A Kaplan

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Assembly, activation, and signaling by kinin-forming proteins on human vascular smooth muscle cells
    Anthony N Fernando
    Divisions of Pulmonary and Critical Care, Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Heart Circ Physiol 289:H251-7. 2005
  2. doi request reprint Pathogenesis and treatment of chronic urticaria
    A P Kaplan
    Medical University of South Carolina, Charleston, SC 29423, USA
    Postgrad Med 106:12-7. 1999
  3. pmc Angioedema
    Allen P Kaplan
    From the National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC
    World Allergy Organ J 1:103-13. 2008
  4. doi request reprint Biologic agents in the treatment of urticaria
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, 29425, USA
    Curr Allergy Asthma Rep 12:288-91. 2012
  5. ncbi request reprint C1 inhibitor deficiency: hereditary and acquired forms
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425, USA
    J Investig Allergol Clin Immunol 11:211-9. 2001
  6. doi request reprint Pathogenesis of chronic urticaria
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA
    Clin Exp Allergy 39:777-87. 2009
  7. doi request reprint Treatment of chronic autoimmune urticaria with omalizumab
    Allen P Kaplan
    National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
    J Allergy Clin Immunol 122:569-73. 2008
  8. ncbi request reprint Chronic urticaria--new concepts regarding pathogenesis and treatment
    Allen P Kaplan
    Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston 29425, USA
    Curr Allergy Asthma Rep 2:263-4. 2002
  9. ncbi request reprint Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled study
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 94:662-9. 2005
  10. pmc A new mechanism for immunologic initiation of asthma
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 102:1267-8. 2005

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Assembly, activation, and signaling by kinin-forming proteins on human vascular smooth muscle cells
    Anthony N Fernando
    Divisions of Pulmonary and Critical Care, Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Heart Circ Physiol 289:H251-7. 2005
    ..This early mitogenic signal, which is also implicated in atherogenesis, may change the metabolic and proliferative activity of VSMC, which are key steps in the progression of atherosclerosis...
  2. doi request reprint Pathogenesis and treatment of chronic urticaria
    A P Kaplan
    Medical University of South Carolina, Charleston, SC 29423, USA
    Postgrad Med 106:12-7. 1999
    ..Corticosteroids given on alternate days are efficacious and have few adverse effects if they are given in a slow, tapering course...
  3. pmc Angioedema
    Allen P Kaplan
    From the National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC
    World Allergy Organ J 1:103-13. 2008
    ..Angioedema that is likely to be life threatening (laryngeal edema or tongue/pharyngeal edema that obstructs the airway) is seen in anaphylactic/anaphylactoid reactions and the disorders mediated by bradykinin...
  4. doi request reprint Biologic agents in the treatment of urticaria
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, 29425, USA
    Curr Allergy Asthma Rep 12:288-91. 2012
    ....
  5. ncbi request reprint C1 inhibitor deficiency: hereditary and acquired forms
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425, USA
    J Investig Allergol Clin Immunol 11:211-9. 2001
    ..Treatment employs androgenic compounds, antifibrinolytic agents, or replacement therapy...
  6. doi request reprint Pathogenesis of chronic urticaria
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA
    Clin Exp Allergy 39:777-87. 2009
    ....
  7. doi request reprint Treatment of chronic autoimmune urticaria with omalizumab
    Allen P Kaplan
    National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
    J Allergy Clin Immunol 122:569-73. 2008
    ..If this occurs in CAU, cross-linking of IgE receptors by autoantibody would be less likely, reducing cell activation and urticaria/angioedema...
  8. ncbi request reprint Chronic urticaria--new concepts regarding pathogenesis and treatment
    Allen P Kaplan
    Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston 29425, USA
    Curr Allergy Asthma Rep 2:263-4. 2002
  9. ncbi request reprint Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled study
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 94:662-9. 2005
    ..Chronic idiopathic urticaria (CIU) can have a profound effect on patients' health and quality of life...
  10. pmc A new mechanism for immunologic initiation of asthma
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 102:1267-8. 2005
  11. ncbi request reprint Chronic urticaria: pathogenesis and treatment
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 92425, USA
    J Allergy Clin Immunol 114:465-74; quiz 475. 2004
    ..Cyclosporine can be steroid-sparing when side effects are encountered or when use of steroids is relatively contraindicated. Careful monitoring of blood pressure, BUN, creatinine, and urinalysis is required...
