Kathryn M Gauthier

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries
    Nitin T Aggarwal
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 296:H678-88. 2009
  2. doi request reprint ACE inhibition enhances bradykinin relaxations through nitric oxide and B1 receptor activation in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Biol Chem 394:1205-12. 2013
  3. ncbi request reprint Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 288:H1344-51. 2005
  4. pmc Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:150-5. 2008
  5. doi request reprint 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1467-72. 2008
  6. ncbi request reprint Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 50:601-8. 2007
  7. pmc Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 300:H725-35. 2011
  8. ncbi request reprint 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 45:666-71. 2005
  9. pmc Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles
    Kathryn M Gauthier
    Department of Pharmacology and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 301:F765-72. 2011
  10. ncbi request reprint Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 43:413-9. 2004

Collaborators

Detail Information

Publications53

  1. pmc Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries
    Nitin T Aggarwal
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 296:H678-88. 2009
    ..Therefore, hypoxia increased the relaxations to agonists in the rabbit mesenteric arteries by enhancing endothelial 15-LO-1 expression and synthesis of the hyperpolarizing factors THETA and HEETA...
  2. doi request reprint ACE inhibition enhances bradykinin relaxations through nitric oxide and B1 receptor activation in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Biol Chem 394:1205-12. 2013
    ..Our results demonstrate that ACE inhibitor-enhanced bradykinin relaxations of bovine coronary arteries occur through endothelial cell B1 receptor activation and NO...
  3. ncbi request reprint Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 288:H1344-51. 2005
    ..2-AG is further hydrolyzed to AA, which is metabolized to vasoactive eicosanoids. These studies reveal a role for 2-AG in EC AA release and the regulation of coronary tone...
  4. pmc Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:150-5. 2008
    ....
  5. doi request reprint 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1467-72. 2008
    ..It relaxes smooth muscle by activating K+ channels. The specific structural and stereochemical requirements for K+ channel activation suggest that a specific binding site or receptor of 11,12,15-THETA is involved in these actions...
  6. ncbi request reprint Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 50:601-8. 2007
    ..Production and metabolism of EETs as well as their specific cellular signaling mechanisms are discussed...
  7. pmc Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 300:H725-35. 2011
    ..Thus, in mouse resistance arteries, 12/15-LO AA metabolites mediate endothelium-dependent relaxations to ACh and AA...
  8. ncbi request reprint 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 45:666-71. 2005
    ..14,15-EEZE blocked the donor artery, endothelium-dependent, bradykinin-induced relaxations, and attenuated relaxations to 14,15-EET. These results suggest that EETs are transferable EDHFs in coronary arteries...
  9. pmc Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles
    Kathryn M Gauthier
    Department of Pharmacology and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 301:F765-72. 2011
    ..However, some commercial catalase preparations are contaminated with sEH, and these contaminated preparations diminish the biological activity of H(2)O(2) and EETs...
  10. ncbi request reprint Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 43:413-9. 2004
    ..These results suggest that arachidonic acid induces endothelium-dependent hyperpolarization and relaxation of rabbit aorta through activation of smooth muscle, apamin-sensitive K+ currents...
  11. pmc Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 57:323-9. 2011
    ..This provides a mechanism by which Ang II concurrently increases adrenal blood flow and steroidogenesis...
  12. doi request reprint Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta
    Yuttana Chawengsub
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1348-56. 2008
    ..These results indicate that 15-H-11,12-EETA is produced by the aorta, hydrolyzed by sEH to 11,12,15-THETA, and mediates relaxations by membrane hyperpolarization. 15-H-11,12-EETA represents an endothelium-derived hyperpolarizing factor...
  13. ncbi request reprint Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation
    Wenqi Yang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:681-6. 2005
    ..PDPAs only activate large conductance calcium-activated K+ channels...
  14. pmc 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits
    Nitin T Aggarwal
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 295:H89-96. 2008
    ..5 +/- 1.4%, and by BW755C to -18.8 +/- 3.5%. The present study indicates that the age-related decrease in ACh-induced hypotension is mediated by the decreased synthesis of the 15-LO-1 metabolites THETAs and HEETAs...
  15. pmc Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Hypertension 55:547-54. 2010
    ..Thus, adrenic acid metabolites could function as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors in the adrenal cortex and contribute to the regulation of adrenal blood flow...
  16. pmc 11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries
    Ishfaq A Bukhari
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53225, USA
    Am J Physiol Heart Circ Physiol 302:H1574-83. 2012
    ..These results indicate that 11,12,20-THE8ZE is a selective antagonist of 11,12-EET relaxations and a useful pharmacological tool to elucidate the function of 11,12-EET in the cardiovascular system...
