Aron M Geurts

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
  2. pmc Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon
    Aron M Geurts
    Department of Genetics, Cell Biology, and Development, The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biotechnol 6:30. 2006
  3. pmc Zinc-finger nucleases: new strategies to target the rat genome
    Aron M Geurts
    Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    Clin Sci (Lond) 119:303-11. 2010
  4. pmc Identifying multiple causative genes at a single GWAS locus
    Michael J Flister
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 23:1996-2002. 2013
  5. ncbi request reprint Transposon vectors for gene-trap insertional mutagenesis in vertebrates
    Karl J Clark
    Department of Genetics, Cell Biology, and Development, Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Minneapolis, Minnesota, USA
    Genesis 39:225-33. 2004
  6. pmc Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition
    Daniel F Carlson
    The Center for Genome Engineering, Minneapolis, MN, USA
    Transgenic Res 20:29-45. 2011
  7. pmc Structure-based prediction of insertion-site preferences of transposons into chromosomes
    Aron M Geurts
    Department of Genetics, Cell Biology and Development, The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:2803-11. 2006
  8. pmc CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney
    Nathan Rudemiller
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
    Hypertension 63:559-64. 2014
  9. pmc Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
    Aron M Geurts
    Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
    PLoS Genet 2:e156. 2006
  10. ncbi request reprint Target-site preferences of Sleeping Beauty transposons
    Geyi Liu
    Department of Genetics, Cell Biology, and Development and The Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Minneapolis, MN 55455, USA
    J Mol Biol 346:161-73. 2005

Collaborators

Detail Information

Publications25

  1. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
    ..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...
  2. pmc Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon
    Aron M Geurts
    Department of Genetics, Cell Biology, and Development, The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biotechnol 6:30. 2006
    ..We sought to generate a transposon system that would be capable of reporting the expression pattern of a mouse gene while allowing for conditional expression of a gene of interest in a tissue- or temporal-specific pattern...
  3. pmc Zinc-finger nucleases: new strategies to target the rat genome
    Aron M Geurts
    Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    Clin Sci (Lond) 119:303-11. 2010
    ..The ability to generate knockout rat models using zinc-finger nuclease technology will now enable its full emergence as an exceptional physiological and genetic research model...
  4. pmc Identifying multiple causative genes at a single GWAS locus
    Michael J Flister
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 23:1996-2002. 2013
    ..Combined, these data demonstrate for the first time that multiple modifiers of hypertension can cosegregate at a single GWAS locus. ..
  5. ncbi request reprint Transposon vectors for gene-trap insertional mutagenesis in vertebrates
    Karl J Clark
    Department of Genetics, Cell Biology, and Development, Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Minneapolis, Minnesota, USA
    Genesis 39:225-33. 2004
    ....
  6. pmc Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition
    Daniel F Carlson
    The Center for Genome Engineering, Minneapolis, MN, USA
    Transgenic Res 20:29-45. 2011
    ..Given its simplicity, versatility and high efficiency, TnT with enhanced Sleeping Beauty components represents a compelling non-viral approach to modifying the mammalian germline...
  7. pmc Structure-based prediction of insertion-site preferences of transposons into chromosomes
    Aron M Geurts
    Department of Genetics, Cell Biology and Development, The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:2803-11. 2006
    ..ProTIS analysis can be useful for functional genomic, gene transfer and human gene therapy applications using the SB system...
  8. pmc CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney
    Nathan Rudemiller
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
    Hypertension 63:559-64. 2014
    ....
  9. pmc Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
    Aron M Geurts
    Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
    PLoS Genet 2:e156. 2006
    ..Additionally, these mice may serve as a model for chromosome rearrangements caused by transposable elements during the evolution of vertebrate genomes...
  10. ncbi request reprint Target-site preferences of Sleeping Beauty transposons
    Geyi Liu
    Department of Genetics, Cell Biology, and Development and The Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Minneapolis, MN 55455, USA
    J Mol Biol 346:161-73. 2005
    ..Our observations suggest that particular deformations of the double helix predicted by the V(step) algorithm can distinguish TA sites that vary by about 16-fold in their preferences for accommodating insertions of SB transposons...
  11. pmc Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 304:R407-14. 2013
    ..These studies demonstrate the importance of renal infiltration of immune cells in the pathogenesis of hypertension and renal damage in Dahl SS rats...
  12. pmc Creation and characterization of a renin knockout rat
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 57:614-9. 2011
    ....
  13. doi request reprint Generation of gene-specific mutated rats using zinc-finger nucleases
    Aron M Geurts
    Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Methods Mol Biol 597:211-25. 2010
    ..This technology allows for the rapid, targeted modification of the rat genome...
  14. pmc Knockout rats via embryo microinjection of zinc-finger nucleases
    Aron M Geurts
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 52336, USA
    Science 325:433. 2009
    ..Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models...
  15. ncbi request reprint Gene transfer into genomes of human cells by the sleeping beauty transposon system
    Aron M Geurts
    Department of Genetics, Cell Biology and Development and The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Ther 8:108-17. 2003
    ..With the recently described improvements to the transposon itself, the SB system appears to be a potential gene-transfer tool for human gene therapy...
  16. pmc Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension
    Di Feng
    Physiology Department, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cell Metab 15:201-8. 2012
    ..These rats exhibited a significant reduction of salt-sensitive hypertension and renal medullary oxidative stress and injury. p67(phox) could represent a target for salt-sensitive hypertension therapy...
  17. pmc Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells
    Andrew Wilber
    Center for Genome Engineering, Gene Therapy Program, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Stem Cells Int 2011:717069. 2011
    ..We conclude that both SB and ϕC31 are effective non-viral integrating systems for genetic engineering of MAPC in basic studies of stem cell biology...
  18. pmc Gene targeting in the rat: advances and opportunities
    Howard J Jacob
    Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Trends Genet 26:510-8. 2010
    ..Here, we provide a high-level description and the potential uses of these new technologies for investigators using the rat for biomedical research...
  19. pmc Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase
    Andreas M Beyer
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Am J Physiol Heart Circ Physiol 306:H339-47. 2014
    ....
  20. pmc The emerging role for rat models in gene discovery
    Melinda R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Mamm Genome 22:466-75. 2011
    ..The strategies used to translate disease traits to genes to function, and, ultimately, to improve human health is discussed. Finally, our perspective on how rat models will continue to positively impact biomedical research is provided...
  21. ncbi request reprint Efficient transgenic rat production by a lentiviral vector
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H881-94. 2007
    ..Thus lentiviral transgenesis provides a powerful tool for the production of transgenic inbred rats and will enhance the usefulness of this species in gene discovery and target validation studies...
  22. pmc Gene targeting in NOD mouse embryos using zinc-finger nucleases
    Yi Guang Chen
    Max McGee National Research Center for Juvenile Diabetes, Medical College of Wisconsin, Milwaukee, WI
    Diabetes 63:68-74. 2014
    ..Our study demonstrates the ability to generate gene-targeted knockouts in a pure NOD background by using ZFNs without potential confounding factors introduced by contaminating genetic materials obtained from other strains. ..
  23. ncbi request reprint Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system
    Baisong Lu
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 18:338-46. 2007
    ..These data suggest that the modified Sleeping Beauty transposon represents a powerful new tool for producing molecularly defined mutagenesis in the rat...
  24. pmc Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy
    Christopher S Hackett
    Biomedical Sciences Graduate Program and Department of Neurology, University of California San Francisco, Room U441K, Parnassus Ave, San Francisco, California 94143 0663, USA
    Genome Biol 8:S12. 2007
    ....
  25. ncbi request reprint Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon
    Zongbin Cui
    Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    J Mol Biol 318:1221-35. 2002
    ..These findings have led to the construction of a more advanced transposon that should be useful in gene transfer and insertional mutagenesis in vertebrates...