Mark George

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint A Two-site Pilot Randomized 3 Day Trial of High Dose Left Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for Suicidal Inpatients
    Mark S George
    Ralph H Johnson VA Medical Center, Charleston, SC, USA Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA Electronic address
    Brain Stimul 7:421-31. 2014
  2. doi request reprint Treating the depressions with superficial brain stimulation methods
    Mark S George
    Brain Stimulation Division, Psychiatry Department, Medical University of South Carolina, and Ralph H Johnson VA Medical Center, Charleston, SC, USA Electronic address
    Handb Clin Neurol 116:399-413. 2013
  3. pmc The expanding evidence base for rTMS treatment of depression
    Mark S George
    Psychiatry Department, Brain Stimulation Laboratory, Medical University of South Carolina, and Ralph H Johnson VA Medical Center, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 26:13-8. 2013
  4. pmc Feature selection for fMRI-based deception detection
    Bo Jin
    Medical University of South Carolina, Charleston, SC, USA
    BMC Bioinformatics 10:S15. 2009
  5. ncbi request reprint Mechanisms and the current state of transcranial magnetic stimulation
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    CNS Spectr 8:496-514. 2003
  6. ncbi request reprint Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders
    Mark S George
    Brain Stimulation Laboratory, Department of Psychiatry, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 6:73-83. 2003
  7. doi request reprint Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder)
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, 29425, USA
    Brain Stimul 2:14-21. 2009
  8. doi request reprint A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 1:112-21. 2008
  9. doi request reprint Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial
    Mark S George
    Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Gen Psychiatry 67:507-16. 2010
  10. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005

Detail Information

Publications92

  1. ncbi request reprint A Two-site Pilot Randomized 3 Day Trial of High Dose Left Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for Suicidal Inpatients
    Mark S George
    Ralph H Johnson VA Medical Center, Charleston, SC, USA Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA Electronic address
    Brain Stimul 7:421-31. 2014
    ..Repeated daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) for 4-6 weeks is a new FDA-approved treatment for acute depression. Some open-label rTMS studies have found rapid reductions in suicidality...
  2. doi request reprint Treating the depressions with superficial brain stimulation methods
    Mark S George
    Brain Stimulation Division, Psychiatry Department, Medical University of South Carolina, and Ralph H Johnson VA Medical Center, Charleston, SC, USA Electronic address
    Handb Clin Neurol 116:399-413. 2013
    ..Much more work is needed to understand best which methods should be used in any given patient, and in what order. ..
  3. pmc The expanding evidence base for rTMS treatment of depression
    Mark S George
    Psychiatry Department, Brain Stimulation Laboratory, Medical University of South Carolina, and Ralph H Johnson VA Medical Center, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 26:13-8. 2013
    ..In the past year, several important studies have been published that extend our understanding of this novel treatment approach...
  4. pmc Feature selection for fMRI-based deception detection
    Bo Jin
    Medical University of South Carolina, Charleston, SC, USA
    BMC Bioinformatics 10:S15. 2009
    ..In this paper, we investigated the procedures of feature selection to enhance fMRI-based deception detection...
  5. ncbi request reprint Mechanisms and the current state of transcranial magnetic stimulation
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    CNS Spectr 8:496-514. 2003
    ..TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular...
  6. ncbi request reprint Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders
    Mark S George
    Brain Stimulation Laboratory, Department of Psychiatry, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 6:73-83. 2003
    ..Comments on the clinical utility of VNS in actual clinical practice are provided...
  7. doi request reprint Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder)
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, 29425, USA
    Brain Stimul 2:14-21. 2009
    ..In general, TMS or tDCS as a treatment for most psychiatric disorders remains exciting but controversial, other than prefrontal TMS for depression...
  8. doi request reprint A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 1:112-21. 2008
    ....
  9. doi request reprint Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial
    Mark S George
    Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Gen Psychiatry 67:507-16. 2010
    ..Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions...
