Research Topics
| Cecilia HillardSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Serum contents of endocannabinoids are correlated with blood pressure in depressed womenW S Vanessa Ho
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Lipids Health Dis 11:32. 2012....- Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidenceC J Hillard
Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
Neuroscience 204:207-29. 2012..These data are reviewed for the purpose of generating hypotheses and to encourage further studies in this very interesting and important area... 
Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activityC J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
FEBS Lett 459:277-81. 1999..These results support the hypothesis that activation of the CB(1) receptor in CGCs results in a decreased influx of calcium in response to membrane depolarization, resulting in a decreased activation of neuronal NOS...- Accumulation of anandamide: evidence for cellular diversityCecilia J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuropharmacology 48:1072-8. 2005..These studies add to the evidence that the neuronal accumulation of AEA uniquely requires more than passive diffusion and fatty acid amide-mediated catabolism of intracellular AEA... - Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619C J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Br J Pharmacol 152:691-8. 2007..The purposes of this study were to examine the extent to which 2-AG is catabolized by cerebral arteries and to determine whether blockade of 2-AG inactivation potentiates its feedback inhibition of U-44619-mediated vasoconstriction... - U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevanceDavid J Rademacher
Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
Am J Physiol Heart Circ Physiol 288:H2694-701. 2005..These results suggest that MCA production of eCBs is not regulated by constriction per se but likely via a signaling pathway that is specific for TXA(2) receptors and not 5-HT receptors... - Cellular accumulation of anandamide: consensus and controversyCecilia J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Br J Pharmacol 140:802-8. 2003..Finally, we discuss the available data that have been presented in support of a transmembrane carrier protein for AEA... - Role of cannabinoids and endocannabinoids in cerebral ischemiaCecilia J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, WI 53226, USA
Curr Pharm Des 14:2347-61. 2008..Overall, the available data suggest that inhibition of CB1 receptor activation together with increased CB2 receptor activation produces beneficial effects... - Lipids and drugs of abuseCecilia J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States
Life Sci 77:1531-42. 2005..Enhanced research in all of these areas will likely provide useful insights into and, perhaps, therapeutic targets for the treatment of drug abuse... - Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolaseCecilia J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Mol Neurosci 33:18-24. 2007.... - Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerolC J Hillard
Department of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
Prostaglandins Other Lipid Mediat 61:3-18. 2000..Two possible physiological roles of the endocannabinoids and the CB1 receptor are discussed: the regulation of gestation and the regulation of gastrointestinal motility... - Endocannabinoids and vascular functionC J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pharmacol Exp Ther 294:27-32. 2000..The data regarding these effects of the cannabinoids and possible sources of endocannabinoid ligands in the vasculature are the subjects of this review... - The movement of N-arachidonoylethanolamine (anandamide) across cellular membranesC J Hillard
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Chem Phys Lipids 108:123-34. 2000..Several important questions remain to be answered regarding the carrier, including its molecular structure and its role in the release and inactivation of endogenously produced AEA... - Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signalingBin Pan
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pharmacol Exp Ther 331:591-7. 2009..These results indicate that the degradation of 2-AG by MAGL is the rate-limiting step that determines the time course of DSE/DSI and that JZL184 is a useful tool for the study of 2-AG-mediated signaling... - Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteriesKathryn M Gauthier
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Heart Circ Physiol 288:H1344-51. 2005..2-AG is further hydrolyzed to AA, which is metabolized to vasoactive eicosanoids. These studies reveal a role for 2-AG in EC AA release and the regulation of coronary tone... - 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasionKasem Nithipatikom
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Cancer Res 64:8826-30. 2004..The results suggest that cellular 2-AG, acting through the CB1 receptor, is an endogenous inhibitor of invasive prostate cancer cells... - Effects of endocannabinoids on discharge of baroreceptive NTS neuronsJeanne L Seagard
Department of Anesthesiology, Zablocki Department of Veterans Affairs Medical Center, Medical College of Wisconsin, Research Service 151, 5000 W National Avenue, Milwaukee, WI 53295, USA
Neurosci Lett 381:334-9. 2005..These results support the hypothesis that ECBs enhance baroreflex function through increases in NTS baroreceptive neuronal activity, due in part to modulation of GABAergic inhibitory effects at the neuronal level... - Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas)David J Rademacher
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neurotoxicology 26:9-15. 2005..As eCBs serve as activity-dependent retrograde inhibitors of neurotransmitter release, the increase in brain eCB content would accentuate Pb2+-induced decreases in evoked neurotransmitter release in male but not female fathead minnows... - Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibitionJeanne L Seagard
Zablocki Dept of Veterans Affairs Medical Center, Research Service 151, 5000 W National Ave, Milwaukee, WI 53295, USA
Am J Physiol Heart Circ Physiol 286:H992-1000. 2004.... - Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogsDavid J Rademacher
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA
Am J Physiol Heart Circ Physiol 284:H1570-6. 2003..Microinjection of WIN-55212-2 had no effect on the baroreflex. These data suggest that endocannabinoids can modulate the excitability of NTS neurons involved in the baroreceptor reflex, leading to modulation of baroreflex regulation... - The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activitySachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
J Lipid Res 46:342-9. 2005..These data demonstrate that FAAH activity differentially affects AEA and OEA/PEA contents postmortem and suggest that AEA formation specifically occurs via an ethanolamine-dependent route postmortem... 
