J C Frisbee

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 97:764-72. 2004
  2. ncbi request reprint Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1304-11. 2001
  3. ncbi request reprint Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1568-74. 2001
  4. ncbi request reprint High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1808-15. 2001
  5. ncbi request reprint Parenchymal tissue cytochrome P450 4A enzymes contribute to oxygen-induced alterations in skeletal muscle arteriolar tone
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee 53226, USA
    Microvasc Res 63:340-3. 2002
  6. ncbi request reprint Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R309-19. 2002
  7. ncbi request reprint Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H2160-8. 2002
  8. ncbi request reprint Regulation of in situ skeletal muscle arteriolar tone: interactions between two parameters
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microcirculation 9:443-62. 2002
  9. ncbi request reprint Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H104-11. 2003
  10. ncbi request reprint Impaired skeletal muscle perfusion in obese Zucker rats
    Jefferson C Frisbee
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1124-34. 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 97:764-72. 2004
    ....
  2. ncbi request reprint Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1304-11. 2001
    ..Taken together, these data suggest that the development of diabetes and hypertension in OZR may be associated with an impaired skeletal muscle perfusion via an elevated vascular oxidant stress...
  3. ncbi request reprint Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1568-74. 2001
    ....
  4. ncbi request reprint High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1808-15. 2001
    ..These data suggest that reduced hypoxic dilation of skeletal muscle microvessels in rats on a HS diet may reflect an impaired ability of VSM to produce cAMP after exposure to prostacyclin...
  5. ncbi request reprint Parenchymal tissue cytochrome P450 4A enzymes contribute to oxygen-induced alterations in skeletal muscle arteriolar tone
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee 53226, USA
    Microvasc Res 63:340-3. 2002
  6. ncbi request reprint Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R309-19. 2002
    ..6-fold with severe hypoxia. These results suggest vascular reactivity to progressive hypoxia represents an integration of NO production (mild hypoxia), PGI(2) production (severe hypoxia), and reduced 20-HETE levels (moderate hypoxia)...
  7. ncbi request reprint Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H2160-8. 2002
    ....
  8. ncbi request reprint Regulation of in situ skeletal muscle arteriolar tone: interactions between two parameters
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microcirculation 9:443-62. 2002
    ....
  9. ncbi request reprint Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H104-11. 2003
    ....
  10. ncbi request reprint Impaired skeletal muscle perfusion in obese Zucker rats
    Jefferson C Frisbee
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1124-34. 2003
    ....
  11. ncbi request reprint Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisc 53226, USA
    J Vasc Res 38:305-14. 2001
    ....
  12. ncbi request reprint Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Microcirculation 8:115-27. 2001
    ..To determine mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries from normotensive (NT) and hypertensive (HT) Dahl salt-sensitive (SS) rats...
  13. ncbi request reprint Polycythemia decreases fatigue in tetanic contractions of canine skeletal muscle
    J C Frisbee
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Med Sci Sports Exerc 31:1293-8. 1999
    ..The effects of an acute polycythemia on muscle fatigue development were investigated in the self-perfused canine gastrocnemius in situ...
  14. ncbi request reprint Development and reversibility of altered skeletal muscle arteriolar structure and reactivity with high salt diet and reduced renal mass hypertension
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Microcirculation 6:215-25. 1999
    ..To determine the development and reversibility of the altered vasodilator reactivity of cremasteric arterioles in rats on high-salt diet and with reduced renal mass hypertension (RRMHT)...
  15. ncbi request reprint Reduced renal mass hypertension, but not high salt diet, alters skeletal muscle arteriolar distensibility and myogenic responses
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Microvasc Res 59:255-64. 2000
    ..The impact of these effects must be taken into account when interpreting data describing alterations in skeletal muscle microvessel reactivity for animals on high salt diet or with RRM hypertension...
  16. ncbi request reprint Short-term angiotensin converting enzyme inhibition reduces basal tone and dilator reactivity in skeletal muscle arterioles
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Hypertens 13:389-95. 2000
    ..These observations indicate that short-term ACE inhibition reduces both resting tone and agonist-induced dilator responses of skeletal muscle arterioles...
  17. ncbi request reprint Chronic captopril administration decreases vasodilator responses in skeletal muscle arterioles
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Hypertens 12:705-15. 1999
    ....
  18. ncbi request reprint Contribution of extrinsic factors and intrinsic vascular alterations to reduced arteriolar reactivity with high-salt diet and hypertension
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Microcirculation 7:281-9. 2000
    ....
  19. ncbi request reprint 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Microcirculation 8:45-55. 2001
    ....
  20. ncbi request reprint Elevated oxygen tension inhibits flow-induced dilation of skeletal muscle arterioles
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Microvasc Res 58:99-107. 1999
    ..These observations demonstrate that elevated PO(2) can override flow-induced vasodilation in the skeletal muscle microcirculation, leading to the persistence of an elevated wall shear rate...
  21. ncbi request reprint 20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 280:H1066-74. 2001
    ....
  22. ncbi request reprint Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Microvasc Res 62:271-83. 2001
    ....
  23. ncbi request reprint Microvascular flow and tissue PO(2) in skeletal muscle of chronic reduced renal mass hypertensive rats
    J H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Am J Physiol Heart Circ Physiol 279:H2295-302. 2000
    ..These results indicate that both RRM-HT and chronic exposure of normotensive rats to a high-salt diet lead to reduced tissue oxygenation, despite the maintenance of normal arteriolar blood flow...
