Azza B el-Remessy

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation
    Azza B el-Remessy
    College of Pharmacy, The University of Georgia, 1120 15th Street, HM 1200, Augusta, GA 30912, USA
    Exp Diabetes Res 2010:247861. 2010
  2. ncbi Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells
    A B El-Remessy
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Athens, USA
    FASEB J 21:2528-39. 2007
  3. pmc Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes
    A B El-Remessy
    Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 16:1487-95. 2010
  4. ncbi Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    Azza B el-Remessy
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Sci 118:243-52. 2005
  5. pmc Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    Invest Ophthalmol Vis Sci 49:3231-8. 2008
  6. ncbi Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3
    Daniel H Platt
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 39:1353-61. 2005
  7. doi Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy
    Mohammed A Abdelsaid
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    J Pharmacol Exp Ther 332:125-34. 2010
  8. pmc Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B
    Sahar Soliman
    Program in Clinical and Experimental Therapeutics, University of Georgia, Augusta, Georgia S S, T I, P R S, A E, A B E, S C F Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia S S, T I, P R S, A E, A B E, S C F and Departments of Psychiatry A P, Medicine P R S, Physiology A E, Pharmacology and Toxicology A B E, and Neurology S C F, Georgia Regents University, Augusta, Georgia
    J Pharmacol Exp Ther 349:444-57. 2014
  9. pmc Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats
    Islam N Mohamed
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 18:1457-66. 2012
  10. ncbi High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation
    Azza B el-Remessy
    Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30909, USA
    Invest Ophthalmol Vis Sci 44:3135-43. 2003

