Cecilia Hillard

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Endocannabinoid signaling in the etiology and treatment of major depressive illness
    Cecilia J Hillard
    Neuroscience Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226
    Curr Pharm Des 20:3795-811. 2014
  2. pmc Serum contents of endocannabinoids are correlated with blood pressure in depressed women
    W S Vanessa Ho
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lipids Health Dis 11:32. 2012
  3. pmc Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence
    C J Hillard
    Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Neuroscience 204:207-29. 2012
  4. ncbi request reprint Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    FEBS Lett 459:277-81. 1999
  5. ncbi request reprint U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005
  6. pmc Cellular accumulation of anandamide: consensus and controversy
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 140:802-8. 2003
  7. ncbi request reprint Lipids and drugs of abuse
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States
    Life Sci 77:1531-42. 2005
  8. pmc Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Br J Pharmacol 152:691-8. 2007
  9. pmc Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Neurosci 33:18-24. 2007
  10. pmc Role of cannabinoids and endocannabinoids in cerebral ischemia
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, WI 53226, USA
    Curr Pharm Des 14:2347-61. 2008

Research Grants

  1. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2010
  2. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2003
  3. BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOID
    Cecilia J Hillard; Fiscal Year: 2010
  4. BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOID
    Cecilia Hillard; Fiscal Year: 2009
  5. Gender differences in the interactions between endocannabinoids and stress
    Cecilia Hillard; Fiscal Year: 2007
  6. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
  7. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2004
  8. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
  9. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2005
  10. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Endocannabinoid signaling in the etiology and treatment of major depressive illness
    Cecilia J Hillard
    Neuroscience Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226
    Curr Pharm Des 20:3795-811. 2014
    ..Together the available data indicate that activators of CB1R signaling, particularly inhibitors of fatty acid amide hydrolase, should be considered for clinical trials for the treatment of depression. ..
  2. pmc Serum contents of endocannabinoids are correlated with blood pressure in depressed women
    W S Vanessa Ho
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lipids Health Dis 11:32. 2012
    ....
  3. pmc Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence
    C J Hillard
    Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Neuroscience 204:207-29. 2012
    ..These data are reviewed for the purpose of generating hypotheses and to encourage further studies in this very interesting and important area...
  4. ncbi request reprint Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    FEBS Lett 459:277-81. 1999
    ..These results support the hypothesis that activation of the CB(1) receptor in CGCs results in a decreased influx of calcium in response to membrane depolarization, resulting in a decreased activation of neuronal NOS...
  5. ncbi request reprint U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005
    ..These results suggest that MCA production of eCBs is not regulated by constriction per se but likely via a signaling pathway that is specific for TXA(2) receptors and not 5-HT receptors...
  6. pmc Cellular accumulation of anandamide: consensus and controversy
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 140:802-8. 2003
    ..Finally, we discuss the available data that have been presented in support of a transmembrane carrier protein for AEA...
  7. ncbi request reprint Lipids and drugs of abuse
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States
    Life Sci 77:1531-42. 2005
    ..Enhanced research in all of these areas will likely provide useful insights into and, perhaps, therapeutic targets for the treatment of drug abuse...
  8. pmc Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Br J Pharmacol 152:691-8. 2007
    ..The purposes of this study were to examine the extent to which 2-AG is catabolized by cerebral arteries and to determine whether blockade of 2-AG inactivation potentiates its feedback inhibition of U-44619-mediated vasoconstriction...
  9. pmc Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Neurosci 33:18-24. 2007
    ....
  10. pmc Role of cannabinoids and endocannabinoids in cerebral ischemia
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, WI 53226, USA
    Curr Pharm Des 14:2347-61. 2008
    ..Overall, the available data suggest that inhibition of CB1 receptor activation together with increased CB2 receptor activation produces beneficial effects...
  11. ncbi request reprint Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol
    C J Hillard
    Department of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Prostaglandins Other Lipid Mediat 61:3-18. 2000
    ..Two possible physiological roles of the endocannabinoids and the CB1 receptor are discussed: the regulation of gestation and the regulation of gastrointestinal motility...
