Zhi Dong Ge

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011
  2. doi Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 112:73-85. 2010
  3. pmc Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor
    Zhi Dong Ge
    Department of Pharmacology and Toxicology and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 319:1200-10. 2006
  4. pmc Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia
    Ines Baotic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 305:H219-27. 2013
  5. pmc Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury
    Thorsten M Leucker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    PLoS ONE 8:e70088. 2013
  6. pmc Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning
    Nikolina Vladic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 301:H2130-9. 2011
  7. pmc The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel
    Tina C Wan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 324:234-43. 2008
  8. ncbi Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Basic Res Cardiol 97:312-9. 2002
  9. pmc Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor
    Richard G Black
    Department of Pharmacology and Toxicology and the Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 91:165-72. 2002
  10. pmc A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 49:280-6. 2010

Collaborators

Detail Information

Publications19

  1. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011
    ....
  2. doi Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 112:73-85. 2010
    ..The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice...
  3. pmc Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor
    Zhi Dong Ge
    Department of Pharmacology and Toxicology and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 319:1200-10. 2006
    ..These data demonstrate that Cl-IB-MECA protects against myocardial ischemia/reperfusion injury in mice principally by activating the A(3)AR...
  4. pmc Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia
    Ines Baotic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 305:H219-27. 2013
    ..In conclusion, D-4F restored the cardioprotective effect of APC during AHG, possibly by decreasing superoxide generation, which promoted isoflurane-induced eNOS signaling and NO biosynthesis. ..
  5. pmc Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury
    Thorsten M Leucker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    PLoS ONE 8:e70088. 2013
    ..Maintaining sufficient endothelial BH4 is crucial for cardioprotection against hypoxia/reoxygenation injury. ..
  6. pmc Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning
    Nikolina Vladic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 301:H2130-9. 2011
    ..The results suggest that eNOS dysregulation may be a central mechanism of impaired cardioprotection during hyperglycemia...
  7. pmc The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel
    Tina C Wan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 324:234-43. 2008
    ..We conclude that CP-532,903 is a highly selective agonist of the mouse A(3)AR that protects against ischemia/reperfusion injury by activating sarcolemmal K(ATP) channels...
  8. ncbi Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Basic Res Cardiol 97:312-9. 2002
    ..These results suggest that myocardial ischemia and reperfusion decrease cADPR in the myocardium by increasing its hydrolysis. Tissue hypoxia may be one of the important mechanisms to activate cADPR hydrolase...
  9. pmc Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor
    Richard G Black
    Department of Pharmacology and Toxicology and the Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 91:165-72. 2002
    ....
  10. pmc A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 49:280-6. 2010
    ....
  11. pmc Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor
    Laura M Kreckler
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Pharmacol Exp Ther 317:172-80. 2006
    ....
  12. pmc Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs
    John A Auchampach
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 308:846-56. 2004
    ..We discuss the possibility that the cardioprotective actions of CPX and BG 9928 may be related to antagonism of A(2B)ARs...
  13. pmc Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
    Irina A Ionova
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 299:H88-96. 2010
    ..The mechanism of the decreased rejection appears related to decreased T cell proliferation and modulation of immune function by higher expression of genes involved in hematopoietic/stromal cell development and recruitment...
  14. ncbi Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 40:28-36. 2003
    ..These results suggest that the cADPR signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors...
  15. pmc Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells
    Timothy J Nelson
    Department of Cell Biology, Neurobiology, and Anatomy and the Cardiovascular Center Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1216-24. 2006
    ..These experiments indicate that the infarcted myocardial environment can support engraftment and cardiomyogenic differentiation of pluripotent ESCs, concomitant with partial functional recovery...
  16. ncbi Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells
    Pin Lan Li
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H1229-36. 2002
    ....
  17. ncbi Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Cardiovasc Pharmacol 41:481-8. 2003
    ..These results suggest that the beneficial effects of KT2-962 may be due to its direct free radical scavenging properties rather than its ability to block TXA receptors.(2) (2) (2)..
  18. pmc 4F decreases IRF5 expression and activation in hearts of tight skin mice
    Hao Xu
    Division of Pediatric Surgery, Department of Surgery, Children s Research Institute, Milwaukee, Wisconsin, USA
    PLoS ONE 7:e52046. 2012
    ..4F treatments decreased both measurements in Tsk(-/+) hearts. IRF5 activation in Tsk(-/+) hearts is increased. 4F treatments decrease IRF5 expression and activation in Tsk(-/+) hearts by a mechanism related to 4F's ability to bind IRF5...
  19. pmc Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo
    David X Zhang
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 53:532-8. 2009
    ..These findings may provide novel insight into mechanisms of Ca2+ entry evoked by chemical agonists in endothelial cells...