  17. pmc Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 297:H47-52. 2009
    ..These results suggest a unique role for endogenous EETs in both IPC and POC...
  18. ncbi request reprint Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 146:3319-24. 2005
    ..Our results demonstrate that AII stimulates adrenal cortical arterial dilation through endothelial cell AT2 receptor activation and NO release and AT1 receptor-dependent constriction...
  19. ncbi request reprint 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H2648-56. 2003
    ..Additionally, this lipoxygenase pathway mediates the nonnitric oxide, nonprostaglandin relaxations to ACh in the rabbit aorta by acting as a source of an endothelium-derived hyperpolarizing factor...
  20. ncbi request reprint Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:4532-9. 2004
    ..The acetylcholine-induced relaxation is largely mediated by an endothelium-dependent hyperpolarization mechanism, presumably through cytochrome P450 metabolites of arachidonic acid...
  21. pmc Endothelial nitric oxide and 15-lipoxygenase-1 metabolites independently mediate relaxation of the rabbit aorta
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Vascul Pharmacol 56:106-12. 2012
    ..5±5% and 44.2±4%, respectively). These results indicate that NO and 15-LO-1 act in parallel to mediate ACH relaxations and NO does not alter 15-LO-1 activity...
  22. ncbi request reprint 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H1656-64. 2002
    ..14,15-DHET relaxes coronary arteries through activation of K(Ca) channels. Endothelial cells, but not smooth muscle cells, convert EETs to DHETs, and this conversion results in a loss of vasodilator activity...
  23. ncbi request reprint Novel mechanism of vasodilation in inflammatory bowel disease
    Ossama A Hatoum
    Department of Medicine, Zablocki VA Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 25:2355-61. 2005
    ..The contributions of both nitric oxide (NO) and endothelial-derived hyperpolarizing factor (EDHF) are decreased. We hypothesized that the remaining dilation results from products of cyclooxygenase...
  24. ncbi request reprint Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation
    J R Falck
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 284:H337-49. 2003
    ..These studies indicate that the structural features of 14,15-EET required for relaxation of the bovine coronary artery include a carbon-1 acidic group, a Delta8 double bond, and a 14(S),15(R)-(cis)-epoxy group...
  25. doi request reprint Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 51:246-51. 2008
    ..Therefore, increased expression of 15-LO-1 increases acetylcholine relaxation in arteries and hypotensive responses in rabbits because of increased hydroxy-epoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid synthesis...
  26. ncbi request reprint 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Circ Res 90:1028-36. 2002
    ..Thus, a distinct molecular structure is required for EET activity, and alteration of this structure modifies agonist and antagonist activity. These findings support a role of EETs as EDHFs...
  27. ncbi request reprint Steroid-producing cells regulate arterial tone of adrenal cortical arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 148:3569-76. 2007
    ..We conclude that ZG cells release EETs and this release is stimulated by ACTH. Interaction of endocrine and vascular cells represents a mechanism for regulating adrenal blood flow and couples steroidogenesis to increased blood flow...
  28. ncbi request reprint ACh-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H152-9. 2007
    ....
  29. pmc Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries
    Yuttana Chawengsub
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 284:31280-90. 2009
    ..These studies demonstrate that 13-H-14,15-EETAs induces vascular relaxation via K(+) channel activation to cause SMC hyperpolarization. Thus, 13-H-14,15-EETA represents a new endothelial factor...
  30. ncbi request reprint Characterization of vasoconstrictor responses in small bovine adrenal cortical arteries in vitro
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Endocrinology 145:1571-8. 2004
    ..The forceful contractile responses of these arterioles are consistent with their potential role in the regulation of adrenal blood flow...
  31. ncbi request reprint 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 42:555-61. 2003
    ..It also inhibits the EDHF component of bradykinin-induced, methacholine-induced, and arachidonic acid-induced relaxation. These results suggest that 14,15- or 5,6 -EET act as an EDHF in bovine coronary arteries...
  32. pmc Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry
    Xiaodong Zheng
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Heart Assoc 2:e000080. 2013
    ..In this study, we investigated the role of the transient receptor potential vanilloid 4 (TRPV4) channel in AA-induced endothelial Ca(2+) response and dilation of HCAs...
  33. pmc Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries
    Lawan Siangjong
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 304:H382-92. 2013
    ..These 12(S)-HETE relaxations are mediated by TP receptor competitive inhibition and inhibition of TP agonist-induced increases in intracellular calcium...
  34. pmc Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H2838-44. 2008
    ..These data also suggest that 14,15-EEZE is not blocking the mitochondrial ATP-sensitive potassium channel as a mechanism for antagonizing the cardioprotective effects of the EETs...
  35. ncbi request reprint Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase
    William B Campbell
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 290:H64-71. 2006
    ..These studies indicate that 14(S),15(R)-EET is a sufficient endogenous activator of BK(Ca) channels in coronary SMCs...
  36. pmc Aldosterone secretagogues increase adrenal blood flow in male rats
