G M Hoffman

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome
    George M Hoffman
    Children s Hospital of Wisconsin, Milwaukee, Wis Medical College of Wisconsin, Milwaukee, Wis Electronic address
    J Thorac Cardiovasc Surg 146:1153-64. 2013
  2. ncbi request reprint Neurologic monitoring on cardiopulmonary bypass: what are we obligated to do?
    George M Hoffman
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 81:S2373-80. 2006
  3. ncbi request reprint Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome
    George M Hoffman
    Department of Pediatric Anesthesiology, Medical College of Wisconsin, Milwaukee, Wis, USA
    J Thorac Cardiovasc Surg 130:1094-100. 2005
  4. ncbi request reprint Pro: near-infrared spectroscopy should be used for all cardiopulmonary bypass
    George M Hoffman
    Department of Anesthesiology and Pediatrics, Medical College of Wisconsin, Pediatric Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiothorac Vasc Anesth 20:606-12. 2006
  5. ncbi request reprint Detection and prevention of neurologic injury in the intensive care unit
    George M Hoffman
    Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States of America
    Cardiol Young 15:149-53. 2005
  6. ncbi request reprint Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure
    George M Hoffman
    Department of Anesthesiology, Pediatric Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, 735, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Thorac Cardiovasc Surg 127:738-45. 2004
  7. ncbi request reprint Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion
    George M Hoffman
    Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 127:223-33. 2004
  8. ncbi request reprint Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model
    George M Hoffman
    Department of Anesthesiology, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 109:236-43. 2002
  9. doi request reprint Outcomes of pediatric anesthesia
    George M Hoffman
    Department of Pediatric Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
    Semin Pediatr Surg 17:141-51. 2008
  10. ncbi request reprint Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome
    G M Hoffman
    Department of Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee 53226, USA
    Ann Thorac Surg 70:1515-20; discussion 1521. 2000

Detail Information

Publications43

  1. doi request reprint Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome
    George M Hoffman
    Children s Hospital of Wisconsin, Milwaukee, Wis Medical College of Wisconsin, Milwaukee, Wis Electronic address
    J Thorac Cardiovasc Surg 146:1153-64. 2013
    ..We hypothesized that cerebral hypoxia, detectable by near-infrared spectroscopy in the early postoperative period, would be related to later neurodevelopmental performance...
  2. ncbi request reprint Neurologic monitoring on cardiopulmonary bypass: what are we obligated to do?
    George M Hoffman
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 81:S2373-80. 2006
    ..This review will advocate wide adoption of near-infrared spectroscopy monitoring throughout the perioperative period, to enhance detection of hypoxic conditions and to drive patient-specific interventions...
  3. ncbi request reprint Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome
    George M Hoffman
    Department of Pediatric Anesthesiology, Medical College of Wisconsin, Milwaukee, Wis, USA
    J Thorac Cardiovasc Surg 130:1094-100. 2005
    ..We hypothesized that decreased postoperative oxygen delivery, as measured on the basis of systemic venous oxyhemoglobin saturation, would be related to persistent neurodevelopmental abnormality assessed in childhood...
  4. ncbi request reprint Pro: near-infrared spectroscopy should be used for all cardiopulmonary bypass
    George M Hoffman
    Department of Anesthesiology and Pediatrics, Medical College of Wisconsin, Pediatric Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiothorac Vasc Anesth 20:606-12. 2006
  5. ncbi request reprint Detection and prevention of neurologic injury in the intensive care unit
    George M Hoffman
    Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States of America
    Cardiol Young 15:149-53. 2005
  6. ncbi request reprint Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure
    George M Hoffman
    Department of Anesthesiology, Pediatric Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, 735, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Thorac Cardiovasc Surg 127:738-45. 2004
    ..In this investigation, we tested the hypothesis that intense afterload reduction with phenoxybenzamine would modify the SvO(2)-SaO(2) relationship by preventing deterioration of systemic oxygen delivery at high SaO(2)...
