Brent M Egan

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Demographic differences in the treatment and control of glucose in type 2 diabetic patients: implications for health care practice
    Brent M Egan
    Department of Medicine, Division of General Internal Medicine, Medical University of South Carolina, Charleston 29425, USA
    Ethn Dis 22:29-37. 2012
  2. pmc Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans
    Y Al-Solaiman
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Hum Hypertens 23:826-35. 2009
  3. pmc DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre
    Y Al-Solaiman
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    J Hum Hypertens 24:237-46. 2010
  4. ncbi request reprint Blood pressure and cholesterol control in hypertensive hypercholesterolemic patients: national health and nutrition examination surveys 1988-2010
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Avenue, RT 1230, Charleston, SC 29425, USA
    Circulation 128:29-41. 2013
  5. pmc Different definitions of prevalent hypertension impact: the clinical epidemiology of hypertension and attainment of Healthy People goals
    Brent M Egan
    General Medicine Division, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 15:154-61. 2013
  6. pmc Initial monotherapy and combination therapy and hypertension control the first year
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 59:1124-31. 2012
  7. doi request reprint Other important applications for beta-blockers in high-risk patients
    Brent M Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Postgrad Med 114:35-48. 2003
  8. ncbi request reprint Beta-blockers for cardioprotection. A forgotten message?
    Brent M Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Postgrad Med 114:3. 2003
  9. ncbi request reprint Controlling blood pressure in 50% of all hypertensive patients: an achievable goal in the healthy people 2010 report?
    Brent M Egan
    Department of Medicine, Division of General Internal Medicine, Geriatrics and Hypertension, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Investig Med 51:373-85. 2003
  10. ncbi request reprint Insulin resistance and the sympathetic nervous system
    Brent M Egan
    Division of General Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 826H, Charleston, SC 29425, USA
    Curr Hypertens Rep 5:247-54. 2003

Research Grants

Detail Information

Publications99

  1. ncbi request reprint Demographic differences in the treatment and control of glucose in type 2 diabetic patients: implications for health care practice
    Brent M Egan
    Department of Medicine, Division of General Internal Medicine, Medical University of South Carolina, Charleston 29425, USA
    Ethn Dis 22:29-37. 2012
    ..Identifying modifiable covariables that reduce demographic disparities in controlling type 2 diabetes could inform efforts to improve health equity...
  2. pmc Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans
    Y Al-Solaiman
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Hum Hypertens 23:826-35. 2009
    ..The results suggest that LS-DASH decreases oxidative stress, improves vascular function and lowers blood pressure in SS but not SR volunteers...
  3. pmc DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre
    Y Al-Solaiman
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    J Hum Hypertens 24:237-46. 2010
    ....
  4. ncbi request reprint Blood pressure and cholesterol control in hypertensive hypercholesterolemic patients: national health and nutrition examination surveys 1988-2010
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Avenue, RT 1230, Charleston, SC 29425, USA
    Circulation 128:29-41. 2013
    ..Hypertension doubles coronary heart disease (CHD) risk. Treating hypertension only reduces CHD risk ≈25%. Treating hypercholesterolemia in hypertensive patients reduces residual CHD risk >35%...
  5. pmc Different definitions of prevalent hypertension impact: the clinical epidemiology of hypertension and attainment of Healthy People goals
    Brent M Egan
    General Medicine Division, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 15:154-61. 2013
    ..9% (31.8% [95% CI, 30.5-33.1]) vs 28.7% [95% CI, 27.5-30.0]) becomes more challenging...
  6. pmc Initial monotherapy and combination therapy and hypertension control the first year
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 59:1124-31. 2012
    ..31-1.37]) or monotherapy (reference) with benefits in black and white patients. Greater use of single-pill combinations as initial therapy may improve hypertension control and cardiovascular outcomes in the first treatment year...
  7. doi request reprint Other important applications for beta-blockers in high-risk patients
    Brent M Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Postgrad Med 114:35-48. 2003
    ..Reviewing the role of beta-blockers in several ancillary conditions should help illuminate various aspects of the complex progression of cardiovascular disease and clarify the drugs' various therapeutic benefits...
  8. ncbi request reprint Beta-blockers for cardioprotection. A forgotten message?
    Brent M Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Postgrad Med 114:3. 2003
  9. ncbi request reprint Controlling blood pressure in 50% of all hypertensive patients: an achievable goal in the healthy people 2010 report?
    Brent M Egan
    Department of Medicine, Division of General Internal Medicine, Geriatrics and Hypertension, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Investig Med 51:373-85. 2003
    ..In the absence of a coordinated strategic plan, achieving this critically important goal for BP control is highly unlikely...
  10. ncbi request reprint Insulin resistance and the sympathetic nervous system
    Brent M Egan
    Division of General Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 826H, Charleston, SC 29425, USA
    Curr Hypertens Rep 5:247-54. 2003
    ..Efforts to further identify the mechanisms and consequences of sympathetic dysfunction in the metabolic syndrome may provide insights for therapeutic advances to ameliorate the excess cardiovascular risk and adverse outcomes...
  11. ncbi request reprint Use of losartan in diabetic patients in the primary care setting: review of the results in LIFE and RENAAL
    Brent Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Med Res Opin 20:1909-17. 2004
    ..To review outcomes of diabetic patients treated with losartan in two recent randomized, double-blind, clinical trials and compare outcomes to similar studies in diabetics...
  12. ncbi request reprint Combination therapy with an angiotensin-converting enzyme inhibitor and a calcium channel blocker
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 9:783-9. 2007
    ..The results of this trial, when reported, should help to clarify the relative benefits of these different therapies...
  13. ncbi request reprint Metabolic syndrome and insulin resistance in the TROPHY sub-study: contrasting views in patients with high-normal blood pressure
    Brent M Egan
    Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Hypertens 18:3-12. 2005
    ..Although insulin resistance and metabolic syndrome are often used synonymously, concordance is not established...
  14. ncbi request reprint Cardioprotection: the role of beta-blocker therapy
    Brent M Egan
    Medical University of South Carolina, Charleston, 29425, USA
    J Clin Hypertens (Greenwich) 7:409-16. 2005
    ..This paper reviews the protective role of beta blockade in the primary and secondary prevention of cardiovascular events and examines some of the potential barriers to appropriate beta blocker use in patients with compelling indications...
  15. doi request reprint Plasma Renin test-guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension: a randomized controlled trial
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Hypertens 22:792-801. 2009
    ..65 ng/ml/h) indicates sodium-volume excess "V" hypertension, whereas values >or=0.65 indicate renin-angiotensin vasoconstriction excess "R" hypertension...
  16. doi request reprint Prehypertension: should we be treating with pharmacologic therapy?
    Brent M Egan
    Medical University of South Carolina, Charleston, SC 29425, USA
    Ther Adv Cardiovasc Dis 2:305-14. 2008
    ....
  17. ncbi request reprint Prehypertension: risk stratification and management considerations
    Brent M Egan
    Medical University of South Carolina, 135 Rutledge Avenue, RT1104, Charleston, SC 29425, USA
    Curr Hypertens Rep 10:359-66. 2008
    ....
  18. ncbi request reprint Challenges and risks in attaining the systolic blood pressure goal of <130 mm Hg in all diabetic patients
    Brent M Egan
    Department of Medicine and Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 8:50-2. 2006
  19. ncbi request reprint Cardiovascular risk factor control in communities--update from the ASH Carolinas-Georgia Chapter, the Hypertension Initiative, and the Community Physicians' Network
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Avenue, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 8:879-86. 2006
    ..Evidence suggests that this collaboration is facilitating application of evidence-based medicine and risk factor control...
  20. ncbi request reprint US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    JAMA 303:2043-50. 2010
    ..Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population...
  21. pmc Impacting population cardiovascular health through a community-based practice network: update on an ASH-supported collaborative
    Brent M Egan
    Department of MedicineNursing, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 13:543-50. 2011
    ..A collaborative practice network is attainable that produces positive, sustainable, and growing impacts on cardiovascular and other chronic diseases...
  22. doi request reprint Is blood pressure control to less than 140/less than 90 mmHg in 50% of all hypertensive patients as good as we can do in the USA: or is this as good as it gets?
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Cardiol 26:300-7. 2011
    ..This review assesses whether controlling hypertension in 50% of all patients is the best we can do...
  23. ncbi request reprint Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Prostaglandins Leukot Essent Fatty Acids 60:411-20. 1999
    ..A better understanding of the signaling mechanisms by which NEFAs exert their vascular effects may facilitate novel and more effective therapeutic approaches to managing the cardiovascular risk factor cluster...
  24. ncbi request reprint Health care improvement and cost reduction opportunities in hypertensive Medicaid beneficiaries
    B M Egan
    Department of Pharmacology and Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 3:279-82, 318. 2001
    ..The findings suggest that the application of evidence-based guidelines would improve health, avoid cost, and reduce racial disparities in health outcomes...
  25. doi request reprint Does dark chocolate have a role in the prevention and management of hypertension?: commentary on the evidence
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 55:1289-95. 2010
    ..This commentary summarizes 13 peer-reviewed studies on dark chocolate and blood pressure and raises questions relevant to its future as an evidence-based lifestyle intervention...
  26. ncbi request reprint Awareness, knowledge, and attitudes of older americans about high blood pressure: implications for health care policy, education, and research
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Intern Med 163:681-7. 2003
    ..The prevalence of high blood pressure (HBP), particularly isolated systolic hypertension, rises with age, whereas control rates decline...
  27. ncbi request reprint Insulin resistance and cardiovascular disease
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Am J Hypertens 14:116S-125S. 2001
    ....
  28. ncbi request reprint Biochemical and metabolic effects of very-low-salt diets
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Am J Med Sci 320:233-9. 2000
    ..Further research on the effects of selective changes of dietary sodium versus more global changes in diet composition on biochemical and hemodynamic variables could provide the basis for an even more effective public health policy...
  29. ncbi request reprint Nonesterified fatty acids in blood pressure control and cardiovascular complications
    B M Egan
    Division of Clinical Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 826 H, Charleston, SC 29425, USA
    Curr Hypertens Rep 3:107-16. 2001
    ..A clearer definition of the specific reactive oxygen signaling pathways involved and interventions aimed at altering these pathways could lead to more rationale antioxidant therapy and improved outcomes...
  30. ncbi request reprint Strategies for cardiovascular disease prevention: importance of public and community health programs
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29464, USA
    Ethn Dis 8:228-39. 1998
    ....
  31. pmc Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    Circulation 124:1046-58. 2011
    ..Despite progress, many hypertensive patients remain uncontrolled. Defining characteristics of uncontrolled hypertensives may facilitate efforts to improve blood pressure control...
  32. ncbi request reprint American Society of Hypertension regional chapters: leveraging the impact of the clinical hypertension specialist in the local community
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Am J Hypertens 15:372-9. 2002
    ....
  33. doi request reprint Prehypertension: an opportunity for a new public health paradigm
    Brent M Egan
    Medical University of South Carolina, Charleston, 29425, USA
    Cardiol Clin 28:561-9. 2010
    ..BP in the range of 120 to 129/80 to 84 mm Hg is also associated with increased risk but roughly half of that of stage 2 prehypertension...
  34. ncbi request reprint Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
    Heno F Lopes
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 16:331-6. 2003
    ..The findings may have important implications for ethnic differences in the prevalence of hypertension and cardiovascular and renal disease...
  35. pmc Differences in cardiovascular disease mortality associated with body mass between Black and White persons
    Jill E Abell
    Medical University of South Carolina, Charleston, SC 29401, USA
    Am J Public Health 98:63-6. 2008
    ..91 (95% CI=0.77, 1.05), respectively. The results suggest that obesity is an independent risk factor in White people, and additional study of body size and disease progression is necessary in the assessment of racial disparities...
  36. ncbi request reprint Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, 295 Calhoun St, Charleston, SC 29425, USA
    Arch Intern Med 167:502-6. 2007
    ..Diets high in fiber are associated with lower levels of inflammatory markers. This study examined the reduction in inflammation from a diet supplemented with fiber compared with a diet naturally high in fiber...
