ANN CHARLOTTE ESTHER GRANHOLM

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Age-related neurodegeneration and memory loss in down syndrome
    Jason P Lockrow
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Curr Gerontol Geriatr Res 2012:463909. 2012
  2. pmc Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice
    Ann Charlotte Granholm
    Department of Neurosciences, Medical University of South Carolina, Center on Aging, Charleston, SC 29425, USA
    Brain Pathol 21:330-48. 2011
  3. pmc Mood, memory and movement: an age-related neurodegenerative complex?
    Ann Charlotte Granholm
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Aging Sci 1:133-9. 2008
  4. pmc Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat
    Ann Charlotte Granholm
    Department of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC 29425, USA
    J Alzheimers Dis 14:133-45. 2008
  5. ncbi request reprint Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts
    A C Granholm
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Microsc Res Tech 54:298-308. 2001
  6. ncbi request reprint Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome
    Ann Charlotte Granholm
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hippocampus 13:905-14. 2003
  7. ncbi request reprint Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome
    Ann Charlotte E Granholm
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Physiol Behav 77:371-85. 2002
  8. pmc Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
    Jason Lockrow
    Department of Neuroscience, and the Center on Aging, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Neurol 216:278-89. 2009
  9. pmc Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice
    Heather A Boger
    Department of Neurosciences and Center on Aging, Medical University of South Carolina 173 Ashley Avenue BSB 403, Charleston, SC 29425, USA
    Neurobiol Dis 33:459-66. 2009
  10. pmc Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
    Brice Williams
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurosci Lett 413:110-4. 2007

Research Grants

  1. An animal model for age-related degeneration
    ANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2010
  2. An animal model for age-related degeneration
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2009
  3. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007
  4. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2004
  5. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002
  6. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2003
  7. An animal model for age-related degeneration
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2006
  8. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2006
  9. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2001
  10. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2004