  12. ncbi request reprint Accumulation of anandamide: evidence for cellular diversity
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 48:1072-8. 2005
    ..These studies add to the evidence that the neuronal accumulation of AEA uniquely requires more than passive diffusion and fatty acid amide-mediated catabolism of intracellular AEA...
  13. ncbi request reprint Endocannabinoids and vascular function
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 294:27-32. 2000
    ..The data regarding these effects of the cannabinoids and possible sources of endocannabinoid ligands in the vasculature are the subjects of this review...
  14. ncbi request reprint The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes
    C J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Chem Phys Lipids 108:123-34. 2000
    ..Several important questions remain to be answered regarding the carrier, including its molecular structure and its role in the release and inactivation of endogenously produced AEA...
  15. pmc Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling
    Bin Pan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 331:591-7. 2009
    ..These results indicate that the degradation of 2-AG by MAGL is the rate-limiting step that determines the time course of DSE/DSI and that JZL184 is a useful tool for the study of 2-AG-mediated signaling...
  16. ncbi request reprint Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas)
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurotoxicology 26:9-15. 2005
    ..As eCBs serve as activity-dependent retrograde inhibitors of neurotransmitter release, the increase in brain eCB content would accentuate Pb2+-induced decreases in evoked neurotransmitter release in male but not female fathead minnows...
  17. ncbi request reprint 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cancer Res 64:8826-30. 2004
    ..The results suggest that cellular 2-AG, acting through the CB1 receptor, is an endogenous inhibitor of invasive prostate cancer cells...
  18. ncbi request reprint The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 46:342-9. 2005
    ..These data demonstrate that FAAH activity differentially affects AEA and OEA/PEA contents postmortem and suggest that AEA formation specifically occurs via an ethanolamine-dependent route postmortem...
  19. ncbi request reprint Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 288:H1344-51. 2005
    ..2-AG is further hydrolyzed to AA, which is metabolized to vasoactive eicosanoids. These studies reveal a role for 2-AG in EC AA release and the regulation of coronary tone...
  20. ncbi request reprint Effects of endocannabinoids on discharge of baroreceptive NTS neurons
    Jeanne L Seagard
    Department of Anesthesiology, Zablocki Department of Veterans Affairs Medical Center, Medical College of Wisconsin, Research Service 151, 5000 W National Avenue, Milwaukee, WI 53295, USA
    Neurosci Lett 381:334-9. 2005
    ..These results support the hypothesis that ECBs enhance baroreflex function through increases in NTS baroreceptive neuronal activity, due in part to modulation of GABAergic inhibitory effects at the neuronal level...
  21. ncbi request reprint Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition
    Jeanne L Seagard
    Zablocki Dept of Veterans Affairs Medical Center, Research Service 151, 5000 W National Ave, Milwaukee, WI 53295, USA
    Am J Physiol Heart Circ Physiol 286:H992-1000. 2004
    ....
  22. ncbi request reprint Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 284:H1570-6. 2003
    ..Microinjection of WIN-55212-2 had no effect on the baroreflex. These data suggest that endocannabinoids can modulate the excitability of NTS neurons involved in the baroreceptor reflex, leading to modulation of baroreflex regulation...
  23. doi request reprint Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons
    Bin Pan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 28:1385-97. 2008
    ..Together, these results suggest that repeated cocaine exposure reduces the strength of GABAergic inhibition in dopamine neurons by inducing I-LTD-like modification in vivo...
  24. doi request reprint Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid
    Wenqi Yang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 324:1019-27. 2008
    ..Using this radioligand, we have identified a specific high-affinity and high-abundance EET binding site in U937 cell membranes. This binding site could represent a specific EET receptor, which is probably a G protein-coupled receptor...
  25. pmc D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling
    Bin Pan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 28:14018-30. 2008
    ....
  26. ncbi request reprint Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 306:880-8. 2003
    ....