  37. pmc Antihypertensive medication prescribing patterns in a university teaching hospital
    R Neal Axon
    Department of Medicine, Division of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, SC, USA
    J Clin Hypertens (Greenwich) 12:246-52. 2010
    ..Understanding and addressing these disparities has the potential to incrementally improve hypertension control rates in the population...
  38. ncbi request reprint Angiotensin receptor blockade improves arterial distensibility and reduces exercise-induced pressor responses in obese hypertensive patients with the metabolic syndrome
    Khaled Nashar
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 17:477-82. 2004
    ..In addition to lowering basal BP, angiotensin receptor blockade in patients with metabolic syndrome improves arterial compliance and reduces pressor reactivity to exercise...
  39. ncbi request reprint DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003
    ..The findings are consistent with evidence that elevated BP in obese subjects may reflect an imbalance between antioxidant capacity and oxidative stress that is improved by the DASH-CD...
  40. pmc Progression is accelerated from prehypertension to hypertension in blacks
    Anbesaw Selassie
    Division of Biostatistics, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 58:579-87. 2011
    ..001). Conversion from prehypertension to hypertension is accelerated in blacks, which suggests that effective interventions in prehypertension could reduce racial disparities in prevalent hypertension...
  41. ncbi request reprint Prevalence, treatment, and control of hypertension among African Americans and Caucasians at primary care sites for medically under-served patients
    Nina Sheats
    Summer Undergraduate Research Training Program, College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ethn Dis 15:25-32. 2005
    ..Hypertension is a major contributor to ethnic disparities in cardiovascular disease, especially among low-income African Americans in the southeast United States...
  42. ncbi request reprint Fiber and C-reactive protein in diabetes, hypertension, and obesity
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, P O Box 250192, 295 Calhoun St, Charleston, SC 29425, USA
    Diabetes Care 28:1487-9. 2005
  43. pmc Effect of psyllium fiber supplementation on C-reactive protein: the trial to reduce inflammatory markers (TRIM)
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Fam Med 6:100-6. 2008
    ..The objective of this study was to determine whether daily fiber supplementation would reduce levels of inflammatory markers...
  44. ncbi request reprint Prevalence, treatment, and control of chest pain syndromes and associated risk factors in hypertensive patients
    Katharine H Hendrix
    Department of General Internal Medicine, Hypertension Section, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Hypertens 18:1026-32. 2005
    ....
  45. ncbi request reprint A statewide primary care approach to cardiovascular risk factor control in high-risk diabetic and nondiabetic patients with hypertension
    Jan N Basile
    Department of Medicine, Medical University of South Carolina, Charleston, SC and the Ralph H Johnson VA Medical Center, Charleston, SC 29401 5703, USA
    J Clin Hypertens (Greenwich) 6:18-25. 2004
    ..These findings confirm the low rates of multiple risk factor control and highlight challenges of reaching evidence-based goals in primary care...
  46. ncbi request reprint A systematic approach to managing hypertension and the metabolic syndrome in primary care
    William H Bestermann
    Low Country Medical Group, Beaufort, SC, USA
    South Med J 97:932-8. 2004
    ..This report summarizes the impact of a standardized, evidence-based approach to managing high blood pressure and associated metabolic syndrome abnormalities that was developed and implemented by one Clinical Hypertension Specialist...
  47. ncbi request reprint Ethnic differences in the treatment and control of hypertension in patients with diabetes
    Jessica Flynn Riehle
    Department of Biometry and Epidemiology and the Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 7:445-54. 2005
    ..The data suggest provider prescribing patterns are not a major contributor to ethnic differences in BP control and outcomes in diabetic hypertensives...
  48. ncbi request reprint Associations between birth weight and antihypertensive medication in black and white medicaid recipients
    Daniel T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 39:179-83. 2002
    ....
  49. ncbi request reprint Platelet and white blood cell counts are elevated in patients with the metabolic syndrome
    Ammar Jesri
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 7:705-11; quiz 712-3. 2005
    ....
