Q H Hogan

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 591:1111-31. 2013
  2. pmc Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons
    Geza Gemes
    Medical College of Wisconsin, Department of Anesthesiology, Milwaukee, WI 53226, USA
    Mol Pain 8:46. 2012
  3. pmc Lentiviral gene transfer into the dorsal root ganglion of adult rats
    Hongwei Yu
    Department of Anesthesiology, Medical College of Wisconsin, 8100 Watertown Plank Rd, Milwaukee, Wisconsin 53226, USA
    Mol Pain 7:63. 2011
  4. pmc KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
    Vasiliki Zoga
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Pain 6:6. 2010
  5. pmc Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Pain 5:12. 2009
  6. ncbi request reprint Epidural catheter tip position and distribution of injectate evaluated by computed tomography
    Q Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 90:964-70. 1999
  7. pmc Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 107:1045-51. 2008
  8. pmc Hyperpolarization-activated current (I(h)) contributes to excitability of primary sensory neurons in rats
    Quinn H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Brain Res 1207:102-10. 2008
  9. ncbi request reprint Detection of neuropathic pain in a rat model of peripheral nerve injury
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Room M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 101:476-87. 2004
  10. pmc Role of decreased sensory neuron membrane calcium currents in the genesis of neuropathic pain
    Quinn H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Room M4280, 8701 Watertown Plank Rd, Milwaukee, WI, USA
    Croat Med J 48:9-21. 2007

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 591:1111-31. 2013
    ....
  2. pmc Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons
    Geza Gemes
    Medical College of Wisconsin, Department of Anesthesiology, Milwaukee, WI 53226, USA
    Mol Pain 8:46. 2012
    ..Here we examine the contribution of PMCA after nerve injury in a rat model of neuropathic pain...
  3. pmc Lentiviral gene transfer into the dorsal root ganglion of adult rats
    Hongwei Yu
    Department of Anesthesiology, Medical College of Wisconsin, 8100 Watertown Plank Rd, Milwaukee, Wisconsin 53226, USA
    Mol Pain 7:63. 2011
    ....
  4. pmc KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
    Vasiliki Zoga
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Pain 6:6. 2010
    ....
  5. pmc Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Pain 5:12. 2009
    ..NO-dependent mechanisms modulate both KATP channels and participate in the pathophysiology and pharmacology of neuropathic pain. Therefore, we investigated NO modulation of KATP channels in control and axotomized DRG neurons...
  6. ncbi request reprint Epidural catheter tip position and distribution of injectate evaluated by computed tomography
    Q Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 90:964-70. 1999
    ..The author therefore examined the site of catheter tips and the spread of contrast material in the epidural space using computed tomographic (CT) imaging in patients receiving successful epidural analgesia...
  7. pmc Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 107:1045-51. 2008
    ..From this, we predicted that increasing I(Ca) in injured neurons should correct their hyperexcitability...
  8. pmc Hyperpolarization-activated current (I(h)) contributes to excitability of primary sensory neurons in rats
    Quinn H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Brain Res 1207:102-10. 2008
    ..We conclude that I(h) supports sensory neuron excitability, and loss of I(h) is not a factor contributing to increased neuronal excitability after peripheral axonal injury...
  9. ncbi request reprint Detection of neuropathic pain in a rat model of peripheral nerve injury
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Room M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 101:476-87. 2004
    ..Therefore, the authors sought clinically relevant measures that distinguish pain behavior of rats with peripheral nerve injury from those with sham injury...
  10. pmc Role of decreased sensory neuron membrane calcium currents in the genesis of neuropathic pain
    Quinn H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Room M4280, 8701 Watertown Plank Rd, Milwaukee, WI, USA
    Croat Med J 48:9-21. 2007
    ..Treatment of neuronal I(Ca) loss at the level of injury of the dorsal root ganglion may provide a novel therapeutic pathway...
  11. ncbi request reprint Distribution of solution in the epidural space: examination by cryomicrotome section
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, 8700 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Reg Anesth Pain Med 27:150-6. 2002
    ..The routes of distribution and barriers to flow of solutions in the epidural space are incompletely determined. This study examined macroscopic details of epidural injectate spread in postmortem humans by cryomicrotome imaging...
  12. ncbi request reprint Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons
    Q H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Pain 86:43-53. 2000
    ..Altered Ca(2+) signalling in injured sensory neurons may contribute to hyperexcitability leading to neuropathic pain...
