall recoil improves hemodynamics during CPR by generating relatively negative intrathoracic pressure, which draws venous blood back to the heart, providing cardiac preload prior to the next chest compression...
  30. ncbi request reprint Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: the Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry
    Mary Eapen
    IBMTR ABMTR Statistical Center, International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Clin Oncol 22:4872-80. 2004
    ..Despite lack of data on PBSC transplantation in children, there has been a change in clinical practice, with increasing numbers of children receiving PBSC allografts...
  31. doi request reprint Risk factors for non-fatal myocardial infarction and cardiac death in incident dialysis patients
    Hariprasad Trivedi
    Medical College of Wisconsin, Milwaukee, WI, USA
    Nephrol Dial Transplant 24:258-66. 2009
    ..The risks of major cardiac events in patients initiating long-term dialysis related to prior coronary disease and various other factors are not well known...
  32. doi request reprint Hospital variability of out-of-hospital cardiac arrest survival
    J Marc Liu
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Prehosp Emerg Care 12:339-46. 2008
    ..Previous literature has identified patient and emergency medical services (EMS) system factors that are associated with survival of out-of-hospital cardiac arrest patients...
  33. ncbi request reprint Incomplete chest wall decompression: a clinical evaluation of CPR performance by EMS personnel and assessment of alternative manual chest compression-decompression techniques
    Tom P Aufderheide
    Department of Emergency Medicine, Medical College of Wisconsin, 9200W Wisconsin Avenue, FEH Room 1870, Milwaukee, WI 53226, USA
    Resuscitation 64:353-62. 2005
    ....
  34. ncbi request reprint Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States
    Fausto R Loberiza
    University of Nebraska Medical Center, Center for International Blood and Marrow Transplant Research CIBMTR, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 105:2979-87. 2005
    ..Greater physician involvement in patient care is important in producing favorable outcomes after HSCT. To more clearly establish the role of the factors we identified, further studies are recommended...
  35. ncbi request reprint Regression models for hazard rates versus cumulative incidence probabilities in hematopoietic cell transplantation data
    Brent R Logan
    Division of Biostatistics and Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, USA
    Biol Blood Marrow Transplant 12:107-12. 2006
    ..Finally, we show how these discrepancies occur because 2 different characteristics of the time-to-event distribution are being modeled...
  36. pmc Inference for current leukemia free survival
    Leiyan Liu
    Division of Biostatistics, Department of Population Health Medical College of Wisconsin, 9701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Lifetime Data Anal 14:432-46. 2008
    ..We illustrate these inference methods on a bone marrow transplant dataset...
  37. ncbi request reprint Trends in survival rates after allogeneic hematopoietic stem-cell transplantation for acute and chronic leukemia by ethnicity in the United States and Canada
    Derek S Serna
    Department of Internal Medicine, Health Policy Institute, Medical College of Wisconsin Milwaukee, WI 53226, USA
    J Clin Oncol 21:3754-60. 2003
    ..Differences in survival among ethnic groups in the United States are reported in numerous diseases and treatment strategies. Whether survival after allogeneic hematopoietic stem-cell transplantation (HSCT) differs by ethnicity is uncertain...
  38. ncbi request reprint Blood group A and B antigens are strongly expressed on platelets of some individuals
    B R Curtis
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53233, USA
    Blood 96:1574-81. 2000
    ..Further studies are needed to define the molecular basis for the high-expresser trait and to characterize its clinical implications. (Blood. 2000;96:1574-1581)..
  39. ncbi request reprint The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit
    S E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Interferon Cytokine Res 21:743-55. 2001
    ....
  40. ncbi request reprint A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome
    Corey S Cutler
    International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Rd, PO Box 26509, Milwaukee, WI 53226, USA
    Blood 104:579-85. 2004
    ..For low- and intermediate-1-risk MDS, delayed BMT is associated with maximal life expectancy, whereas immediate transplantation for intermediate-2- and high-risk disease is associated with maximal life expectancy...
  41. ncbi request reprint Managed care, doctors, and patients: focusing on relationships, not rights
    Robyn S Shapiro
    Center for the Study of Bioethics, Medical College of Wisconsin, USA
    Camb Q Healthc Ethics 12:300-7. 2003
  42. pmc Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia
    Parinda A Mehta
    Division of Haematology Oncology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 137:152-7. 2007
    ..We did not observe an association with IL-1alpha genotype in donor and/or recipient and transplant-outcome. These data suggest that the outcome of unrelated donor transplant for CML is not influenced by IL-1alpha genotype...