  50. ncbi request reprint Ethnic differences in older americans: awareness, knowledge, and beliefs about hypertension
    Eni C Okonofua
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 18:972-9. 2005
    ..Ethnic differences in awareness, knowledge, and beliefs about hypertension may contribute to these disparities, but information is limited...
  51. ncbi request reprint Therapeutic inertia is an impediment to achieving the Healthy People 2010 blood pressure control goals
    Eni C Okonofua
    Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 47:345-51. 2006
    ..TI has a major impact on BP control in hypertensive subjects receiving regular care. Reducing TI is critical in attaining the Healthy People 2010 goal of controlling hypertension in 50% of all patients...
  52. ncbi request reprint Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster
    Milos P Stojiljkovic
    Department of Pharmacology and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Hypertens 20:1215-21. 2002
    ..To determine whether raised concentrations of non-esterified fatty acids (NEFAs) may contribute to the cardiovascular risk factor cluster by increasing oxidative stress in vivo...
  53. ncbi request reprint Prehypertension and mortality in a nationally representative cohort
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Cardiol 94:1496-500. 2004
    ..Lifestyle interventions targeting multiple risk factors including BP may be the most effective prevention strategy...
  54. ncbi request reprint Cardiovascular risk factor control and treatment patterns in primary care
    Katharine H Hendrix
    College of Health Professions, Department of Medicine, Medical University of South Carolina, Charleston, USA
    Manag Care Interface 16:21-6. 2003
    ..Multiple risk factor control was rare, especially among women and African Americans. It appears that programs to improve CV risk factor control using audit and feedback in primary care are feasible and instructive...
  55. pmc Age and race impact the association between BMI and CVD mortality in women
    Jill E Abell
    Medical University of South Carolina, Charleston, SC, USA
    Public Health Rep 122:507-12. 2007
    ..This study examines the effect of age on the association of BMI to CVD in black and white women...
  56. ncbi request reprint An assessment of racial differences in clinical practices for hypertension at primary care sites for medically underserved patients
    Daniel T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 6:26-31; quiz 32-3. 2004
    ..Based on the sites examined, ethnic variations in important process and treatment indicators do not explain racial differences in cardiovascular and renal outcomes...
  57. ncbi request reprint Ethnic, gender, and age-related differences in treatment and control of dyslipidemia in hypertensive patients
    Katharine H Hendrix
    College of Health Professions, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ethn Dis 15:11-6. 2005
    ..Demographic differences in management of concomitant lipid disorders among hypertensive patients may contribute to health disparities...
  58. ncbi request reprint Elevation of C-reactive protein in people with prehypertension
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 6:562-8. 2004
    ..20; 95% confidence interval, 1.02-1.41, respectively). CRP and BP are positively related across a wide range of BP categories. A substantial proportion of prehypertensive individuals have elevated CRP independent of multiple confounders...
  59. pmc Prehypertension and cardiovascular morbidity
    Heather A Liszka
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Fam Med 3:294-9. 2005
    ..We aim to determine the risk of major cardiovascular events associated with blood pressure in the prehypertensive range in a longitudinal, population-based cohort...
  60. ncbi request reprint The effect of extended-release metoprolol succinate on C-reactive protein levels in persons with hypertension
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 8:257-60. 2006
    ..If CRP evolves into a confirmed modifiable risk factor, a beta blocker such as metoprolol may be a useful addition to pharmacotherapy options...
  61. pmc Use of statins and blood pressure
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 20:937-41. 2007
    ..The objective of this study was to determine whether statin use was associated with better blood-pressure control in adults with hypertension and whether inflammation levels mediated this relationship...
  62. ncbi request reprint Raising lipids acutely reduces baroreflex sensitivity
    Crystal A Gadegbeku
    Department of Medicine, Medical University of South Carolina, Charleston 29425 2227, USA
    Am J Hypertens 15:479-85. 2002
    ..07, P = NS). These observations indicate that elevating NEFAs acutely impairs BRS. The findings suggest that lipid abnormalities in obese hypertensives may contribute to elevated BP and increased cardiovascular events by impairing BRS...