  10. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  11. ncbi request reprint Transcranial magnetic stimulation: a stimulating new method for treating depression, but saddled with the same old problems
    Mark S George
    Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 9:637-40. 2006
  12. pmc Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
    Mark S George
    Departments of Psychiatry, Radiology and Neuroscience, Institute of Psychiatry, MUSC Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 35:301-16. 2010
    ..These techniques are transcranial magnetic stimulation, vagus nerve stimulation, and transcranial direct current stimulation. Two of these approaches have FDA approval as therapies...
  13. ncbi request reprint Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders
    Mark S George
    Institute of Psychiatry MUSC, Brain Stimulation Laboratory, 67 President Street, Room 502 North, Charleston, SC 29425, USA
    Expert Rev Neurother 7:63-74. 2007
    ..Much more research is needed regarding exactly how to refine and deliver the electrical pulses and how this differentially affects brain function in health and disease...
  14. ncbi request reprint Brain stimulation for the treatment of psychiatric disorders
    Mark S George
    Brain Stimulation Laboratory and Mood Disorders Clinic, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 20:250-4; discussion 247-9. 2007
    ..The methods in this class range from non-invasive (transcranial magnetic stimulation) to invasive brain surgery (deep brain stimulation)...
  15. ncbi request reprint A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia
    Mark S George
    Brain Stimulation Laboratory BSL, Psychiatry Department, Medical University of South Carolina MUSC 29425, United States
    Schizophr Res 93:42-50. 2007
    ..No medication interactions were seen. Thus, a single subcutaneous dose of dihydrexidine is tolerated and safe in patients with schizophrenia and does not produce delayed clinical or neuropsychological improvements...
  16. ncbi request reprint Transcranial magnetic stimulation
    Mark S George
    Department of Psychiatry, 502 North, Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC, USA
    Neurosurg Clin N Am 14:283-301. 2003
    ..Whatever road the future takes, TMS is an important new tool that will likely be of interest to neurosurgeons over the next 20 years and perhaps even longer...
  17. doi request reprint Transcranial magnetic stimulation for the treatment of depression
    Mark S George
    Institute of Psychiatry, Medical University of South Carolina, 502 N, 67 President St, Charleston, SC 29425, USA
    Expert Rev Neurother 10:1761-72. 2010
    ..It is a safe, relatively noninvasive, focal brain stimulation treatment that does not involve seizures or implanted wires, and does not have drug-drug interactions or systemic side effects...
  18. ncbi request reprint Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial
    M S George
    Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1752-6. 1997
    ..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design...
  19. ncbi request reprint Transcranial magnetic stimulation: applications in neuropsychiatry
    M S George
    Department of Radiology, Medical University of South Carolina, Charleston 29425, USA
    Arch Gen Psychiatry 56:300-11. 1999
    ..Transcranial magnetic stimulation is a promising new research and, perhaps, therapeutic tool, but more work remains before it can be fully integrated in psychiatry's diagnostic and therapeutic armamentarium...
  20. ncbi request reprint Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues
    M S George
    Radiology Department, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    Arch Gen Psychiatry 58:345-52. 2001
    ....
  21. ncbi request reprint Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century
    M S George
    Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J Neuropsychiatry Clin Neurosci 8:373-82. 1996
    ..Preliminary investigations have also used rapid-rate TMS to improve motor speed in Parkinson's disease and mood in depression. TMS is likely to be an important future neuropsychiatric tool...
  22. ncbi request reprint Understanding emotional prosody activates right hemisphere regions
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Neurol 53:665-70. 1996
    ..The brain regions involved in recognition of emotional prosody in healthy subjects is less clear...
  23. ncbi request reprint New methods of minimally invasive brain modulation as therapies in psychiatry: TMS, MST, VNS and DBS
    Mark S George
    Center for Advanced Imaging Research, Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Zhonghua Yi Xue Za Zhi (Taipei) 65:349-60. 2002
    ..These brain stimulation tools, or their next iterations, will play an ever-larger role in clinical neuropsychiatric practice...