  43. ncbi request reprint Utility of single versus tandem autotransplants for advanced testes/germ cell cancer: a center for international blood and marrow transplant research (CIBMTR) analysis
    Hillard M Lazarus
    University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 13:778-89. 2007
    ..Patient selection bias for either transplant approach, however, may affect the results of this observational study; a randomized trial is needed to determine which approach, if either, is better...
  44. pmc Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
    Hubert Schrezenmeier
    Institute of Clinical Transfusion Medicine and Immunogenetics, University of Ulm, Germany
    Blood 110:1397-400. 2007
    ..Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA...
  45. pmc Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
    Jeffery S Miller
    Divisions of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
    Blood 109:5058-61. 2007
    ..58, 95% CI 1.13-2.22; P = .008). These data support a genetically determined role for NK cells following unrelated HCT in myeloid leukemia...
  46. pmc Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens
    Richard E Champlin
    M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Blood 109:4582-5. 2007
    ..In conclusion, the results of allogeneic BMT for SAA have improved over time related to advances in supportive care. The addition of ATG to the preparative regimen did not significantly improve the outcome...
  47. ncbi request reprint Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission
    Mark R Litzow
    Mayo Clinic and Foundation, Rochester, MN, USA
    Br J Haematol 119:1115-24. 2002
    ..016). There were no differences in TRM, LFS and OS. CyTBI conditioning may lower relapse risk but produces comparable TRM, LFS and OS to BuCy for HLA-matched sibling transplantation in first remission AML...
  48. ncbi request reprint Survival of patients with chronic-phase chronic myeloid leukaemia on imatinib after failure on interferon alfa
    David Marin
    Department of Haematology, Hammersmith Hospital, W12 0NN, London, UK
    Lancet 362:617-9. 2003
    ..64). Our findings suggest that cytogenetic responders obtain benefit from imatinib but patients who show no cytogenetic response should be given alternative treatment without delay. We confirmed these results in a case-matched analysis...
  49. ncbi request reprint Validation and extension of the EBMT Risk Score for patients with chronic myeloid leukaemia (CML) receiving allogeneic haematopoietic stem cell transplants
    Jakob R Passweg
    Kantonsspital Basel, Basel, Switzerland
    Br J Haematol 125:613-20. 2004
    ..Sokal and Hasford Scores did not predict survival after HSCT. We concluded that the EBMT Risk Score does not currently require modification...
  50. ncbi request reprint High-dose versus standard chemotherapy in metastatic breast cancer: comparison of Cancer and Leukemia Group B trials with data from the Autologous Blood and Marrow Transplant Registry
    Donald A Berry
    University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Clin Oncol 20:743-50. 2002
    ..To assess survival of patients with metastatic breast cancer treated with high-dose chemotherapy (HDC) versus standard-dose chemotherapy (SDC)...
  51. ncbi request reprint Regression analysis of restricted mean survival time based on pseudo-observations
    Per Kragh Andersen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Lifetime Data Anal 10:335-50. 2004
    ..Both Monte Carlo simulations and two real data sets are studied. It is concluded that while existing methods may be superior for analysis of the mean, pseudo-observations seem well suited when the restricted mean is studied...
  52. ncbi request reprint A random effects model for multistate survival analysis with application to bone marrow transplants
    Mouchumi Bhattacharyya
    Department of Mathematics, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA
    Math Biosci 194:37-48. 2005
    ..We use these estimates to make predictions of patient's eventual prognosis given the current medical history of the patient. Estimates of the uncertainty in our predictions are obtained by a modified bootstrap technique...
  53. pmc Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) pros
    Jean Yves Cahn
    Department of Onco Hematology, Hopital Michallon, Centre Hospitalo Universitaire, INSERM EMI 353, 38700 Grenoble Cedex 9, France
    Blood 106:1495-500. 2005
    ..Validity of these results in populations receiving peripheral blood transplants or nonmyeloablative conditioning regimens remains to be tested...
  54. ncbi request reprint A note on testing in Aalen's additive hazards regression models
    Mouchumi Bhattacharyya
    Mathematics Department, University of Pacific, USA
    Stat Med 24:2235-40. 2005
    ..We show that 'consistent' tests are obtained by using common weight functions for all comparisons and we make some suggestions...