  63. ncbi request reprint Gender- and age-related differences in treatment and control of cardiovascular risk factors among high-risk patients with angina
    Katherine H Hendrix
    Department of Medicine, Hypertension Section, Medical University of South Carolina, Charleston, 29425, USA
    J Clin Hypertens (Greenwich) 7:386-94. 2005
    ..75). Primary care providers treat high-risk patients relatively aggressively; however, opportunities to forestall cardiovascular disease may be missed in hypertensive, dyslipidemic women whose LDL-C is often not measured and controlled...
  64. ncbi request reprint Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects
    Crystal A Gadegbeku
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Hypertens 16:67-71. 2003
    ..The adjustment in vascular compliance may be an important factor in determining overall BP response to NA...
  65. ncbi request reprint Dietary salt restriction and blood pressure in clinical trials
    Daniel T Lackland
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Charleston, SC 29425, USA
    Curr Hypertens Rep 9:314-9. 2007
    ..Limitations in the methodology of different studies have reduced the value of the results to provide specific and reliable sodium intake levels essential for clinical and lifestyle guidelines...
  66. doi request reprint Prevalence and management of hypertension in the inpatient setting: a systematic review
    R Neal Axon
    Department of Internal Medicine, Division of General Internal Medicine and Geriatrics, The Medical University of South Carolina, Charleston, South Carolina, USA
    J Hosp Med 6:417-22. 2011
    ..Current consensus guidelines do not address inpatient HTN, and little is known about HTN prevalence or patterns of care in this setting...
  67. ncbi request reprint Ethnic differences in blood pressure control among men at Veterans Affairs clinics and other health care sites
    Shakaib U Rehman
    Department of Medicine, Ralph H Johnson VA Medical Center, Charleston, SC 29401, USA
    Arch Intern Med 165:1041-7. 2005
    ..The Department of Veterans Affairs (VA) system, which provides access to health care and medications across ethnic and economic boundaries, may reduce disparities in BP control...
  68. ncbi request reprint Alcohol biomarker screening in medical and surgical settings
    Peter M Miller
    Center for Drug and Alcohol Programs, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:185-93. 2006
    ..Presentations were discussed by Raymond Anton...
  69. ncbi request reprint Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425
    Am J Hypertens 7:886-93. 1994
    ..Plasma renin activity also tended to increase more on the low salt diet in the high risk group. Ambulatory blood pressures were greater on the low than the high salt diet only in the high risk group.(ABSTRACT TRUNCATED AT 250 WORDS)..
  70. ncbi request reprint Short-term impact of a church-based approach to lifestyle change on cardiovascular risk in African Americans
    M J Oexmann
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Ethn Dis 10:17-23. 2000
    ..Of the 133 participants, 70% attended half or more of the sessions, and several components of the risk factor cluster were favorably affected...
  71. ncbi request reprint Low birth weights contribute to high rates of early-onset chronic renal failure in the Southeastern United States
    D T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston 29425, USA
    Arch Intern Med 160:1472-6. 2000
    ..Within the Southeast, South Carolina has unusually high rates of end-stage renal disease (ESRD) in young people, with more than 70% of cases attributed to hypertension and diabetes...
  72. ncbi request reprint Low birth weight as a risk factor for hypertension
    D T Lackland
    Department of Biometry, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 5:133-6. 2003
    ..Still, considerable work needs to be done to explain the birth weight/blood pressure relationship. The findings to date and the clinical significance warrant continued research in this intriguing area of study...
  73. ncbi request reprint Low birth weight contributes to the excess prevalence of end-stage renal disease in African Americans
    D T Lackland
    Department of Biometry and Epidemiology, Rutledge Towers Ste. 1125, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 3:29-31. 2001
    ..Continued study of the biological factors linking early development with later risk of hypertension-related diseases is important and may shed light on racial disparities in health outcomes. (c)2001 by Le Jacq Communications, Inc...
  74. ncbi request reprint The dominant role of systolic hypertension as a vascular risk factor: evidence from the southeastern United States
    D T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston 29425, USA
    Am J Med Sci 318:365-8. 1999
    ..Thus, a high priority should be given to the recognition, treatment, and control of systolic hypertension in the Southeast...