  24. ncbi request reprint Mechanisms and state of the art of transcranial magnetic stimulation
    Mark S George
    Psychiatry Departmemt, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    J ECT 18:170-81. 2002
    ..This article reviews the major recent advances with this interesting noninvasive technique for stimulating the brain, critically reviewing the data on whether TMS has anticonvulsant effects or modulates cortical-limbic loops...
  25. ncbi request reprint Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Neuropsychiatry Clin Neurosci 9:55-63. 1997
    ..This study supports theories of blunted limbic and paralimbic activation and abnormal cingulate activity in depression and adds to the growing knowledge of the functional neuroanatomy of depression...
  26. ncbi request reprint Abnormal facial emotion recognition in depression: serial testing in an ultra-rapid-cycling patient
    M S George
    Department of Radiology, Medical University of South Carolina, Charleston 29425, USA
    Behav Modif 22:192-204. 1998
    ..He also demonstrated a significant negative bias when he was depressed compared with nondepressed states. This case study demonstrates the state dependency of the defect in human facial emotion recognition...
  27. ncbi request reprint Acute vagus nerve stimulation using different pulse widths produces varying brain effects
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina, Institute of Psychiatry 502N, 67 President Street, Charleston, SC 29425, USA
    Biol Psychiatry 55:816-25. 2004
    ....
  28. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  29. ncbi request reprint Cerebral blood flow changes during vagus nerve stimulation for depression
    Charles R Conway
    Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
    Psychiatry Res 146:179-84. 2006
    ..Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve...
  30. ncbi request reprint A potential role for thalamocingulate circuitry in human maternal behavior
    Jeffrey P Lorberbaum
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 51:431-45. 2002
    ..Little is known about the regional brain basis of human maternal behavior. To understand this better, we have been examining brain activity in mothers listening to infant cries...
  31. ncbi request reprint Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:355-63. 2005
    ..The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established...
  32. ncbi request reprint Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Bipolar Disord 5:40-7. 2003
    ..We designed and carried out the following left prefrontal rTMS study to determine the safety, feasibility, and potential efficacy of using TMS to treat the depressive symptoms of bipolar affective disorder (BPAD)...
  33. pmc Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia
    Leonardo Bonilha
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Schizophr Res 101:142-51. 2008
    ..We investigated the relationship between prefrontal cortical atrophy as measured by MRI and the neuropsychological performance of participants diagnosed with DSM-IV-TR schizophrenia...
  34. ncbi request reprint Detecting deception using functional magnetic resonance imaging
    F Andrew Kozel
    Center for Advanced Imaging Research CAIR, Medical University of South Carolina, Charleston, SC, USA
    Biol Psychiatry 58:605-13. 2005
    ..e., conduct disorder, antisocial personality disorder, etc.)...
  35. pmc Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance
    Tal Herbsman
    Mood Disorders Program and Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Brain Mapp 30:2044-55. 2009
    ..82, F = 20.27, P < 0.0001) in measurements of MT. The corticospinal tract's anterior-posterior direction alone contributes 13% of the variance explained...
  36. ncbi request reprint Acute left prefrontal transcranial magnetic stimulation in depressed patients is associated with immediately increased activity in prefrontal cortical as well as subcortical regions
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Charleston, South Carolina 29425, USA
    Biol Psychiatry 55:882-90. 2004
    ....
  37. doi request reprint Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 34:522-34. 2009
    ..Shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS...
  38. doi request reprint A pilot functional MRI study of the effects of prefrontal rTMS on pain perception
    Laura Martin
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pain Med 14:999-1009. 2013
    ..The present exploratory pilot study used functional magnetic resonance imaging (fMRI) to examine the effects of left prefrontal rTMS on brain activity and pain perception...