Collaborators

Detail Information

Publications44

  1. pmc Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation
    Azza B el-Remessy
    College of Pharmacy, The University of Georgia, 1120 15th Street, HM 1200, Augusta, GA 30912, USA
    Exp Diabetes Res 2010:247861. 2010
    ..Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction...
  2. ncbi Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells
    A B El-Remessy
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Athens, USA
    FASEB J 21:2528-39. 2007
    ..In conclusion, peroxynitrite is critically involved in transducing VEGF's angiogenic signal via nitration-independent and oxidation-mediated tyrosine phosphorylation...
  3. pmc Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes
    A B El-Remessy
    Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 16:1487-95. 2010
    ..We propose to test the hypothesis that diabetes-induced glutamate accumulation in the retina is associated with tyrosine nitration of GS and that CBD treatment inhibits this process...
  4. ncbi Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    Azza B el-Remessy
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Sci 118:243-52. 2005
    ....
  5. pmc Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    Invest Ophthalmol Vis Sci 49:3231-8. 2008
    ....
  6. ncbi Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3
    Daniel H Platt
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 39:1353-61. 2005
    ..These results indicate that peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3...
  7. doi Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy
    Mohammed A Abdelsaid
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    J Pharmacol Exp Ther 332:125-34. 2010
    ..Early inhibition of tyrosine nitration with use of epicatechin or NAC can represent safe and effective vascular-protective agents in ischemic retinopathy...
  8. pmc Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B
    Sahar Soliman
    Program in Clinical and Experimental Therapeutics, University of Georgia, Augusta, Georgia S S, T I, P R S, A E, A B E, S C F Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia S S, T I, P R S, A E, A B E, S C F and Departments of Psychiatry A P, Medicine P R S, Physiology A E, Pharmacology and Toxicology A B E, and Neurology S C F, Georgia Regents University, Augusta, Georgia
    J Pharmacol Exp Ther 349:444-57. 2014
    ..Taken together, this study highlights the potential usefulness of augmenting the endogenous restorative capacity of the brain through the administration of ARBs. ..
  9. pmc Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats
    Islam N Mohamed
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 18:1457-66. 2012
    ..However, the combined effects of diabetes with early and established stages of hypertension on retinal microvascular degeneration remain incompletely understood...
  10. ncbi High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation
    Azza B el-Remessy
    Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30909, USA
    Invest Ophthalmol Vis Sci 44:3135-43. 2003
    ....
  11. pmc Neurovascular protective effect of FeTPPs in N-methyl-D-aspartate model: similarities to diabetes
    Mohammed M H Al-Gayyar
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Am J Pathol 177:1187-97. 2010
    ..In addition to acute RGC death, an NMDA model can be a useful tool to study glial activation and capillary degeneration in retinal neurodegenerative disorders, including diabetic retinopathy...
  12. pmc Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 2500, USA
    Am J Pathol 167:599-607. 2005
    ..In conclusion, NAD(P)H oxidase activity is required for hypoxia-stimulated increases in VEGF expression and retinal neovascularization. Inhibition of NAD(P)H oxidase offers a new therapeutic target for the treatment of retinopathy...
  13. pmc Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Am J Pathol 168:235-44. 2006
    ..These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals through activities that may involve inhibition of p38 MAP kinase...
  14. pmc Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration
    Suraporn Matragoon
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 18:2993-3003. 2012
    ..Since systemic overexpression of proNGF exhibits embryonic lethality, we aimed to establish a model that specifically and stably overexpresses a cleavage-resistant mutant of proNGF (proNGF123) plasmid in the retina using electroporation...
  15. pmc Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke
    Anna Kozak
    University of Georgia College of Pharmacy, Veterans Administration Medical Center, Augusta, GA 30912 2450, USA
    Stroke 40:1870-6. 2009
    ..We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatment paradigm...
  16. ncbi Simvastatin improves diabetes-induced coronary endothelial dysfunction
    Huda E Tawfik
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, CB 3624, Augusta, GA 30912, USA
    J Pharmacol Exp Ther 319:386-95. 2006
    ..Taken together, these data suggest that SIM improves diabetes-induced coronary dysfunction by reducing oxidative stress and increasing NO bioavailability...
  17. pmc Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity
    Mohammed M H Al-Gayyar
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912, USA
    Br J Pharmacol 164:170-80. 2011
    ..Here we have examined the causal role of TXNIP expression in mediating retinal neurotoxicity and assessed the neuroprotective actions of verapamil, a calcium channel blocker and an inhibitor of TXNIP expression...
  18. pmc Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway
    Mohammed M H Al-Gayyar
    Program in Clinical and Experimental Therapeutics College of Pharmacy, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 8:e54692. 2013
    ..Taken together, these results provide compelling evidence for a causal role of proNGF in diabetes-induced retinal neurodegeneration through enhancing p75(NTR) expression and direct activation of RhoA and p38MAPK/JNK apoptotic pathways...
  19. pmc Diabetes-induced coronary vascular dysfunction involves increased arginase activity
    Maritza J Romero
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Circ Res 102:95-102. 2008
    ..These results indicate that increased arginase activity in diabetes contributes to vascular endothelial dysfunction by decreasing L-arginine availability to NO synthase...
  20. ncbi Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite
    Xiaolin Gu
    Department of Cellular Biology and Anatomy, and Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Cell Physiol 285:C546-54. 2003
    ..These data may have important clinical implications for infants at risk of retinopathy of prematurity...
  21. pmc Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Am J Pathol 163:1997-2008. 2003
    ..The effect of THC was in part mediated by the cannabinoid receptor CB1. These results suggest the potential use of CBD as a novel topical therapy for the treatment of glaucoma...
  22. doi Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    Tayyeba K Ali
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Diabetes 57:889-98. 2008
    ..However, the causal role of peroxynitrite and the impact of tyrosine nitration on diabetes-induced retinal neurodegeneration and NGF survival signaling have not been elucidated...
  23. pmc Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy
    Sally L Elshaer
    Center for Pharmacy and Experimental Therapeutics, University of Georgia, 1120 15th Street HM 1200, Augusta, GA 30912, USA
    J Diabetes Res 2013:432659. 2013
    ..Taken together, these results provide evidence that proNGF can contribute to PDR at least in part via activation of TrkA. ..
