Sidney E Grossberg

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems
    S E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Interferon Cytokine Res 21:729-42. 2001
  2. ncbi request reprint The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit
    S E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Interferon Cytokine Res 21:743-55. 2001
  3. ncbi request reprint Perspectives on the neutralization of interferons by antibody
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 61:S21-3. 2003
  4. pmc The neutralization of interferons by antibody III. The constant antibody bioassay, a highly sensitive quantitative detector of low antibody levels
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Interferon Cytokine Res 29:93-104. 2009
  5. pmc Quantification of the neutralization of cytokine biological activity by antibody: the ten-fold reduction bioassay of interleukin-6 as growth factor
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Interferon Cytokine Res 29:421-6. 2009
  6. ncbi request reprint Neutralization of the biological activity of cytokines and other protein effectors by antibody: theoretical formulation of antibody titration curves in relation to antibody affinity
    Yoshimi Kawade
    Kyoto University, Kyoto, Japan
    J Immunol Methods 278:127-44. 2003
  7. ncbi request reprint Interferon-beta antibodies: implications for the treatment of MS
    Jerry S Wolinsky
    Lancet Neurol 2:528. 2003
  8. ncbi request reprint Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection
    Donna Mildvan
    Beth Israel Medical Center, New York, New York 10003, USA
    Clin Infect Dis 40:853-8. 2005

Collaborators

  • M Kohase
  • J P Klein
  • Donna Mildvan
  • Yoshimi Kawade
  • Jerry S Wolinsky
  • John L Fahey
  • Jonathan Kagan
  • David M Johnston
  • Barbara R Schock
  • John Spritzler
  • Klaus V Toyka
  • Ludwig Kappos
  • Norman Finter

Detail Information

Publications8

  1. ncbi request reprint The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems
    S E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Interferon Cytokine Res 21:729-42. 2001
    ..The accompanying paper relates neutralization results to the sensitivity of the bioassay to IFN and describes the rationale for a recommended unit of antibody neutralization...
  2. ncbi request reprint The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit
    S E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Interferon Cytokine Res 21:743-55. 2001
    ....
  3. ncbi request reprint Perspectives on the neutralization of interferons by antibody
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 61:S21-3. 2003
    ....
  4. pmc The neutralization of interferons by antibody III. The constant antibody bioassay, a highly sensitive quantitative detector of low antibody levels
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Interferon Cytokine Res 29:93-104. 2009
    ..The method may be useful to test monoclonal antibodies for otherwise undetectable NAbs. In principle, the constant Ab method should be applicable to the measurement of NAbs against any cytokine or other protein-effector molecule...
  5. pmc Quantification of the neutralization of cytokine biological activity by antibody: the ten-fold reduction bioassay of interleukin-6 as growth factor
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Interferon Cytokine Res 29:421-6. 2009
    ..This bioassay design should be applicable to any cytokine, growth factor, protein hormone, or similar effector molecules for which an adequately sensitive cellular response can be quantified...
  6. ncbi request reprint Neutralization of the biological activity of cytokines and other protein effectors by antibody: theoretical formulation of antibody titration curves in relation to antibody affinity
    Yoshimi Kawade
    Kyoto University, Kyoto, Japan
    J Immunol Methods 278:127-44. 2003
    ..These relationships should apply generally to antibody neutralization reactions with all biologically active soluble protein effector molecules that have a single and nonrepetitive epitope...
  7. ncbi request reprint Interferon-beta antibodies: implications for the treatment of MS
    Jerry S Wolinsky
    Lancet Neurol 2:528. 2003
  8. ncbi request reprint Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection
    Donna Mildvan
    Beth Israel Medical Center, New York, New York 10003, USA
    Clin Infect Dis 40:853-8. 2005
    ..Our objective was to assess the independent prognostic value for disease progression of soluble markers of immune system activation...