Peter Kalivas

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi How do we determine which drug-induced neuroplastic changes are important?
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Neurosci 8:1440-1. 2005
  2. ncbi Is cocaine desire reduced by N-acetylcysteine?
    Steven D LaRowe
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 164:1115-7. 2007
  3. ncbi NAC1 regulates the recruitment of the proteasome complex into dendritic spines
    Haowei Shen
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 27:8903-13. 2007
  4. pmc N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking
    Wenhua Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 63:338-40. 2008
  5. ncbi Drug addiction as a pathology of staged neuroplasticity
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 33:166-80. 2008
  6. pmc Extracellular glutamate: functional compartments operate in different concentration ranges
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina Charleston, SC, USA
    Front Syst Neurosci 5:94. 2011
  7. pmc Optogenetic inhibition of cocaine seeking in rats
    Michael T Stefanik
    Department of Neurosciences, Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 18:50-3. 2013
  8. ncbi Glutamate systems in cocaine addiction
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29465, USA
    Curr Opin Pharmacol 4:23-9. 2004
  9. ncbi Recent understanding in the mechanisms of addiction
    Peter W Kalivas
    Department of Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29464, USA
    Curr Psychiatry Rep 6:347-51. 2004
  10. ncbi Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29465, USA
    Neurotox Res 6:385-7. 2004

Research Grants

  1. Cocaine, Opoids and Drug Abuse
    Peter W Kalivas; Fiscal Year: 2010
  2. Neurobiology of Addiction Research Center (NARC)
    Peter Kalivas; Fiscal Year: 2007
  3. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 2003
  4. GLUTAMATE AND CRAVING FOR COCAINE
    Peter Kalivas; Fiscal Year: 2004
  5. Stress-induced reinstatement of cocaine-seeking behavior
    Peter Kalivas; Fiscal Year: 2007
  6. COCAINE, OPIOIDS AND DRUG ABUSE
    Peter Kalivas; Fiscal Year: 2007
  7. GLUTAMATE AND CRAVING FOR COCAINE
    Peter Kalivas; Fiscal Year: 2009
  8. GLUTAMATE AND CRAVING FOR COCAINE
    Peter W Kalivas; Fiscal Year: 2010
  9. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 1999

Detail Information

Publications90

  1. ncbi How do we determine which drug-induced neuroplastic changes are important?
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Neurosci 8:1440-1. 2005
    ..Identifying changes that are specific to particular elements of the transition from initial to habitual to relapsing drug use may be a fruitful strategy for pinpointing which forms of drug-induced plasticity are critical for addiction...
  2. ncbi Is cocaine desire reduced by N-acetylcysteine?
    Steven D LaRowe
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 164:1115-7. 2007
    ..Animal models suggest that N-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans...
  3. ncbi NAC1 regulates the recruitment of the proteasome complex into dendritic spines
    Haowei Shen
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 27:8903-13. 2007
    ..These experiments show that NAC1 modulates the translocation of the UPS from the nucleus into dendritic spines, thereby suggesting a potential missing link in the recruitment of necessary proteolysis machinery for synaptic remodeling...
  4. pmc N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking
    Wenhua Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 63:338-40. 2008
    ..Previous studies show that the acute administration of N-acetylcysteine (NAC) inhibits the desire for cocaine in addicts and cocaine-seeking in animals...
  5. ncbi Drug addiction as a pathology of staged neuroplasticity
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 33:166-80. 2008
    ....
  6. pmc Extracellular glutamate: functional compartments operate in different concentration ranges
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina Charleston, SC, USA
    Front Syst Neurosci 5:94. 2011
    ....
  7. pmc Optogenetic inhibition of cocaine seeking in rats
    Michael T Stefanik
    Department of Neurosciences, Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 18:50-3. 2013
    ..Bilateral optical inhibition of the PL, NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking...
