Monika Gooz

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells
    Pal Gooz
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 7:e33350. 2012
  2. ncbi request reprint Elevated blood levels of endogenous ouabain-like factor in preterm versus mature newborns at birth
    Monika Gooz
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Biol Neonate 85:155-8. 2004
  3. pmc ADAM-17: the enzyme that does it all
    Monika Gooz
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Crit Rev Biochem Mol Biol 45:146-69. 2010
  4. ncbi request reprint Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells
    Monika Gooz
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
    Life Sci 74:2111-28. 2004
  5. pmc Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors
    Rany T Abdallah
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:35206-15. 2010
  6. pmc Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement
    Mamon Dey
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 334:775-83. 2010
  7. pmc The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription
    Arindam Saha
    Medical Univ of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 295:G977-86. 2008
  8. pmc Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor
    Aleksander Baldys
    Nephrology Division, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biochemistry 48:1462-73. 2009
  9. pmc Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit
    Arindam Saha
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    Gastroenterology 139:239-48. 2010
  10. pmc TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells
    Zhi Ren Zhang
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e73424. 2013

Research Grants

Collaborators

  • Stanley Hoffman
  • Peter Komlosi
  • Robert A Fenton
  • Steffen Backert
  • Grzegorz Owsianik
  • Hanna E Abboud
  • Jeffrey L Barnes
  • Shigeki Higashiyama
  • Hesham M El-Shewy
  • Bing Wang
  • Maria N Garnovskaya
  • L M Luttrell
  • Pal Gooz
  • Arindam Saha
  • Aleksander Baldys
  • P Darwin Bell
  • Courtney J Haycraft
  • Stacy L Steele
  • Adam J Smolka
  • John R Raymond
  • Charles E Hammond
  • Sandra K Gilley
  • Zhi Ren Zhang
  • Bridget M Ford
  • Stacy Steele
  • Takamitsu Saigusa
  • Robert J Kolb
  • Rany T Abdallah
  • Mamon Dey
  • Hannah L Bell
  • Mi Hye Lee
  • Yurii V Mukhin
  • Kelli M Sas
  • Caroline Miller
  • Bradley K Yoder
  • Jacqueline A Pavlik
  • Lisa M Schwiebert
  • Patrick Flume
  • Raymond C Pasek
  • Kimberly P Estell
  • Joseph H Sisson
  • Antine E Stenbit
  • Marlene A Bunni
  • May Amria
  • Grant A Turner
  • Assaad A Eid
  • Yves C Gorin
  • Chang Jiang Yu
  • Binlin Song
  • Jia Ning Zhang
  • Bernd Nilius
  • Shuai Jiang
  • Wen Feng Chu
  • Yujing Dang
  • Jennifer Guare
  • Waleed O Twal
  • Brian J Siroky
  • Ryan Reichert
  • Deirdre K Luttrell
  • Joo Seob Keum
  • Dezmond B Sumter
  • Hai Yao
  • Lisa Guay-Woodford
  • Yongren Wu
  • Ayad A Jaffa
  • Kent T Keyser
  • Thomas A Morinelli