  12. doi request reprint Kinins, airway obstruction, and anaphylaxis
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Chem Immunol Allergy 95:67-84. 2010
    ..The hypotension associated with IgE-dependent anaphylaxis maybe mediated, in part, by massive proteolytic digestion of HK by kallikreins (tissue or plasma-derived) or other cell-derived kininogenases...
  13. doi request reprint The plasma bradykinin-forming pathways and its interrelationships with complement
    Allen P Kaplan
    Medical University of South Carolina, Department of Medicine, 96 Jonathan Lucas Street, Charleston, SC 29425, United States
    Mol Immunol 47:2161-9. 2010
    ....
  14. ncbi request reprint Clinical practice. Chronic urticaria and angioedema
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 346:175-9. 2002
  15. doi request reprint Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapy
    Allen P Kaplan
    Medical University of South Carolina, Charleston, SC, USA
    J Allergy Clin Immunol 126:918-25. 2010
    ..New therapies for HAE focus on the bradykinin-forming cascade and include a kallikrein inhibitor and a bradykinin B-2 receptor antagonist in addition to administration of purified C1INH...
  16. doi request reprint The bradykinin-forming cascade and its role in hereditary angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann Allergy Asthma Immunol 104:193-204. 2010
    ..To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells...
  17. ncbi request reprint Chemokines, chemokine receptors and allergy
    A P Kaplan
    Division of Pulmonary Diseases and Central Case Medicine and Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston 29425 2220, USA
    Int Arch Allergy Immunol 124:423-31. 2001
    ....
  18. ncbi request reprint Activation of the plasma kinin forming cascade along cell surfaces
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and the Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
    Int Arch Allergy Immunol 124:339-42. 2001
    ..Thus factor XII is critical for activation to proceed. Augmentation of these reactions may occur when C1 inhibitor is functionally deficient or with ACE inhibitors which also inhibit kininases...
  19. ncbi request reprint Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1
    K Joseph
    Department of Medicine and Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
    Thromb Haemost 85:119-24. 2001
    ..Thus, gC1qR and cytokeratin 1, represent potential initiating surfaces for activation of the plasma kinin-forming cascade and may do so as a result of their expression along cell surfaces...
  20. pmc Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R)
    K Joseph
    Department of Medicine, State University of New York, Stony Brook 11794 8161, USA
    Proc Natl Acad Sci U S A 93:8552-7. 1996
    ..Taken together, the data suggest that HK (and factor XII) bind to HUVECs via a 33-kDa cell surface glycoprotein that appears to be identical to gC1q-R but interact with a site on gC1q-R distinct from that which binds C1q...
  21. ncbi request reprint Mechanisms of autoimmune activation of basophils in chronic urticaria
    Y Kikuchi
    Department of Medicine, Division of Pulmonary and Critical Care, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    J Allergy Clin Immunol 107:1056-62. 2001
    ..This IgG activates basophils, which is dependent on or augmented by complement. Binding assays for the FcepsilonRI alpha subunit, such as immunoblotting, are not currently feasible as a screening method. A functional assay is required...
  22. ncbi request reprint Assessment of the role of heparan sulfate in high molecular weight kininogen binding to human umbilical vein endothelial cells
    L P Fernando
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Thromb Haemost 1:2444-9. 2003
    ..All of these data indicate that heparan sulfate does not contribute significantly to HK binding to HUVEC...
  23. ncbi request reprint Activation of the kinin-forming cascade on the surface of endothelial cells
    K Joseph
    Department of Medicine, and the Konishi-MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
    Biol Chem 382:71-5. 2001
    ..Our data support both factor XII-dependent (rapid) and factor XII-independent (slow) mechanisms; the latter may require a cell-derived protease to activate prekallikrein and the presence of zinc ions and HK...
  24. ncbi request reprint Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria
    A M Marsland
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and the Clinical Immunology and the Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Exp Allergy 35:554-9. 2005
    ....
  25. ncbi request reprint Immediate pressure urticaria
    S P Commins
    Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, USA
    Allergy 57:56-7. 2002
  26. doi request reprint Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 101:279-86. 2008
    ..Factor XII-dependent bradykinin formation is thought to be responsible for the swelling associated with the various forms of C1 inhibitor deficiency, and complement activation is augmented during attacks of swelling...
  27. ncbi request reprint TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction
    Sun Ying
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
    J Allergy Clin Immunol 109:694-700. 2002
    ....
  28. ncbi request reprint High molecular weight kininogen and factor XII binding to endothelial cells and astrocytes
    Lawrence P Fernando
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, P O Box 250623, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Thromb Haemost 90:787-95. 2003
    ....
