Research Topics
| A KaplanSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Assembly, activation, and signaling by kinin-forming proteins on human vascular smooth muscle cellsAnthony N Fernando
Divisions of Pulmonary and Critical Care, Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, 29425, USA
Am J Physiol Heart Circ Physiol 289:H251-7. 2005..This early mitogenic signal, which is also implicated in atherogenesis, may change the metabolic and proliferative activity of VSMC, which are key steps in the progression of atherosclerosis...
Pathogenesis and treatment of chronic urticariaA P Kaplan
Medical University of South Carolina, Charleston, SC 29423, USA
Postgrad Med 106:12-7. 1999..Corticosteroids given on alternate days are efficacious and have few adverse effects if they are given in a slow, tapering course...- Biologic agents in the treatment of urticariaAllen P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, 29425, USA
Curr Allergy Asthma Rep 12:288-91. 2012.... - C1 inhibitor deficiency: hereditary and acquired formsA P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425, USA
J Investig Allergol Clin Immunol 11:211-9. 2001..Treatment employs androgenic compounds, antifibrinolytic agents, or replacement therapy... - Chronic urticaria: pathogenesis and treatmentAllen P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 92425, USA
J Allergy Clin Immunol 114:465-74; quiz 475. 2004..Cyclosporine can be steroid-sparing when side effects are encountered or when use of steroids is relatively contraindicated. Careful monitoring of blood pressure, BUN, creatinine, and urinalysis is required... 
A new mechanism for immunologic initiation of asthmaAllen P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 102:1267-8. 2005- Chronic urticaria--new concepts regarding pathogenesis and treatmentAllen P Kaplan
Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston 29425, USA
Curr Allergy Asthma Rep 2:263-4. 2002 - Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled studyAllen P Kaplan
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Allergy Asthma Immunol 94:662-9. 2005..Chronic idiopathic urticaria (CIU) can have a profound effect on patients' health and quality of life... - Treatment of chronic autoimmune urticaria with omalizumabAllen P Kaplan
National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
J Allergy Clin Immunol 122:569-73. 2008..If this occurs in CAU, cross-linking of IgE receptors by autoantibody would be less likely, reducing cell activation and urticaria/angioedema... - Pathogenesis of chronic urticariaA P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA
Clin Exp Allergy 39:777-87. 2009.... - The bradykinin-forming cascade and its role in hereditary angioedemaAllen P Kaplan
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Ann Allergy Asthma Immunol 104:193-204. 2010..To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells... - Kinins, airway obstruction, and anaphylaxisAllen P Kaplan
Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
Chem Immunol Allergy 95:67-84. 2010..The hypotension associated with IgE-dependent anaphylaxis maybe mediated, in part, by massive proteolytic digestion of HK by kallikreins (tissue or plasma-derived) or other cell-derived kininogenases... - Clinical practice. Chronic urticaria and angioedemaAllen P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston 29425, USA
N Engl J Med 346:175-9. 2002 - The plasma bradykinin-forming pathways and its interrelationships with complementAllen P Kaplan
Medical University of South Carolina, Department of Medicine, 96 Jonathan Lucas Street, Charleston, SC 29425, United States
Mol Immunol 47:2161-9. 2010.... - Chemokines, chemokine receptors and allergyA P Kaplan
Division of Pulmonary Diseases and Central Case Medicine and Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston 29425 2220, USA
Int Arch Allergy Immunol 124:423-31. 2001.... - Activation of the plasma kinin forming cascade along cell surfacesA P Kaplan
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and the Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
Int Arch Allergy Immunol 124:339-42. 2001..Thus factor XII is critical for activation to proceed. Augmentation of these reactions may occur when C1 inhibitor is functionally deficient or with ACE inhibitors which also inhibit kininases... - Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapyAllen P Kaplan
Medical University of South Carolina, Charleston, SC, USA
J Allergy Clin Immunol 126:918-25. 2010..New therapies for HAE focus on the bradykinin-forming cascade and include a kallikrein inhibitor and a bradykinin B-2 receptor antagonist in addition to administration of purified C1INH... - Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1K Joseph
Department of Medicine and Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
Thromb Haemost 85:119-24. 2001..Thus, gC1qR and cytokeratin 1, represent potential initiating surfaces for activation of the plasma kinin-forming cascade and may do so as a result of their expression along cell surfaces... - Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R)K Joseph
Department of Medicine, State University of New York, Stony Brook 11794 8161, USA
Proc Natl Acad Sci U S A 93:8552-7. 1996..Taken together, the data suggest that HK (and factor XII) bind to HUVECs via a 33-kDa cell surface glycoprotein that appears to be identical to gC1q-R but interact with a site on gC1q-R distinct from that which binds C1q... - Mechanisms of autoimmune activation of basophils in chronic urticariaY Kikuchi
Department of Medicine, Division of Pulmonary and Critical Care, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
J Allergy Clin Immunol 107:1056-62. 2001..This IgG activates basophils, which is dependent on or augmented by complement. Binding assays for the FcepsilonRI alpha subunit, such as immunoblotting, are not currently feasible as a screening method. A functional assay is required... - Assessment of the role of heparan sulfate in high molecular weight kininogen binding to human umbilical vein endothelial cellsL P Fernando
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Thromb Haemost 1:2444-9. 2003..All of these data indicate that heparan sulfate does not contribute significantly to HK binding to HUVEC... - Activation of the kinin-forming cascade on the surface of endothelial cellsK Joseph
Department of Medicine, and the Konishi-MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston 29425, USA
