Sam T Hwang

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc CCR7-expressing B16 melanoma cells downregulate interferon-γ-mediated inflammation and increase lymphangiogenesis in the tumor microenvironment
    T Takekoshi
    Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, WI, USA
    Oncogenesis 1:e9. 2012
  2. pmc CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Invest Dermatol 133:164-71. 2013
  3. doi request reprint Homeward bound: how do skin dendritic cells find their way into the lymph system?
    Sam T Hwang
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Invest Dermatol 132:1070-3. 2012
  4. pmc CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis
    Tomonori Takekoshi
    1 Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin, USA 2 Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 133:2530-7. 2013
  5. doi request reprint Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 187:5026-31. 2011
  6. doi request reprint Chemokine receptors in the pathogenesis and therapy of psoriasis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, WI, USA
    J Dermatol Sci 65:4-11. 2012
  7. doi request reprint Paradoxical increase in skin inflammation in the absence of CCR4
    Ryan E Sells
    Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin, USA
    J Invest Dermatol 130:2697-9. 2010
  8. doi request reprint Upregulation of inflammatory cytokines and oncogenic signal pathways preceding tumor formation in a murine model of T-cell lymphoma in skin
    Xuesong Wu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Invest Dermatol 131:1727-34. 2011
  9. pmc A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability
    Tomonori Takekoshi
    Department of Dermatology, Medical College of Wisconsin, FEC 4100, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Mol Cancer Ther 11:2516-25. 2012
  10. ncbi request reprint Chemokine receptors as targets for cancer therapy
    Xuesong Wu
    Department of Dermatology Froedtert Clinics, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Curr Pharm Des 15:742-57. 2009

Collaborators

Detail Information

Publications11

  1. pmc CCR7-expressing B16 melanoma cells downregulate interferon-γ-mediated inflammation and increase lymphangiogenesis in the tumor microenvironment
    T Takekoshi
    Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, WI, USA
    Oncogenesis 1:e9. 2012
    ..Enhanced lymphangiogenesis may contribute to the dramatic increase in LN metastasis that is observed in the CCR7-expressing tumors...
  2. pmc CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Invest Dermatol 133:164-71. 2013
    ..Thus, these data show that CCR6 regulates epidermal trafficking of γδ-T-cell subsets in the skin and suggest the potential of CCR6 as a therapeutic target for psoriasis...
  3. doi request reprint Homeward bound: how do skin dendritic cells find their way into the lymph system?
    Sam T Hwang
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Invest Dermatol 132:1070-3. 2012
    ..Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics...
  4. pmc CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis
    Tomonori Takekoshi
    1 Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin, USA 2 Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 133:2530-7. 2013
    ..Thus, CXCR4 has an unexpected role in inhibiting KC proliferation and mitigating the effects of proliferative T helper type 17 cytokines. ..
  5. doi request reprint Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 187:5026-31. 2011
    ..Our data suggest that a subset of γδ T cells play a critical role in IL-23-mediated psoriasiform dermatitis...
  6. doi request reprint Chemokine receptors in the pathogenesis and therapy of psoriasis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, WI, USA
    J Dermatol Sci 65:4-11. 2012
    ..In this review, we focus on the roles of chemokine receptors, particularly of CCR6, in the pathogenesis of psoriasis and discuss chemokine receptors as novel therapeutic targets for psoriasis...
  7. doi request reprint Paradoxical increase in skin inflammation in the absence of CCR4
    Ryan E Sells
    Department of Dermatology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin, USA
    J Invest Dermatol 130:2697-9. 2010
    ..Finally, we discuss other possible roles for CCR4 in the homing of T cells to skin...
  8. doi request reprint Upregulation of inflammatory cytokines and oncogenic signal pathways preceding tumor formation in a murine model of T-cell lymphoma in skin
    Xuesong Wu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Invest Dermatol 131:1727-34. 2011
    ..This work provides insights into the cellular and molecular pathways that mediate lymphoma progression and may have applicability to human cutaneous T-cell lymphomas...
  9. pmc A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability
    Tomonori Takekoshi
    Department of Dermatology, Medical College of Wisconsin, FEC 4100, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Mol Cancer Ther 11:2516-25. 2012
    ..In summary, our results suggest CXCL122 possesses greater potential as an antimetastatic drug as compared with AMD3100 or wtCXCL12, potentially due to enhanced serum stability in the presence of N-terminal degrading enzymes...
  10. ncbi request reprint Chemokine receptors as targets for cancer therapy
    Xuesong Wu
    Department of Dermatology Froedtert Clinics, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Curr Pharm Des 15:742-57. 2009
    ....
  11. pmc 56th annual Montagna Symposium on the Biology of Skin: Epidermal T-cell interactions--clinicopathological and basic mechanisms
    Kevin D Cooper
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
    J Invest Dermatol 128:1351-3. 2008