Research Topics
Species | Liming JinSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Detail Information
Publications
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aortaLiming Jin
Dept of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
Am J Physiol Heart Circ Physiol 287:H1495-500. 2004..These observations demonstrate that ROS-induced Ca(2+) sensitization is through activation of Rho and a subsequent increase in Rho kinase activity but not Ca(2+)-independent PKC...- Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac arteryCleber E Teixeira
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
Clin Exp Pharmacol Physiol 32:817-24. 2005..The findings of the present study suggest that endogenous nitric oxide-induced relaxation is mediated, in part, by inhibition of RhoA/ROK signalling in this tissue... - Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive ratsLiming Jin
Department of Physiology, Medical College of Georgia, Augusta, GA, USA
J Pharmacol Exp Ther 318:288-95. 2006..Increased NADPH oxidase-dependent reactive oxygen species may be one of the mechanisms mediating the RhoA/Rho-kinase activation... - Cytochrome P450 epoxygenases provide a novel mechanism for penile erectionLiming Jin
Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
FASEB J 20:539-41. 2006..Inhibition of this pathway attenuated erectile function, suggesting that EETs are required for normal erection... - Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cellsZhekang Ying
Department of Physiology, Medical College of Georgia, 1120 Fifteenth St, CA3099, Augusta, GA 30912 3000, USA
Mol Pharmacol 69:932-40. 2006..These observations support the hypothesis that RhoGEFs, particularly LARG, participate in linking GPCR to RhoA activation in vascular smooth muscle... - Ca2+ sensitization and the regulation of contractility in rat anococcygeus and retractor penis muscleCleber E Teixeira
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
Biochem Pharmacol 69:1483-92. 2005..The results indicate that the RhoA/ROK-mediated Ca(2+) sensitization pathway is expressed in anococcygeus and retractor penis muscles and enhances contractions produced by receptor-dependent and independent mechanisms... - Inhibition of the tonic contraction in the treatment of erectile dysfunctionLiming Jin
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
Expert Opin Ther Targets 7:265-76. 2003..Studies have shown that inhibition of the RhoA/Rho-kinase signalling pathway induces penile erection. Further understanding of this RhoA/Rho-kinase pathway may provide a novel alternative treatment for ED... - Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2Amany Tawfik
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Vascul Pharmacol 43:320-6. 2005..In conclusion the activation of JAK2 plays a pivotal role in oxidant stress-induced commitment of ECs to apoptosis, based on studies with HG and H(2)O(2)... - Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literatureDexter L Lee
Department of Physiology, Medical College of Georgia, Augusta 30912-3000, USA
Hypertension 44:796-9. 2004..This brief review will highlight recent studies demonstrating a role for the RhoA/Rho-kinase signaling pathway in the increased vasoconstriction characteristic of hypertension... - Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive ratsZhekang Ying
Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 17:981-5. 2004..The RhoGEF, providing this coupling, contain the regulator of G protein signaling (RGS) domain. We hypothesized higher mRNA expression levels for these RhoGEF in aorta from stroke-prone spontaneously hypertensive rats (SHRSP)... - Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker ratsXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
Am J Physiol Regul Integr Comp Physiol 288:R188-96. 2005.... 
Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysisBiljana Musicki
Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
J Sex Med 5:552-61. 2008..Diet and exercise affect endothelial function in the penis, but the molecular mechanisms underlying their effects are not understood...- FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanismsGwen Lagoda
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N Wolfe Street Marburg 407, Baltimore, MD 21287, USA
J Sex Med 4:908-16. 2007..Immunophilin ligands and phosphodiesterase type 5 (PDE5) inhibitors are touted to promote erectile function recovery after cavernous nerve (CN) injury. However, the mechanisms for their effects remain unclear... - Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tractCleber E Teixeira
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
Biochem Pharmacol 74:647-58. 2007..Manipulation of RhoGEF expression may provide further understanding of mechanisms involving Ca(2+) sensitization in the lower urinary tract... - RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insightsLiming Jin
Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
Clin Sci (Lond) 110:153-65. 2006..Understanding the RhoA/Rho-kinase signalling pathway in the regulation of erection is important for the development of therapeutic interventions for erectile dysfunction... - Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunctionLiming Jin
Department of Urology, Johns Hopkins University, Baltimore, Maryland 21287, USA
FASEB J 20:536-8. 2006..05). Taken together, these data suggest that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signaling, and this pathway may be exploited for the treatment of age-associated ED... 
Comparison of the involvement of protein kinase C in agonist-induced contractions in mouse aorta and corpus cavernosumLiming Jin
Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, University of California, Davis, CA 95616, United States
Eur J Pharmacol 590:363-8. 2008..Taken together, our data indicate that PKC does not have a significant role in agonist-induced contractions in mouse corpus cavernosum, whereas it mediates the contractile response to agonists in the aorta...- Nitric oxide/redox-based signalling as a therapeutic target for penile disordersArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
Expert Opin Ther Targets 10:445-57. 2006..The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ... - NADPH oxidase: recent evidence for its role in erectile dysfunctionLiming Jin
Department of Internal Medicine, University of California, Davis, CA 95616, USA
Asian J Androl 10:6-13. 2008..In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED...