Hiroko Hama

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase
    Phyllis Dan
    Department of Genetics and Metabolic Diseases and the Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Lipids Health Dis 10:84. 2011
  2. pmc Fatty acid 2-Hydroxylation in mammalian sphingolipid biology
    Hiroko Hama
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochim Biophys Acta 1801:405-14. 2010
  3. pmc FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin
    Eduardo N Maldonado
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    J Lipid Res 49:153-61. 2008
  4. ncbi request reprint 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells
    Venkatesh Kota
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, United States
    J Proteome Res 12:4366-75. 2013
  5. pmc Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 50:1203-8. 2009
  6. ncbi request reprint A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 46:1569-75. 2005
  7. ncbi request reprint FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 47:2772-80. 2006
  8. pmc Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function
    Suriyan Ponnusamy
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:27514-24. 2008
  9. pmc Identification of C(6) -ceramide-interacting proteins in D6P2T Schwannoma cells
    Venkatesh Kota
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 12:2179-84. 2012
  10. pmc Central nervous system dysfunction in a mouse model of FA2H deficiency
    Kathleen A Potter
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Glia 59:1009-21. 2011

Collaborators

Detail Information

Publications12

  1. pmc 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase
    Phyllis Dan
    Department of Genetics and Metabolic Diseases and the Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Lipids Health Dis 10:84. 2011
    ....
  2. pmc Fatty acid 2-Hydroxylation in mammalian sphingolipid biology
    Hiroko Hama
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochim Biophys Acta 1801:405-14. 2010
    ..Physiological function of hFA-sphingolipids in other organs remains largely unknown. Recent evidence indicates that hFA-sphingolipids have specific roles in cell signaling...
  3. pmc FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin
    Eduardo N Maldonado
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    J Lipid Res 49:153-61. 2008
    ..Interestingly, FA2H-directed RNAi enhanced the migration of D6P2T cells, suggesting that, in addition to their structural role in myelin, 2-hydroxy lipids may greatly influence the migratory properties of Schwann cells...
  4. ncbi request reprint 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells
    Venkatesh Kota
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, United States
    J Proteome Res 12:4366-75. 2013
    ....
  5. pmc Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 50:1203-8. 2009
    ..These results provide evidence that FA2H is a negative regulator of the cell cycle and facilitates db-cAMP-induced cell cycle exit in D6P2T cells...
  6. ncbi request reprint A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 46:1569-75. 2005
    ..With this method, FA2H activities were reproducibly measured in murine brains and tissue culture cell lines...
  7. ncbi request reprint FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 47:2772-80. 2006
    ..Together, these data provide evidence that FA2H is the major fatty acid 2-hydroxylase in brain and that 2-hydroxylation of free fatty acids is the first step in the synthesis of 2-hydroxy galactolipids...
  8. pmc Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function
    Suriyan Ponnusamy
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:27514-24. 2008
    ....
  9. pmc Identification of C(6) -ceramide-interacting proteins in D6P2T Schwannoma cells
    Venkatesh Kota
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 12:2179-84. 2012
    ..The identified proteins are involved in various cellular processes, including apoptosis, cellular stress, cell cycle, cell differentiation, signaling, transcription, translation, protein biogenesis, metabolism, and transport...
  10. pmc Central nervous system dysfunction in a mouse model of FA2H deficiency
    Kathleen A Potter
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Glia 59:1009-21. 2011
    ..These findings provide the first evidence that FA2H has an important function outside of oligodendrocytes in the CNS...
  11. pmc 2'-Hydroxy ceramide in membrane homeostasis and cell signaling
    Venkatesh Kota
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Adv Biol Regul 54:223-30. 2014
    ..Collectively, current evidence clearly shows that 2'-hydroxy ceramide and 2'-hydroxy complex sphingolipids have unique functions in membrane homeostasis and cell signaling that could not be substituted by non-hydroxy counterparts. ..
  12. ncbi request reprint The human FA2H gene encodes a fatty acid 2-hydroxylase
    Nathan L Alderson
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 279:48562-8. 2004
    ..These results demonstrate that the human FA2H gene encodes a fatty acid 2-hydroxylase. FA2H is likely involved in the formation of myelin 2-hydroxy galactosylceramides and -sulfatides...

Research Grants9

  1. FUNCTION AND REGULATION OF MAMMALIAN FAAH
    Hiroko Hama; Fiscal Year: 2002
    ..We hypothesize that the FAAH gene encodes the fatty acid alpha-hydroxylase that produces alpha-hydroxy glycosphingolipids in brain, and that lack of this enzyme results in defects in myelin biogenesis and function. ..
  2. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2010
    ..Results obtained from this study will aid in developing better therapeutic agents for neurodegenerative diseases, such as multiple sclerosis. ..
  3. Creation of a fatty acid 2-hydoxylase-knockout mouse model
    Hiroko Hama; Fiscal Year: 2007
    ..The Fa2h-knockout mouse will be used in future studies to determine the role of 2- hydroxy fatty acids of GalC/sGalC in myelination and myelin function. ..
  4. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..Results obtained from this study will aid in developing better therapeutic agents for neurodegenerative diseases, such as multiple sclerosis. ..
  5. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..Results obtained from this study will aid in developing better therapeutic agents for neurodegenerative diseases, such as multiple sclerosis. ..
  6. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..Results obtained from this study will aid in developing better therapeutic agents for neurodegenerative diseases, such as multiple sclerosis. ..