M W Hamrick

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    J Musculoskelet Neuronal Interact 6:258-63. 2006
  2. pmc The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 400:379-83. 2010
  3. ncbi Leptin, bone mass, and the thrifty phenotype
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    J Bone Miner Res 19:1607-11. 2004
  4. ncbi Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 20:994-1001. 2005
  5. ncbi Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Obes (Lond) 30:868-70. 2006
  6. ncbi Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise
    Mark W Hamrick
    Department of Cellular Biology and Anatomy Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 21:477-83. 2006
  7. ncbi Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 39:845-53. 2006
  8. ncbi Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Laney Walker Blvd CB2915, Augusta, GA 30912, USA
    Cell Tissue Res 327:133-41. 2007
  9. pmc Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 40:1544-53. 2007
  10. ncbi Leptin and the sympathetic connection of fat to bone
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Department of Orthopaedic Surgery, Medical College of Georgia, Augusta, GA, 30912, USA
    Osteoporos Int 19:905-12. 2008

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    J Musculoskelet Neuronal Interact 6:258-63. 2006
    ....
  2. pmc The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 400:379-83. 2010
    ....
  3. ncbi Leptin, bone mass, and the thrifty phenotype
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    J Bone Miner Res 19:1607-11. 2004
  4. ncbi Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 20:994-1001. 2005
    ..The results suggest that, in leptin-sensitive animals, the reduction in marrow adipocytes has positive effects on bone formation...
  5. ncbi Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Obes (Lond) 30:868-70. 2006
    ..To determine if myostatin deficiency attenuates body fat gain with increased dietary fat intake...
  6. ncbi Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise
    Mark W Hamrick
    Department of Cellular Biology and Anatomy Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 21:477-83. 2006
    ....
  7. ncbi Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 39:845-53. 2006
    ..Our data show that mice lose a significant amount of muscle and bone tissue with age, and this loss of musculoskeletal tissue is accompanied by a drop in serum leptin and preceded by a significant decrease in physical activity...
  8. ncbi Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Laney Walker Blvd CB2915, Augusta, GA 30912, USA
    Cell Tissue Res 327:133-41. 2007
    ..Elimination of marrow adipocytes via this central pathway may represent a useful strategy for the treatment and prevention of osteoporosis...
  9. pmc Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 40:1544-53. 2007
    ..Furthermore, although myostatin deficiency increases muscle mass and bone strength, it does not prevent muscle and bone catabolism with unloading...
  10. ncbi Leptin and the sympathetic connection of fat to bone
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Department of Orthopaedic Surgery, Medical College of Georgia, Augusta, GA, 30912, USA
    Osteoporos Int 19:905-12. 2008
    ..Furthermore, pharmacological manipulation of the signaling pathways activated by leptin may have significant potential for the treatment and prevention of bone loss...
  11. doi Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 23:870-8. 2008
    ..We examined bone metabolism in calorically restricted mice to determine how alterations in soft tissue mass affect bone mass, density, and strength...
  12. pmc A role for myokines in muscle-bone interactions
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, and Department of Orthopaedic Surgery, Medical College of Georgia, Augusta, GA 30912, USA
    Exerc Sport Sci Rev 39:43-7. 2011
    ..Growth factor secretion by muscle may therefore be one pathway through which mechanical signals are transduced biologically...
  13. pmc Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Trauma 69:579-83. 2010
    ..The purpose of this study was to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in cases of deep penetrant injury...
  14. ncbi Leptin deficiency produces contrasting phenotypes in bones of the limb and spine
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 34:376-83. 2004
    ....
  15. ncbi Bone architecture and disc degeneration in the lumbar spine of mice lacking GDF-8 (myostatin)
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Laney Wlker Blvds CB 2915, Augusta, GA 30912, USA
    J Orthop Res 21:1025-32. 2003
    ..Results from this study suggest that increased muscle mass in mice lacking myostatin is associated with increased bone mass as well as degenerative changes in the intervertebral disc...
  16. ncbi Developmental mechanisms of digit reduction
    Mark W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, OH 44242, USA
    Evol Dev 4:247-8. 2002
  17. pmc Role of muscle-derived growth factors in bone formation
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, GA, USA
    J Musculoskelet Neuronal Interact 10:64-70. 2010
    ..Hence, the integrated growth and development of bone and muscle is likely to be regulated in part by paracrine mechanisms at the muscle-bone interface involving growth factor signaling...
  18. ncbi Bone mineral content and density in the humerus of adult myostatin-deficient mice
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Calcif Tissue Int 71:63-8. 2002
    ..These results suggest that the effects of increased muscle mass on the mouse humerus are localized to regions where muscles attach; furthermore, these effects include increased mineral content of both trabecular and cortical bone...
  19. ncbi Increased bone mineral density in the femora of GDF8 knockout mice
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Anat Rec A Discov Mol Cell Evol Biol 272:388-91. 2003
    ..001) and significantly greater cortical BMD (P <.001) at both locations. These results suggest that inhibitors of GDF8 function may be useful pharmacological agents for increasing both muscle mass and BMD...
  20. ncbi Evolution and development of mammalian limb integumentary structures
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Zool B Mol Dev Evol 298:152-63. 2003
    ..Evidence from comparative morphology, development, and functional genomics therefore sheds new light on both the patterns and mechanisms of evolutionary change in mammalian limb integumentary structures...
  21. ncbi Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice
    M W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA
    Bone 27:343-9. 2000
    ....
  22. ncbi CART deficiency increases body weight but does not alter bone strength
    S M Bartell
    Animal and Dairy Science, University of Georgia, Athens, GA, USA
    J Musculoskelet Neuronal Interact 8:146-53. 2008
    ..Our data suggest that while the central, neuroendocrine regulation of bone mass via CART signaling may have effects on trabecular mass, absence of CART expression does not significantly alter cortical bone geometry, density, or strength...
  23. ncbi Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice
    Eric Montgomery
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Anat Rec A Discov Mol Cell Evol Biol 286:814-22. 2005
    ..Likewise, increased muscle mass produces a marked increase in the external dimensions of muscle attachment sites, even when increased muscle size is accompanied by extensive fibrosis and muscle weakness...
  24. pmc Myostatin (GDF-8) as a key factor linking muscle mass and bone structure
    M N Elkasrawy
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    J Musculoskelet Neuronal Interact 10:56-63. 2010
    ..Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength...
  25. doi Bone and fat relationships in postadolescent black females: a pQCT study
    N K Pollock
    Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA
    Osteoporos Int 22:655-65. 2011
    ..Our findings in postadolescent black females suggest that excess weight in the form of fat mass may adversely influence cortical bone structure and strength...
  26. ncbi Development and evolution of the mammalian limb: adaptive diversification of nails, hooves, and claws
    M W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, OH 44242, USA
    Evol Dev 3:355-63. 2001
    ..The prevalence of convergences and parallelisms in nail and claw structure among mammals underscores the existence of multiple morphogenetic pathways for evolutionary change in distal limb appendages...
  27. ncbi A chondral modeling theory revisited
    M W Hamrick
    Department of Anthropology and Division of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA
    J Theor Biol 201:201-8. 1999
    ..The chondral modeling response is therefore an important physiological mechanism that maintains the match between skeletal structure, function, and locomotor performance throughout mammalian ontogeny and phylogeny...
  28. ncbi Alterations of temporalis muscle contractile force and histological content from the myostatin and Mdx deficient mouse
    Craig D Byron
    Department of Surgery, CJ 1117, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
    Arch Oral Biol 51:396-405. 2006
    ....
  29. doi Comparisons of trabecular and cortical bone in late adolescent black and white females
    Norman K Pollock
    Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    J Bone Miner Metab 29:44-53. 2011
    ....
  30. doi Effect of whole-body vibration on bone properties in aging mice
    Karl H Wenger
    Medical College of Georgia, Department of Orthopaedic Surgery, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Bone 47:746-55. 2010
    ..Although the purported anabolic effect of WBV on bone homeostasis may depend on location and the parameter of interest, this emerging therapy at a minimum does not appear to compromise bone health by the measures studied here...