  39. doi request reprint Conditioning of transcranial magnetic stimulation: evidence of sensory-induced responding and prepulse inhibition
    Kevin A Johnson
    Department of Neuroscience, Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 3:78-86. 2010
    ..Our primary objective was to determine whether TMS effects could be conditioned. Prepulse inhibition represents another relationship between two stimuli, and a secondary assessment was performed to explore this relationship...
  40. pmc Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Pain 152:182-7. 2011
    ..Despite evidence that prefrontal TMS can have analgesic effects, fast left prefrontal TMS appears to acutely suppress analgesia associated with perceived-control. This effect may be limited to the emotional dimension of pain experience...
  41. pmc An efficient and accurate new method for locating the F3 position for prefrontal TMS applications
    William Beam
    Medical University of South Carolina, Charleston, 29425, USA
    Brain Stimul 2:50-4. 2009
    ..This system requires less time and training to find the optimal position for prefrontal coil placement and it saves considerable time compared to the 10-20 EEG system...
  42. ncbi request reprint Serial vagus nerve stimulation functional MRI in treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Brain Stimulation Laboratory, Mood Disorders Program, Institute of Psychiatry, Charleston, SC 29403, USA
    Neuropsychopharmacology 32:1649-60. 2007
    ..Future interleaved VNS/fMRI studies to confirm these findings and further clarify the regional neurobiological effects of VNS...
  43. pmc Fifteen minutes of left prefrontal repetitive transcranial magnetic stimulation acutely increases thermal pain thresholds in healthy adults
    Jeffery J Borckardt
    Depart of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Pain Res Manag 12:287-90. 2007
    ..There is, however, emerging brain imaging evidence that the left prefrontal cortex is involved in pain inhibition in humans...
  44. doi request reprint Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, MUSC IOP, 502 N, 67 President Street, Charleston, SC, 29425, USA
    J Neural Transm 116:423-9. 2009
    ..07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS...
  45. pmc Decreasing procedural pain over time of left prefrontal rTMS for depression: initial results from the open-label phase of a multi-site trial (OPT-TMS)
    Berry S Anderson
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Stimul 2:88-92. 2009
    ..We analyzed interim results from the open-label phase of a multi-site randomized trial of rTMS as a treatment for depression to investigate whether the procedural pain of left prefrontal rTMS changes over time...
  46. pmc Cerebral cortex plasticity after 90 days of bed rest: data from TMS and fMRI
    Donna R Roberts
    Department of Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Aviat Space Environ Med 81:30-40. 2010
    ..In this pilot study, we explored corticospinal plasticity in a bed rest model. We hypothesized that the lack of weight bearing would induce cortical reorganization correlating with performance...
  47. ncbi request reprint A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia
    Qiwen Mu
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Schizophr Res 94:332-41. 2007
    ..These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function...
  48. pmc Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Mood Disorders Program and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA
    Biol Psychiatry 67:101-9. 2010
    ..We chose to pilot the safety and therapeutic benefits of chronic and intermittent epidural prefrontal cortical stimulation (EpCS) in patients with treatment-resistant depression...
  49. doi request reprint Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 502N, 67 President St, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 209:233-44. 2010
    ..A previous study showed that lamotrigine (LTG) inhibited brain activation induced when TMS was applied over motor cortex, whereas it increased activation induced by TMS applied over prefrontal cortex...
  50. pmc A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pain Med 10:840-9. 2009
    ..It is unclear whether the motor cortex is the only effective cortical target for managing neuropathic pain, and no published studies to date have investigated the effects of prefrontal stimulation on neuropathic pain...
  51. ncbi request reprint Prefrontal EEG asymmetry as a potential biomarker of antidepressant treatment response with transcranial magnetic stimulation (TMS): a case series
    Agnes P Funk
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina MUSC, Charleston, South Carolina, USA
    Clin EEG Neurosci 39:125-30. 2008
    ..EEG shows potential as a biomarker of response for depression treatments, particularly the brain stimulation devices, which, unlike medications, can focally interact with neural tissue in specific frequency patterns...