Biol Chem 382:71-5. 2001..Our data support both factor XII-dependent (rapid) and factor XII-independent (slow) mechanisms; the latter may require a cell-derived protease to activate prekallikrein and the presence of zinc ions and HK... - Effects of calcineurin inhibitors on an in vitro assay for chronic urticariaA M Marsland
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and the Clinical Immunology and the Konishi-MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, SC 29425, USA
Clin Exp Allergy 35:554-9. 2005..These drugs may work by interfering with intracellular signalling in cells following cross-linking of the IgE receptor, but not following stimulation of the C5a receptor... - Immediate pressure urticariaS P Commins
Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, USA
Allergy 57:56-7. 2002 - Interaction of high molecular weight kininogen binding proteins on endothelial cellsKusumam Joseph
Medical University of South Carolina, Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, P O Box 250623, Charleston, South Carolina 29425, USA
Thromb Haemost 91:61-70. 2004..Our data suggest that formation of HK (and Factor XII) binding sites along endothelial cell membranes consists of bimolecular com-plexes of gC1qR-cytokeratin 1 and u-PAR-cytokeratin 1, with gC1qR binding being favored... - A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticariaYoko Kikuchi
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston 29425, USA
J Allergy Clin Immunol 109:114-8. 2002..C5a is the complement agonist that is responsible for the augmented histamine release... - Studies of the mechanisms of bradykinin generation in hereditary angioedema plasmaKusumam Joseph
Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Allergy Asthma Immunol 101:279-86. 2008..Factor XII-dependent bradykinin formation is thought to be responsible for the swelling associated with the various forms of C1 inhibitor deficiency, and complement activation is augmented during attacks of swelling... - TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reactionSun Ying
Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
J Allergy Clin Immunol 109:694-700. 2002..CONCLUSION: The molecular immunopathology of CIU is that of an eosinophil and basophil cell-mediated hypersensitivity reaction. Thus it is similar to the allergic skin LPR but has a T(H)0 rather than a T(H)2 cytokine profile... - Basophil secretion in chronic urticaria: autoantibody-dependent or not?Allen P Kaplan
J Allergy Clin Immunol 120:729-30. 2007 - Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XIIKusumam Joseph
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi Medical University of South Carolina, Institute for Inflammation Research, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 99:896-900. 2002.... - Antithyroid antibodies in chronic urticaria and angioedemaYoko Kikuchi
J Allergy Clin Immunol 112:218. 2003 - High molecular weight kininogen and factor XII binding to endothelial cells and astrocytesLawrence P Fernando
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, P O Box 250623, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Thromb Haemost 90:787-95. 2003.... - Inhibition of contact activation by a kininogen peptide (HKH20) derived from domain 5Yoshitaka Nakazawa
Konishi-MUSC Institute for Inflammation Research, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
Int Immunopharmacol 2:1875-85. 2002.... - Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90Kusumam Joseph
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi-MUSC, Institute for Inflammation Research, 96 Jonathan Lucas Street, P.O. Box 250623, Charleston, SC 29425, USA
Int Immunopharmacol 2:1851-9. 2002.... - Surfactant protein A and D in human sinus mucosa: a preliminary reportBradford A Woodworth
Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
ORL J Otorhinolaryngol Relat Spec 69:57-60. 2007..The objective of this study was to test our hypothesis that SP-A and SP-D are present in the human sinus... - Secretion of cytokines, histamine and leukotrienes in chronic urticariaMarta Ferrer
Department of Allergy and Clinical Immunology, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Int Arch Allergy Immunol 129:254-60. 2002..Finally we assessed cytokine expression at the single-cell level and characterized the T cell subpopulations involved in their production. We chose IL-4 as representative of Th2 lymphocytes and IFN-gamma for Th1 lymphocytes... - Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticariaSridharan Soundararajan
Department of Medicine, Division of Pulmonary/Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
J Allergy Clin Immunol 115:815-21. 2005.... - Formation of bradykinin: a major contributor to the innate inflammatory responseKusumam Joseph
Division of Pulmonary/Critical Care Medicine and Allergy/Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Adv Immunol 86:159-208. 2005.... - Pathways for bradykinin formation and inflammatory diseaseAllen P Kaplan
Department of Medicine, Medical University of South Carolina, 29425, USA
J Allergy Clin Immunol 109:195-209. 2002..Activation of the plasma cascade occurs as a result of heparin release and endothelial-cell activation and as a secondary event caused by other pathways of inflammation... - The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in ratsHui Ping Li
Department of Respiratory Diseases, Shanghai Pulmonary Hospital, Shanghai, China
Respirology 9:25-32. 2004..The aim of this study was to investigate the inhibitory effect of dexamethasone on the state of proliferation/apoptosis of the pulmonary inflammatory cells in a rat pulmonary fibrosis model induced by bleomycin... - A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ophthalmic solution with loratadine 10 mg and their combination in the human conjunctival allergen challenge modelMark B Abelson
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Ther 24:445-56. 2002..05). CONCLUSION: In this study, emedastine was more efficacious than loratadine for reducing the itching and redness associated with allergic conjunctivitis in the human conjunctival allergen challenge model... - AngioedemaAllen P Kaplan
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
J Am Acad Dermatol 53:373-88; quiz 389-92. 2005.... - Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polypsBradford A Woodworth
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
Otolaryngol Head Neck Surg 131:585-9. 2004..SIGNIFICANCE: Novel approaches to block inflammatory mediators, particularly Th2 chemokines, may lead to better control of nasal polyposis in the future...