  24. doi S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration
    Mohammed A Abdelsaid
    Program in Clinical and Experimental Therapeutics, University of Georgia, USA
    J Cell Sci 125:4751-60. 2012
    ..Shifting the redox-state to reductive stress or oxidative stress inhibited the VEGF-mediated angiogenic response...
  25. pmc Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor
    Azza B el-Remessy
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30909, USA
    Am J Pathol 162:1995-2004. 2003
    ..Taken together, these data indicate that early diabetes causes breakdown of the BRB by a mechanism involving the action of reactive nitrogen species in promoting expression of VEGF and uPAR...
  26. pmc Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats
    Barbara A Mysona
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, 1120 15th Street HM 1200, Augusta, GA 30912, USA
    Diabetologia 56:2329-39. 2013
    ..To date, the role of this axis in diabetes-induced retinal inflammation and BRB breakdown has not been explored. We hypothesised that modulating p75(NTR) would prevent diabetes- and proNGF-induced retinal inflammation and BRB breakdown...
  27. pmc Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling
    Roshini Prakash
    Charlie Norwood Veterans Administration Medical Center, University of Georgia College of Pharmacy, Athens, Georgia, USA
    Diabetes 61:1533-42. 2012
    ..Diabetes increases and spatially regulates cerebral neovascularization. Increased VEGF-dependent angiogenic function in BMECs is mediated by peroxynitrite and involves c-src and MT1-MMP activation...
  28. pmc Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia
    Weiguo Li
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 59:228-35. 2010
    ..However, how diabetes influences cerebral neovascularization is not clear. Our aim was to determine diabetes-mediated changes in the cerebrovasculature and its impact on the short-term outcome of cerebral ischemia...
  29. pmc Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke
    Weihua Guan
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, Georgia, United States of America
    PLoS ONE 6:e24551. 2011
    ..These vascular changes in both hemispheres after effective treatment are likely to contribute to enhanced recovery after stroke...
  30. doi Diverse effects of statins on angiogenesis: new therapeutic avenues
    Hazem F Elewa
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912 2450, USA
    Pharmacotherapy 30:169-76. 2010
    ..Statins are safe, orally available agents that may acquire novel therapeutic indications through their angiogenic modulating effects...
  31. pmc Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels
    Yashoda Puttabyatappa
    Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, USA
    J Pharmacol Exp Ther 345:7-14. 2013
    ..We propose this mechanism could account for TES-stimulated cGMP production in microvessels and, ultimately, vasodilation...
  32. pmc Alteration of growth factors and neuronal death in diabetic retinopathy: what we have learned so far
    Will Whitmire
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Mol Vis 17:300-8. 2011
    ....
  33. pmc Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats
    Hazem F Elewa
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912 2450, USA
    J Pharmacol Exp Ther 330:532-40. 2009
    ..0007). We concluded that atorvastatin is a vascular protective agent after experimental ischemic stroke, especially in diabetes...
  34. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
    ..The mechanism by which diabetes activates microglia to release those inflammatory mediators is unclear and was therefore elucidated...
  35. ncbi Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence
    LAUREN M WILLIS
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Charlie Norwood VA Medical Center, Augusta, GA 30912, U S A
    Clin Sci (Lond) 120:307-19. 2010
    ..The aim of the present review is to examine the angiogenic effects of ARBs in animal and cellular models of relevant disease states, including proposed molecular mechanisms of action of ARBs and the clinical consequences of ARB use...
  36. ncbi Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence
    LAUREN M WILLIS
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
    Clin Sci (Lond) 120:307-19. 2011
    ..The aim of the present review is to examine the angiogenic effects of ARBs in animal and cellular models of relevant disease states, including proposed molecular mechanisms of action of ARBs and the clinical consequences of ARB use...
  37. pmc HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy
    Manuela Bartoli
    Department of Ophthalmology, University of South Carolina School of Medicine, Columbia, South Carolina 29203, USA
    Invest Ophthalmol Vis Sci 50:4934-40. 2009
    ..Recent studies have emphasized the beneficial effects of inhibitors of HMG-CoA reductase (statins) in preventing vascular dysfunction. In the present study, the authors characterized the therapeutic effects of statins on RNV...
  38. pmc Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats
    Kanchan Bhatia
    Department of Medicine, Georgia Health Sciences Univ, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 302:R274-82. 2012
    ..151 ± 1 mmHg, P < 0.05), with no effect in females (160 ± 11 vs. 163 ± 10 mmHg). These data suggest that ANG II hypertension in male SHR is more dependent on increases in oxidative stress than in female SHR...
  39. pmc Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet
    Islam N Mohamed
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, 1120 15th Street, HM 1200, Augusta, GA, 30912, USA
    Diabetologia 57:413-23. 2014
    ..This study aims to examine TXNIP expression and elucidate its role in endothelial inflammasome activation and retinal lesions...
  40. pmc Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells
    Mohammed A Abdelsaid
    1 Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia
    Antioxid Redox Signal 19:2199-212. 2013
    ..TXNIP-knockout mice (TKO) or wild-type (WT) treated with the reduced glutathione (GSH)-precursor, N-acetyl cysteine (WT-NAC, 500 mg/kg) were compared to WT using hypoxia-induced neovascularization model...
  41. pmc Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway
    Azza B el-Remessy
    Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e71868. 2013
    ..Together, these data indicate that diabetes-induced oxidative stress triggers BRB breakdown by a mechanism involving uPAR expression through VEGF-induced activation of the GSK3β/β-catenin signaling pathway. ..
  42. doi Diabetic retinopathy: current management and experimental therapeutic targets
    Tayyeba K Ali
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Pharmacotherapy 29:182-92. 2009
    ..Additional studies are needed to identify treatments that selectively target oxidative stress-mediated protein modification and thus prevent or at least delay diabetic retinopathy...
  43. ncbi Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice
    Nicole A Rozette
    Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, USA
    Neonatology 106:37-41. 2014
    ..These preclinical findings provide rationale for further studies in neonatal patients. © 2014 S. Karger AG, Basel. ..
  44. pmc Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential
    Livia S Machado
    Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Augusta, GA 30912 2450, USA
    Stroke 40:3028-33. 2009
    ..This study aimed to determine the effect of minocycline on t-PA clot lysis and t-PA-induced hemorrhage formation after ischemia...