  52. ncbi request reprint Interregional cerebral metabolic associativity during a continuous performance task (Part II) : differential alterations in bipolar and unipolar disorders
    Brenda E Benson
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, United States
    Psychiatry Res 164:30-47. 2008
    ....
  53. ncbi request reprint Vagus nerve stimulation (VNS) for depression: what do we know now and what should be done next?
    Ziad Nahas
    Mood Disorders Program, Medical Director of Brain Stimulation Laboratory Institute of Psychiatry, 67 President Street, Room 502 North, Charleston, SC 29403, USA
    Curr Psychiatry Rep 8:445-51. 2006
    ..Further clinical studies, in addition to prospective cost utilization and health economic investigations, are needed to better understand VNS therapy and the impact it holds on TRD care...
  54. ncbi request reprint Estimating resting motor thresholds in transcranial magnetic stimulation research and practice: a computer simulation evaluation of best methods
    Jeffrey J Borckardt
    Brain Stimulation Laboratory, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, USA
    J ECT 22:169-75. 2006
    ..The current study investigates the accuracy and efficiency of 5 different approaches to motor threshold assessment for TMS research and practice applications...
  55. ncbi request reprint Regional brain activity in women grieving a romantic relationship breakup
    Arif Najib
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 161:2245-56. 2004
    ....
  56. ncbi request reprint Cortical and subcortical brain effects of transcranial magnetic stimulation (TMS)-induced movement: an interleaved TMS/functional magnetic resonance imaging study
    Stewart Denslow
    Department of Radiology, Center for Advanced Imaging Research and Brain Stimulation Laboratories, Medical University of South Carolina, Charlestown, SC 29425, USA
    Biol Psychiatry 57:752-60. 2005
    ..We hypothesized that TMS would activate known motor circuitry with some additional regions plus some areas dropping out...
  57. ncbi request reprint Vagus nerve stimulation affects pain perception in depressed adults
    Jeffrey J Borckardt
    Medical University of South Carolina, Charleston 29425, USA
    Pain Res Manag 10:9-14. 2005
    ....
  58. ncbi request reprint Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:393-402. 2004
    ..This study suggests, as did our earlier study, that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances...
  59. ncbi request reprint Decreased cortical response to verbal working memory following sleep deprivation
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina, Charleston 29425, USA
    Sleep 28:55-67. 2005
    ..To investigate the cerebral hemodynamic response to verbal working memory following sleep deprivation...
  60. ncbi request reprint Neural correlates of speech anticipatory anxiety in generalized social phobia
    Jeffrey P Lorberbaum
    Department of Psychiatry and Center for Advanced Imaging, Medical University of South Carolina Charleston MUSC, SC 29425, USA
    Neuroreport 15:2701-5. 2004
    ..Phobics may become so anxious, they cannot think clearly or vice versa...
  61. ncbi request reprint Interleaved transcranial magnetic stimulation/functional MRI confirms that lamotrigine inhibits cortical excitability in healthy young men
    Xingbao Li
    Brain Stimulation Laboratory, Center for Advanced Imaging Research CAIR, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:1395-407. 2004
    ..Furthermore, the interleaved TMS/fMRI technique may be a useful tool for investigating regional brain effects of psychoactive compounds...
  62. ncbi request reprint Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Room 502 North, PO Box 250861, Charleston, SC 29425, USA
    Depress Anxiety 20:98-100. 2004
    ..9) over the year. These data suggest but do not prove that TMS might eventually be used as an adjunctive maintenance treatment for at least some patients with bipolar depression. Much work remains...
  63. ncbi request reprint The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precision
    Alexander Mishory
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J ECT 20:160-5. 2004
    ....
  64. ncbi request reprint A replication study of the neural correlates of deception
    Frank Andrew Kozel
    Center for Advanced Imaging Research and the Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Behav Neurosci 118:852-6. 2004
    ..Individual results of the lie minus true condition were variable. Results show that functional MRI is a reasonable tool with which to study deception...