  8. ncbi Glutamate systems in cocaine addiction
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29465, USA
    Curr Opin Pharmacol 4:23-9. 2004
    ..Recent studies have particularly focused on involvement of a circuit that includes glutamate projections from the prefrontal cortex to the nucleus accumbens...
  9. ncbi Recent understanding in the mechanisms of addiction
    Peter W Kalivas
    Department of Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29464, USA
    Curr Psychiatry Rep 6:347-51. 2004
    ..This review describes the brain adaptations produced in excitatory transmission by addictive drugs and identifies new potential sites of pharmacotherapeutic intervention to ameliorate addiction...
  10. ncbi Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29465, USA
    Neurotox Res 6:385-7. 2004
    ....
  11. ncbi Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
    P W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29465, USA
    Neuron 45:647-50. 2005
    ..A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs...
  12. ncbi The neural basis of addiction: a pathology of motivation and choice
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    Am J Psychiatry 162:1403-13. 2005
    ....
  13. ncbi Exciting inhibition in psychostimulant addiction
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Trends Neurosci 29:610-6. 2006
    ....
  14. ncbi Animal models and brain circuits in drug addiction
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29464, USA
    Mol Interv 6:339-44. 2006
    ....
  15. ncbi Neurobiology of cocaine addiction: implications for new pharmacotherapy
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina Charleston, South Carolina 29425, USA
    Am J Addict 16:71-8. 2007
    ....
  16. pmc Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Dialogues Clin Neurosci 9:389-97. 2007
    ....
  17. pmc Glutamate transmission in addiction
    Peter W Kalivas
    Department of Neurosciences, 173 Ashley Ave, BSB410, Medical University of South Carolina, Charleston, SC 29464, USA
    Neuropharmacology 56:169-73. 2009
    ..This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction...
  18. doi Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neurotox Res 14:185-9. 2008
    ..These findings will be described and integrated relative to modeling the transition from regulated relapse (social use) to compulsive (addicted) relapse...
  19. doi The glutamate homeostasis hypothesis of addiction
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Rev Neurosci 10:561-72. 2009
    ..Some of these pathological changes are amenable to new glutamate- and neuroplasticity-based pharmacotherapies for treating addiction...
  20. pmc New medications for drug addiction hiding in glutamatergic neuroplasticity
    P W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston National Institute on Drug Abuse, Charleston, SC 29425, USA
    Mol Psychiatry 16:974-86. 2011
    ....
  21. ncbi Glutamate transmission and addiction to cocaine
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29464, USA
    Ann N Y Acad Sci 1003:169-75. 2003
    ..These adaptations are hypothesized to facilitate glutamate release in response to a cocaine injection or acute stress and lead to the reinstatement of drug-seeking behavior...
  22. ncbi Involvement of pallidothalamic circuitry in working memory
    P W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29464, USA
    Neuroscience 104:129-36. 2001
    ..Moreover, it is hypothesized that mu receptors in the ventral pallidum gate the recruitment of working memory into ongoing behavioral activity...
  23. ncbi Neural systems for behavioral activation and reward
    P W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, 167 Ashley Avenue Suite 607, 250677, Charleston, South Carolina 29425, USA
    Curr Opin Neurobiol 9:223-7. 1999
    ....
  24. ncbi Interrupted expression of NAC-1 augments the behavioral responses to cocaine
    P W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Synapse 33:153-9. 1999
    ..These data suggest that the induction of NAC-1 by cocaine may be a compensatory mechanism that minimizes the behavioral impact of cocaine administration by regulating postsynaptic dopamine transmission within the nucleus accumbens...
  25. ncbi Brain circuitry and the reinstatement of cocaine-seeking behavior
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29464, USA
    Psychopharmacology (Berl) 168:44-56. 2003
    ..Identification of neuronal substrates will provide a logical rationale for designing pharmacological interventions in treating drug relapse...