  24. ncbi request reprint Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Dept of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, West Virginia Univ School of Medicine, Morgantown, WV 26505, USA
    J Appl Physiol (1985) 100:465-73. 2006
    ..LZR. These results suggest that a combination of reduced blood volume and elevated peripheral adrenergic constriction contribute to impaired hemorrhage tolerance in OZR...
  25. ncbi request reprint Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Heart Circ Physiol 290:H2066-74. 2006
    ....
  26. ncbi request reprint Exercise training blunts microvascular rarefaction in the metabolic syndrome
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Dept of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, P O Box 9105, West Virginia Univ School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Heart Circ Physiol 291:H2483-92. 2006
    ..These data suggest that exercise-induced improvements in skeletal muscle MVD in OZR are associated with increased NO bioavailability and may stem from altered inflammatory profiles rather than MMP function...
  27. ncbi request reprint Growth-dependent changes in endothelial factors regulating arteriolar tone
    Julie Balch Samora
    Center for Interdisciplinary Research in Cardiovascular Sciences, Robert C Byrd Health Sciences Center, PO Box 9105, West Virginia Univ School of Medicine, Morgantown, WV 26506 9105, USA
    Am J Physiol Heart Circ Physiol 292:H207-14. 2007
    ..However, during earlier microvascular growth, this dilation is mediated by other factors yet to be identified. This may have significant implications for the regulation of tissue perfusion during microvascular development...
  28. ncbi request reprint Vascular function in the metabolic syndrome and the effects on skeletal muscle perfusion: lessons from the obese Zucker rat
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia School of Medicine, Morgantown, USA
    Essays Biochem 42:145-61. 2006
    ....
  29. ncbi request reprint Angiostatin does not contribute to skeletal muscle microvascular rarefaction with low nitric oxide bioavailability
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Microcirculation 14:145-53. 2007
    ....
  30. ncbi request reprint Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia
    Phoebe A Stapleton
    Center for Interdisciplinary Research in Cardiovascular Science, Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1110-9. 2007
    ..These results suggest that with development of hypercholesterolemia, mechanisms contributing to dilator reactivity in skeletal muscle arterioles are modified such that net reactivity to endothelium-dependent stimuli is largely intact...
  31. pmc Hydrogen peroxide emerges as a regulator of tone in skeletal muscle arterioles during juvenile growth
    Julie Balch Samora
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26505 9105, USA
    Microcirculation 15:151-61. 2008
    ..This study was designed to determine if endogenous hydrogen peroxide (H2O2) contributes to this arteriolar dilation at either of these growth stages...
  32. ncbi request reprint Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1770-6. 2005
    ..Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant...
  33. ncbi request reprint Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    Microcirculation 12:383-92. 2005
    ..To test the hypothesis that reduced skeletal muscle microvessel density (MVD) in obese Zucker rats (OZR) is independent of chronic elevations in mean arterial pressure (MAP)...
  34. ncbi request reprint Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Dept of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, PO Box 9105, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 289:R307-R316. 2005
    ....
  35. ncbi request reprint Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats
    David W Stepp
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H816-20. 2002
    ....
  36. ncbi request reprint High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries
    Francis A Sylvester
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 283:H353-63. 2002
    ....
  37. ncbi request reprint High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1124-33. 2003
    ..These observations suggest that angiotensin II suppression with a HS diet leads to impaired relaxation of cerebral arteries in response to vasodilator stimuli acting at the cell membrane...
  38. ncbi request reprint Skeletal muscle arteriolar reactivity in SS.BN13 consomic rats and Dahl salt-sensitive rats
    Ines Drenjancevic-Peric
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wis 53226, USA
    Hypertension 41:1012-5. 2003
    ..BN13 rats versus Dahl S rats but does not affect constrictor responses to oxygen, and (2) factors in the Dahl S genetic background contribute to an enhanced sensitivity of arterioles to elevated PO2 independent of elevated blood pressure...
  39. ncbi request reprint Low-flow vascular remodeling in the metabolic syndrome X
    David W Stepp
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 286:H964-70. 2004
    ..This remodeling may result in an architectural limitation of maximum perfusion capacity and may be an important maladaption in the progression of peripheral microvascular disease...
  40. ncbi request reprint Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H545-52. 2004
    ..These data suggest that AT(1) receptor activation has an important role in maintaining the vascular release of prostaglandins responsible for mediating hypoxic dilation in skeletal muscle microvessels...
  41. ncbi request reprint Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226 1408, USA
    Methods Enzymol 381:140-65. 2004
  42. ncbi request reprint Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 288:R522-30. 2005
    ..However, oxidative stress-independent increases in myogenic tone and constrictor reactivity may contribute to blunted dilator responses of cerebral microvessels...
  43. doi request reprint Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth
    Julie Balch Samora
    Center for Interdisciplinary Research in Cardiovascular Sciences, Robert C Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26505 9105, USA
    Am J Physiol Heart Circ Physiol 294:H2344-51. 2008
    ..As a result, the relative contribution of myogenic activity to blood flow regulation in skeletal muscle may increase during rapid juvenile growth...
  44. ncbi request reprint Vascular dysfunction in obesity and insulin resistance
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26505, USA
    Microcirculation 14:269-71. 2007
    ..The authors hope that this Special Topics Issue will be informative for its readers and will provide a basis for future investigation into microvasculopathy in obesity and insulin-resistance...
  45. ncbi request reprint Obesity, insulin resistance, and microvessel density
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26505, USA
    Microcirculation 14:289-98. 2007
    ....