B W Hollis

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Nutr 135:317-22. 2005
  2. doi request reprint Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes
    Bruce W Hollis
    Department of Pediatrics, Darby Children s Research Institute, Medical University of South Carolina, 173 Ashley Ave, Room 313, Charleston, SC 29425, USA
    Calcif Tissue Int 92:128-39. 2013
  3. ncbi request reprint Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment
    Bruce W Hollis
    Department of Biochemistry and Molecular Biology, Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Rheum Dis Clin North Am 38:29-44. 2012
  4. pmc Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Cancer Res 13:R50. 2011
  5. doi request reprint Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Endocrinol Diabetes Obes 15:489-94. 2008
  6. ncbi request reprint Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs
    Bruce W Hollis
    Medical University of South Carolina, Charleston, SC, USA
    Am J Clin Nutr 88:507S-510S. 2008
  7. ncbi request reprint Comparison of commercially available (125)I-based RIA methods for the determination of circulating 25-hydroxyvitamin D
    B W Hollis
    Departments of Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425
    Clin Chem 46:1657-61. 2000
  8. pmc Nutritional vitamin D status during pregnancy: reasons for concern
    Bruce W Hollis
    Pediatric Nutritional Sciences, Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    CMAJ 174:1287-90. 2006
  9. ncbi request reprint Assessment of circulating 25(OH)D and 1,25(OH)2D: emergence as clinically important diagnostic tools
    Bruce W Hollis
    Department of Pediatrics, Darby Children s Research Institute, Medical University of South Carolina, 173 Ashley Ave, CRI, Room 313, Charleston, SC 29425, USA
    Nutr Rev 65:S87-90. 2007
  10. pmc The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going
    Bruce W Hollis
    Departments of Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Steroid Biochem Mol Biol 103:473-6. 2007

Detail Information

Publications67

  1. ncbi request reprint Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Nutr 135:317-22. 2005
    ..Recent studies reveal that current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation...
  2. doi request reprint Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes
    Bruce W Hollis
    Department of Pediatrics, Darby Children s Research Institute, Medical University of South Carolina, 173 Ashley Ave, Room 313, Charleston, SC 29425, USA
    Calcif Tissue Int 92:128-39. 2013
    ..The new RCT data indicate that 4,000 IU/day vitamin D(3) during pregnancy will "normalize" vitamin D metabolism and improve birth outcomes including primary cesarean section and comorbidities of pregnancy with no risk of side effects...
  3. ncbi request reprint Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment
    Bruce W Hollis
    Department of Biochemistry and Molecular Biology, Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Rheum Dis Clin North Am 38:29-44. 2012
    ..At present, the reference ranges for circulating 25(OH)D and 1,25(OH)2D are 32 to 100 ng/mL and 16 to 56 ng/mL, respectively, and are largely based on clinical data derived from the FDA-cleared DiaSorin assay procedures...
  4. pmc Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Cancer Res 13:R50. 2011
    ..Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status...
  5. doi request reprint Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Endocrinol Diabetes Obes 15:489-94. 2008
    ..It is thus timely to review the reasons for this increase as well as the diverse analytical methods used to meet this need...
  6. ncbi request reprint Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs
    Bruce W Hollis
    Medical University of South Carolina, Charleston, SC, USA
    Am J Clin Nutr 88:507S-510S. 2008
    ..I also briefly discuss the stability of 25(OH)D in biological media and present an overview of the Vitamin D External Quality Assessment Scheme...
  7. ncbi request reprint Comparison of commercially available (125)I-based RIA methods for the determination of circulating 25-hydroxyvitamin D
    B W Hollis
    Departments of Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425
    Clin Chem 46:1657-61. 2000
    ....
  8. pmc Nutritional vitamin D status during pregnancy: reasons for concern
    Bruce W Hollis
    Pediatric Nutritional Sciences, Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    CMAJ 174:1287-90. 2006
  9. ncbi request reprint Assessment of circulating 25(OH)D and 1,25(OH)2D: emergence as clinically important diagnostic tools
    Bruce W Hollis
    Department of Pediatrics, Darby Children s Research Institute, Medical University of South Carolina, 173 Ashley Ave, CRI, Room 313, Charleston, SC 29425, USA
    Nutr Rev 65:S87-90. 2007
  10. pmc The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going
    Bruce W Hollis
    Departments of Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Steroid Biochem Mol Biol 103:473-6. 2007
    ..These advances will allow both 25(OH)D and 1,25(OH)(2)D to be detected in an accurate, rapid fashion to meet the clinical demands we see emerging...
  11. pmc Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Steroid Biochem Mol Biol 103:631-4. 2007
    ..Thus, the relationship between circulating vitamin D and 25(OH)D may represent what "normal" vitamin D status should be...
  12. ncbi request reprint Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant
    Bruce W Hollis
    Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Clin Nutr 80:1752S-8S. 2004
    ..A maternal intake of 4000 IU/d could achieve substantial progress toward improving both maternal and neonatal nutritional vitamin D status...
  13. doi request reprint Short-term and long-term consequences and concerns regarding valid assessment of vitamin D deficiency: comparison of recent food supplementation and clinical guidance reports
    Bruce W Hollis
    Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Clin Nutr Metab Care 14:598-604. 2011
    ..The function and use of vitamin D supplementation has become very controversial. This review attempts to provide a balanced perspective with respect to the experimental findings published in the past 18 months...
  14. doi request reprint Vitamin D requirements and supplementation during pregnancy
    Bruce W Hollis
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Endocrinol Diabetes Obes 18:371-5. 2011
    ..The topic of vitamin D supplementation during pregnancy is very controversial. This review attempts to provide balanced knowledge with respect to this topic gained in the past 18 months...
  15. ncbi request reprint Assessment of dietary vitamin D requirements during pregnancy and lactation
    Bruce W Hollis
    Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, 114 Doughty Street, PO Box 205770, Charleston, SC 29403, USA
    Am J Clin Nutr 79:717-26. 2004
    ..Further studies are necessary to determine optimal vitamin D intakes for pregnant and lactating women as a function of latitude and race...
  16. pmc Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment
    Bruce W Hollis
    Department of Biochemistry and Molecular Biology, Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Endocrinol Metab Clin North Am 39:271-86, table of contents. 2010
    ..25(OH)D(2) and 25(OH)D(3) are commonly known as calcifediol and the 1,25(OH)(2)D metabolites as calcitriol. In this review the current state of the science on the clinical assessment of circulating 25(OH)D and 1,25(OH)(2)D is described...
  17. pmc Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness
    Bruce W Hollis
    Division of Neonatology and Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Bone Miner Res 26:2341-57. 2011
    ....
  18. ncbi request reprint Vitamin D deficiency in breastfed infants in Iowa
    Ekhard E Ziegler
    Department of Pediatrics, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, Iowa 52242, USA
    Pediatrics 118:603-10. 2006
    ..The purpose of this work was to assess the vitamin D status of breastfed infants living in Iowa (latitude: 41 degrees N)...
  19. ncbi request reprint Effects of race on diurnal patterns of renal conservation of calcium and bone resorption in premenopausal women
    N H Bell
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Osteoporos Int 12:43-8. 2001
    ..In both groups, maintenance of serum calcium at night is achieved by increased bone resorption and renal conservation of calcium...
  20. pmc Does vitamin D make the world go 'round'?
    Carol L Wagner
    Department of Pediatrics, Pediatric Nutritional Research Center, Darby Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Breastfeed Med 3:239-50. 2008
    ..We then discuss the needs of vitamin D in the context of the breastfeeding mother and her infant and child, why breastfed infants are particularly at risk, and what to do about it...
  21. ncbi request reprint Vitamin D deficiency in systemic lupus erythematosus
    Diane L Kamen
    Medical University of South Carolina, Charleston, SC, USA
    Autoimmun Rev 5:114-7. 2006
    ..9, p<0.01). These results suggest vitamin D deficiency as a possible risk factor for SLE and provide guidance for future studies looking at a potential role of vitamin D in the prevention and/or treatment of SLE...
  22. ncbi request reprint High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study
    Carol L Wagner
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Breastfeed Med 1:59-70. 2006
    ....
  23. ncbi request reprint Vitamin D status as related to race and feeding type in preterm infants
    Sarah N Taylor
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Breastfeed Med 1:156-63. 2006
    ..In addition, with the combination of parenteral and enteral nutritional support that preterm infants receive, the effect of vitamin D-deficient breast milk on vitamin D status is unknown...
  24. pmc Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia
    Christopher J Robinson
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA
    Am J Obstet Gynecol 203:366.e1-6. 2010
    ..Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE)...
  25. ncbi request reprint Vitamin D requirement during pregnancy and lactation
    Bruce W Hollis
    Department of Pediatrics, Division of Pediatric Nutritional Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    J Bone Miner Res 22:V39-44. 2007
    ..Current research has shown that the actual dietary requirement during pregnancy and lactation may actually be as high as 6000 IU/d. Current data on which these new recommendations could be based are presented...
  26. ncbi request reprint Vitamin D supplementation during lactation to support infant and mother
    Sarah N Taylor
    Medical University of South Carolina Darby Children s Research Institute, Charleston, South Carolina 29425, USA
    J Am Coll Nutr 27:690-701. 2008
    ..Current investigation of the role of vitamin D in diseases beyond bone health is revealing the significance of early life vitamin D sufficiency in establishing lifelong health...
  27. ncbi request reprint The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants
    Laura A Basile
    Department of Pediatrics Division of Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA
    Breastfeed Med 1:27-35. 2006
    ..Improve vitamin D status in lactating women and their recipient infants, and measure breast milk calcium concentration [Ca] as a function of vitamin D regimen...
  28. doi request reprint Vitamin D deficiency and insufficiency is common during pregnancy
    Donna D Johnson
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina 29425 0619, USA
    Am J Perinatol 28:7-12. 2011
    ..This study demonstrates widespread vitamin D deficiency and insufficiency in pregnant females living at a southern latitude. African-Americans are at greatest risk...
  29. ncbi request reprint Neonatal vitamin D status at birth at latitude 32 degrees 72': evidence of deficiency
    L A Basile
    Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Perinatol 27:568-71. 2007
    ..With vitamin D deficiency as a serious public health problem, vitamin D status at birth was measured in neonates at latitude 32 degrees 72' (southeastern United States)...
  30. ncbi request reprint ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men
    N H Bell
    Departments of Medicine, Pharmacology, and Pediatrics, Medical University of South Carolina, Charleston, USA
    J Lab Clin Med 137:133-40. 2001
    ..In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men...
  31. ncbi request reprint CYP3A4 is a human microsomal vitamin D 25-hydroxylase
    Ram P Gupta
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Bone Miner Res 19:680-8. 2004
    ..Activity in pooled liver microsomes was inhibited by known inhibitors of CYP3A4 and by an antibody to CYP3A2. Thus, CYP3A4 is a hepatic microsomal vitamin D 25-hydroxylase...
  32. ncbi request reprint Vitamin D insufficiency in southern Arizona
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Am J Clin Nutr 87:608-13. 2008
    ..Vitamin D deficiency or insufficiency has been observed among populations in the northern United States. However, data on the prevalence of vitamin D deficiency in areas of high sun exposure, such as Arizona, are limited...
  33. pmc Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Endocrinology 149:3656-67. 2008
    ....
  34. ncbi request reprint 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 87:1738-42. 2008
    ..Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans...
  35. pmc Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors
    Marian L Neuhouser
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 88:133-9. 2008
    ..Little is known about vitamin D status in breast cancer survivors. This issue is important because vitamin D influences pathways related to carcinogenesis...
  36. ncbi request reprint Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color
    Laura A G Armas
    Creighton University Medical Center, Omaha, Nebraska 68131, USA
    J Am Acad Dermatol 57:588-93. 2007
    ..Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized...
  37. ncbi request reprint Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    Kassandra L Munger
    Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:2832-8. 2006
    ..Epidemiological and experimental evidence suggests that high levels of vitamin D, a potent immunomodulator, may decrease the risk of multiple sclerosis. There are no prospective studies addressing this hypothesis...
  38. ncbi request reprint Prospective study of predictors of vitamin D status and cancer incidence and mortality in men
    Edward Giovannucci
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 98:451-9. 2006
    ....
  39. ncbi request reprint Vitamin D2 is much less effective than vitamin D3 in humans
    Laura A G Armas
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:5387-91. 2004
    ..5:1. Vitamin D(2) potency is less than one third that of vitamin D(3). Physicians resorting to use of vitamin D(2) should be aware of its markedly lower potency and shorter duration of action relative to vitamin D(3)...
  40. ncbi request reprint Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    Shanna Nesby-O'Dell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
    Am J Clin Nutr 76:187-92. 2002
    ..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population...
  41. ncbi request reprint Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 25:479-85. 2007
    ..We further investigated the results of circulating 25-hydroxyvitamin D (25[OH]D) levels on overall survival (OS) and recurrence-free survival (RFS) in NSCLC patients...
  42. ncbi request reprint The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  43. ncbi request reprint Vitamin D deficiency during pregnancy: an ongoing epidemic
    Bruce W Hollis
    Am J Clin Nutr 84:273. 2006
  44. ncbi request reprint Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Prostate 67:911-23. 2007
    ..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes...
  45. ncbi request reprint Plasma vitamin D metabolites and risk of colorectal cancer in women
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1502-8. 2004
    ..We therefore examined risk in relation to plasma concentrations of these vitamin D metabolites...
  46. ncbi request reprint Normal serum vitamin D levels
    Bruce W Hollis
    N Engl J Med 352:515-6; author reply 515-6. 2005
  47. ncbi request reprint Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Causes Control 15:255-65. 2004
    ..To address this hypothesis, we evaluated the association of circulating concentrations of 1,25(OH)2D and its precursor 25-hydroxyvitamin D (25(OH)D) with subsequent risk of prostate cancer...