  29. ncbi request reprint Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria
    Sridharan Soundararajan
    Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    J Allergy Clin Immunol 115:815-21. 2005
    ..We considered the possibility that pathogenic antibody may be present within particular IgG subclasses, which might facilitate development of a binding method that can reliably screen patients...
  30. ncbi request reprint A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria
    Yoko Kikuchi
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston 29425, USA
    J Allergy Clin Immunol 109:114-8. 2002
    ..Histamine release in chronic urticaria is initiated by cross-linking of the alpha subunit of FcepsilonRI by means of IgG antibody, followed by complement activation...
  31. pmc Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII
    Kusumam Joseph
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi Medical University of South Carolina, Institute for Inflammation Research, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 99:896-900. 2002
    ....
  32. ncbi request reprint Surfactant protein A and D in human sinus mucosa: a preliminary report
    Bradford A Woodworth
    Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    ORL J Otorhinolaryngol Relat Spec 69:57-60. 2007
    ..The objective of this study was to test our hypothesis that SP-A and SP-D are present in the human sinus...
  33. ncbi request reprint Basophil secretion in chronic urticaria: autoantibody-dependent or not?
    Allen P Kaplan
    J Allergy Clin Immunol 120:729-30. 2007
  34. ncbi request reprint Secretion of cytokines, histamine and leukotrienes in chronic urticaria
    Marta Ferrer
    Department of Allergy and Clinical Immunology, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Int Arch Allergy Immunol 129:254-60. 2002
    ..Finally we assessed cytokine expression at the single-cell level and characterized the T cell subpopulations involved in their production. We chose IL-4 as representative of Th2 lymphocytes and IFN-gamma for Th1 lymphocytes...
  35. ncbi request reprint Interaction of high molecular weight kininogen binding proteins on endothelial cells
    Kusumam Joseph
    Medical University of South Carolina, Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, P O Box 250623, Charleston, South Carolina 29425, USA
    Thromb Haemost 91:61-70. 2004
    ..Our data suggest that formation of HK (and Factor XII) binding sites along endothelial cell membranes consists of bimolecular com-plexes of gC1qR-cytokeratin 1 and u-PAR-cytokeratin 1, with gC1qR binding being favored...
  36. ncbi request reprint Antithyroid antibodies in chronic urticaria and angioedema
    Yoko Kikuchi
    J Allergy Clin Immunol 112:218. 2003
  37. ncbi request reprint Inhibition of contact activation by a kininogen peptide (HKH20) derived from domain 5
    Yoshitaka Nakazawa
    Konishi MUSC Institute for Inflammation Research, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1875-85. 2002
    ....
  38. ncbi request reprint Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90
    Kusumam Joseph
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi MUSC, Institute for Inflammation Research, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1851-9. 2002
    ....
  39. ncbi request reprint Pathways for bradykinin formation and inflammatory disease
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, 29425, USA
    J Allergy Clin Immunol 109:195-209. 2002
    ..Activation of the plasma cascade occurs as a result of heparin release and endothelial-cell activation and as a secondary event caused by other pathways of inflammation...
  40. ncbi request reprint Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps
    Bradford A Woodworth
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Otolaryngol Head Neck Surg 131:585-9. 2004
    ..To determine alterations in Th2 chemokines eotaxin and monocyte chemoattractant protein-4 (MCP-4), and cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13), in nasal polyps (NP) after steroid treatment...
  41. ncbi request reprint Formation of bradykinin: a major contributor to the innate inflammatory response
    Kusumam Joseph
    Division of Pulmonary Critical Care Medicine and Allergy Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Adv Immunol 86:159-208. 2005
    ....
  42. ncbi request reprint The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats
    Hui Ping Li
    Department of Respiratory Diseases, Shanghai Pulmonary Hospital, Shanghai, China
    Respirology 9:25-32. 2004
    ..The aim of this study was to investigate the inhibitory effect of dexamethasone on the state of proliferation/apoptosis of the pulmonary inflammatory cells in a rat pulmonary fibrosis model induced by bleomycin...
  43. ncbi request reprint A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ophthalmic solution with loratadine 10 mg and their combination in the human conjunctival allergen challenge model
    Mark B Abelson
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 24:445-56. 2002
    ..When selecting treatment for allergic conjunctivitis, a primary concern is whether to choose local or systemic therapy...
  44. ncbi request reprint Angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    J Am Acad Dermatol 53:373-88; quiz 389-92. 2005
    ..It can also occur as a consequence of specific anti-C'1 esterase autoantibodies in some patients. We have reviewed the clinical features, diagnosis, and management of these different subtypes of angioedema...