  7. ncbi request reprint Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion
    George M Hoffman
    Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 127:223-33. 2004
    ..We examined relative changes in cerebral and somatic oxygenation with near-infrared spectroscopy while using a modified perfusion strategy that allowed continuous cerebral perfusion...
  8. ncbi request reprint Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model
    George M Hoffman
    Department of Anesthesiology, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 109:236-43. 2002
    ..In this article, we tested the hypothesis that application of an AAP/ASA-structured model would reduce the risk of sedation-related adverse events...
  9. doi request reprint Outcomes of pediatric anesthesia
    George M Hoffman
    Department of Pediatric Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
    Semin Pediatr Surg 17:141-51. 2008
    ..Because of the limitations of small numbers, future improvement efforts will necessarily involve multiple disciplines, institutions, and regions, and will require sophisticated systems approaches...
  10. ncbi request reprint Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome
    G M Hoffman
    Department of Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee 53226, USA
    Ann Thorac Surg 70:1515-20; discussion 1521. 2000
    ..We sought to determine the critical level of venous oxygen saturation to maintain aerobic metabolism in neonates after the Norwood procedure (NP) for the hypoplastic left heart syndrome (HLHS)...
  11. ncbi request reprint Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure
    J S Tweddell
    Department of Surgery, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53201, USA
    Ann Thorac Surg 67:161-7; discussion 167-8. 1999
    ..We hypothesized that phenoxybenzamine could achieve a balanced circulation through reduction of systemic vascular resistance...
  12. ncbi request reprint Patients at risk for low systemic oxygen delivery after the Norwood procedure
    J S Tweddell
    Department of Surgery Cardiothoracic Surgery, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee 53226, USA
    Ann Thorac Surg 69:1893-9. 2000
    ....
  13. ncbi request reprint Home surveillance program prevents interstage mortality after the Norwood procedure
    N S Ghanayem
    Department of Pediatrics, and National Outcomes Center, Inc, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, 53226, USA
    J Thorac Cardiovasc Surg 126:1367-77. 2003
    ..To determine whether early identification of physiologic variances associated with interstage death would reduce mortality, we developed a home surveillance program...
  14. ncbi request reprint Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome
    James S Tweddell
    Herma Heart Center and Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 84:1301-10; discussion 1310-1. 2007
    ....
  15. ncbi request reprint Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients
    James S Tweddell
    Cardiothoracic Surgery, Children s Hospital of Wisconsin and the Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circulation 106:I82-9. 2002
    ....
  16. doi request reprint Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome
    Beth Ann Johnson
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 87:571-7; discussion 577-9. 2009
    ..We hypothesized that preoperative use of near-infrared spectroscopy (NIRS) would reduce the need for invasive therapies, including controlled ventilation and inspired gas manipulation...
  17. ncbi request reprint Postoperative management in patients with complex congenital heart disease
    James S Tweddell
    Divisions of Cardiothoracic Surgery, Pediatric Anesthesia, and Critical Care, The Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 5:187-205. 2002
    ..Management of any individual patient should be driven by objective analysis of available data and must include efforts to re-evaluate the treatment plan as well as to identify unanticipated problems...
  18. ncbi request reprint Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality
    Robert D B Jaquiss
    Division of Pediatric Cardiothoracic Surgery Medical College of Wisconsin, and Children s Hospital of Wisconsin, Milwaukee, 53226, USA
    J Thorac Cardiovasc Surg 127:982-9. 2004
    ..Potential disadvantages include severe cyanosis, prolonged pleural drainage and hospitalization, and excess mortality. We reviewed our recent experience to evaluate the safety of early cavopulmonary anastomosis...
  19. doi request reprint Gas embolus and cardiac arrest during laparoscopic pyloromyotomy in an infant
    Susan P Taylor
    Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin, Milwaukee, USA
    Can J Anaesth 57:774-8. 2010
    ..Persistent intracranial emboli following the arrest may have resulted from nitrogen contamination of the delivered gas...
