W T Gunning

Summary

Affiliation: Medical College of Ohio
Country: USA

Publications

  1. pmc Mutant Rab24 GTPase is targeted to nuclear inclusions
    William A Maltese
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo, OH 43614, USA
    BMC Cell Biol 3:25. 2002
  2. ncbi request reprint Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777
    William T Gunning
    Department of Pathology, Medical College of Ohio, Toledo 43614, USA
    Clin Cancer Res 9:1927-30. 2003
  3. ncbi request reprint Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice
    W T Gunning
    Department of Pathology, Block Health Science Building, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH 43614 5806, USA
    Exp Lung Res 26:757-72. 2000
  4. ncbi request reprint Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice
    William T Gunning
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Cancer Res 62:4199-201. 2002
  5. ncbi request reprint Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens
    W T Gunning
    Department of Pathology, Medical College of Ohio, Toledo 43699
    Toxicol Pathol 19:168-75. 1991
  6. ncbi request reprint Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors
    Lianhui Tao
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Mol Carcinog 35:93-102. 2002
  7. ncbi request reprint Prevention of mouse lung tumors by budesonide and its modulation of biomarkers
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, HEB, Room 200F, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    Carcinogenesis 23:1185-92. 2002
  8. ncbi request reprint Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture
    Keith A Crist
    Department of Surgery, Medical College of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 26:951-7. 2005
  9. ncbi request reprint Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA
    Exp Lung Res 31:145-63. 2005
  10. ncbi request reprint Prevention of mouse lung tumors by targretin
    Michael A Pereira
    Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Int J Cancer 118:2359-62. 2006

Collaborators

Detail Information

Publications13

  1. pmc Mutant Rab24 GTPase is targeted to nuclear inclusions
    William A Maltese
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo, OH 43614, USA
    BMC Cell Biol 3:25. 2002
    ..Several attributes distinguish this protein from other members of the Rab family, including a low intrinsic GTPase activity...
  2. ncbi request reprint Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777
    William T Gunning
    Department of Pathology, Medical College of Ohio, Toledo 43614, USA
    Clin Cancer Res 9:1927-30. 2003
    ..The efficacy of R115777 [Zarnestra; (B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] to prevent the development of lung tumors in mice was determined...
  3. ncbi request reprint Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice
    W T Gunning
    Department of Pathology, Block Health Science Building, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH 43614 5806, USA
    Exp Lung Res 26:757-72. 2000
    ..In summary, selected chemopreventive agents previously shown to inhibit lung tumors by other chemical carcinogens also inhibited vinyl carbamate-induced lung tumors...
  4. ncbi request reprint Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice
    William T Gunning
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Cancer Res 62:4199-201. 2002
    ..These results demonstrate that leukotriene inhibitors prevent lung tumors and slow the growth and progression of adenomas to carcinoma; leukotriene inhibitors warrant further consideration for potential use in humans...
  5. ncbi request reprint Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens
    W T Gunning
    Department of Pathology, Medical College of Ohio, Toledo 43699
    Toxicol Pathol 19:168-75. 1991
    ..If, as suggested by others, solid tumors are derived from alveolar type II cells and papillary tumors from Clara cells, then carcinogens may differ with respect to their ability to transform one cell type or the other...
  6. ncbi request reprint Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors
    Lianhui Tao
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Mol Carcinog 35:93-102. 2002
    ..The results support the possibility of using decreased mRNA expression and remethylation of the Igf-II and c-myc genes as biomarkers for the efficacy of budesonide...
  7. ncbi request reprint Prevention of mouse lung tumors by budesonide and its modulation of biomarkers
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, HEB, Room 200F, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    Carcinogenesis 23:1185-92. 2002
    ..Thus, short-term treatment with budesonide modulated biological and molecular end-points in lung tumors that might be developed further as biomarkers for its clinical chemopreventive efficacy in the lung...
  8. ncbi request reprint Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture
    Keith A Crist
    Department of Surgery, Medical College of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 26:951-7. 2005
    ..Thus, the DMBA suture model in rats yields epithelial derived tumors histologically similar to humans and should prove suitable for the testing of preventive or therapeutic agents...
  9. ncbi request reprint Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA
    Exp Lung Res 31:145-63. 2005
    ..These results indicate that reversal of the hypomethylation of DNA and of specific genes in lung tumors may be applicable as a surrogate end-point biomarker for chemoprevention...
  10. ncbi request reprint Prevention of mouse lung tumors by targretin
    Michael A Pereira
    Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Int J Cancer 118:2359-62. 2006
    ..75 and 4.60 +/- 0.70, respectively. Hence, targretin demonstrated both preventive and therapeutic activity with respect to mouse lung tumors supporting its further development as a preventive and therapeutic agent for lung cancer...
  11. ncbi request reprint Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)
    Fadel S Alyaqoub
    Medical University of Ohio, Toledo OH 43614, USA
    Carcinogenesis 27:2442-7. 2006
    ..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate endpoint biomarker for prevention...
  12. ncbi request reprint Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT)
    Fadel S Alyaqoub
    Medical University of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 28:124-9. 2007
    ..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate end-point biomarker for prevention...
  13. ncbi request reprint Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    Alexander Yu Nikitin
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 64:2307-16. 2004
    ....