Ahmed A Elmarakby

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats
    Ahmed A Elmarakby
    Department of Oral Biology Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, U S A
    Clin Sci (Lond) 118:291-301. 2010
  2. doi Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, United States
    Pharmacol Res 62:400-7. 2010
  3. pmc TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Regul Integr Comp Physiol 294:R76-83. 2008
  4. pmc Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Vascul Pharmacol 46:144-51. 2007
  5. pmc Induction of hemeoxygenase-1 reduces glomerular injury and apoptosis in diabetic spontaneously hypertensive rats
    Ahmed A Elmarakby
    Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 302:F791-800. 2012
  6. pmc Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension
    Jeffrey E Quigley
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Clin Exp Pharmacol Physiol 36:724-8. 2009
  7. pmc Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta 30912 2500, USA
    Hypertension 50:1069-76. 2007
  8. pmc SPARC ameliorates ovarian cancer-associated inflammation
    Neveen A Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Neoplasia 10:1092-104. 2008
  9. pmc Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats
    Kanchan Bhatia
    Department of Medicine, Georgia Health Sciences Univ, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 302:R274-82. 2012
  10. ncbi Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Vascul Pharmacol 40:253-9. 2003

Detail Information

Publications22

  1. pmc Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats
    Ahmed A Elmarakby
    Department of Oral Biology Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, U S A
    Clin Sci (Lond) 118:291-301. 2010
    ..These results suggest that ANG-induced hypertension exacerbates oxidative stress and renal inflammation without further impairment in vascular dysfunction in high-fat diet-induced obesity...
  2. doi Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, United States
    Pharmacol Res 62:400-7. 2010
    ..These data demonstrate that induction of HO-1 slows the progression of hypertension and proteinuria in SHR and these changes were associated with reduced renal oxidative stress and inflammation...
  3. pmc TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Regul Integr Comp Physiol 294:R76-83. 2008
    ..These data support the hypothesis that TNF-alpha contributes to the increase in renal inflammation in DOCA-salt rats...
  4. pmc Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Vascul Pharmacol 46:144-51. 2007
    ..These data support the hypothesis that combined reduction of superoxide along with enhanced endogenous kinins may facilitate blood pressure lowering in Ang II hypertension...
  5. pmc Induction of hemeoxygenase-1 reduces glomerular injury and apoptosis in diabetic spontaneously hypertensive rats
    Ahmed A Elmarakby
    Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 302:F791-800. 2012
    ..These data suggest that induction of HO-1 reduces diabetic induced-glomerular injury and apoptosis and these effects are associated with decreased NF-κB-induced inflammation and oxidative stress...
  6. pmc Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension
    Jeffrey E Quigley
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Clin Exp Pharmacol Physiol 36:724-8. 2009
    ....
  7. pmc Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension
    Ahmed A Elmarakby
    Vascular Biology Center, Medical College of Georgia, Augusta 30912 2500, USA
    Hypertension 50:1069-76. 2007
    ..These data suggest that CCR2b inhibition protects the kidney in hypertension by reducing inflammation and delaying the progression of hypertension...
  8. pmc SPARC ameliorates ovarian cancer-associated inflammation
    Neveen A Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Neoplasia 10:1092-104. 2008
    ..These results indicate, for the first time, that the effects of tumor SPARC as a negative regulator of ovarian cancer are mediated through decreased recruitment of macrophages and downregulation of the associated inflammation...
  9. pmc Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats
    Kanchan Bhatia
    Department of Medicine, Georgia Health Sciences Univ, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 302:R274-82. 2012
    ..151 ± 1 mmHg, P < 0.05), with no effect in females (160 ± 11 vs. 163 ± 10 mmHg). These data suggest that ANG II hypertension in male SHR is more dependent on increases in oxidative stress than in female SHR...
  10. ncbi Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Vascul Pharmacol 40:253-9. 2003
    ..These results also support the hypothesis that combined ACE/NEP inhibition can increase renal ET production...
  11. ncbi Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension
    Ahmed A Elmarakby
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 47:557-62. 2006
    ..These data suggest that TNF-alpha contributes to downregulation of Cyp2c23, blood pressure regulation, and renal injury in angiotensin high-salt hypertension...
  12. doi Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure
    Kelly A Hyndman
    Section of Experimental Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA
    Hypertension 62:91-8. 2013
    ..These findings reveal that NOS1 in the CD is critical in the regulation of fluid-electrolyte balance, and this new genetic model of CD NOS1 gene deletion will be a valuable tool to study salt-dependent blood pressure mechanisms...
  13. doi Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy
    Ahmed A Elmarakby
    Department of Oral Biology, Medical College of Georgia, Augusta, GA, USA Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Cardiovasc Ther 30:49-59. 2012
    ....
  14. pmc Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats
    Jennifer C Sullivan
    Department of Pharmacology and Toxicology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Hypertension 56:658-66. 2010
    ..In conclusion, angiotensin (1-7) contributes to the sex difference in angiotensin II-induced increases in blood pressure in spontaneously hypertensive rats...
  15. ncbi Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Curr Opin Investig Drugs 4:282-90. 2003
    ..While results from animal studies are promising, no consensus has been reached on identifying a drug target for the reliable and effective treatment of oxidative stress in hypertension...
  16. doi Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice
    Ahmed A Elmarakby
    Department of Oral Biology, Georgia Health Sciences University, Augusta, GA 30912, United States
    Vascul Pharmacol 55:149-56. 2011
    ..Collectively, the results suggest that the reno-protective effect of genistein likely relates to reduced renal inflammation, oxidative stress and apoptosis in diabetic mice...
  17. ncbi Normalization of the ovarian cancer microenvironment by SPARC
    Neveen Said
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgea 30912, USA
    Mol Cancer Res 5:1015-30. 2007
    ....
  18. ncbi Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats
    Gerard D'Angelo
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 46:806-11. 2005
    ..We propose that previous reports of fructose-induced hypertension reflect a heightened stress response by fructose-fed rats associated with restraint and tail cuff inflation...
  19. pmc Induction of hemeoxygenase-1 reduces renal oxidative stress and inflammation in diabetic spontaneously hypertensive rats
    Ahmed A Elmarakby
    Department of Oral Biology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Int J Hypertens 2012:957235. 2012
    ....
  20. doi Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats
    Ahmed A Elmarakby
    Department of Oral Biology, Georgia Regents University, Augusta, GA, USA
    Clin Sci (Lond) 125:349-59. 2013
    ..These findings suggest that HO-1 induction is involved in the protective effect of sEH inhibition against diabetic renal injury...
  21. pmc Inflammatory cytokines as predictive markers for early detection and progression of diabetic nephropathy
    Ahmed A Elmarakby
    Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 USA
    EPMA J 1:117-29. 2010
    ..These cytokines-chemokines may also be helpful as biomarkers to monitor the progression of the disease and the impact of interventional modalities aimed at halting eventual manifestation of end-stage renal disease in diabetic patients...
  22. ncbi Enalapril attenuates endothelin-1-induced hypertension via increased kinin survival
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Vascular Biology Center, Medical College of Georgia, Augusta 30912, USA
    Am J Physiol Heart Circ Physiol 284:H1899-903. 2003
    ..These findings support the hypothesis that decreased catabolism of bradykinin and its subsequent vasodilator activity oppose the actions of ET-1 to increase MAP...