Shilenath Ghatak


Affiliation: Medical University of South Carolina
Country: USA


  1. Ghatak S, Markwald R, Hascall V, Dowling W, Lottes R, Baatz J, et al. Transforming growth factor ?1 (TGF?1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem. 2017;292:10465-10489 pubmed publisher
    ..These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGF?1-stimulated CD44V6/ERK/EGR1 signaling. ..
  2. Ghatak S, Misra S, Toole B. Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. J Biol Chem. 2005;280:8875-83 pubmed
    ..Stimulation of hyaluronan production in MCF-7 cells induces assembly of this complex. We conclude that hyaluronan regulates ErbB2 activity and its interactions with other signaling factors in carcinoma cells. ..
  3. Ghatak S, Hascall V, Markwald R, Feghali Bostwick C, Artlett C, Gooz M, et al. Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem. 2017;292:10490-10519 pubmed publisher
    ..These studies support a function for CD44V6 in lung fibrosis and offer proof of concept for therapeutic targeting of CD44V6 in lung fibrosis disorders. ..