W Timothy Garvey

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition
    W T Garvey
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 46:444-50. 1997
  2. pmc Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    W T Garvey
    Department of Medicine, Medical University of South Carolina and Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
    J Clin Invest 101:2377-86. 1998
  3. ncbi request reprint Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
  4. pmc The role of uncoupling protein 3 in human physiology
    W Timothy Garvey
    Division of Endocrinology, Diabetes, and Medical Genetics and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Invest 111:438-41. 2003
  5. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort
    Richard L Klein
    Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Diabetes Complications 19:18-25. 2005
  6. ncbi request reprint Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 64:817-28. 2003
  7. ncbi request reprint Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin
    Steven M Willi
    Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 51:2895-902. 2002
  8. pmc Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications
    Maria F Lopes-Virella
    Department of Medicine and Laboratory Services, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Diabetes Care 31:2006-12. 2008
  9. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclasses
    Richard L Klein
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Metabolism 53:1296-304. 2004
  10. doi request reprint Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC, USA
    J Diabetes Complications 22:153-63. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition
    W T Garvey
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 46:444-50. 1997
    ..However, these data, for the first time, implicate a role for Rad in regulating body composition and energy expenditure and provide a framework for studies designed to elucidate Rad's cellular functions...
  2. pmc Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    W T Garvey
    Department of Medicine, Medical University of South Carolina and Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
    J Clin Invest 101:2377-86. 1998
    ..Based on these data, we propose that human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface...
  3. ncbi request reprint Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  4. pmc The role of uncoupling protein 3 in human physiology
    W Timothy Garvey
    Division of Endocrinology, Diabetes, and Medical Genetics and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Invest 111:438-41. 2003
  5. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort
    Richard L Klein
    Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Diabetes Complications 19:18-25. 2005
    ..We investigated the associations of apolipoprotein C-III (apoCIII) protein and apoCIII gene variation with microvascular disease complications in Type 1 diabetes...
  6. ncbi request reprint Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 64:817-28. 2003
    ..The relationship between detailed lipoprotein analyses and diabetic nephropathy is of interest...
  7. ncbi request reprint Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin
    Steven M Willi
    Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 51:2895-902. 2002
    ..By preventing or reversing insulin resistance, troglitazone may prove to be a valuable therapeutic agent in the difficult clinical task of controlling diabetes in patients receiving glucocorticoids...
  8. pmc Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications
    Maria F Lopes-Virella
    Department of Medicine and Laboratory Services, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Diabetes Care 31:2006-12. 2008
    ....
  9. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclasses
    Richard L Klein
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Metabolism 53:1296-304. 2004
    ....
  10. doi request reprint Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC, USA
    J Diabetes Complications 22:153-63. 2008
    ..To determine the relationships between C-reactive protein (CRP) levels and features of Type 1 diabetes...
  11. ncbi request reprint Critical evaluation of adult treatment panel III criteria in identifying insulin resistance with dyslipidemia
    Youlian Liao
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Diabetes Care 27:978-83. 2004
    ....
  12. ncbi request reprint Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort
    Richard L Klein
    Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes Care 26:1439-48. 2003
    ..045). Last, hyperfibrinogenemia in type 1 diabetes is associated with components of the insulin resistance syndrome trait cluster, and the association is influenced by sex...
  13. ncbi request reprint Mitochondrial DNA (mtDNA) haplotypes reveal maternal population genetic affinities of Sea Island Gullah-speaking African Americans
    David C McLean
    Division of Endocrinology, Diabetes, and Medical Genetics, Department of Medicine, Sea Island Families Project and Project Sugar, Medical University of South Carolina, Charleston, SC 20425, USA
    Am J Phys Anthropol 127:427-38. 2005
    ....
  14. ncbi request reprint Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemia
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Diabetes Care 26:810-8. 2003
    ..To relate the nuclear magnetic resonance (NMR)-determined lipoprotein profile, conventional lipid and apolipoprotein measures, and in vitro oxidizibility of LDL with gender and glycemia in type 1 diabetes...
  15. ncbi request reprint Estimation of resting energy expenditure considering effects of race and diabetes status
    Kelley Martin
    General Clinical Research Center, Medical University of South Carolina, Charleston, SC, USA
    Diabetes Care 27:1405-11. 2004
    ..To evaluate the impact of diabetes status and race, in addition to other covariables, on the estimation of resting energy expenditure (REE)...
  16. ncbi request reprint Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, PO Box 250776, Charleston, SC 29425, USA
    Diabetes 52:1215-21. 2003
    ....