  20. ncbi request reprint Effect of shunt type on echocardiographic indices after initial palliations for hypoplastic left heart syndrome: Blalock-Taussig shunt versus right ventricle-pulmonary artery conduit
    Peter C Frommelt
    Division of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Am Soc Echocardiogr 20:1364-73. 2007
    ..The study objective was to compare echocardiographic indices in infants with hypoplastic left heart syndrome (HLHS) randomized to different surgical pathways...
  21. ncbi request reprint Assent for treatment: clinician knowledge, attitudes, and practice
    K Jane Lee
    Departments of Pediatrics, bSurgery, and cAnesthesia, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatrics 118:723-30. 2006
    ..Our purpose for this work was to explore clinician knowledge, attitudes, and practice regarding assent for medical treatment and to compare current practice with existing American Academy of Pediatrics guidelines...
  22. ncbi request reprint Right ventricle-to-pulmonary artery conduit versus Blalock-Taussig shunt: a hemodynamic comparison
    Nancy S Ghanayem
    Herma Heart Center at the Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Ann Thorac Surg 82:1603-9; discussion 1609-10. 2006
    ....
  23. doi request reprint Effect of volume resuscitation on regional perfusion in dehydrated pediatric patients as measured by two-site near-infrared spectroscopy
    Sheila J Hanson
    Division of Critical Care Medicine, Department of Pediatrics, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Emerg Care 25:150-3. 2009
    ..The aim of this study was to measure the change of cerebral and somatic regional oxygen saturation (rSO2) using near-infrared spectroscopic (NIRS) monitoring during volume resuscitation of dehydrated children...
  24. ncbi request reprint Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy
    Lynn M Rusy
    Department of Pediatric Anesthesiology, Medical College of Wisconsin Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 96:300-5. 2002
    ..The authors studied the effect of electrical P6 acupuncture in awake pediatric patients who had undergone surgery associated with a high incidence of PONV...
  25. doi request reprint Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease
    Nancy S Ghanayem
    Herma Heart Center at the Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Thorac Cardiovasc Surg 140:857-63. 2010
    ..We hypothesized that early goal-directed monitoring with venous oximetry and near-infrared spectroscopy would offset their increased vulnerability and improve survival...
  26. ncbi request reprint Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia
    Eckehard A E Stuth
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Paediatr Anaesth 14:831-7. 2004
    ..However, droperidol has been associated with QT prolongation and ventricular arrhythmias. We investigated, if neuroleptanalgesic doses of droperidol led to QT prolongation and cardiac arrhythmias in children undergoing cardiac surgery...
  27. ncbi request reprint Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome
    Robert D B Jaquiss
    Division of Pediatric Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Thorac Surg 82:1260-5; discussion 1265-6. 2006
    ..Early SCPA results in lower initial O2 saturation and longer hospitalization, but not increased mortality. We sought to determine the impact of early SCPA on Fontan candidacy and outcomes...
  28. ncbi request reprint Survival after treatment of rabies with induction of coma
    Rodney E Willoughby
    Department of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 352:2508-14. 2005
    ..At nearly five months after her initial hospitalization, she was alert and communicative, but with choreoathetosis, dysarthria, and an unsteady gait...
  29. ncbi request reprint Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis
    Nancy S Ghanayem
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cardiol Young 16:61-6. 2006
  30. ncbi request reprint Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets
    J B Gordon
    Department of Pediatrics, Medical College of Wisconsin, and Zablocki VAMC, Milwaukee, USA
    Pediatr Res 46:735-41. 1999
    ....
  31. ncbi request reprint Near infrared spectroscopy monitoring during pediatric aortic coarctation repair
    Richard J Berens
    Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI, USA
    Paediatr Anaesth 16:777-81. 2006
    ..Near infrared spectroscopy (NIRS) measures regional tissue oxygenation continuously and noninvasively and may allow assessment of changes in regional perfusion in real time...
  32. doi request reprint Cerebral and somatic near-infrared spectroscopy in normal newborns
    Nicole P Bernal
    Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Pediatr Surg 45:1306-10. 2010
    ..We studied healthy newborn babies to establish normal values during rest and feeding...