  13. pmc Pathophysiology of peripheral nerve injury during regional anesthesia
    Quinn H Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Reg Anesth Pain Med 33:435-41. 2008
    ..Despite attention to technical details in performance of regional anesthetics, damage to nerves continues to be a concern. Understanding of pathophysiological mechanisms may aid in decreasing the incidence and severity of such injuries...
  14. pmc Contribution of calcium channel subtypes to the intracellular calcium signal in sensory neurons: the effect of injury
    Andreas Fuchs
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 107:117-27. 2007
    ..Although the activation-induced intracellular Ca signal is disrupted by sensory neuron injury, the contribution of specific Ca channel subtypes is unknown...
  15. pmc Painful nerve injury shortens the intracellular Ca2+ signal in axotomized sensory neurons of rats
    Andreas Fuchs
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 107:106-16. 2007
    ..Because intracellular Ca signaling critically regulates diverse neuronal functions, the authors examined effects of peripheral nerve injury on the Ca transient that follows neuronal activation...
  16. doi request reprint ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury
    T Kawano
    Department of Anesthesiology, Anesthesia Research MEB, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 162:431-43. 2009
    ..Their biophysical and pharmacological properties are preserved even after axotomy, suggesting that K(ATP) channels in primary afferents remain available for therapeutic targeting against established neuropathic pain...
  17. pmc Subtype-specific reduction of voltage-gated calcium current in medium-sized dorsal root ganglion neurons after painful peripheral nerve injury
    J B McCallum
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroscience 179:244-55. 2011
    ..Our findings suggest that diminished Ca2+ influx through N-type and L-type channels may contribute to sensory neuron dysfunction and pain after nerve injury...
  18. ncbi request reprint Distinct membrane effects of spinal nerve ligation on injured and adjacent dorsal root ganglion neurons in rats
    Damir Sapunar
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 103:360-76. 2005
    ..An essential first step is identification of electrophysiologic changes in these two neuronal populations after partial nerve damage...
  19. pmc Painful nerve injury decreases sarco-endoplasmic reticulum Ca²⁺-ATPase activity in axotomized sensory neurons
    C Duncan
    Medical College of Wisconsin, Department of Anesthesiology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 231:247-57. 2013
    ..These findings suggest that injury-induced loss of SERCA function in small sensory neurons may contribute to the generation of pain following peripheral nerve injury...
  20. pmc Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons
    J Bruce McCallum
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:160-8. 2006
    ..The authors hypothesized that I(Ca) loss is a result of neuronal injury, so they compared axotomized L5 dorsal root ganglion neurons to spared L4 neurons, as well as neurons from rats undergoing skin incision alone...
  21. pmc Calcium signaling in intact dorsal root ganglia: new observations and the effect of injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 113:134-46. 2010
    ..Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dorsal root ganglia, we used a method of simultaneous electrophysiologic and microfluorimetric recording...
  22. pmc Axotomy depletes intracellular calcium stores in primary sensory neurons
    Marcel Rigaud
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 111:381-92. 2009
    ..The authors examined the effect of injury on intracellular Ca stores of the endoplasmic reticulum, which critically regulate the Ca signal and neuronal function...
  23. pmc Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons
    Constantine D Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1132:84-99. 2007
    ..In an additional set of experiments we found that small-sized control DRG neurons also expressed iberiotoxin-sensitive currents, which are reduced in both axotomized (L5) and adjacent (L4) neurons...
  24. ncbi request reprint Permeability of injured and intact peripheral nerves and dorsal root ganglia
    Stephen E Abram
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:146-53. 2006
    ....
  25. ncbi request reprint Loss of T-type calcium current in sensory neurons of rats with neuropathic pain
    J Bruce McCallum
    Department of Anesthesiology, Medical College of Wisconsin, Wisconsi 53226, USA
    Anesthesiology 98:209-16. 2003
    ..However, the physiologic function of these channels is unknown. Their possible role in rebound burst firing makes them a candidate for increased excitability after neuropathic injury...
  26. pmc Learned avoidance from noxious mechanical simulation but not threshold semmes weinstein filament stimulation after nerve injury in rats
    Hsiang En Wu
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pain 11:280-6. 2010
    ..We demonstrated that needle stimulation is aversive in rats that respond with hyperalgesic-type behavior and is therefore a valid indicator of pain. Stimulation by SW is minimally aversive and is a problematic indicator of pain...