  75. ncbi request reprint Impact of nativity and race on "Stroke Belt" mortality
    D T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    Hypertension 34:57-62. 1999
    ..An understanding of factors linking birthplace to risk for cerebrovascular mortality could facilitate efforts directed at stroke prevention...
  76. ncbi request reprint Efficacy of a church-based intervention on cardiovascular risk reduction
    M J Oexmann
    Department of Pharmacology and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ethn Dis 11:817-22. 2001
    ..Whites appear to have greater reductions in risk factors than did Blacks. However, Lighten Up is reaching both Blacks and Whites with multiple cardiovascular risk factors, and short- and long-term improvements are being made...
  77. ncbi request reprint Relation of dietary fat and fiber to elevation of C-reactive protein
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Cardiol 92:1335-9. 2003
    ..58, 95% CI 1.02 to 2.44; fourth quartile 1.44, 95% CI 0.80 to 2.58). The findings suggest that inflammation may link dietary fiber and fat to cardiovascular disease...
  78. ncbi request reprint Arterial compression of the retro-olivary sulcus of the medulla in essential hypertension: a multivariate analysis
    Robert E Coffee
    College of Medicine, Medical University of South Carolina, Charleston, 29425, USA
    J Hypertens 23:2027-31. 2005
    ..We aimed to establish whether the association between AC of specifically the retro-olivary sulcus (ROS) of the VLM and EHTN was significant, while controlling for other risks associated with EHTN...
  79. ncbi request reprint Excessive alcohol consumption and hypertension: clinical implications of current research
    Peter M Miller
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 25086, USA
    J Clin Hypertens (Greenwich) 7:346-51. 2005
    ..A routine search for excessive use of alcohol, along with brief interventions and monitoring, can have a major impact on reducing the prevalence of hypertension in the general population...
  80. ncbi request reprint The pressor response to acute hyperlipidemia is enhanced in lean normotensive offspring of hypertensive parents
    H F Lopes
    Division of Clinical Pharmacology, Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    Am J Hypertens 14:1032-7. 2001
    ..05). These results suggest that higher plasma lipids combined with a greater pressor response to hyperlipidemia may contribute to the development of high BP in subjects with a family history of hypertension...
  81. ncbi request reprint Hemodynamic effects of lipids in humans
    M P Stojiljkovic
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1674-9. 2001
    ....
  82. ncbi request reprint Elevated blood pressures in obese young men with mild hypertension are sustained during the day and night
    P Nazzaro
    Division of Clinical Pharmacology, Medical University of South Carolina, Charleston 29425
    Am J Hypertens 7:609-14. 1994
    ..The diurnal increases of systolic and diastolic blood pressure as well as heart rate and pressure-rate product were similar in all four groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
  83. ncbi request reprint Moderate sodium restriction enhances the pressor response to hyperlipidemia in obese, hypertensive patients
    H F Lopes
    Department of Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 4:173-80. 2002
    ..05). These data suggest that modest dietary sodium restriction in obese hypertensives does not adversely affect baseline blood pressure or lipids, but it does magnify their adverse lipid and hemodynamic response to fat loading...
  84. ncbi request reprint Autonomic dysregulation and the metabolic syndrome: pathologic partners in an emerging global pandemic
    Heno Ferreira Lopes
    Unidade de Hipertensao, Instituto do Coracao, FM, USP, Sao Paulo, Brasil
    Arq Bras Cardiol 87:538-47. 2006
  85. ncbi request reprint Mechanism of lipid enhancement of alpha1-adrenoceptor pressor sensitivity in hypertension
    Crystal A Gadegbeku
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0725, USA
    J Hypertens 24:1383-9. 2006
    ....
  86. ncbi request reprint Feasibility of treating prehypertension with an angiotensin-receptor blocker
    Stevo Julius
    University of Michigan, Department of Internal Medicine, Division of Cardiovascular Medicine, Ann Arbor, MI 48106, USA
    N Engl J Med 354:1685-97. 2006
    ..Prehypertension is considered a precursor of stage 1 hypertension and a predictor of excessive cardiovascular risk. We investigated whether pharmacologic treatment of prehypertension prevents or postpones stage 1 hypertension...
