ANTHONY GEORGE HUDETZ

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Neurosci Lett 387:145-50. 2005
  2. ncbi request reprint Are we unconscious during general anesthesia?
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int Anesthesiol Clin 46:25-42. 2008
  3. pmc General anesthesia and human brain connectivity
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Connect 2:291-302. 2012
  4. ncbi request reprint Burst activation of the cerebral cortex by flash stimuli during isoflurane anesthesia in rats
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 107:983-91. 2007
  5. pmc Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 111:231-9. 2009
  6. doi request reprint Feedback suppression in anesthesia. Is it reversible?
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Conscious Cogn 18:1079-81. 2009
  7. ncbi request reprint Cholinergic reversal of isoflurane anesthesia in rats as measured by cross-approximate entropy of the electroencephalogram
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 99:1125-31. 2003
  8. ncbi request reprint Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 954:123-31. 2002
  9. pmc Differential effects of isoflurane on high-frequency and low-frequency γ oscillations in the cerebral cortex and hippocampus in freely moving rats
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 114:588-95. 2011
  10. ncbi request reprint Volatile anesthetics enhance flash-induced gamma oscillations in rat visual cortex
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 102:937-47. 2005

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Neurosci Lett 387:145-50. 2005
    ..Our findings suggest that inhalational anesthetics preferentially impair frontal-posterior FB information transfer at high gamma frequencies consistent with the postulated role of frontal-posterior interactions in consciousness...
  2. ncbi request reprint Are we unconscious during general anesthesia?
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int Anesthesiol Clin 46:25-42. 2008
  3. pmc General anesthesia and human brain connectivity
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Connect 2:291-302. 2012
    ..The prime candidates for functional networks of the forebrain that play a critical role in maintaining the state of consciousness are those based on the posterior parietal-cingulate-precuneus region and the nonspecific thalamus...
  4. ncbi request reprint Burst activation of the cerebral cortex by flash stimuli during isoflurane anesthesia in rats
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 107:983-91. 2007
    ....
  5. pmc Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 111:231-9. 2009
    ..The authors studied the effect of desflurane on resting and visual evoked unit activity in rat visual cortex in vivo...
  6. doi request reprint Feedback suppression in anesthesia. Is it reversible?
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Conscious Cogn 18:1079-81. 2009
    ..Possible interpretations of the results and their implications with respect to the neural correlates of consciousness and unconsciousness are discussed...
  7. ncbi request reprint Cholinergic reversal of isoflurane anesthesia in rats as measured by cross-approximate entropy of the electroencephalogram
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 99:1125-31. 2003
    ..The effect of cholinergic agents on C-ApEn has not been examined. Here, the authors test the hypothesis that cholinergic activation reverses the effect of isoflurane anesthesia on C-ApEn...
  8. ncbi request reprint Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 954:123-31. 2002
    ..The results suggest that C-ApEn of bihemispheric EEG is a sensitive, agent-specific correlate of anesthetics' central effect...
  9. pmc Differential effects of isoflurane on high-frequency and low-frequency γ oscillations in the cerebral cortex and hippocampus in freely moving rats
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 114:588-95. 2011
    ..The authors investigated the concentration-dependent effect of isoflurane on spontaneous γ oscillations in two frequency bands and three distinct brain regions in the rat...
  10. ncbi request reprint Volatile anesthetics enhance flash-induced gamma oscillations in rat visual cortex
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 102:937-47. 2005
    ....
  11. ncbi request reprint Isoflurane disrupts anterio-posterior phase synchronization of flash-induced field potentials in the rat
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Neurosci Lett 402:216-21. 2006
    ..These findings suggest that a disruption of long-range anterio-posterior rather than local anterior synchronization of neuronal activity precedes the anesthetic-induced loss of consciousness...
  12. ncbi request reprint Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam
    Izabela Jugovac
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 105:764-78. 2006
    ..The authors aimed to produce progressively increasing anesthetic depths, indicated by electro-encephalographic synchronization and behavioral change...
  13. ncbi request reprint Isoflurane-induced cerebral hyperemia is partially mediated by nitric oxide and epoxyeicosatrienoic acids in mice in vivo
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 97:1528-33. 2002
