Research Topics
Genomes and GenesSpecies | Nikki JohnstonSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Detail Information
Publications
Activity/stability of human pepsin: implications for reflux attributed laryngeal diseaseNikki Johnston
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee 53226, USA
Laryngoscope 117:1036-9. 2007..The second objective was to investigate the effect of pH on the activity and stability of human pepsin 3b under conditions that might be found in the human esophagus and larynx...- Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cellsNikki Johnston
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Ann Otol Rhinol Laryngol 118:677-85. 2009..The objective of this study was to determine whether pepsin, at pH 7.4 and thus in nonacidic refluxate, causes cell damage... - Rationale for targeting pepsin in the treatment of reflux diseaseNikki Johnston
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Ann Otol Rhinol Laryngol 119:547-58. 2010.... 
Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cellsNikki Johnston
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Laryngoscope 122:1317-25. 2012..The objective of this study was to test the hypothesis that reflux of pepsin into the laryngopharynx can promote carcinogenesis...- Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal refluxTina L Samuels
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Ann Otol Rhinol Laryngol 117:688-95. 2008..We also investigated the effect of low pH with or without pepsin on mucin messenger RNA levels in vitro... - Evidence of extraesophageal reflux in idiopathic subglottic stenosisJoel H Blumin
Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Laryngoscope 121:1266-73. 2011..It is hypothesized that iSGS is a reflux mediated disease and that evidence of EER exists in affected patients... - Analysis of pepsin in tracheoesophageal puncture sitesJonathan M Bock
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Ann Otol Rhinol Laryngol 119:799-805. 2010..The sites of TEP were evaluated for the presence of pepsin in tissue biopsy specimens and tract secretions to explore this association... - Pepsin as a causal agent of inflammation during nonacidic refluxTina L Samuels
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Otolaryngol Head Neck Surg 141:559-63. 2009..To investigate the contribution of pepsin to inflammation attributed to nonacidic gastric reflux via analysis of inflammatory cytokine and cytokine receptor gene expression in pepsin-treated human hypopharyngeal epithelial cells in vitro... - Pepsin as a marker of extraesophageal refluxTina L Samuels
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
Ann Otol Rhinol Laryngol 119:203-8. 2010..Pepsin assay is a useful tool for correlation of reflux with airway disease and is a reliable diagnostic marker of EER... - Role of extra-esophageal reflux in chronic otitis media with effusionMatthew Crapko
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Laryngoscope 117:1419-23. 2007..The objective of this study was to confirm that children with OME have EER into the middle ear as measured by the presence of pepsin in middle ear effusions (MEE) removed during tympanostomy tube (TT) placement... - Receptor-mediated uptake of pepsin by laryngeal epithelial cellsNikki Johnston
Department of Otolaryngology, Medical College of Wisconsin, Milwaukee 53226, USA
Ann Otol Rhinol Laryngol 116:934-8. 2007..The objective of this study was to use electron microscopy to confirm the initial confocal findings and to determine whether uptake of pepsin by laryngeal epithelial cells is receptor-mediated... - Cell biology of laryngeal epithelial defenses in health and disease: further studiesNikki Johnston
Center for Voice Disorders of Wake Forest University, Department of Otolaryngology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1034, USA
Ann Otol Rhinol Laryngol 112:481-91. 2003..In conclusion, the laryngeal epithelium lacks defenses comparable to those in esophageal epithelium, and these differences may contribute to the increased susceptibility of laryngeal epithelium to reflux-related injury... - Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux diseaseNikki Johnston
Center for Voice and Swallowing Disorders, Dept of Otolaryngology, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157-1034, USA
Ann Otol Rhinol Laryngol 115:47-58. 2006..This altered stress protein response may lead to cellular injury and thus play a role in the development of disease... - Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsinGulnaz A Gill
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, England
Ann Otol Rhinol Laryngol 114:913-21. 2005..The reduced protective response indicated by the reduced expression of CAIII may play an important role in the disruption of the intercellular barrier associated with the down-regulation of E-cadherin... - Sensitive pepsin immunoassay for detection of laryngopharyngeal refluxJohn Knight
Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A
Laryngoscope 115:1473-8. 2005..CONCLUSIONS: Detection of pepsin in throat sputum by immunoassay appears to provide a sensitive, noninvasive method to detect LPR... - Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux diseaseNikki Johnston
Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1034, U S A
Laryngoscope 114:2129-34. 2004..The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA-III) as diagnostic markers for laryngopharyngeal reflux disease... 
The mucosal immune response to laryngopharyngeal refluxLouisa E N Rees
Laryngeal Research Group, University of Bristol, Langford House, Bristol, UK
Am J Respir Crit Care Med 177:1187-93. 2008..To date, there have been no studies of the mucosal immune response to this common inflammatory disease...