  87. ncbi request reprint Geographical patterns of end-stage renal disease incidence and risk factors in rural and urban areas of South Carolina
    Z Joyce Fan
    Sharp, Washington State Department of Labor and Industries, Olympia, WA, USA
    Health Place 13:179-87. 2007
    ..The strong relationship between ESRD and physician density suggests that access to adequate treatment of diabetes and hypertension is of paramount importance for ESRD prevention, and has important public policy implications...
  88. ncbi request reprint Lipids enhance alpha1-adrenoceptor pressor sensitivity in patients with chronic kidney disease
    Crystal A Gadegbeku
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Kidney Dis 44:446-54. 2004
    ....
  89. ncbi request reprint Reproducibility of BP responses to changes in dietary salt: compelling evidence for universal sodium restriction?
    Brent M Egan
    Hypertension 42:457-8. 2003
  90. ncbi request reprint Concordance between self-reported heights and weights and current and ideal body images in young adult African American men and women
    Theodosha S Gilliard
    University of South Carolina, School of Public Health, Columbia, SC, USA
    Ethn Dis 17:617-23. 2007
    ..Of concern, nearly half of men with normal BMI want to be heavier, while approximately 5/8 of overweight men are satisfied with being overweight or want to be heavier...
  91. ncbi request reprint An evaluation of the effects of an angiotensin receptor blocker on health-related quality of life in patients with high-normal blood pressure (prehypertension) in the Trial of Preventing Hypertension (TROPHY)
    Setareh A Williams
    AstraZeneca LP, Wilmington, DE 19850, USA
    J Clin Hypertens (Greenwich) 10:436-42. 2008
    ..05). In TROPHY, patients with prehypertension had relatively high baseline HRQL, and HRQL was maintained with the angiotensin receptor blocker candesartan over both the 2-year treatment period and a total 4-year trial period...
  92. doi request reprint Sleep-disordered breathing and blood pressure in children
    Brent M Egan
    Hypertension 52:807. 2008
  93. ncbi request reprint Is low-risk hypertension fact or fiction? cardiovascular risk profile in the TROPHY study
    Shawna D Nesbitt
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8899, USA
    Am J Hypertens 18:980-5. 2005
    ..5 % (men) and >or=41.2% (women)...
  94. ncbi request reprint Ethnicity and unprovoked hypokalemia in the ARIC Study
    Brent M Egan
    Am J Hypertens 15:660-1. 2002
  95. ncbi request reprint Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion
    Theodore L Goodfriend
    William S Middleton Memorial Veterans Hospital and Department of Medicine of the University of Wisconsin 53705, USA
    Hypertension 43:358-63. 2004
    ..Compounds like EKODE, derived from linoleic acid, may affect adrenal steroid production in humans and mediate some of the deleterious effects of obesity and oxidative stress, especially in blacks...
  96. ncbi request reprint Hypertension in the 21st century: the tide is rising; our daze must end
    Brent M Egan
    Hypertension 44:389. 2004
  97. ncbi request reprint Sleep and hypertension: burning the candle at both ends really is hazardous to your health
    Brent M Egan
    Hypertension 47:816-7. 2006
  98. ncbi request reprint Does life-long reduction in low-density lipoprotein cholesterol reduce the risk of new-onset hypertension?
    Franz H Messerli
    Am J Cardiol 98:1122. 2006
  99. ncbi request reprint From TROPHY with pride
    Stevo Julius
    Am J Hypertens 20:342-3; author reply 343-5. 2007

Research Grants10

  1. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  2. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2002
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  3. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2003
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  4. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2002
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  5. FATTY ACIDS EFFECTS ON VASCULAR REACTIVITY
    Brent Egan; Fiscal Year: 1999
    ..The studies could provide a basis for longer-term clinical studies on NEFAs and BP regulation as well as basic experiments to elucidate signaling mechanisms. ..
  6. INSULIN RESISTANCE AND CARDIOVASCULAR RISK FACTORS
    Brent Egan; Fiscal Year: 2003
    ..abstract_text> ..