- A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stabilityTomonori Takekoshi
Department of Dermatology, Medical College of Wisconsin, FEC 4100, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
Mol Cancer Ther 11:2516-25. 2012..In summary, our results suggest CXCL122 possesses greater potential as an antimetastatic drug as compared with AMD3100 or wtCXCL12, potentially due to enhanced serum stability in the presence of N-terminal degrading enzymes...
- Homeward bound: how do skin dendritic cells find their way into the lymph system?Sam T Hwang
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Invest Dermatol 132:1070-3. 2012..Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics...