P A Flume

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Ivacaftor in subjects with cystic fibrosis who are homozygous for the F508del-CFTR mutation
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 142:718-24. 2012
  2. doi request reprint Smoothing the transition from pediatric to adult care: lessons learned
    Patrick A Flume
    Departments of Pediatrics and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Pulm Med 15:611-4. 2009
  3. pmc State of progress in treating cystic fibrosis respiratory disease
    Patrick A Flume
    Medical University of South Carolina, Charleston, SC, USA
    BMC Med 10:88. 2012
  4. ncbi request reprint Relief of the 'air hunger' of breathholding. A role for pulmonary stretch receptors
    P A Flume
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Respir Physiol 103:221-32. 1996
  5. ncbi request reprint Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Respir Crit Care Med 176:957-69. 2007
  6. doi request reprint Making the diagnosis of cystic fibrosis
    Patrick A Flume
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 335:51-4. 2008
  7. ncbi request reprint Cystic fibrosis pulmonary guidelines: airway clearance therapies
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston SC 29425, USA
    Respir Care 54:522-37. 2009
  8. ncbi request reprint Pulmonary complications of cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
    Respir Care 54:618-27. 2009
  9. doi request reprint Patient-reported pain and impaired sleep quality in adult patients with cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, 29425, United States
    J Cyst Fibros 8:321-5. 2009
  10. doi request reprint Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations
    Patrick A Flume
    Department of Medicine and Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Respir Crit Care Med 180:802-8. 2009

Detail Information

Publications33

  1. pmc Ivacaftor in subjects with cystic fibrosis who are homozygous for the F508del-CFTR mutation
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 142:718-24. 2012
    ....
  2. doi request reprint Smoothing the transition from pediatric to adult care: lessons learned
    Patrick A Flume
    Departments of Pediatrics and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Pulm Med 15:611-4. 2009
    ....
  3. pmc State of progress in treating cystic fibrosis respiratory disease
    Patrick A Flume
    Medical University of South Carolina, Charleston, SC, USA
    BMC Med 10:88. 2012
    ....
  4. ncbi request reprint Relief of the 'air hunger' of breathholding. A role for pulmonary stretch receptors
    P A Flume
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Respir Physiol 103:221-32. 1996
    ..This is compatible with the loss during rebreathing of the inhibitory effect of PSR input on neural mechanisms that lead to respiratory distress...
  5. ncbi request reprint Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Respir Crit Care Med 176:957-69. 2007
    ..Hence, it is important that treatments should be recommended on the basis of available evidence of efficacy and safety...
  6. doi request reprint Making the diagnosis of cystic fibrosis
    Patrick A Flume
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 335:51-4. 2008
    ..With more sophisticated testing, we are able to make the diagnosis in the newborn or even the fetus. In this report, we discuss our current approach to making a diagnosis of CF...
  7. ncbi request reprint Cystic fibrosis pulmonary guidelines: airway clearance therapies
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston SC 29425, USA
    Respir Care 54:522-37. 2009
    ..Aerobic exercise is recommended as an adjunctive therapy for airway clearance and for its additional benefits to overall health...
  8. ncbi request reprint Pulmonary complications of cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
    Respir Care 54:618-27. 2009
    ..Now, more than ever, the patient needs caregivers with the knowledge and sensitivity to provide appropriate palliative care...
  9. doi request reprint Patient-reported pain and impaired sleep quality in adult patients with cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, 29425, United States
    J Cyst Fibros 8:321-5. 2009
    ..Pain is a known cause of sleep disturbance and as pain is commonly reported in patients with CF, we sought to find an association between impaired sleep quality and pain...
  10. doi request reprint Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations
    Patrick A Flume
    Department of Medicine and Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Respir Crit Care Med 180:802-8. 2009
    ..It is hoped that these guidelines will be helpful to clinicians in the treatment of individuals with cystic fibrosis...
  11. doi request reprint Cystic fibrosis pulmonary guidelines: pulmonary complications: hemoptysis and pneumothorax
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 182:298-306. 2010
    ..There may be intermittent pulmonary exacerbations or acute worsening of infection and obstruction, which require more intensive therapies. Hemoptysis and pneumothorax are complications commonly reported in patients with cystic fibrosis...
  12. doi request reprint Pneumothorax in cystic fibrosis
    Patrick A Flume
    Departments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Opin Pulm Med 17:220-5. 2011
    ..This review describes our current understanding of the pathogenesis of pneumothorax in CF and its treatment...
  13. ncbi request reprint Massive hemoptysis in cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, 812 CSB, Charleston, SC 29425, USA
    Chest 128:729-38. 2005
    ..Massive hemoptysis is a complication commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology of this complication and its consequences is important for the management of patients with CF...
  14. ncbi request reprint Pneumothorax in cystic fibrosis
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, 812 CSB, Charleston, SC 29425, USA
    Chest 128:720-8. 2005
    ..An understanding of the pathophysiology of this complication and its consequences is important for the management of patients with CF...
  15. ncbi request reprint Transition programs in cystic fibrosis centers: perceptions of pediatric and adult program directors
    P A Flume
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pediatr Pulmonol 31:443-50. 2001
    ..These differences may impede the successful transition of patients into an adult program...
  16. ncbi request reprint Transition programs in cystic fibrosis centers: perceptions of team members
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pediatr Pulmonol 37:4-7. 2004
    ..Standard programs of transition should be developed, and team members should be engaged in that process...
  17. ncbi request reprint Pneumothorax in cystic fibrosis
    Patrick A Flume
    Department of Pediatrics and Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 123:217-21. 2003
    ..The following is a review of what has been published regarding the incidence and management of pneumothorax in this population, with some comment on the pathogenesis of the complication...
  18. ncbi request reprint An unusual presentation of cystic fibrosis in an adult
    Shoban Dave
    Department of Medicine, Medical University of South Carolina, Ralph H Johnson VA Medical Center, Charleston, SC 29425, USA
    Am J Kidney Dis 45:e41-4. 2005
    ..These are known complications of CF but are not common presenting features that lead to the diagnosis of CF. The authors discuss their patient's presentation and review his metabolic manifestations of CF...
  19. ncbi request reprint Treatment of pulmonary exacerbations in adult cystic fibrosis patients: a review
    Tara Lynn Barto
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Hosp Pract (Minneap) 38:26-34. 2010
    ..Proper treatment of pulmonary exacerbations in CF patients will continue to improve their health and quality of life...
  20. ncbi request reprint A "story" of a woman with cystic fibrosis
    Kristin B Highland
    Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 121:1704-7. 2002
    ..Such knowledge is likely to result in less harm to the patient through unnecessary testing and treatment...
  21. ncbi request reprint Airway-clearance therapy guidelines and implementation
    Mary K Lester
    Department of Respiratory Therapy, Medical University of South Carolina, 169 Ashley Avenue, PO Box 250906, Charleston SC 29425, USA
    Respir Care 54:733-50; discussion 751-3. 2009
    ....
  22. ncbi request reprint The delta F508 mutation in cystic fibrosis and impact on sinus development
    Bradford A Woodworth
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Rhinol 21:122-7. 2007
    ..The purpose of this study was to determine whether the homozygous delta F508 mutation is associated with an increased incidence of sinus hypoplasia when compared with other mutations...
  23. doi request reprint Pulmonary complications in adult patients with cystic fibrosis
    Antine Stenbit
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 335:55-9. 2008
    ..In this report, we review the most common life-threatening respiratory complications of cystic fibrosis, including pneumothorax, massive hemoptysis, and respiratory failure...
  24. pmc Linezolid pharmacokinetics in adult patients with cystic fibrosis
    John A Bosso
    Department of Pharmaceutical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Antimicrob Agents Chemother 48:281-4. 2004
    ..Patients with inadequate clinical responses to linezolid may require more frequent dosing...
  25. ncbi request reprint Impact of lung transplantation on site of death in cystic fibrosis
    Dee Ford
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Cyst Fibros 6:391-5. 2007
    ..Cystic fibrosis (CF) remains a lethal condition where a palliative approach is often taken at the end of life. We wanted to evaluate how lung transplantation impacts end of life care in adult CF patients...
  26. ncbi request reprint Nebulizer use and maintenance by cystic fibrosis patients: a survey study
    Mary K Lester
    Department of Respiratory Therapy, Respiratory Care Services, Medical University of South Carolina, 169 Ashley Avenue, Charleston SC 29425, USA
    Respir Care 49:1504-8. 2004
    ..A recent consensus document on infection-control issues for the CF population included recommendations on cleaning and disinfecting nebulizers...
  27. ncbi request reprint Transition programs in cystic fibrosis centers: perceptions of patients
    Deborah L Anderson
    Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
    Pediatr Pulmonol 33:327-31. 2002
    ..Most importantly, the patients reported their level of concern about transfer as minimal, far less than what CF physicians had perceived. These differences may impede the successful transition of patients into an adult program...
  28. ncbi request reprint Psychological functioning of adults with cystic fibrosis
    D L Anderson
    Departments of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 119:1079-84. 2001
    ..Better lung function and a strong social support system predicted better psychological functioning, which may have implications for clinical intervention...
  29. doi request reprint Cost-effective airway cultures in the cystic fibrosis patient
    Mark D Ghegan
    Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Am J Otolaryngol 30:150-2. 2009
    ..Cystic fibrosis (CF) patients have a high incidence of multidrug-resistant infections, rendering CF patients a treatment challenge...
  30. ncbi request reprint Superior vena cava syndrome related to indwelling intravenous catheters in patients with cystic fibrosis
    Susan Garwood
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pediatr Pulmonol 41:683-7. 2006
    ..SVC syndrome in CF patients, however, is rarely reported in the literature, suggesting that its incidence is uncommon. We describe three patients with SVC syndrome as a consequence of implanted vascular-access devices...
  31. ncbi request reprint Pulmonary complications after esophagectomy
    Christopher E Avendano
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Ann Thorac Surg 73:922-6. 2002
    ..There are no good predictive variables for these complications. In addition, the role that preoperative treatment with chemotherapy and radiation may play in postoperative complications remains unclear...
  32. ncbi request reprint Medicinal treatment of intractable dyspnea in terminally ill patients
    Patrick A Flume
    MUSC, 812 CSB, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    J S C Med Assoc 98:196-9. 2002
  33. ncbi request reprint Treatment options for cystic fibrosis: case study and panel discussion
    Robert J Kuhn
    Pharmacotherapy 22:86S-87S. 2002