    ..The current study was designed to determine the contributions of neuronal nitric oxide synthase, prostaglandins, and epoxyeicosatrienoic acids to isoflurane-induced cerebral hyperemia...
  14. ncbi request reprint Functional hyperemic response in the rat visual cortex under halothane anesthesia
    Marie L Schulte
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurosci Lett 394:63-8. 2006
    ....
  15. ncbi request reprint Focal cerebral ischemia in rats produced by intracarotid embolization with viscous silicone
    Kathryn K Lauer
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurol Res 24:181-90. 2002
    ..The smaller embolus produces cortical infarction with high rate of survival and neurological recovery...
  16. ncbi request reprint Digit tapping model of functional activation in the rat somatosensory cortex
    Marie L Schulte
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Neurosci Methods 157:48-53. 2006
    ....
  17. pmc Cortical brain mapping of peripheral nerves using functional magnetic resonance imaging in a rodent model
    Younghoon R Cho
    Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Reconstr Microsurg 24:551-7. 2008
    ..This direct nerve stimulation rat model can provide insight into peripheral nerve injury...
  18. pmc Resting-state functional connectivity of the rat brain
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Magn Reson Med 59:1021-9. 2008
    ..Consistent results in two different rat-brain systems, the sensorimotor and visual, strongly support the hypothesis that resting-state BOLD fluctuations are conserved across mammalian species and can be used to map brain systems...
  19. pmc Modeling of region-specific fMRI BOLD neurovascular response functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroimage 41:525-34. 2008
    ..This is the first report that regional differences in neuronal activation to the same stimulus lead to differential BOLD activation...
  20. ncbi request reprint Postoperative cognitive dysfunction in older patients with a history of alcohol abuse
    Judith A Hudetz
    Clinical Research, Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53295, USA
    Anesthesiology 106:423-30. 2007
    ..The goal of this study was to determine whether neurocognitive function is impaired after noncardiac surgery during general anesthesia in older patients with a history of alcohol abuse...
  21. ncbi request reprint Effect of relaxation on working memory and the Bispectral Index of the EEG
    Judith A Hudetz
    University of Wisconsin Milwaukee, Medical College of Wisconsin, VA Medical Center, 53295, USA
    Psychol Rep 95:53-70. 2004
    ..The results suggest that guided imagery of short duration produces relaxation as measured by psychological and neurophysiological indices and improves working memory performance...
  22. pmc A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 46:1137-47. 2009
    ..In the secondary infusion period using 300 microg/kg/h, resting-state functional connectivity is enhanced...
  23. ncbi request reprint Functional cerebral hyperemia is unaffected by isovolemic hemodilution
    Hui Shen
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 96:142-7. 2002
    ..The authors investigated the effects of isovolemic hemodilution on vibrissal stimulation-induced changes in cerebrocortical laser Doppler flow and tissue oxygen tension in the rat...
  24. pmc Interhemispheric neuroplasticity following limb deafferentation detected by resting-state functional connectivity magnetic resonance imaging (fcMRI) and functional magnetic resonance imaging (fMRI)
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroimage 49:2467-78. 2010
    ..Differences were noted in regions responsible for processing multisensory visual-motor information. This incidental discovery is considered to be significant. It may provide insight into phantom limb epiphenomena...
  25. ncbi request reprint 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat
    Franz Kehl
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H1556-65. 2002
    ..These results indicate that 20-HETE contributes to the acute fall in rCBF after SAH in rats...
  26. doi request reprint Source of low-frequency fluctuations in functional MRI signal
    Mehrdad Razavi
    Division of Behavioral Neurology and Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, Iowa, USA
    J Magn Reson Imaging 27:891-7. 2008
    ..To investigate the source of native low-frequency fluctuations (LFF) in functional MRI (fMRI) signal...

Research Grants11

  1. Anesthetics & cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2006
    ..abstract_text> ..
  2. VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATION
    ANTHONY HUDETZ; Fiscal Year: 2000
    ..They will determine if regional and agent-specific differences in microvascular vasodilation in response to volatile anesthetics are due to the effects of these agents on the GABA and NO neuronal systems. ..
  3. General anesthetics and cerebral cortical sensory integration
    ANTHONY GEORGE HUDETZ; Fiscal Year: 2010
    ..It should help develop novel methods for monitoring the state of consciousness based on established neurobiological mechanisms and of new anesthetic agents with more specific hypnotic effects. ..