Nikki Johnston

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Activity/stability of human pepsin: implications for reflux attributed laryngeal disease
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee 53226, USA
    Laryngoscope 117:1036-9. 2007
  2. ncbi request reprint Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Ann Otol Rhinol Laryngol 118:677-85. 2009
  3. ncbi request reprint Rationale for targeting pepsin in the treatment of reflux disease
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 119:547-58. 2010
  4. doi request reprint Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 122:1317-25. 2012
  5. ncbi request reprint Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 117:688-95. 2008
  6. doi request reprint Evidence of extraesophageal reflux in idiopathic subglottic stenosis
    Joel H Blumin
    Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 121:1266-73. 2011
  7. ncbi request reprint Analysis of pepsin in tracheoesophageal puncture sites
    Jonathan M Bock
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 119:799-805. 2010
  8. doi request reprint Pepsin as a causal agent of inflammation during nonacidic reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Otolaryngol Head Neck Surg 141:559-63. 2009
  9. ncbi request reprint Pepsin as a marker of extraesophageal reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Ann Otol Rhinol Laryngol 119:203-8. 2010
  10. ncbi request reprint Role of extra-esophageal reflux in chronic otitis media with effusion
    Matthew Crapko
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1419-23. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Activity/stability of human pepsin: implications for reflux attributed laryngeal disease
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee 53226, USA
    Laryngoscope 117:1036-9. 2007
    ..The second objective was to investigate the effect of pH on the activity and stability of human pepsin 3b under conditions that might be found in the human esophagus and larynx...
  2. ncbi request reprint Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Ann Otol Rhinol Laryngol 118:677-85. 2009
    ..The objective of this study was to determine whether pepsin, at pH 7.4 and thus in nonacidic refluxate, causes cell damage...
  3. ncbi request reprint Rationale for targeting pepsin in the treatment of reflux disease
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 119:547-58. 2010
    ....
  4. doi request reprint Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells
    Nikki Johnston
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 122:1317-25. 2012
    ..The objective of this study was to test the hypothesis that reflux of pepsin into the laryngopharynx can promote carcinogenesis...
  5. ncbi request reprint Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 117:688-95. 2008
    ..We also investigated the effect of low pH with or without pepsin on mucin messenger RNA levels in vitro...
  6. doi request reprint Evidence of extraesophageal reflux in idiopathic subglottic stenosis
    Joel H Blumin
    Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 121:1266-73. 2011
    ..It is hypothesized that iSGS is a reflux mediated disease and that evidence of EER exists in affected patients...
  7. ncbi request reprint Analysis of pepsin in tracheoesophageal puncture sites
    Jonathan M Bock
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 119:799-805. 2010
    ..The sites of TEP were evaluated for the presence of pepsin in tissue biopsy specimens and tract secretions to explore this association...
  8. doi request reprint Pepsin as a causal agent of inflammation during nonacidic reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Otolaryngol Head Neck Surg 141:559-63. 2009
    ..To investigate the contribution of pepsin to inflammation attributed to nonacidic gastric reflux via analysis of inflammatory cytokine and cytokine receptor gene expression in pepsin-treated human hypopharyngeal epithelial cells in vitro...
  9. ncbi request reprint Pepsin as a marker of extraesophageal reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Ann Otol Rhinol Laryngol 119:203-8. 2010
    ..Pepsin assay is a useful tool for correlation of reflux with airway disease and is a reliable diagnostic marker of EER...
  10. ncbi request reprint Role of extra-esophageal reflux in chronic otitis media with effusion
    Matthew Crapko
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1419-23. 2007
    ..The objective of this study was to confirm that children with OME have EER into the middle ear as measured by the presence of pepsin in middle ear effusions (MEE) removed during tympanostomy tube (TT) placement...
  11. ncbi request reprint Receptor-mediated uptake of pepsin by laryngeal epithelial cells
    Nikki Johnston
    Department of Otolaryngology, Medical College of Wisconsin, Milwaukee 53226, USA
    Ann Otol Rhinol Laryngol 116:934-8. 2007
    ..The objective of this study was to use electron microscopy to confirm the initial confocal findings and to determine whether uptake of pepsin by laryngeal epithelial cells is receptor-mediated...
  12. ncbi request reprint Cell biology of laryngeal epithelial defenses in health and disease: further studies
    Nikki Johnston
    Center for Voice Disorders of Wake Forest University, Department of Otolaryngology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1034, USA
    Ann Otol Rhinol Laryngol 112:481-91. 2003
    ..In conclusion, the laryngeal epithelium lacks defenses comparable to those in esophageal epithelium, and these differences may contribute to the increased susceptibility of laryngeal epithelium to reflux-related injury...
  13. ncbi request reprint Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease
    Nikki Johnston
    Center for Voice and Swallowing Disorders, Dept of Otolaryngology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1034, USA
    Ann Otol Rhinol Laryngol 115:47-58. 2006
    ..The objectives of this study were to define the conditions that give rise to a stress protein response in laryngeal epithelium and to investigate whether and how stress protein dysfunction contributes to reflux-related laryngeal disease...
  14. ncbi request reprint Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin
    Gulnaz A Gill
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, England
    Ann Otol Rhinol Laryngol 114:913-21. 2005
    ....
  15. ncbi request reprint Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux
    John Knight
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Winston Salem, NC 27157, U S A
    Laryngoscope 115:1473-8. 2005
    ....
  16. ncbi request reprint Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease
    Nikki Johnston
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1034, U S A
    Laryngoscope 114:2129-34. 2004
    ..The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA-III) as diagnostic markers for laryngopharyngeal reflux disease...
  17. pmc The mucosal immune response to laryngopharyngeal reflux
    Louisa E N Rees
    Laryngeal Research Group, University of Bristol, Langford House, Bristol, UK
    Am J Respir Crit Care Med 177:1187-93. 2008
    ..To date, there have been no studies of the mucosal immune response to this common inflammatory disease...