  27. ncbi request reprint Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 54:108-16. 2008
    ..These studies are consistent with the hypothesis that stress exposure alters endocannabinoid signaling in the brain and that alterations in endocannabinoid signaling occur during habituation to stress...
  28. ncbi request reprint Cannabinoid-induced Fos expression within A10 dopaminergic neurons
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 963:15-25. 2003
    ....
  29. ncbi request reprint 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3
    Tiesong Shang
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurochem 85:358-67. 2003
    ..In summary, CGNs accumulate MPP+ in manner that is consistent with uptake via OCT3 and the presence of this protein in CGNs explains their sensitivity to MPP+ toxicity...
  30. pmc The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 139:1005-13. 2003
    ....
  31. ncbi request reprint Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    Erica J Carrier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Mol Pharmacol 65:999-1007. 2004
    ..These data suggest that 2-AG activation of CB(2) receptors may contribute to the proliferative response of microglial cells, as occurs in neurodegenerative disorders...
  32. ncbi request reprint Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
    ....
  33. ncbi request reprint Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Neuroimmunol 149:130-41. 2004
    ..RTMGL1 synthesize 5-HETE from arachidonic acid (AA) likely via a 5-lipoxygenase (LO). Thus, RTMGL1 have morphological and histological characteristics of primary microglia and metabolize AA via both COX and LO pathways...
  34. ncbi request reprint The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53223, USA
    Neurosci Lett 335:95-8. 2002
    ..These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation...
  35. ncbi request reprint Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta
    Xin Tang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 26:78-84. 2006
    ..These metabolites contribute to endothelium-dependent relaxations of rabbit aorta to AA and acetylcholine. We investigated the identity of rabbit aortic 15-LO and studied its importance in the regulation of vascular tone...
  36. pmc Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:633-41. 2007
    ..The findings of the present study indicate that the CB(1)/endocannabinoid signaling system is an important allostatic mediator that both modulates the responses of mice to stress and is itself modulated by stress...
  37. ncbi request reprint Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  38. ncbi request reprint Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuropsychopharmacology 30:497-507. 2005
    ....
  39. ncbi request reprint Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells
    Kasem Nithipatikom
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Endocrinol Metab 287:E820-7. 2004
    ..This study demonstrates that chronic administration of NO inhibits aldosterone synthesis in ZG cells by downregulation of the expression of both AT1 receptors and cholesterol side-chain cleavage enzyme...
  40. ncbi request reprint Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    Katarzyna Maresz
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
    Nat Med 13:492-7. 2007
    ..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor...
  41. pmc 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
    Shasi V Kalivendi
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochem J 371:151-64. 2003
    ..Overall, these results suggest that MPP(+)-induced cell death in CGNs and neuroblastoma cells proceeds via apoptosis and involves mitochondrial release of ROS and TfR-dependent iron...
  42. pmc Endocannabinoid signalling: has it got rhythm?
    Linda K Vaughn
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA
    Br J Pharmacol 160:530-43. 2010
    ....
  43. ncbi request reprint 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide
    Tiesong Shang
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Biol Chem 279:19099-112. 2004
    ..Implications of these results in unraveling the molecular mechanisms of neurodegenerative diseases (Parkinson's and Alzheimer's disease) are discussed...
  44. ncbi request reprint Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 318:304-11. 2006
    ..These results suggest that pharmacological modulation of this system could represent a new approach to the treatment of anxiety-related psychiatric disorders...
  45. pmc Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
    Yi Zhang
    Medical College of Wisconsin, Milwaukee, Wisconsin, WI 53226, USA
    Pharmacogenomics 10:1929-39. 2009
    ..In recent years, there has been tremendous interest in understanding the endocannabinoid system as a novel therapeutic target for the treatment of obesity-related dyslipidemia...
  46. ncbi request reprint Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide
    Shasi V Kalivendi
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 279:15240-7. 2004
    ..We conclude that MPP(+)-induced iron signaling is responsible for intracellular oxidant generation, alpha-syn expression, proteasomal dysfunction, and apoptosis. Relevance to Parkinson's disease is discussed...
  47. ncbi request reprint Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death
    Tiesong Shang
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:34644-53. 2005
    ..Inhibition of class III phosphoinositide 3-kinase attenuated MPP(+)-induced lysosome reduction and cell death. The role of DAPK as a sensor of mitochondrial membrane potential in mitochondrial diseases was addressed...
  48. ncbi request reprint Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
    Katarzyna Maresz
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA
    J Neurochem 95:437-45. 2005
    ..These data demonstrate that microglial cell activation is accompanied by CB2 receptor up-regulation, suggesting that this receptor plays an important role in microglial cell function in the CNS during autoimmune-induced inflammation...
  49. ncbi request reprint Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 103:47-56. 2007
    ....
  50. ncbi request reprint Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues
    Siham El Fangour
    UMR CNRS 5074, Faculte de Pharmacie, 15 av C Flahault, BP 14491, F 34093 5, Montpellier Cedex, France
    Bioorg Med Chem Lett 13:1977-80. 2003
    ....
  51. pmc Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain
    Michiru Hirasawa
    Calgary Brain Institute, Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    J Physiol 559:611-24. 2004
    ..This indicates that somatodendritic peptide release and action on previously identified autoreceptors facilitates the release of endocannabinoids that act as mediators of presynaptic inhibition...
  52. ncbi request reprint Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 31:2591-9. 2006
    ....
  53. ncbi request reprint Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C Canada V6T1Z4
    Eur J Pharmacol 528:99-102. 2005
    ..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content...
  54. ncbi request reprint Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Hippocampus 18:221-6. 2008
    ....
  55. ncbi request reprint Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuropsychopharmacology 30:508-15. 2005
    ....
  56. ncbi request reprint Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Alcorcon, Madrid, Spain
    J Neurosci 23:11136-41. 2003
    ..Thus, some elements of the endocannabinoid system may be postulated as possible modulators of the inflammatory response associated with this neurodegenerative process and as possible targets for new therapeutic approaches...
  57. doi request reprint Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Neurosci Biobehav Rev 32:1152-60. 2008
    ....
  58. pmc Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    Erica J Carrier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 103:7895-900. 2006
    ..These studies demonstrate that CBD has the ability to enhance adenosine signaling through inhibition of uptake and provide a non-cannabinoid receptor mechanism by which CBD can decrease inflammation...
  59. pmc Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 106:2322-36. 2008
    ....
  60. pmc Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation
    Sachin Patel
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 27:2821-9. 2008
    ..The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed...
  61. ncbi request reprint Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Madrid, Spain
    J Neurosci 27:2396-402. 2007
    ....
  62. ncbi request reprint Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research
    Robert Katz
    Omega 3 Research Institute, Inc, 16700 Sioux Lane, Gaithersburg, MD 20878, USA
    J Mol Neurosci 33:146-50. 2007
    ..12) The relationship between LC-PUFA, stroke, and AD should be clarified, and neurogenetic metabolic diseases that could benefit from supplementation with omega3 LC-PUFA such as DHA should be identified...

Research Grants14

  1. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2010
    ....
  2. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2003
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  3. BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOID
    Cecilia J Hillard; Fiscal Year: 2010
    ..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..
  4. BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOID
    Cecilia Hillard; Fiscal Year: 2009
    ..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..
  5. Gender differences in the interactions between endocannabinoids and stress
    Cecilia Hillard; Fiscal Year: 2007
    Long-term objectives: This is a collaborative research effort between the laboratories of Dr. Cecilia Hillard, a basic scientist studying cannabinoid receptor function using animal and cellular models; and Dr...
  6. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  7. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2004
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  8. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  9. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2005
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  10. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2004
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  11. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2004
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  12. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2003
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  13. BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOID
    Cecilia Hillard; Fiscal Year: 2009
    ..We have coupled this technique with our ability to culture cells from the cerebellum as a unique approach to these goals. ..