  17. ncbi request reprint Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes
    Steven M Willi
    Department of Pediatrics and General Clinical Research Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Diabetes Res Clin Pract 58:87-96. 2002
    ..Thiazolidinediones may improve diabetes-related parameters by antagonizing pathways of glucocorticoid-induced insulin resistance and by reversing adverse effects of glucocorticoids on beta cell function...
  18. ncbi request reprint The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages
    Yuchang Fu
    Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, STB 514, 114 Doughty Street, Charleston, SC 29403, USA
    Atherosclerosis 165:259-69. 2002
    ..e. thiazolidinediones) to treat Type 2 Diabetes could exacerbate atherosclerosis, and highlight the need for clinical trials that address this issue...
  19. ncbi request reprint Three novel mtDNA restriction site polymorphisms allow exploration of population affinities of African Americans
    David C McLean
    Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Sea Island Families Project and Project Sugar, The Medical University of South Carolina, Ralph H Johnson Veteran Affairs Medical Center, Charleston, South Carolina, USA
    Hum Biol 75:147-61. 2003
    ..These RSPs may become valuable new tools in the study of ancestral affinities and admixture dynamics of African Americans...
  20. ncbi request reprint Administration of pioglitazone in low-density lipoprotein receptor-deficient mice inhibits lesion progression and matrix metalloproteinase expression in advanced atherosclerotic plaques
    Lin He
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29403, USA
    J Cardiovasc Pharmacol 48:212-22. 2006
    ....
  21. ncbi request reprint Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Curr Opin Lipidol 18:263-70. 2007
    ..This review summarizes recent studies highlighting cellular effects of adiponectin and its role in human lipid metabolism and atherosclerosis...
  22. ncbi request reprint NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    J Biol Chem 282:31525-33. 2007
    ..Thus, NR4A3 and NR4A1 are attractive novel therapeutic targets for potential amelioration of insulin resistance, and treatment and prevention of type 2 diabetes and the metabolic syndrome...
  23. pmc Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
    Metabolism 57:1-8. 2008
    ..These observations are consistent with the idea that insulin resistance is more directly related to IMCL rather than to body fat per se...
  24. ncbi request reprint Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women
    Julian Munoz
    Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Building, Room 241, University of Alabama, Birmingham, AL 35294, USA
    Diabetes 55:3630-4. 2006
    ..Our data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes...
  25. ncbi request reprint Uncoupling protein 3 and human metabolism
    W Timothy Garvey
    J Clin Endocrinol Metab 91:1226-8. 2006
  26. ncbi request reprint Adiponectin multimeric complexes and the metabolic syndrome trait cluster
    Cristina Lara-Castro
    Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Bldg, Room 244, University of Alabama, Birmingham, AL 35294, USA
    Diabetes 55:249-59. 2006
    ..Finally, HMW adiponectin is an important factor in explaining the metabolic syndrome...
  27. ncbi request reprint Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Atherosclerosis 188:102-11. 2006
    ....
  28. ncbi request reprint Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    J Lipid Res 46:1369-79. 2005
    ....
  29. ncbi request reprint Mitochondrial DNA genetic diversity among four ethnic groups in Sierra Leone
    Bruce A Jackson
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Phys Anthropol 128:156-63. 2005
    ..Therefore, we may have evidence for mtDNA lineages that are unique to this region of West Africa...
  30. ncbi request reprint Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort
    Timothy J Lyons
    Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 45:910-8. 2004
    ..To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort...
  31. ncbi request reprint Role of UCP2 and UCP3 in nutrition and obesity
    Tim R Nagy
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    Nutrition 20:139-44. 2004
  32. ncbi request reprint Individual differences in the response to ingested nutrients
    David B Allison
    Department of Biostatistics Section on Statistical Genetics Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 20:1. 2004
  33. ncbi request reprint Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation
    Yuchang Fu
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Blood Cells Mol Dis 32:182-90. 2004
    ..The role for high levels of the fructose transporter GLUT 5 in macrophages and foam cells is unknown since interstitial and circulating fructose concentrations are low in these cells...
  34. ncbi request reprint The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle
    Xuxia Wu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Endocrine 31:5-17. 2007
    ..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action...
  35. ncbi request reprint Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis
    Helliner S Vestri
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Neuropsychopharmacology 32:765-72. 2007
    ..These effects of SGAs on adipocytes could explain, in part, the association of SGAs with weight gain and diabetes...
  36. ncbi request reprint Diet, insulin resistance, and obesity: zoning in on data for Atkins dieters living in South Beach
    Cristina Lara-Castro
    Department of Nutrition Sciences, Webb 232, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, Alabama 35294 3360, USA
    J Clin Endocrinol Metab 89:4197-205. 2004
    ..Long-term studies to determine the efficacy and safety of both popular and experimental diets are warranted...