Detail Information

Publications19

  1. pmc A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells
    Pal Gooz
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 7:e33350. 2012
    ..At present, we have little understanding how the enzyme activity is regulated. In this study we wanted to characterize the role of α5β1 integrin in ADAM17 activity regulation during G protein-coupled receptor (GPCR) stimulation...
  2. ncbi request reprint Elevated blood levels of endogenous ouabain-like factor in preterm versus mature newborns at birth
    Monika Gooz
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Biol Neonate 85:155-8. 2004
    ..26 +/- 7 vs. 35.47 +/- 1.84 pg/ml, p = NS). Further studies are needed to evaluate the physiological relevance of higher OLF in preterm versus mature newborns...
  3. pmc ADAM-17: the enzyme that does it all
    Monika Gooz
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Crit Rev Biochem Mol Biol 45:146-69. 2010
    ..To exploit the therapeutic potential of ADAM-17, it is important to understand how its activity is regulated and how specific organs and cells can be targeted to inactivate or activate the enzyme...
  4. ncbi request reprint Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells
    Monika Gooz
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
    Life Sci 74:2111-28. 2004
    ..These data suggest that nicotinic regulation may underlie OLF secretion by rat adrenocortical cells, and strongly suggest presence of functional nicotinic acetylcholine receptors on these cells...
  5. pmc Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors
    Rany T Abdallah
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:35206-15. 2010
    ..These results suggest a novel mechanism of bradykinin-independent kallikrein action that may contribute to the regulation of vascular responses in pathophysiologic states, such as diabetes mellitus...
  6. pmc Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement
    Mamon Dey
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 334:775-83. 2010
    ..Our data indicate that ADAM17 and the EGFR may be potential novel therapeutic targets in diabetic nephropathy and other chronic kidney diseases...
  7. pmc The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription
    Arindam Saha
    Medical Univ of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 295:G977-86. 2008
    ..pylori perturbation of HKalpha gene expression is independent of Sp1-mediated basal HKalpha transcription...
  8. pmc Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor
    Aleksander Baldys
    Nephrology Division, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biochemistry 48:1462-73. 2009
    ..These data support novel functions of c-Cbl in mediating recycling of EGF receptors to the plasma membrane, as well as in mediating the duration of activation (transient vs sustained) of ERK1/2 MAPK phosphorylation...
  9. pmc Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit
    Arindam Saha
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    Gastroenterology 139:239-48. 2010
    ..We investigated whether H pylori-induced repression of HKalpha is mediated by CagL activation of ADAM17 and release of heparin-binding epidermal growth factor (HB-EGF)...
  10. pmc TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells
    Zhi Ren Zhang
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e73424. 2013
    ..However, the molecular identity and the regulators of the transporter/channel, which is responsible for apical calcium entry and what factors regulate the calcium conduction remain unclear...
  11. pmc ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis
    Pal Gooz
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425, USA
    Biochem Biophys Res Commun 380:33-8. 2009
    ..Based on our findings we propose that ADAM-17 is part of a novel pro-angiogenic pathway leading to MMP-2 activation and vessel formation...
  12. pmc Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors
    Takamitsu Saigusa
    Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 302:F801-8. 2012
    ..Whether such apical localization contributes to enhanced fluid retention and hypertension in PKD remains to be determined...
  13. ncbi request reprint 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells
    Monika Gooz
    Nephrology, Rheumatology and Endocrinology Divisions, Department of Medicine of the Medical University of South Carolina, Charleston, 29425, USA
    J Biol Chem 281:21004-12. 2006
    ..To our knowledge, this is the first time that TACE has been implicated in 5-HT-induced EGFR transactivation or in proliferation induced by a G protein-coupled receptor in native cells in culture...
  14. pmc ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney fibrosis
    Hannah L Bell
    Medical University of South Carolina, Charleston, 29425, USA
    Am J Med Sci 339:105-7. 2010
    ..7-fold) binding of activated ERK to ADAM-17 during 5-HT stimulation. We concluded that, during profibrotic stimulus, ERK phosphorylates ADAM-17 in kidney cells which induces concomitant increase in the enzyme activity...
  15. pmc Telomerase immortalization of principal cells from mouse collecting duct
    Stacy L Steele
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Am J Physiol Renal Physiol 299:F1507-14. 2010
    ..This technique should be valuable in generating cell lines from genetically engineered mouse models...
  16. ncbi request reprint IL-1beta modulation of H,K-ATPase alpha-subunit gene transcription in Helicobacter pylori infection
    Arindam Saha
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1055-61. 2007
    ..We conclude that an IL-1beta-responsive HKalpha cis element positively regulates HKalpha gene transcription in shortened deletion constructs and that H. pylori-induced inhibition of HKalpha transcription is not mediated by IL-1beta...
  17. pmc Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways
    Sandra K Gilley
    70 President St, DDB520, MUSC, Charleston, SC 29425
    Am J Physiol Lung Cell Mol Physiol 306:L162-9. 2014
    ..This monocilium is a prerequisite for these progenitor cells to transition into respiratory epithelial cells. In conclusion, motile cilia may play an important role in controlling airway structure and function. ..
  18. pmc ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice
    Bridget M Ford
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Am J Physiol Renal Physiol 305:F323-32. 2013
    ..Additionally, our study is the first to provide evidence that Nox4 is downstream of ADAM17. ..
  19. ncbi request reprint Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells
    Yurii V Mukhin
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425 2227, USA
    J Pharmacol Exp Ther 318:1033-43. 2006
    ..This study demonstrates a novel role for collagenase-2 and -3 in signaling of the G(q)-coupled BK B(2) receptor in mIMCD-3 cells...

Research Grants2

  1. Crosstalk among Growth Factors, ADAMs and Integrins
    Monika Gooz; Fiscal Year: 2007
    ..involved in GPCR-RTK cross-talk? c) Does overexpression of a TACE enzyme lacking the disintegrin domain alter signaling? d) Is physical interaction of TACE with integrins necessary for the GPCR-RTK cross-talk to occur? ..