Collaborators

Detail Information

Publications28

  1. pmc Age-related neurodegeneration and memory loss in down syndrome
    Jason P Lockrow
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Curr Gerontol Geriatr Res 2012:463909. 2012
    ..Here we discuss recent findings and potential treatment avenues regarding development of AD neuropathology and memory loss in DS...
  2. pmc Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice
    Ann Charlotte Granholm
    Department of Neurosciences, Medical University of South Carolina, Center on Aging, Charleston, SC 29425, USA
    Brain Pathol 21:330-48. 2011
    ....
  3. pmc Mood, memory and movement: an age-related neurodegenerative complex?
    Ann Charlotte Granholm
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Aging Sci 1:133-9. 2008
    ..We have also summarized the emerging need for relevant animal models and how these could be developed and utilized...
  4. pmc Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat
    Ann Charlotte Granholm
    Department of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC 29425, USA
    J Alzheimers Dis 14:133-45. 2008
    ..These data suggest that saturated fat, hydrogenated fat and cholesterol can profoundly impair memory and hippocampal morphology...
  5. ncbi request reprint Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts
    A C Granholm
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Microsc Res Tech 54:298-308. 2001
    ..These findings demonstrate that target-derived factors may regulate neuronal plasticity, and that the age of the target is more important for innervation properties than the age of the neuron innervating a particular target...
  6. ncbi request reprint Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome
    Ann Charlotte Granholm
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hippocampus 13:905-14. 2003
    ..These findings demonstrate that estrogen can alleviate deficits in cholinergic and dendritic elements in the hippocampal formation and further strengthens the rationale to explore estrogen replacement therapy in women with DS...
  7. ncbi request reprint Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome
    Ann Charlotte E Granholm
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Physiol Behav 77:371-85. 2002
    ..The findings also indicate that estrogen may act, at least partially, via endogenous growth factors. Collectively, the data suggest that ERT may be a viable therapeutic approach for women with DS coupled with dementia...
  8. pmc Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
    Jason Lockrow
    Department of Neuroscience, and the Center on Aging, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Neurol 216:278-89. 2009
    ..This study provides evidence that vitamin E delays onset of cognitive and morphological abnormalities in a mouse model of DS, and may represent a safe and effective treatment early in the progression of DS neuropathology...
  9. pmc Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice
    Heather A Boger
    Department of Neurosciences and Center on Aging, Medical University of South Carolina 173 Ashley Avenue BSB 403, Charleston, SC 29425, USA
    Neurobiol Dis 33:459-66. 2009
    ..The results suggest that neuroinflammation is deleterious to the dopamine system of GDNF(+/-) mice but is not the primary cause of methamphetamine-induced damage to the dopamine system in either GDNF(+/-) or wildtype mice...
  10. pmc Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
    Brice Williams
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurosci Lett 413:110-4. 2007
    ..These findings might lead to development of novel treatment therapies for the memory loss associated with AD and other age-associated neurodegenerative diseases...
  11. pmc Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice
    Heather A Boger
    Department of Neurosciences and Center on Aging, Medical University of South Carolina, South Carolina 29425, USA
    J Neurosci 27:8816-25. 2007
    ..These data suggest the possibility that methamphetamine use in young adults, when combined with lower levels of GDNF throughout life, may precipitate the appearance of parkinsonian-like behaviors during aging...
  12. pmc Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts
    LAUREN M WILLIS
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Glia 58:679-90. 2010
    ..These studies demonstrate direct effects of blueberry upon microglial activation both during isolated conditions and in the aged host brain and suggest that this nutraceutical can attenuate age-induced inflammation...
  13. pmc A dual-hit animal model for age-related parkinsonism
    Heather A Boger
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Prog Neurobiol 90:217-29. 2010
    ..The work discussed in this review is consistent with earlier work demonstrating the importance of GDNF for maintenance of DA neurons and also provides a novel model for progressive DA degeneration and motor dysfunction...
  14. ncbi request reprint Blueberry extract enhances survival of intraocular hippocampal transplants
    Lauren Willis
    Department of Neurosciences and the Center on Aging, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Transplant 14:213-23. 2005
    ..Thus, the data suggest that factor(s) in blueberries may have significant effects on development and organization of this important brain region...
  15. ncbi request reprint Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors
    Kumar Sambamurti
    Department of Physiology and Neuroscience, and Center on Aging, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Curr Drug Targets 5:517-28. 2004
    ..The present review summarizes our current understanding of the relationship of AD pathogenesis with cholesterol, lipids and other genetic and environmental risk factors...
  16. pmc The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior
    Vandana Zaman
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 28:1557-68. 2008
    ....
  17. pmc Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene
    Heather A Boger
    Department of Neurosciences, Center on Aging, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Res 1241:18-28. 2008
    ..The findings point to increased sensitivity of the DAergic system with age and neurotoxic exposure as a result of a genetic reduction of GFR alpha1...
  18. ncbi request reprint Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease
    Elias Matthew Quintero
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
    Brain Res 1093:198-207. 2006
    ..These data suggest that the therapeutic potential of minocycline may depend on the time of drug administration relative to neuropathogenic event...
  19. ncbi request reprint Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion
    John McGrath
    Alkermes, Inc, Cambridge, MA, USA
    Cell Transplant 11:215-27. 2002
    ..These data provide further support for the therapeutic potential of rAAV-GDNF-based gene therapy in the treatment of PD...
  20. ncbi request reprint Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen
    Christopher L Hunter
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 26 Bee Street, Charleston, SC 29425, USA
    Neurobiol Aging 25:873-84. 2004
    ..These findings further support Ts65Dn mice as a model for specific AD-like symptoms, and demonstrate that estrogen treatment of this type does not improve the cognitive ability of male Ts65Dn mice...
  21. ncbi request reprint Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome
    Christopher L Hunter
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Neurosci Res 45:437-45. 2003
    ..These findings demonstrate that elevated APP and decreased NGF levels in limbic areas correlate with the progressive memory decline and cholinergic degeneration seen in middle-aged trisomic mice...
  22. ncbi request reprint Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats
    Heather A Bimonte-Nelson
    Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287, USA
    Eur J Neurosci 24:229-42. 2006
    ..Further, there appears to be a dissociation between HT effects on cognition and mortality rates...
  23. ncbi request reprint Altered NGF response but not release in the aged septo-hippocampal cholinergic system
    Brice Williams
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29401, USA
    Exp Neurol 196:30-40. 2005
    ..Since cholinergic degeneration coupled with altered levels of NGF and TrkA receptors are also seen in human aging and AD, the loss of acute responsivity to NGF in the BFCNs may also play a role in these processes...
  24. ncbi request reprint Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
    Christopher L Hunter
    Medical University of South Carolina, Department of Neuroscience, and the Center on Aging, Charleston, SC 29425, USA
    Ann Neurol 56:675-88. 2004
    ..Minocycline is an established antiinflammatory and neuroprotective drug and may provide a novel approach to treat specific AD-like pathologies...
  25. ncbi request reprint Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning
    Christopher L Hunter
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 26 Bee Street, Charleston, SC 29425, USA
    Eur J Neurosci 19:3305-16. 2004
    ....
  26. ncbi request reprint Nerve growth factor in treatment and pathogenesis of Alzheimer's disease
    Brice J Williams
    Department of Neurosciences and the Center on Aging, Medical University of South Carolina, 173 Ashley Ave BSB 403, Charleston, SC 29425, United States
    Prog Neurobiol 80:114-28. 2006
    ....
  27. pmc Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures
    Sara af Bjerkén
    Department of Integrative Medical Biology, Umea University, S 901 87 Umea, Sweden
    Brain Res 1133:10-9. 2007
    ..In conclusion, cultured midbrain dopamine neurons survive in the absence of GDNF, and the addition of GDNF improved dopamine nerve fiber formation - possibly as an indirect effect of astrocytic stimulation...
  28. ncbi request reprint Environmental influences on brain neurotrophins in rats
    Therese M Pham
    Department of Clinical Neuroscience, Occupational Therapy, Elderly Care Research, Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Pharmacol Biochem Behav 73:167-75. 2002
    ..Because neurotrophic factors are essential for neural development and survival, they are likely to be involved in the cerebral consequences modified by enriched experiences...