  65. ncbi request reprint Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55-75 years of age: a pilot study
    Ziad Nahas
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Depress Anxiety 19:249-56. 2004
    ....
  66. ncbi request reprint An increased precision comparison of TMS-induced motor cortex BOLD fMRI response for image-guided versus function-guided coil placement
    Stewart Denslow
    Department of Radiology, Center for Advanced Imaging Research and Brain Stimulation Laboratories, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cogn Behav Neurol 18:119-26. 2005
    ..To examine with high precision the differences between function-guided and image-guided transcranial magnetic stimulation (TMS)...
  67. ncbi request reprint Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study
    Ziad Nahas
    Brain Stimulation Laboratory, Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurocase 9:274-82. 2003
    ..This pilot study supports the cingulate's role in modulating cognition and neuronal connectivity in schizophrenia...
  68. ncbi request reprint Postoperative left prefrontal repetitive transcranial magnetic stimulation reduces patient-controlled analgesia use
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Anesthesiology 105:557-62. 2006
    ..No studies have investigated the effects of prefrontal cortex stimulation using transcranial magnetic stimulation on postoperative pain...
  69. ncbi request reprint Tolerability and safety of high daily doses of repetitive transcranial magnetic stimulation in healthy young men
    Berry Anderson
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, 29425, USA
    J ECT 22:49-53. 2006
    ..Despite this intense treatment regimen, we failed to produce significant side effects. Doses of up to 12,960 pulses per day appear safe and tolerable in healthy young men...
  70. ncbi request reprint Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina IOP, 502 N, 67 President St, Charleston, SC 29425, USA
    Sleep 28:433-46. 2005
    ..To examine whether differences in patterns of brain activation under baseline conditions relate to the differences in sleep-deprivation vulnerability...
  71. ncbi request reprint Vagus nerve stimulation therapy: a research update
    Mark S George
    502 North, IoP, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neurology 59:S56-61. 2002
    ....
  72. ncbi request reprint Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects
    Mikhail Lomarev
    Department of Radiology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Psychiatr Res 36:219-27. 2002
    ..g. hearing a tone)...
  73. ncbi request reprint Prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression
    Xingbao Li
    Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cogn Behav Neurol 16:128-35. 2003
    ....
  74. ncbi request reprint Decision analysis of the cost-effectiveness of repetitive transcranial magnetic stimulation versus electroconvulsive therapy for treatment of nonpsychotic severe depression
    F Andrew Kozel
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, and Ralph H Johnson Veterans Affairs Medical Center, Charleston, USA
    CNS Spectr 9:476-82. 2004
    ..Repetitive transcranial magnetic stimulation (rTMS) is a new treatment with promise for resistant depression...
  75. ncbi request reprint Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers
    Timothy A Kimbrell
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 115:101-13. 2002
    ..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS...
  76. ncbi request reprint BOLD-fMRI response vs. transcranial magnetic stimulation (TMS) pulse-train length: testing for linearity
    Daryl E Bohning
    Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Magn Reson Imaging 17:279-90. 2003
    ..To measure motor and auditory cortex blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) response to impulse-like transcranial magnetic stimulation (TMS) pulses as a function of train length...
  77. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  78. ncbi request reprint SPECT study of Chinese schizophrenic patients suggests that cerebral hypoperfusion and laterality exist in different ethnic groups
    Xingbao Li
    Psychiatry Department, Shandong University, Jinan, Shandong, China
    World J Biol Psychiatry 6:98-106. 2005
    ..Improved memory quotient (MQ) was significantly correlated with increased rCBF in the left temporal lobe. These findings from Chinese patients confirm a similar regional neuroanatomic dysfunction as in Western patients with the disease...
