Hongkuan Fan

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation
    Hongkuan Fan
    Department of Neuroscience, The Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Inflammation 35:130-7. 2012
  2. pmc Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochim Biophys Acta 1813:466-72. 2011
  3. pmc Beta-arrestin 2 negatively regulates sepsis-induced inflammation
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Immunology 130:344-51. 2010
  4. ncbi request reprint Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins
    Hongkuan Fan
    Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
    Biochim Biophys Acta 1763:1051-8. 2006
  5. pmc Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Immunology 122:116-23. 2007
  6. ncbi request reprint Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
    Am J Physiol Cell Physiol 289:C293-301. 2005
  7. pmc Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Mol Med 14:422-8. 2008
  8. ncbi request reprint The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
    Octavia M Peck
    Department of Neurosciences, The Medical University of South Carolina, Charleston, SC 29425, USA
    Shock 26:31-6. 2006
  9. pmc Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 44:3092-9. 2007
  10. ncbi request reprint Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Shock 22:57-62. 2004

Collaborators

Detail Information

Publications17

  1. pmc Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation
    Hongkuan Fan
    Department of Neuroscience, The Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Inflammation 35:130-7. 2012
    ..CTCE-0214 therefore may be beneficial in controlling inflammation sepsis and systemic inflammatory syndromes...
  2. pmc Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochim Biophys Acta 1813:466-72. 2011
    ..Understanding the role of Gα(i2) protein in regulation of the inflammatory response in sepsis may provide novel targets for treatment of sepsis...
  3. pmc Beta-arrestin 2 negatively regulates sepsis-induced inflammation
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Immunology 130:344-51. 2010
    ..Our data demonstrate that beta-arrestin 2 functions to negatively regulate the inflammatory response in polymicrobial sepsis...
  4. ncbi request reprint Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins
    Hongkuan Fan
    Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
    Biochim Biophys Acta 1763:1051-8. 2006
    ....
  5. pmc Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Immunology 122:116-23. 2007
    ..These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli...
  6. ncbi request reprint Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
    Am J Physiol Cell Physiol 289:C293-301. 2005
    ..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli...
  7. pmc Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Mol Med 14:422-8. 2008
    ..These studies demonstrate that LPA has significant anti-inflammatory activities involving activation of ERK 1/2, serine/threonine phosphatases, and PI3 kinase signaling pathways...
  8. ncbi request reprint The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
    Octavia M Peck
    Department of Neurosciences, The Medical University of South Carolina, Charleston, SC 29425, USA
    Shock 26:31-6. 2006
    ..In contrast, mice pretreated with LPS and wortmannin demonstrated LPS tolerance reversal. These data suggest that PI3 kinase is essential for LPS induced homologous tolerance and reciprocal LPS and S. aureus induced priming responses...
  9. pmc Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 44:3092-9. 2007
    ..Understanding the role of beta-arrestins in regulation of TLR signaling pathways may provide novel insights into control mechanisms for inflammatory gene expression...
  10. ncbi request reprint Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Shock 22:57-62. 2004
    ..The TLR4-activated Galphai signaling pathway activates ERK 1/2 phosphorylation and AP-1 activation independently of TLR4-mediated signaling to NFkappaB activation...
  11. ncbi request reprint Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Front Biosci 11:2264-74. 2006
    ..In contrast, the effect of soluble glucan on inhibiting cellular activation by LPS and SA is Gi protein independent...
  12. pmc Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation
    Pengfei Li
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 49:64-74. 2011
    ..Thus β-arrestin 2 is anti-inflammatory in CAIA. These composite observations suggest that β-arrestin 1 and 2 differentially regulate FLS inflammation and increased β-arrestin 2 may reduce experimental arthritis severity...
  13. pmc Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein
    Pengfei Li
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
    Inflammation 35:1611-7. 2012
    ..In parallel studies, Raw Gα(i2) cells also exhibit decreased TNF-α and IL-6 production in response to LPS and Pam3CSK4. These studies support our hypothesis that Gα(i2) proteins are novel negative regulators of TLR activation...
  14. ncbi request reprint Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming
    Octavia M Peck
    Department of Physiology and Neuroscience, The Medical University of South Carolina, Charleston 29425, SC, USA
    Cytokine 26:202-8. 2004
    ..These data support our hypothesis of differential regulation of cytokines and chemokines in gram-negative- and gram-positive-induced inflammatory events. Such changes may have implications in the pathogenesis of polymicrobial sepsis...
  15. ncbi request reprint Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma
    Octavia M Peck
    Department of Physiology and Neuroscience, The Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Shock 21:254-60. 2004
    ..In contrast, exogenous IFN-gamma pretreatment prevented the induction of LPS homologous tolerance resulting in an increase in TNF-alpha production. The data demonstrate that HKSa induces homologous tolerance but causes priming to LPS...
  16. ncbi request reprint Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB Room 403, Charleston, SC 29425, USA
    Cytokine 22:126-33. 2003
    ..However, unlike LPS, involvement of PI3 Kinase in Gram-positive bacteria induced signaling pathways are species dependent...
  17. ncbi request reprint Molecular mechanisms of endotoxin tolerance
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Endotoxin Res 10:71-84. 2004
    ..Although there are species and cellular variations in manifestation of the LPS tolerant phenotype, it is clear that the tolerance phenomena have evolved as a complex orchestrated counter regulatory response to inflammation...