  31. ncbi Phalangeal morphology of the paromomyidae (?primates, plesiadapiformes): the evidence for gliding behavior reconsidered
    M W Hamrick
    Department of Anthropology, Kent State University, Ohio 44240, USA
    Am J Phys Anthropol 109:397-413. 1999
    ....
  32. pmc Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume
    Ethan Kellum
    Department of Orthopaedic Surgery, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 44:17-23. 2009
    ..While myostatin is most well known for its effects on muscle development, it is also clear that myostatin plays a significant, direct role in bone formation and regeneration...
  33. ncbi EMG of the human flexor pollicis longus muscle: implications for the evolution of hominid tool use
    M W Hamrick
    Department of Anthropology, Kent State University, Ohio 44242, USA
    J Hum Evol 34:123-36. 1998
    ....
  34. ncbi Functional and adaptive significance of primate pads and claws: evidence from New World anthropoids
    M W Hamrick
    Department of Anthropology, Kent State University, Ohio 44242, USA
    Am J Phys Anthropol 106:113-27. 1998
    ..Finally, results from this study support previous suggestions that the keeled tegulae of callitrichines represent a derived postural adaptation rather than a primitive retention from an ancestral eutherian condition...
  35. ncbi Primate origins: evolutionary change in digital ray patterning and segmentation
    M W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, OH 44242, U S A
    J Hum Evol 40:339-51. 2001
    ....
  36. ncbi Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice
    Hye Kyeong Kim
    Department of Animal and Diary Science, Medical College of Georgia, Augusta, GA 30912, USA
    J Nutr 136:409-14. 2006
    ..Thus, genistein may be useful in treating or preventing increased adiposity after menopause...
  37. ncbi New wrist bones of the Malagasy giant subfossil lemurs
    M W Hamrick
    Department of Anthropology and Division of Biomedical Sciences, Kent State University, Kent, OH 44242, USA
    J Hum Evol 38:635-50. 2000
    ....
  38. pmc Morphological diversity in digital skin microstructure of didelphid marsupials
    M W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, OH 44242, USA
    J Anat 198:683-8. 2001
    ..The reduced claws and unusual digit skin microstructure of Chironectes likely improve this animal's ability to recognise and identify live animal prey under water using only its sense of touch...
  39. ncbi Spatial distribution of osteocyte lacunae in equine radii and third metacarpals: considerations for cellular communication, microdamage detection and metabolism
    John G Skedros
    Department of Orthopaedic Surgery, University of Utah, Salt Lake City, USA
    Cells Tissues Organs 180:215-36. 2005
    ..The results of this study provide little or no evidence that the number of osteocyte lacunae has a functional role in mechanotransduction pathways that are typically considered in bone adaptation...
  40. ncbi Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss
    Ke Hong Ding
    Department of Medicine, Medical College of Georgia, Augusta, GA, USA
    Biochem Biophys Res Commun 340:1091-7. 2006
    ....
  41. ncbi Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females
    Norman K Pollock
    Departments of Foods and Nutrition and Statistics, The University of Georgia, Athens, GA 30602, USA
    Am J Clin Nutr 86:1530-8. 2007
    ..Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal...
  42. ncbi Plasticity of mandibular biomineralization in myostatin-deficient mice
    Matthew J Ravosa
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Morphol 268:275-82. 2007
    ....
  43. ncbi Biomineralization and adaptive plasticity of the temporomandibular joint in myostatin knockout mice
    Elisabeth K Nicholson
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Arch Oral Biol 51:37-49. 2006
    ....
  44. doi Intrinsic hand proportions of euarchontans and other mammals: implications for the locomotor behavior of plesiadapiforms
    E Christopher Kirk
    Department of Anthropology, University of Texas at Austin, Austin, TX 78712, USA
    J Hum Evol 55:278-99. 2008
    ..These results provide additional evidence that plesiadapiforms were arboreal and support the hypothesis that Euarchonta originated in an arboreal milieu...

Research Grants4

  1. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007
    ..abstract_text> ..