  26. ncbi Involvement of the pallidal-thalamocortical circuit in adaptive behavior
    P W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston 29425, USA
    Ann N Y Acad Sci 877:64-70. 1999
    ..In the present report we show that this connection is critical in the expression of motor behavior elicited by opioids and the capacity of a rat to perform in a task requiring spatial working memory...
  27. pmc N-Acetylcysteine reverses cocaine-induced metaplasticity
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue BSB410, Charleston, South Carolina, USA
    Nat Neurosci 12:182-9. 2009
    ..Our findings show that cocaine self-administration induces metaplasticity that inhibits further induction of synaptic plasticity, and this impairment can be reversed by NAC, a drug that also prevents relapse...
  28. ncbi Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity
    M Behnam Ghasemzadeh
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB 403 Charleston, SC 29425, USA
    Eur J Neurosci 18:1645-51. 2003
    ..These data indicate that the expression of behavioural sensitization arises in part from a reduction in Homer1 gene products in the accumbens, while the development of sensitization requires stimulation of AMPA/kainate receptors...
  29. ncbi Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Neurosci 6:743-9. 2003
    ..Thus, withdrawal from repeated cocaine increases susceptibility to relapse in part by reducing cystine/glutamate exchange, and restoring exchanger activity prevents cocaine-primed drug seeking...
  30. pmc The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA
    Mary M Torregrossa
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neurosci Lett 438:142-5. 2008
    ....
  31. ncbi GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
    ..The increase may be mediated in part by functional desensitization of GABA(B) receptors, likely the result of diminished Ser phosphorylation of the GABA(B2) receptor...
  32. ncbi Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice
    Karen K Szumlinski
    Department of Physiology and Neuroscience and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:468-71. 2003
  33. ncbi Homer isoforms differentially regulate cocaine-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 31:768-77. 2006
    ..Together, these data indicate that the enduring reduction of long Homer isoforms in the nucleus accumbens of cocaine-withdrawn rats is necessary for the expression of cocaine-induced neuroplasticity...
  34. pmc Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    Megan M Moran
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:6389-93. 2005
    ..These data demonstrate that nonsynaptic glutamate derived from xc- modulates synaptic glutamate release and thereby regulates cocaine-induced drug seeking...
  35. pmc Altered dendritic spine plasticity in cocaine-withdrawn rats
    Hao wei Shen
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 29:2876-84. 2009
    ..These data indicate that daily cocaine pretreatment dysregulates dendritic spine plasticity elicited by a subsequent cocaine injection...
  36. ncbi Homer2 is necessary for EtOH-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:7054-61. 2005
    ..These data demonstrate a necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticity...
  37. ncbi Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum
    Xing Chun Tang
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:4512-20. 2005
    ....
  38. doi Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking
    Angelica Rocha
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB410SC, Charleston, SC 29425, USA
    Eur J Neurosci 31:903-9. 2010
    ....
  39. pmc The role of cystine-glutamate exchange in nicotine dependence in rats and humans
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 65:841-5. 2009
    ....
  40. ncbi Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function
    Kevin D Lominac
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:11586-94. 2005
    ....
  41. ncbi Cocaine increases actin cycling: effects in the reinstatement model of drug seeking
    Shigenobu Toda
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29464, USA
    J Neurosci 26:1579-87. 2006
    ..Thus, withdrawal from repeated cocaine induces a restructuring of actin-ABP complexes, which increases actin cycling and may modulate cocaine-induced reinstatement of drug seeking...
  42. ncbi Long-term neuroadaptations produced by withdrawal from repeated cocaine treatment: role of dopaminergic receptors in modulating cortical excitability
    Lourdes Nogueira
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:12308-13. 2006
    ....
  43. pmc A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens
    William J Berglind
    Department of Neurosciences and Neurobiology of Addiction Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 29:3715-9. 2009
    ..These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc...
  44. ncbi Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    J Neurochem 87:1204-12. 2003
    ..Together, these data indicate that group III mGluRs regulate in vivo extracellular glutamate in the nucleus accumbens by inhibiting non-vesicular glutamate release...