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acidWenqi Yang
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 324:1019-27. 2008..Using this radioligand, we have identified a specific high-affinity and high-abundance EET binding site in U937 cell membranes. This binding site could represent a specific EET receptor, which is probably a G protein-coupled receptor...- Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neuronsBin Pan
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci 28:1385-97. 2008..Together, these results suggest that repeated cocaine exposure reduces the strength of GABAergic inhibition in dopamine neurons by inducing I-LTD-like modification in vivo... - D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signalingBin Pan
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci 28:14018-30. 2008.... - Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in miceDavid J Rademacher
Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuropharmacology 54:108-16. 2008..These studies are consistent with the hypothesis that stress exposure alters endocannabinoid signaling in the brain and that alterations in endocannabinoid signaling occur during habituation to stress... - Cannabinoid-induced Fos expression within A10 dopaminergic neuronsSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Brain Res 963:15-25. 2003.... - Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signallingSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Eur J Neurosci 21:1057-69. 2005.... - 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3Tiesong Shang
Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurochem 85:358-67. 2003..In summary, CGNs accumulate MPP+ in manner that is consistent with uptake via OCT3 and the presence of this protein in CGNs explains their sensitivity to MPP+ toxicity... - Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanismErica J Carrier
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA
Mol Pharmacol 65:999-1007. 2004..These data suggest that 2-AG activation of CB(2) receptors may contribute to the proliferative response of microglial cells, as occurs in neurodegenerative disorders... - The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolaseSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Br J Pharmacol 139:1005-13. 2003.... - Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activitySachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 306:880-8. 2003.... - The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the ratSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53223, USA
Neurosci Lett 335:95-8. 2002..These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation... - Interactions between endocannabinoids and stress-induced decreased sensitivity to natural rewardDavid J Rademacher
Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA
Prog Neuropsychopharmacol Biol Psychiatry 31:633-41. 2007..The findings of the present study indicate that the CB(1)/endocannabinoid signaling system is an important allostatic mediator that both modulates the responses of mice to stress and is itself modulated by stress... - Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell lineDavid J Rademacher
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Neuroimmunol 149:130-41. 2004..RTMGL1 synthesize 5-HETE from arachidonic acid (AA) likely via a 5-lipoxygenase (LO). Thus, RTMGL1 have morphological and histological characteristics of primary microglia and metabolize AA via both COX and LO pathways... - Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aortaXin Tang
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Arterioscler Thromb Vasc Biol 26:78-84. 2006..CONCLUSIONS: 15-LO-I is expressed in rabbit aortic endothelium and is important in endothelium-dependent regulation of vascular tone... - Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxideShasi V Kalivendi
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 279:15240-7. 2004..We conclude that MPP(+)-induced iron signaling is responsible for intracellular oxidant generation, alpha-syn expression, proteasomal dysfunction, and apoptosis. Relevance to Parkinson's disease is discussed... - Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signalingSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 318:304-11. 2006..These results suggest that pharmacological modulation of this system could represent a new approach to the treatment of anxiety-related psychiatric disorders... - Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axisSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Endocrinology 145:5431-8. 2004.... - 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxideShasi V Kalivendi
Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Biochem J 371:151-64. 2003..Overall, these results suggest that MPP(+)-induced cell death in CGNs and neuroblastoma cells proceeds via apoptosis and involves mitochondrial release of ROS and TfR-dependent iron... - Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descentYi Zhang
Medical College of Wisconsin, Milwaukee, Wisconsin, WI 53226, USA
Pharmacogenomics 10:1929-39. 2009..In recent years, there has been tremendous interest in understanding the endocannabinoid system as a novel therapeutic target for the treatment of obesity-related dyslipidemia... - Endocannabinoid signalling: has it got rhythm?Linda K Vaughn
Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA
Br J Pharmacol 160:530-43. 2010.... - 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxideTiesong Shang
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
J Biol Chem 279:19099-112. 2004..Implications of these results in unraveling the molecular mechanisms of neurodegenerative diseases (Parkinson's and Alzheimer's disease) are discussed... - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cellsKatarzyna Maresz
BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
Nat Med 13:492-7. 2007..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor... - Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdalaSachin Patel
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neuropsychopharmacology 30:497-507. 2005.... - Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cellsKasem Nithipatikom
Dept. of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Endocrinol Metab 287:E820-7. 2004..This study demonstrates that chronic administration of NO inhibits aldosterone synthesis in ZG cells by downregulation of the expression of both AT1 receptors and cholesterol side-chain cleavage enzyme... - Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell deathTiesong Shang
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 280:34644-53. 2005..Inhibition of class III phosphoinositide 3-kinase attenuated MPP(+)-induced lysosome reduction and cell death. The role of DAPK as a sensor of mitochondrial membrane potential in mitochondrial diseases was addressed... - Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuliKatarzyna Maresz
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA
J Neurochem 95:437-45. 2005..These data demonstrate that microglial cell activation is accompanied by CB2 receptor up-regulation, suggesting that this receptor plays an important role in microglial cell function in the CNS during autoimmune-induced inflammation... - Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activityMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 103:47-56. 2007.... - Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 31:2591-9. 2006.... - Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brainMichiru Hirasawa
Calgary Brain Institute, Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
J Physiol 559:611-24. 2004..This indicates that somatodendritic peptide release and action on previously identified autoreceptors facilitates the release of endocannabinoids that act as mediators of presynaptic inhibition... - Hemisynthesis and preliminary evaluation of novel endocannabinoid analoguesSiham El Fangour
UMR CNRS 5074, Faculte de Pharmacie, 15 av C Flahault, BP 14491, F 34093 5, Montpellier Cedex, France
Bioorg Med Chem Lett 13:1977-80. 2003.... - Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdalaMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B.C. Canada V6T1Z4
Eur J Pharmacol 528:99-102. 2005..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content... - Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituationSachin Patel
Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Eur J Neurosci 27:2821-9. 2008..The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed... - Regulation of endocannabinoid signaling by stress: implications for stress-related affective disordersBoris B Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Neurosci Biobehav Rev 32:1152-60. 2008.... - Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neuropsychopharmacology 30:508-15. 2005.... - Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppressionErica J Carrier
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 103:7895-900. 2006..These studies demonstrate that CBD has the ability to enhance adenosine signaling through inhibition of uptake and provide a non-cannabinoid receptor mechanism by which CBD can decrease inflammation... - Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampusMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Hippocampus 18:221-6. 2008.... - Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future researchRobert Katz
Omega 3 Research Institute, Inc, 16700 Sioux Lane, Gaithersburg, MD 20878, USA
J Mol Neurosci 33:146-50. 2007..12) The relationship between LC-PUFA, stroke, and AD should be clarified, and neurogenetic metabolic diseases that could benefit from supplementation with omega3 LC-PUFA such as DHA should be identified... - Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brainsCristina Benito
Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Alcorcon, Madrid, Spain
J Neurosci 23:11136-41. 2003..Thus, some elements of the endocannabinoid system may be postulated as possible modulators of the inflammatory response associated with this neurodegenerative process and as possible targets for new therapeutic approaches... - Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosisCristina Benito
Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Madrid, Spain
J Neurosci 27:2396-402. 2007.... - Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatmentMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 106:2322-36. 2008....
Research Grants
- Cannabinoid regulation of glycogen synthase kinase-3Cecilia J Hillard; Fiscal Year: 2010....
- BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOIDCecilia J Hillard; Fiscal Year: 2010..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..
- BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOIDCecilia Hillard; Fiscal Year: 2009..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..
- Gender differences in the interactions between endocannabinoids and stressCecilia Hillard; Fiscal Year: 2007Long-term objectives: This is a collaborative research effort between the laboratories of Dr. Cecilia Hillard, a basic scientist studying cannabinoid receptor function using animal and cellular models; and Dr...
- Cannabinoid Receptors and Cerebrovascular FunctionCecilia Hillard; Fiscal Year: 2006..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
- Brain Endocannabinoids and Chronic StressCecilia Hillard; Fiscal Year: 2005..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
- BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOIDCecilia Hillard; Fiscal Year: 2009..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..