    Ishrath Ansurudeen
    Departments of Pharmacology and Toxicology I A, P G K, K M G, W B C and Physiology A W C, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 Department of Medicine III I A, S R B, Carl Gustav Carus Medical School, University of Technology, D 01307 Dresden, Germany and Department of Pharmacology P G K, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515
    Endocrinology 155:127-32. 2014
    ..Our results demonstrate that Ang II and ACTH increases in ABF are mediated by a cytochrome P450 metabolite. ..
  37. ncbi request reprint Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries
    Xiu Yu Yi
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H2265-74. 2007
    ..Our results suggest a role of adrenic acid metabolites, specifically, DH-EETs as endothelium-derived hyperpolarizing factors in the coronary circulation...
  38. pmc 14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries
    Ishfaq A Bukhari
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 336:47-55. 2011
    ..The present study indicates that conversion of 14,15-EE5ZE to 14,15-DHE5ZE produces a 14,15-EET-selective antagonist that will be a useful pharmacological tool to identify EET receptor(s) and EET function in the cardiovascular system...
  39. ncbi request reprint Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Endocrinol Metab 289:E1058-63. 2005
    ..The potential role of histamine in linking adrenal vascular events and steroid secretion requires further investigation...
  40. ncbi request reprint 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pharmacol Res 49:515-24. 2004
    ..These studies have revealed that specific structural components of the 14,15-EET molecule are critical for dilator activity and that alteration of these components influences agonist activity and may confer antagonist properties...
  41. ncbi request reprint Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 288:H302-9. 2005
    ..These findings provide functional and biochemical evidence that AA-induced relaxation in rabbit small mesenteric arteries is mediated through both COX and lipoxygenase pathways...
  42. doi request reprint Role of macrophage PPARγ in experimental hypertension
    Tamas Kriska
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Am J Physiol Heart Circ Physiol 306:H26-32. 2014
    ..These results indicate a regulatory role for macrophage-localized PPARγ in L-NAME-induced experimental hypertension...
  43. pmc Inducible endothelium-derived hyperpolarizing factor: role of the 15-lipoxygenase-EDHF pathway
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 61:176-87. 2013
    ..This new EDHF classification provides a framework for understanding EDHF activity in physiological and pathological conditions...
  44. pmc Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone
    Yuttana Chawengsub
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 297:H495-507. 2009
    ..Thus formation of vasodilator eicosanoids derived from LO pathways contributes to the regulation of vascular tone, local blood flow, and blood pressure...
  45. pmc Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts
    Tamas Kriska
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States Electronic address
    Prostaglandins Other Lipid Mediat 106:8-15. 2013
    ..03 and 3.22 times greater, respectively. These results indicate that h15-LO-1-derived metabolites are highly vasoactive and may play a critical role in regulating coronary blood flow. ..
  46. ncbi request reprint U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005
    ..These results suggest that MCA production of eCBs is not regulated by constriction per se but likely via a signaling pathway that is specific for TXA(2) receptors and not 5-HT receptors...
  47. pmc Freshly isolated bovine coronary endothelial cells do not express the BK Ca channel gene
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Physiol 545:829-36. 2002
    ..These findings indicate a cell-specific distribution of Ca(2+)-activated K(+) channels in SMCs and ECs from a single arterial site...
  48. pmc Impaired voltage gated potassium channel responses in a fetal lamb model of persistent pulmonary hypertension of the newborn
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Pediatr Res 66:289-94. 2009
    ..Oxidative stress impairs Kv channel function in PPHN. Superoxide scavengers may improve pulmonary vasodilation in PPHN in part by restoring Kv channel function...
  49. pmc Vascular pharmacology of epoxyeicosatrienoic acids
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Adv Pharmacol 60:27-59. 2010
    ..Furthermore, the therapeutic potential of targeting the EET pathway in vascular disease will be highlighted...
  50. ncbi request reprint What is new in endothelium-derived hyperpolarizing factors?
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Opin Nephrol Hypertens 11:177-83. 2002
    ..This article reviews the latest studies concerning the characterization of endothelium-derived hyperpolarizing factors, the mechanisms of factor release and alterations of the factors...
  51. pmc Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension
    Tamas Kriska
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Am J Physiol Heart Circ Physiol 302:H2428-38. 2012
    ..These studies indicate that Alox15 is involved in development of experimental hypertension by altering macrophage functions but not via synthesis of the vasoactive LO metabolites in mouse arteries...
  52. pmc Quantifying mitochondrial and plasma membrane potentials in intact pulmonary arterial endothelial cells based on extracellular disposition of rhodamine dyes
    Zhuohui Gan
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 300:L762-72. 2011
    ....
  53. ncbi request reprint Hypoxia-induced vascular smooth muscle relaxation: increased ATP-sensitive K+ efflux or decreased voltage-sensitive Ca2+ influx?
    Kathryn M Gauthier
    Am J Physiol Heart Circ Physiol 291:H24-5. 2006