Research Grants24

  1. An animal model for age-related degeneration
    ANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2010
    ..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
  2. An animal model for age-related degeneration
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2009
    ..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
  3. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007
    ..abstract_text> ..
  4. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2004
    ..abstract_text> ..
  5. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..
  6. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2003
    ..abstract_text> ..
  7. An animal model for age-related degeneration
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2006
    ..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
  8. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2006
    ..abstract_text> ..
  9. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2001
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..
  10. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2004
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..
  11. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2003
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..
  12. International meeting Neural Transplantation and Repair
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002
    ..In addition, previous statistics demonstrate that we have favored women and minorities in the past (33% of the travel award recipients for this years' meeting were women, and women serve on all the committees in our organization). ..
  13. MECHANISMS OF NGF-INDUCED COGNITIVE IMPROVEMENT IN AGING
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2000
    ..Finally, this work will evaluate the efficacy of a novel means of delivering NGF to the brain which has clear advantages over conventional techniques in terms of potential clinical application. ..
  14. MECHANISMS OF NGF-INDUCED COGNITIVE IMPROVEMENT IN AGING
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2001
    ..Finally, this work will evaluate the efficacy of a novel means of delivering NGF to the brain which has clear advantages over conventional techniques in terms of potential clinical application. ..
  15. An animal model for age-related degeneration
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007
    ..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
  16. Mechanisms of neurotrophin-improved cognition in aging
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2005
    ..abstract_text> ..
  17. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2001
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..
  18. MECHANISMS OF NGF-INDUCED COGNITIVE IMPROVEMENT IN AGING
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2001
    ..Finally, this work will evaluate the efficacy of a novel means of delivering NGF to the brain which has clear advantages over conventional techniques in terms of potential clinical application. ..
  19. AGED FOREBRAIN CHOLINERGIC NEURONS--ESTROGEN AND NGF
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2000
    ..of wildtype cholinergic neurons succumb to the same phenotype loss when grafted into a TS65DN host? And 4) Can treatment with NGF and/or estrogen alleviate cognitive alterations and cholinergic phenotype loss in the Ts65Dn mouse? ..