  45. ncbi Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29464, USA
    J Pharmacol Exp Ther 303:608-15. 2002
    ..Together, these data demonstrate that repeated cocaine produces an enduring reduction in mGluR2/3 function in the nucleus accumbens...
  46. pmc Microdialysis and the neurochemistry of addiction
    Mary M Torregrossa
    Medical University of South Carolina, Suite 403 Basic Science Building, 173 Ashley Avenue, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 90:261-72. 2008
    ....
  47. ncbi Opposing roles for the ventral prefrontal cortex and the basolateral amygdala on the spontaneous recovery of cocaine-seeking in rats
    Jamie Peters
    Department of Neurosciences, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 197:319-26. 2008
    ..Spontaneous recovery of cocaine-seeking, a model, which incorporates both extinction and abstinence, depends on an unknown neural circuit...
  48. pmc Using glutamate homeostasis as a target for treating addictive disorders
    Kathryn J Reissner
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Behav Pharmacol 21:514-22. 2010
    ....
  49. ncbi N-acetyl cysteine-induced blockade of cocaine-induced reinstatement
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:349-51. 2003
  50. ncbi Nucleus accumbens Homer proteins regulate behavioral sensitization to cocaine
    M Behnam Ghasemzadeh
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:395-7. 2003
  51. pmc Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking
    M Scott Bowers
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuron 42:269-81. 2004
    ..When antisense oligonucleotide infusion was discontinued, drug seeking and sensitization were restored. It is proposed that AGS3 gates the expression of cocaine-induced plasticity by regulating G protein signaling in the PFC...
  52. doi Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbens
    Haowei Shen
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Brain Struct Funct 213:149-57. 2008
    ..The capacity to rapidly assess spine density and spine head diameter will facilitate quantifying spine plasticity induced by pharmacological and environmental manipulations...
  53. pmc Integrin expression is altered after acute and chronic cocaine
    Armina t Wiggins
    Department of Neuroscience, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Neurosci Lett 450:321-3. 2009
    ..These data demonstrate a bidirectional regulation of beta-integrins by chronic cocaine treatment that may contribute to cocaine-induced changes in actin cycling and dendrite morphology...
  54. pmc Brain norepinephrine rediscovered in addiction research
    Gary Aston-Jones
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Biol Psychiatry 63:1005-6. 2008
  55. ncbi Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone
    Lawrence D Middaugh
    Center for Drug and Alcohol Programs, Alcohol Research Center, Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston 29425, USA
    Alcohol Clin Exp Res 27:1892-900. 2003
    ....
  56. pmc Glutamate and reinstatement
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, United States
    Curr Opin Pharmacol 9:59-64. 2009
    ..The similarities in the neurochemistry behind relapse to these varied drug classes indicate that drugs that target the glutamate system could be effective at treating relapse to multiple types of drugs...
  57. ncbi Bidirectional modulation of cystine/glutamate exchanger activity in cultured cortical astrocytes
    Xing Chun Tang
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:472-5. 2003
  58. pmc Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 30:7984-92. 2010
    ..These data identify a cellular mechanism that may contribute to extinction-induced inhibition of cocaine seeking...
  59. doi Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Pharmacol 639:115-22. 2010
    ....
  60. ncbi Prefrontal group II metabotropic glutamate receptor activation decreases performance on a working memory task
    Mary L Gregory
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina, 29425, USA
    Ann N Y Acad Sci 1003:405-9. 2003
  61. doi Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats
    Joachim D Uys
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Mass Spectrom 45:97-103. 2010
    ..In addition, the distribution of m/z 3653 in the nucleus accumbens was determined by MALDI tissue imaging, and the increased expression of its precursor protein, secretogranin II, was verified by immunoblotting...
  62. pmc Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South, Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 67:81-4. 2010
    ..Another regulator of extracellular glutamate is the glial glutamate transporter GLT-1. We hypothesized that cocaine self-administration reduces GLT-1 and that GLT-1 upregulation inhibits cocaine seeking...
