Bashar Kahaleh

Summary

Affiliation: Medical College of Ohio
Country: USA

Publications

  1. pmc A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
    Betti Giusti
    Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
    Arthritis Res Ther 8:R115. 2006
  2. ncbi request reprint Assessment of vascular involvement
    B Kahaleh
    Division of Rheumatology and Immunology, Medical College of Ohio, USA
    Clin Exp Rheumatol 21:S9-14. 2003
  3. ncbi request reprint Progress in research into systemic sclerosis
    Bashar Kahaleh
    Department of Medicine, Division of Rheumatology, Medical College of Ohio, Toledo, OH 43614, USA
    Lancet 364:561-2. 2004
  4. ncbi request reprint Raynaud phenomenon and the vascular disease in scleroderma
    M Bashar Kahaleh
    Division of Rheumatology, Department of Medicine, Medical College of Ohio, 1321 Glendale Avenue, Toledo, OH 43617, USA
    Curr Opin Rheumatol 16:718-22. 2004
  5. pmc Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA
    Am J Physiol Renal Physiol 296:F1219-26. 2009
  6. pmc Effects of cardiotonic steroids on dermal collagen synthesis and wound healing
    Nasser El-Okdi
    Department of Medicine, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1186, Toledo, OH 43614 2598, USA
    J Appl Physiol (1985) 105:30-6. 2008
  7. doi request reprint Vascular disease in scleroderma: mechanisms of vascular injury
    Bashar Kahaleh
    Division of Rheumatology and Immunology, University of Toledo Medical Center, 3120 Glendale Avenue, Toledo, OH 43617, USA
    Rheum Dis Clin North Am 34:57-71; vi. 2008
  8. ncbi request reprint Outcome measurements in scleroderma: results from a delphi exercise
    Hashim Gazi
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 34:501-9. 2007
  9. ncbi request reprint Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    Youngqing Wang
    Medical University of Ohio, Division of Rheumatology and Immunology, 3120 Glendale Avenue, Toledo, OH 43614, USA
    Arthritis Rheum 54:2271-9. 2006
  10. ncbi request reprint Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma
    Yongqing Wang
    Division of Rheumatology and Immunology, University of Toledo, Toledo, OH, USA
    J Cell Mol Med 17:1291-9. 2013

Collaborators

Detail Information

Publications14

  1. pmc A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
    Betti Giusti
    Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
    Arthritis Res Ther 8:R115. 2006
    ..These observations indicate that microvascular endothelial cells of patients with SSc show abnormalities in a variety of genes that are able to account for defective angiogenesis...
  2. ncbi request reprint Assessment of vascular involvement
    B Kahaleh
    Division of Rheumatology and Immunology, Medical College of Ohio, USA
    Clin Exp Rheumatol 21:S9-14. 2003
    ..The subcommittee also however recognizes that there exists a promising set of vascular variable that still needs further investigation...
  3. ncbi request reprint Progress in research into systemic sclerosis
    Bashar Kahaleh
    Department of Medicine, Division of Rheumatology, Medical College of Ohio, Toledo, OH 43614, USA
    Lancet 364:561-2. 2004
  4. ncbi request reprint Raynaud phenomenon and the vascular disease in scleroderma
    M Bashar Kahaleh
    Division of Rheumatology, Department of Medicine, Medical College of Ohio, 1321 Glendale Avenue, Toledo, OH 43617, USA
    Curr Opin Rheumatol 16:718-22. 2004
    ....
  5. pmc Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA
    Am J Physiol Renal Physiol 296:F1219-26. 2009
    ..Should these findings be confirmed, we speculate that this pathway may represent a therapeutic target for uremic cardiomyopathy as well as other conditions associated with excessive fibrosis...
  6. pmc Effects of cardiotonic steroids on dermal collagen synthesis and wound healing
    Nasser El-Okdi
    Department of Medicine, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1186, Toledo, OH 43614 2598, USA
    J Appl Physiol (1985) 105:30-6. 2008
    ..01). The data suggest that cardiotonic steroids induce increases in collagen synthesis by dermal fibroblasts, as could potentially be exploited to accelerate wound healing...
  7. doi request reprint Vascular disease in scleroderma: mechanisms of vascular injury
    Bashar Kahaleh
    Division of Rheumatology and Immunology, University of Toledo Medical Center, 3120 Glendale Avenue, Toledo, OH 43617, USA
    Rheum Dis Clin North Am 34:57-71; vi. 2008
    ..Current hypotheses in SSc vascular disease suggest a possible chemical or infectious trigger...
  8. ncbi request reprint Outcome measurements in scleroderma: results from a delphi exercise
    Hashim Gazi
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 34:501-9. 2007
    ..To obtain a consensus on the minimal clinically relevant treatment effect in various scleroderma disease outcome measures to be used in future clinical trials...
  9. ncbi request reprint Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    Youngqing Wang
    Medical University of Ohio, Division of Rheumatology and Immunology, 3120 Glendale Avenue, Toledo, OH 43614, USA
    Arthritis Rheum 54:2271-9. 2006
    ..We undertook this study to investigate the possibility that epigenetic mechanisms mediate the emergence and persistence of the altered SSc fibroblast phenotype...
  10. ncbi request reprint Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma
    Yongqing Wang
    Division of Rheumatology and Immunology, University of Toledo, Toledo, OH, USA
    J Cell Mol Med 17:1291-9. 2013
    ..The role of BMPRII underexpression in the pathogenesis of SSc vasculopathy is suggested and should be investigated further. ..
  11. ncbi request reprint Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43614 5809, USA
    Hypertension 49:215-24. 2007
    ..Based on these findings, we propose that MBG directly induces increases in collagen expression by fibroblasts, and we suggest that this may be important in the cardiac fibrosis seen with experimental renal failure...
  12. doi request reprint The microvascular endothelium in scleroderma
    B Kahaleh
    Division of Rheumatology and Immunology, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43617, USA
    Rheumatology (Oxford) 47:v14-5. 2008
    ..Knowledge of the initial trigger of immune activation in SSc may offer an opportunity to develop a multiple step strategy for therapeutic intervention...
  13. pmc Development of a provisional core set of response measures for clinical trials of systemic sclerosis
    D Khanna
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    Ann Rheum Dis 67:703-9. 2008
    ..To develop a provisional core set of response measures for clinical trials of systemic sclerosis (SSc)...
  14. ncbi request reprint Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy
    David J Kennedy
    Department of Medicine, Medical University of Ohio, Toledo, OH 43614 5809, USA
    Hypertension 47:488-95. 2006
    ..These data suggest that the increased concentrations of MBG are important in the cardiac disease and oxidant stress state seen with renal failure...