  33. doi request reprint Pro: NIRS is "standard of care" for postoperative management
    James S Tweddell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 13:44-50. 2010
    ..NIRS provides continuous, non-invasive measures that are suitable targets for goal-directed therapy to treat deficiencies in global and regional perfusion and should be standard of care...
  34. doi request reprint Cerebral hemodynamics in the presence of decreased systemic venous compliance in patients with Fontan physiology may limit anaerobic exercise capacity
    Rohit P Rao
    Department of Pediatrics, Division of Cardiology and Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA
    Pediatr Cardiol 31:208-14. 2010
    ....
  35. doi request reprint Fontan palliation in the modern era: factors impacting mortality and morbidity
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Sections of Pediatric Cardiology and Critical Care, Medical College of Wisconsin and Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 88:1291-9. 2009
    ..Coincident with these improvements, Fontan palliation has been applied to a wider ranger of anatomic subgroups...
  36. doi request reprint Measurement of regional tissue bed venous weighted oximetric trends during exercise by near infrared spectroscopy
    Rohit P Rao
    Department of Pediatrics, Division of Cardiology and Critical Care, Medical College of Wisconsin, Milwaukee, USA
    Pediatr Cardiol 30:465-71. 2009
    ..Near Infrared Spectroscopy (NIRS) devices measure regional oxyhemoglobin saturation (rSO2). We aim to predict anaerobic threshold (AT) during CPET using multiorgan NIRS monitoring...
  37. ncbi request reprint L-arginine infusion lowers blood pressure in children
    L D Nelin
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    J Pediatr 139:747-9. 2001
    ..The change in blood pressure was inversely related to the change in plasma L-citrulline. These results suggest that L-arginine decreased blood pressure via increased nitric oxide production...
  38. ncbi request reprint Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 88:1624-33. 1998
    ..Previously, inhibitors of the beta-lyase pathway (aminooxyacetic acid and probenecid) diminished the nephrotoxicity of intraperitoneal compound A. This investigation determined inhibitor effects on the toxicity of inhaled compound A...
  39. ncbi request reprint Clinical evaluation of the effects of signal integrity and saturation on data availability and accuracy of Masimo SE and Nellcor N-395 oximeters in children
    Frederick A Robertson
    Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin, Milwaukee, WI 53201, USA
    Anesth Analg 98:617-22, table of contents. 2004
    ..Therefore, with poor SIQ or during hypoxemia, the Nellcor N-395 and Masimo oximeters are not clinically equivalent to each other or to the older Solar 8000 oximeter...
  40. ncbi request reprint A prospective evaluation of opioid weaning in opioid-dependent pediatric critical care patients
    Richard J Berens
    Department of Anesthesiology, Medical College of Wisconsin, Children s Hospital of Wisconsin, USA
    Anesth Analg 102:1045-50. 2006
    ..Patients may be able to be weaned successfully in 5 days once converted to oral methadone, with a follow-up period after medication wean to observe for a delayed withdrawal syndrome...
  41. ncbi request reprint Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease
    James S Tweddell
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 129:551-8. 2005
    ..This study was undertaken to determine the utility of aortic valve repair in children...
  42. ncbi request reprint Monitoring the brain before, during, and after cardiac surgery to improve long-term neurodevelopmental outcomes
    Nancy S Ghanayem
    Department of Pediatrics, Division of Cardiothoracic Surgery, Medical College of Wisconsin 53122, USA
    Cardiol Young 16:103-9. 2006
  43. doi request reprint Cardiopulmonary resuscitation: special considerations for infants and children with cardiac disease
    Stacie B Peddy
    Department of Pediatrics, Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine 19104, United States of America
    Cardiol Young 17:116-26. 2007
    ..In this review, therefore, we summarize the newest developments in paediatric resuscitation, with an expanded focus upon the unique challenges and importance of anticipatory care in infants and children with cardiac disease...