  63. pmc Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion
    Marek Schwendt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 331:555-62. 2009
    ..Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions...
  64. ncbi Metabotropic glutamate receptor regulation of extracellular glutamate levels in the prefrontal cortex
    Roberto I Melendez
    Neuroscience Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:443-4. 2003
  65. ncbi Cystine/glutamate antiporter regulation of vesicular glutamate release
    Megan M Moran
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1003:445-7. 2003
  66. ncbi Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior
    Krista McFarland
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 24:1551-60. 2004
    ..The rise in dopamine within the PFCd initiates reinstatement via a glutamatergic projection to the NAcore...
  67. ncbi An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study
    Pascale N Mardikian
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:389-94. 2007
    ..Overall the findings suggest that it is feasible to treat cocaine-dependent treatment seekers with N-acetylcysteine on an outpatient basis...
  68. pmc The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration
    Ryan T Lalumiere
    Neurobiology of Addiction Research Center, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Learn Mem 17:168-75. 2010
    ....
  69. ncbi Dissociable roles for the dorsal and median raphé in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitization
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:1675-87. 2004
    ..While the DRN is involved in the acute effects of cocaine, neuroadaptations in the MRN may regulate the long-term consequences of repeated cocaine exposure...
  70. ncbi Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Basic Science Building, Suite 403, Medical University of South Carolina, 173 Ashely Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 165:329-36. 2003
    ..Serotonin 5-HT(3) receptor antagonists are proposed to serve as potential anti-addictive and anti-psychotic therapies...
  71. ncbi Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB Suite 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 322:1103-9. 2007
    ..Furthermore, the differences in reinstatement are predicted more by length of cocaine access than by escalation of drug intake...
  72. pmc Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals
    Steven D LaRowe
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 15:105-10. 2006
    ..These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving...
  73. pmc Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats
    Ziad Nahas
    Mood Disorders Program, University of South Carolina, Charleston, SC 29425, USA
    Behav Brain Res 197:41-4. 2009
    ..The availability of anti-ceramidase pro-apoptocic compound (LCL385) provides an opportunity to test in vivo the relation between hippocampal apopotosis and learned helplessness...
  74. ncbi The origin and neuronal function of in vivo nonsynaptic glutamate
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 22:9134-41. 2002
    ..These results suggest that nonvesicular release from the cystine-glutamate antiporter is the primary source of in vivo extracellular glutamate and that this glutamate can modulate both glutamate and dopamine transmission...
  75. ncbi Activity-dependent subcellular localization of NAC1
    Laxman Korutla
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 22:397-403. 2005
    ..These observations indicate a potential non-transcriptional role for NAC1 in the brain...
  76. ncbi Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior
    Krista McFarland
    Department of Physiology ad Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3531-7. 2003
    ..Together, these data demonstrate that activation of a glutamatergic projection from the prefrontal cortex to the nucleus accumbens underlies cocaine-primed reinstatement of drug-seeking behavior...
  77. ncbi Repeated cocaine administration changes the function and subcellular distribution of adenosine A1 receptor in the rat nucleus accumbens
    Shigenobu Toda
    Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 87:1478-84. 2003
    ..These data suggest that the sorting and recycling of A1 receptors is dysregulated in the nucleus accumbens as the consequence of repeated cocaine administration...
  78. ncbi Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors
    Roberto I Melendez
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, Suite 403 BSB, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 314:139-47. 2005
    ..The accumulation of glutamate elicited by mGluR1/5 stimulation does not seem to result from modulating X(AG)-, x(c)-, or synaptic glutamate release...
  79. ncbi Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration
    M Scott Bowers
    Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB Suite 403, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 17:1273-8. 2003
    ..Furthermore, the increase in GFAP may arise from regionally distinct mechanisms, with the NAcore relying more on cell proliferation while the PFC relies on a larger reactive astrocyte population...
  80. ncbi Ethanol exposure decreases glutamate uptake in the nucleus accumbens
    Roberto I Melendez
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Alcohol Clin Exp Res 29:326-33. 2005
    ..An increased level of extracellular glutamate is a key neurochemical feature associated with ethanol exposure and withdrawal...
  81. ncbi Homer proteins regulate sensitivity to cocaine
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuron 43:401-13. 2004
    ..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine...
  82. ncbi The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
    Jamie Peters
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, 29425, USA
    Psychopharmacology (Berl) 186:143-9. 2006
    ..Group II metabotropic glutamate receptor (mGluR2/3) agonists are proposed to serve as potential treatment for addiction...
  83. ncbi Predisposition to addiction: pharmacokinetics, pharmacodynamics, and brain circuitry
    Peter W Kalivas
    Am J Psychiatry 160:1-2. 2003
  84. pmc Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity
    Alejandra M Pacchioni
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403C, Charleston, SC 29425, USA
    Brain Res 1127:26-35. 2007
    ....
  85. ncbi Neuroadaptive changes in NMDAR1 gene expression after extinction of cocaine self-administration
    Jose A Crespo
    Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria, 28040 Madrid, Spain
    Ann N Y Acad Sci 965:78-91. 2002
    ....
  86. ncbi Development of an alcohol deprivation and escalation effect in C57BL/6J mice
    Roberto I Melendez
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:2017-25. 2006
    ..No studies have characterized the ADE in C57BL/6J (B6) mice. The present study examined the effects of length and number of deprivations on the expression of the ADE in B6 mice...
  87. ncbi Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 300:162-71. 2002
    ....
  88. doi Neuroscience: Brain's defence against cocaine
    L Judson Chandler
    Nature 455:743-4. 2008
  89. ncbi Choose to study choice in addiction
    Peter W Kalivas
    Am J Psychiatry 161:193-4. 2004
  90. ncbi Repeated cocaine administration alters the expression of genes in corticolimbic circuitry after a 3-week withdrawal: a DNA macroarray study
    Shigenobu Toda
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston 29425, USA
    J Neurochem 82:1290-9. 2002
    ..These changes of gene expression in corticolimbic circuitry may contribute to the psychostimulant-induced behavioral changes associated with addiction...

Research Grants25

  1. Cocaine, Opoids and Drug Abuse
    Peter W Kalivas; Fiscal Year: 2010
    ..Accordingly, we propose to characterize the ability of daily N-acetylcysteine treatment to produce enduring protection from the reinstatement of cocaine seeking, and associate this protection with restoring neuroplasticity. ..
  2. Neurobiology of Addiction Research Center (NARC)
    Peter Kalivas; Fiscal Year: 2007
    ..The NARC also takes advantage of the rapid growth in basic neuroscience at MUSC, as well as the existing clinical strengths in addiction research to provide a means for actively mentoring faculty and trainees. ..
  3. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 2003
    ..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
  4. GLUTAMATE AND CRAVING FOR COCAINE
    Peter Kalivas; Fiscal Year: 2004
    ..In addition, microdialysis will be employed to estimate changes in glutamate transmission in the nucleus accumbens following cocaine or cue-induced reinstatement. ..
  5. Stress-induced reinstatement of cocaine-seeking behavior
    Peter Kalivas; Fiscal Year: 2007
    ..abstract_text> ..
  6. COCAINE, OPIOIDS AND DRUG ABUSE
    Peter Kalivas; Fiscal Year: 2007
    ..abstract_text> ..
  7. GLUTAMATE AND CRAVING FOR COCAINE
    Peter Kalivas; Fiscal Year: 2009
    ..The overarching goal of the proposal is to identify novel molecular targets for pharmacotherapeutic intervention in cocaine craving and relapse. ..
  8. GLUTAMATE AND CRAVING FOR COCAINE
    Peter W Kalivas; Fiscal Year: 2010
    ....
  9. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 1999
    ....