  79. ncbi request reprint Age, sex and laterality effects on cerebral glucose metabolism in healthy adults
    Mark W Willis
    Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 114:23-37. 2002
    ..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared...
  80. ncbi request reprint Stimulating the brain
    Mark S George
    Sci Am 289:66-73. 2003
  81. ncbi request reprint A pilot study of functional magnetic resonance imaging brain correlates of deception in healthy young men
    F Andrew Kozel
    Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, South Carolina, USA
    J Neuropsychiatry Clin Neurosci 16:295-305. 2004
    ..Individually and as a group, EDA correlated with blood flow changes in the OFCx and AC. Specific brain regions were activated during deception, but the present technique lacks good predictive power for individuals...
  82. ncbi request reprint Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation
    Jeffrey J Borckardt
    Medical University of South Carolina, Charleston, SC, USA
    J ECT 22:259-64. 2006
    ..More systematic research is needed on the effectiveness of different strategies for reducing rTMS-related pain and discomfort...
  83. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  84. ncbi request reprint Emotion facilitates action: a transcranial magnetic stimulation study of motor cortex excitability during picture viewing
    Greg Hajcak
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Psychophysiology 44:91-7. 2007
    ..Thus, viewing arousing stimuli, regardless of valence, increased motor cortex excitability. Implications and directions for future research are discussed...
  85. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
    ..Yet patients who showed substantial clinical benefit maintained the improvement at remarkably high rates. This durability of benefit was not attributable to alterations in other treatments...
  86. ncbi request reprint Functional neuroanatomy of subcomponent cognitive processes involved in verbal working memory
    Jeffrey S Bedwell
    Department of Psychology, University of Central Florida, Orlando, Florida 32816 1390, USA
    Int J Neurosci 115:1017-32. 2005
    ..Several other brain regions showed activation limited to specific subcomponent processes...
  87. ncbi request reprint Are individual differences in fatigue vulnerability related to baseline differences in cortical activation?
    John A Caldwell
    Aviation Sustained Operations Research, U S Air Force Research Laboratory, Brooks City Base, TX 78235, USA
    Behav Neurosci 119:694-707. 2005
    ..These preliminary data suggest that baseline fMRI scan activation during a working memory task may correlate with fatigue susceptibility...
  88. ncbi request reprint Cerebral activation patterns related to initiation and inhibition of hand movement
    Carolien M Toxopeus
    Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Neuroreport 18:1557-60. 2007
    ..This indicates a specific basal ganglia-thalamocortical circuit involved in motor inhibition...
  89. ncbi request reprint Transcranial magnetic stimulation in the acute treatment of major depressive disorder: clinical response in an open-label extension trial
    David H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    J Clin Psychiatry 69:441-51. 2008
    ....
  90. ncbi request reprint A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations
    Seung Hwan Lee
    Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea, Koyang, South Korea
    Neurosci Lett 376:177-81. 2005
    ....
  91. ncbi request reprint Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neurocase 12:216-20. 2006
    ..If the acutely increased sensitivity sets the stage for the slower chronic anti-pain effects, the increased acute sensitivity does not disappear. Acute and chronic effects of VNS on pain perception merit further research...
  92. ncbi request reprint Regional cerebral glucose utilization in patients with a range of severities of unipolar depression
    Tim A Kimbrell
    North Little Rock VA Medical Center TAKi, North Little Rock, Arkansas, USA
    Biol Psychiatry 51:237-52. 2002
    ....

Research Grants15

  1. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2000
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  2. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2006
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). [unreadable] [unreadable]..
  3. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2007
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] [unreadable] [unreadable]..
  4. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2005
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). ..
  5. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2005
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  6. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2001
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  7. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2004
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). ..
  8. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  9. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2001
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  10. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2009
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  11. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2007
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). [unreadable] [unreadable]..
  12. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2009
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). ..
  13. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2006
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). [unreadable] [unreadable]..
  14. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2006
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] [unreadable] [unreadable]..
  15. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2004
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..