J S Hyde

..1995. Magn. Reson. Med. 34:537-541). In this method, a whole volume time course of images is collected while the brain is nominally at rest and connectivity is studied by cross-correlation of pixel time courses...

..The paper discusses technical advances required to reach this goal. The hypothesis that trapezoidal frequency sweep is an enabling technology for FT EPR is supported by this study...

..Robust fMRI data were obtained across all subjects using 1 x 1 x 1 mm(3) cubic voxels with 10 contiguous slices, although 1.5 x 1.5 x 1.5 mm(3) was found to be optimum. Magn Reson Med 46:114-125, 2001...

..3 G at one W incident power, and the frequency deviation was 11.3 MHz p-p, which is equivalent to a field modulation amplitude of 4 G. W-band EPR using an LGR is a favorable configuration for microwave FM experiments...

..These benefits, together with other factors such as a higher resonator efficiency parameter and a new technique for canceling free induction decay signals, are discussed...

..It is concluded that L24 is highly miscible in POPC membranes even at high concentrations in the membrane...

..When combined with biofeedback therapy, this technique may help to improve the outcome of facial reanimation procedures in the future...

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..Perfusion activation maps will likely represent the sites of neuronal activity better than do BOLD activation maps. Magn Reson Med 44:137-143, 2000...

..Minimum return loss was about 30 dB. This paper provides a foundation for further optimization, if needed. Methods are not specific to EPR or the microwave frequency band...

..Typically, the SNR was improved by a factor of five to eight. Oxygen accessibility applications in site-directed spin labeling studies are discussed...

..Third, the transmembrane OTP profile in the liquid-ordered domain that contained 50 mol % cholesterol dramatically differed from that which contained 27 mol % cholesterol...

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..This explanation was confirmed by calculating the orientational order of leucine side chains in (LA)(12) and L(24) from molecular dynamics simulation studies...

..K. Subczynski, T.G. Camenisch, J.J. Ratke, W. Froncisz, Spin label EPR T(1) values using saturation recovery from 2 to 35 GHz. J. Phys. Chem. B 108 (2004) 9524-9529]. The values of T(1e) decrease at 94 GHz relative to values at 35 GHz...

..Feasibility has been established for the use of this technique for site-directed spin-labeling studies of biologically relevant samples, particularly the study of protein structure and dynamics...

..These signal enhancements are predicted with sample holders fabricated from polytetrafluoroethylene. Additional improvement in EPR signal of up to 75% can be achieved by using sample holder materials with lower dielectric constants...

..Most of the pixels that exhibited high BOLD responses had high blood volume weightings. The benefits of this technique are expected to increase for high-resolution fMRI at higher magnetic fields, where T(2) (*) is shorter...

..Values ranged from 0.035 to 0.165 parts per million (ppm)...

..Consistent results in two different rat-brain systems, the sensorimotor and visual, strongly support the hypothesis that resting-state BOLD fluctuations are conserved across mammalian species and can be used to map brain systems...

..This is the first report that regional differences in neuronal activation to the same stimulus lead to differential BOLD activation...

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..It is proposed that in clinical use, maps of alpha can be created using diffusion-weighting gradients applied in a single direction that reflect the tissue heterogeneity...

..9. The results indicate that transient data sets can provide additional information that is useful for both localization and characterization of the functionally relevant BOLD response...

..However, significant deviations exist when the stimulus duration is manipulated, particularly in the trailing edge of the CBV-fMRI response curves...

..We conclude that neuronal activity can be inferred from CBV fMRI data with high spatial accuracy. The data indicate that both intracolumn functional connectivity and neurovascular coupling can be studied using CBV fMRI...

..The benefits of this design include improved gradient field uniformity and efficiency, with a shorter length than gradient coil designs using coaxial return paths...

..Rectangular UF modes have an RF magnetic field magnitude that is uniform in a plane. Based on this analysis, a practical multiple flat-cell design is proposed...

..Willful contraction of the EAS is associated with multifocal cerebral cortical activity. The volume and intensity of cerebral cortical activation is commensurate with the level of contractile effort...

..In addition, the work proposed here is expected to contribute fundamentally to knowledge of brain plasticity following nerve injury. 2. ..

..There are many more. ..

..It is the only method that can detect the formation of free radicals in biology unambiguously. It contributes to health-related research at the basic fundamental level. ..

..The investigator asserts that only on such a foundation can a rational approach to improved human health be based. ..

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..It will have no clinical fee-for-service usage. The fMRI group at MCW is superbly positioned to provide leadership at a national level in the use of fMRI in medicine. ..

..Work proposed here will improve the quality of data obtained in these experiments. ..

..An additional benefit is provided by Uniform Field resonators. Because the microwave field is uniform over the sample, all portions respond in the same way, which improves the data quality. ..

..Information on protein and membrane dynamics can be obtained on a time scale that is believed not only to be inaccessible using other modalities, but also to be of high biological relevance. ..

..Contributions to the underlying technological base of fMRI methodology will be of increasing significance for improved health care in future years as the methods enter clinical practice. ..

..The proposed research has significant opportunity to enhance knowledge and could well serve as the basis of a research career in medicine. ..

..Applications focus on tissue grafts and possible rejection including kidneys, heart and skin...

..Instrumental development proposed here can contribute to instrumental design in other fields of spectroscopy including spin-echo EPR and high-resolution NMR. ..

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..The costs of the units are relatively modest, and the designs will be readily transportable to other laboratories, which should increase the overall use of ESR saturation-recovery methodology...

..ESR is a widely used basic spectroscopic technique that results in more than 2000 scientific papers per year, with about half in the life sciences over a wide variety of subjects...

..The research proposed here is in support of these four streams of fMRI research. ..