  27. pmc Depletion of calcium stores in injured sensory neurons: anatomic and functional correlates
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 111:393-405. 2009
    ..This study examines potential causes and functional consequences of Ca store limitation after injury...
  28. pmc Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pain 146:293-300. 2009
    ..If baroreceptor reflex suppression is also found in human subjects during chronic neuropathic pain, this may adversely affect survival...
  29. ncbi request reprint Painful nerve injury decreases resting cytosolic calcium concentrations in sensory neurons of rats
    Andreas Fuchs
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 102:1217-25. 2005
    ..Although cytoplasmic calcium ([Ca]c) critically regulates neuronal function, the effects of peripheral nerve injury on resting sensory neuronal [Ca]c are unknown...
  30. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..Also, SNL had no effect on heat responses in medium-large-diameter neurons from either the injured or adjacent ganglia...
  31. ncbi request reprint Intracellular mechanism of mitochondrial adenosine triphosphate-sensitive potassium channel activation with isoflurane
    Yuri Nakae
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesth Analg 97:1025-32, table of contents. 2003
    ..However, our data do not support an action of isoflurane through pathways involving adenosine, PKC, tyrosine kinase, or mitogen-activated protein kinase. These results suggest that isoflurane may directly activate mitoK(ATP)...
  32. pmc Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain
    Marcel Rigaud
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Pain 136:188-201. 2008
    ..Strain-dependent variability in segmental contributions to the sciatic nerve may account in part for genetic differences in pain behavior after spinal nerve ligation...
  33. pmc ASRA Practice Advisory on Neurologic Complications in Regional Anesthesia and Pain Medicine
    Joseph M Neal
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA, USA
    Reg Anesth Pain Med 33:404-15. 2008
    ..The current Practice Advisory offers recommendations to aid in the understanding and potential limitation of neurologic complications that may arise during the practice of regional anesthesia and pain medicine...
  34. ncbi request reprint Repeated or prolonged isoflurane exposure reduces mitochondrial oxidizing effects
    Shinji Kohro
    Departments of Anesthesiology and Anesthesiology Research, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:275-8. 2003
  35. ncbi request reprint Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes
    Shinji Kohro
    Anesthesiology Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 99:1316-22; table of contents. 2004
    ..Instead of a simple mediator, PKC may act as a regulator of the mitoK(ATP) channel to prevent excessive mitochondrial oxidation...
  36. ncbi request reprint Effect of peripheral axotomy on pain-related behavior and dorsal root ganglion neurons excitability in NPY transgenic rats
    Damir Sapunar
    Department of Anatomy, Histology and Embryology, University of Split Medical School, PAK, KB Split, Spinciceva 1, 21000 Split, Croatia
    Brain Res 1063:48-58. 2005
    ..In conclusion, our observations suggest that NPY overexpression leads to reduced neuronal activity following nerve injury in a cell-specific manner...
  37. ncbi request reprint Brachial plexus anesthesia: essentials of our current understanding
    Joseph M Neal
    Virginia Mason Medical Center, Seattle, Washington, USA
    Reg Anesth Pain Med 27:402-28. 2002
  38. ncbi request reprint No preemptive analgesia: is that so bad?
    Quinn H Hogan
    Anesthesiology 96:526-7. 2002

Research Grants9

  1. TRAUMATIC PAINFUL NEUROPATHY AND CALCIUM SIGNALING
    Quinn Hogan; Fiscal Year: 2004
    ..This translational research will be valuable in identifying pharmacologically and anatomically specific sites for application of agents to treat neuropathic pain while preserving desired sensory and motor function. ..
  2. TRAUMATIC PAINFUL NEUROPATHY AND CALCIUM SIGNALING
    Quinn H Hogan; Fiscal Year: 2010
    ..This new knowledge may lead to the development of therapies that are delivered selectively to the peripheral nerve, in order to correct abnormal Ca2+ signaling and thereby relieve nerve injury pain. ..
  3. TRAUMATIC PAINFUL NEUROPATHY AND CALCIUM SIGNALING
    Quinn Hogan; Fiscal Year: 2009
    ..This new knowledge may lead to the development of therapies that are delivered selectively to the peripheral nerve, in order to correct abnormal Ca2+ signaling and thereby relieve nerve injury pain. ..