  48. ncbi request reprint Editorial: The determination of circulating 25-hydroxyvitamin D: no easy task
    Bruce W Hollis
    J Clin Endocrinol Metab 89:3149-51. 2004
  49. ncbi request reprint Plasma levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the risk of prostate cancer
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tuscon 85724 5024, USA
    J Steroid Biochem Mol Biol 89:533-7. 2004
    ....
  50. ncbi request reprint A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1120-9. 2007
    ..We investigated this relationship in a nested case-control study within the Health Professionals Follow-up Study (HPFS), a large ongoing study of male health professionals living in the United States...
  51. ncbi request reprint Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:546-52. 2004
    ..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer...
  52. ncbi request reprint Pharmacokinetics and safety of ILX23-7553, a non-calcemic-vitamin D3 analogue, in a phase I study of patients with advanced malignancies
    Robert Wieder
    Division of Oncology Hematology, Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Invest New Drugs 21:445-52. 2003
    ....
  53. ncbi request reprint Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25-dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers
    Mara J Horwitz
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 88:1603-9. 2003
    ....
  54. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer
    Elizabeth R Bertone-Johnson
    Department of Public Health, University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003 9304, USA
    Cancer Epidemiol Biomarkers Prev 14:1991-7. 2005
    ..Our findings suggest that high levels of 25(OH)D, and perhaps 1,25(OH)2D, may be modestly associated with reduced risk of breast cancer...
  55. ncbi request reprint Analyzing vitamin D in foods and supplements: methodologic challenges
    W Craig Byrdwell
    Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture, Beltsville, USA
    Am J Clin Nutr 88:554S-557S. 2008
    ..A new, simpler, and faster method, however, would greatly benefit the field. To guarantee accuracy, we need certified reference materials for foods...
  56. ncbi request reprint Safety and tolerability of subcutaneous PTHrP(1-36) in healthy human volunteers: a dose escalation study
    Mara J Horwitz
    Division of Endocrinology, University of Pittsburgh School of Medicine, Falk 580 3601 Fifth Ave, Pittsburgh, PA 15213, USA
    Osteoporos Int 17:225-30. 2006
    ..0 mg. These findings indicate that the therapeutic window for PTHrP(1-36) in humans is wide and permit the design and implementation of longer safety and efficacy trials...
  57. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:783-8. 2007
    ..However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt...
  58. doi request reprint Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States)
    Kathleen M Egan
    Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    Cancer Causes Control 19:527-35. 2008
    ..To determine the prevalence and predictors of vitamin D insufficiency among black and white adult residents of the southern US...
  59. doi request reprint Phase switching SPE for faster 1,25-dihydroxyvitamin D analysis. 1986
    Bruce W Hollis
    Clin Chem 54:446-7. 2008
  60. pmc Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    J Steroid Biochem Mol Biol 103:752-6. 2007
    ..In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women...
  61. ncbi request reprint Laboratory reporting of 25-hydroxyvitamin D results: potential for clinical misinterpretation
    Neil Binkley
    Clin Chem 52:2124-5. 2006
  62. doi request reprint Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 17:889-94. 2008
    ....
  63. pmc Serum vitamin D concentration and prostate cancer risk: a nested case-control study
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 100:796-804. 2008
    ....
  64. ncbi request reprint Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  65. doi request reprint Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer
    Kimmie Ng
    Division of Medical Oncology, Dana Farber Cancer Institute Boston, MA 02115, USA
    J Clin Oncol 26:2984-91. 2008
    ..Higher plasma 25-hydroxyvitamin D(3) (25(OH)D) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma 25(OH)D on the outcome of patients with established colorectal cancer is unknown...
  66. ncbi request reprint Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D
    Mara J Horwitz
    Division of Endocrinology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 20:1792-803. 2005
    ..Continuous infusion of both PTH and PTHrP results in marked and prolonged suppression of bone formation; renal 1,25(OH)2D synthesis was stimulated effectively by PTH but poorly by PTHrP...
  67. pmc 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 168:1174-80. 2008
    ..Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans...

Research Grants11

  1. Establishing the Vitamin D Requirements During Lactation
    Bruce W Hollis; Fiscal Year: 2010
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
  2. Establishing the Vitamin D Requirements During Lactation
    Bruce Hollis; Fiscal Year: 2009
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
  3. Establishing the Vitamin D Requirements During Lactation
    Bruce Hollis; Fiscal Year: 2007
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
  4. Evaluation of Vitamin D Requirements During Pregnancy
    Bruce Hollis; Fiscal Year: 2007
    ....
  5. Establishing the Vitamin D Requirements During Lactation
    Bruce Hollis; Fiscal Year: 2009
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..