  55. ncbi request reprint Effects of the toe-only rocker on gait kinematics and kinetics in able-bodied persons
    James J Van Bogart
    Orthopaedic and Rehabilitation Engineering Center, Marquette University Medical College of Wisconsin, Milwaukee 53233, USA
    IEEE Trans Neural Syst Rehabil Eng 13:542-50. 2005
    ..These kinematic and kinetic changes, along with previously studied effects of pressure relief at the metatarsal heads, should aid medical professionals in prescribing prophylactic footwear...
  56. ncbi request reprint A class of goodness of fit tests for a copula based on bivariate right-censored data
    Per K Andersen
    Department of Biostatistics, University of Copenhagen, 5 O Farimagsgade, P O Box 2099, DK 1014 Copenhagen K, Denmark
    Biom J 47:815-24. 2005
    ..Significance levels of the test are found by a modified bootstrap procedure. The procedure is used to check the appropriateness of a gamma or a positive stable frailty model in a set of survival data on Danish twins...
  57. ncbi request reprint Autotransplantation versus HLA-matched unrelated donor transplantation for acute myeloid leukaemia: a retrospective analysis from the Center for International Blood and Marrow Transplant Research
    Hillard M Lazarus
    University Hospitals of Cleveland, Ireland Cancer Center, Cleveland, OH, USA
    Br J Haematol 132:755-69. 2006
    ..Cytogenetics, however, were known in only two-thirds of patients and treatment bias cannot be eliminated...
  58. pmc Long-term outcome of patients given transplants of mobilized blood or bone marrow: A report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation
    Norbert Schmitz
    Department of Hematology, Asklepios Klinik St Georg, Hamburg, Germany
    Blood 108:4288-90. 2006
    ..These data represent the early experience with PBSC grafts. Long-term outcomes in recipients of more recent transplants are required to better evaluate the role of PBSC grafts relative to BM transplantation...
  59. ncbi request reprint Asymptotic theory for the Cox semi-Markov illness-death model
    Youyi Shu
    Department of Biometrics and Reporting, Centocor, Inc, 200 Great Valley Parkway, Mailstop C 4 1, Malvern, PA 19355, USA
    Lifetime Data Anal 13:91-117. 2007
    ..A Monte Carlo study is conducted to investigate the robustness and efficiency of Markov/Semi-Markov estimators. A real data example from the PROVA (1991, Hepatology 14:1016-1024) trial is used to illustrate the theory...
  60. ncbi request reprint Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitation
    Demetris Yannopoulos
    University of Minnesota, Minneapolis, MN, USA
    Crit Care Med 34:1444-9. 2006
    ..To compare cardiopulmonary resuscitation (CPR) with a compression to ventilation (C:V) ratio of 15:2 vs. 30:2, with and without use of an impedance threshold device (ITD)...
  61. ncbi request reprint A SAS macro for estimation of direct adjusted survival curves based on a stratified Cox regression model
    Xu Zhang
    Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA
    Comput Methods Programs Biomed 88:95-101. 2007
    ..We have written a SAS macro to estimate and compare the direct adjusted survival curves. We illustrate the SAS macro through the examples analyzing stem cell transplant data and Ewing's sarcoma data...

Research Grants14

  1. TECHNIQUES FOR MODELING COMPLEX LONGITUDINAL STUDIES
    John Klein; Fiscal Year: 1993
    ..In each of these three areas, a study of both the large and small sample properties will be given and appropriate software will be developed to implement these methods...
  2. Techniques for modeling complex longitidinal studies
    John Klein; Fiscal Year: 2007
    ..This involves writing expository articles for the medical literature, the development of user-friendly software and presentations to medical investigators. ..
  3. TECHNIQUES FOR MODELING COMPLEX LONGITUDINAL STUDIES
    John Klein; Fiscal Year: 2005
    ..abstract_text> ..
  4. TECHNIQUES FOR MODELING COMPLEX LONGITUDINAL STUDIES
    John Klein; Fiscal Year: 2001
    ..We will develop statistical software for the techniques we develop and apply these methods to medical data available to us through our collaborations with medical investigators. ..
  5. Techniques for modeling complex longitidinal studies
    John P Klein; Fiscal Year: 2010
    ..This involves writing expository articles for the medical literature, the development of user-friendly software and presentations to medical investigators. ..