Q H Hogan
Affiliation: Medical College of Wisconsin
Wu H, Gemes G, Hogan Q. Recording SOCE Activity in Neurons by Patch-Clamp Electrophysiology and Microfluorometric Calcium Imaging. Methods Mol Biol. 2018;1843:41-53 pubmed publisher
..Here, we describe specific methods for studying SOCE using these approaches in rat dorsal root ganglion neurons. ..
Hogan Q, Lirk P, Poroli M, Rigaud M, Fuchs A, Fillip P, et al
. Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons. Anesth Analg. 2008;107:1045-51 pubmed publisher
Hogan Q. Pathophysiology of peripheral nerve injury during regional anesthesia. Reg Anesth Pain Med. 2008;33:435-41 pubmed publisher
..Ischemia may also contribute to neuronal injury in proportion to the duration of blood flow interruption. The relative importance of these pathogenic factors in cases of nerve injury after regional anesthesia is not resolved. ..
Yu H, Fischer G, Ebert A, Wu H, Bai X, Hogan Q. Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. Mol Pain. 2015;11:5 pubmed publisher
Yu H, Pan B, Weyer A, Wu H, Meng J, Fischer G, et al
. CaMKII Controls Whether Touch Is Painful. J Neurosci. 2015;35:14086-102 pubmed publisher
..Because limbs are protected from use during a painful condition, this sensitization of LTMRs may perpetuate pain and prevent functional rehabilitation. ..
Hogan Q. Role of decreased sensory neuron membrane calcium currents in the genesis of neuropathic pain. Croat Med J. 2007;48:9-21 pubmed
..Treatment of neuronal I(Ca) loss at the level of injury of the dorsal root ganglion may provide a novel therapeutic pathway. ..
Hogan Q, Poroli M. Hyperpolarization-activated current (I(h)) contributes to excitability of primary sensory neurons in rats. Brain Res. 2008;1207:102-10 pubmed publisher
..We conclude that I(h) supports sensory neuron excitability, and loss of I(h) is not a factor contributing to increased neuronal excitability after peripheral axonal injury. ..
Hogan Q, McCallum J, Sarantopoulos C, Aason M, Mynlieff M, Kwok W, et al
. Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons. Pain. 2000;86:43-53 pubmed
..Altered Ca(2+) signalling in injured sensory neurons may contribute to hyperexcitability leading to neuropathic pain. ..
Pan B, Yu H, Fischer G, Kramer J, Hogan Q. Dorsal Root Ganglionic Field Stimulation Relieves Spontaneous and Induced Neuropathic Pain in Rats. J Pain. 2016;17:1349-1358 pubmed publisher
..This confirms analgesic efficacy of DRG stimulation in an animal model, and provides a platform for preclinical exploration. ..