Melinda R Dwinell

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Postnatal ventilatory response to CO₂ in awake piglets
    M R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Respir Physiol Neurobiol 175:49-54. 2011
  2. pmc Online tools for understanding rat physiology
    Melinda R Dwinell
    Human and Molecular Genetics Center at Medical College of Wisconsin, USA
    Brief Bioinform 11:431-9. 2010
  3. pmc The Rat Genome Database 2009: variation, ontologies and pathways
    Melinda R Dwinell
    Department of Physiology and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Nucleic Acids Res 37:D744-9. 2009
  4. pmc The emerging role for rat models in gene discovery
    Melinda R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Mamm Genome 22:466-75. 2011
  5. ncbi request reprint Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains
    M R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Appl Physiol (1985) 98:1630-8. 2005
  6. pmc Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 295:F837-42. 2008
  7. pmc Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data
    Rajni Nigam
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 45:809-16. 2013
  8. pmc Analysis of disease-associated objects at the Rat Genome Database
    Shur Jen Wang
    Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Database (Oxford) 2013:bat046. 2013
  9. pmc Exploring genetic, genomic, and phenotypic data at the rat genome database
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Protoc Bioinformatics . 2012
  10. ncbi request reprint Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
    David L Mattson
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F1905-14. 2007

Research Grants

Collaborators

Detail Information

Publications27

  1. doi request reprint Postnatal ventilatory response to CO₂ in awake piglets
    M R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Respir Physiol Neurobiol 175:49-54. 2011
    ..We conclude that the previously documented apparent critical period of development in piglets between 10 and 15 days of age is not associated with attenuation of the ventilatory response to 5% inspired CO₂...
  2. pmc Online tools for understanding rat physiology
    Melinda R Dwinell
    Human and Molecular Genetics Center at Medical College of Wisconsin, USA
    Brief Bioinform 11:431-9. 2010
    ..Integrating functional and physiological data with the rat genome will build a solid research platform to facilitate innovative studies to unravel the mechanisms resulting in disease...
  3. pmc The Rat Genome Database 2009: variation, ontologies and pathways
    Melinda R Dwinell
    Department of Physiology and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Nucleic Acids Res 37:D744-9. 2009
    ..By curating, storing, integrating, visualizing and promoting rat data, RGD ensures that the investment made into rat genomics and genetics can be leveraged by all interested investigators...
  4. pmc The emerging role for rat models in gene discovery
    Melinda R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Mamm Genome 22:466-75. 2011
    ..The strategies used to translate disease traits to genes to function, and, ultimately, to improve human health is discussed. Finally, our perspective on how rat models will continue to positively impact biomedical research is provided...
  5. ncbi request reprint Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains
    M R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Appl Physiol (1985) 98:1630-8. 2005
    ..Several chromosomal substitutions slightly altered the ventilatory responses to hypoxia and exercise. However, genes on chromosomes 6 and Y of those studied are of primary importance in aspects of ventilatory control currently studied...
  6. pmc Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 295:F837-42. 2008
    ..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats...
  7. pmc Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data
    Rajni Nigam
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 45:809-16. 2013
    ..The QTL data at RGD provide valuable information for the study of mapped phenotypes and identification of candidate genes for disease associations...
  8. pmc Analysis of disease-associated objects at the Rat Genome Database
    Shur Jen Wang
    Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Database (Oxford) 2013:bat046. 2013
    ..Furthermore, we were able to enhance enrichment of neurological diseases by combining 'G-protein coupled receptor binding' annotated genes with 'protein kinase binding' annotated genes. Database URL: http://rgd.mcw.edu..
  9. pmc Exploring genetic, genomic, and phenotypic data at the rat genome database
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Protoc Bioinformatics . 2012
    ..We present an overview of the database followed by specific examples that can be used to gain experience in employing RGD to explore the wealth of functional data available for the rat...
  10. ncbi request reprint Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
    David L Mattson
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F1905-14. 2007
    ..The present data indicate that genes that can modify l-NAME-induced hypertension and proteinuria are on chromosomes 1, 15, 16, 18, and 20...
  11. pmc PhenoMiner: quantitative phenotype curation at the rat genome database
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, Human and Molecular Genetics Center, 8701 Watertown Plank Rd, Milwaukee, WI 53226 3548, USA
    Database (Oxford) 2013:bat015. 2013
    ..The curation interface development, as well as ontology development, was an ongoing process during the early stages of the PhenoMiner curation project. Database URL: http://rgd.mcw.edu...
  12. pmc Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross
    Mary Pat Kunert
    College of Nursing, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, USA
    Am J Physiol Regul Integr Comp Physiol 295:R516-27. 2008
    ..Our findings are the first to link physiological traits with specific chromosomes in female SS rats and support the idea that sex is an important environmental variable that plays a role in the expression and regulation of genes...
  13. pmc The Rat Genome Database 2013--data, tools and users
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 3548, USA
    Brief Bioinform 14:520-6. 2013
    ..The value of RGD continues to grow as more types of data and more tools are added, while reaching more types of end users. ..
  14. pmc Ontology searching and browsing at the Rat Genome Database
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226 3548, USA
    Database (Oxford) 2012:bas016. 2012
    ..The new ontology search, browser and report features have been designed to enhance both manual data curation and manual data extraction. DATABASE URL: http://rgd.mcw.edu/rgdweb/ontology/search.html...
  15. pmc Identifying multiple causative genes at a single GWAS locus
    Michael J Flister
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 23:1996-2002. 2013
    ..Combined, these data demonstrate for the first time that multiple modifiers of hypertension can cosegregate at a single GWAS locus. ..
  16. pmc The updated RGD Pathway Portal utilizes increased curation efficiency and provides expanded pathway information
    G Thomas Hayman
    Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hum Genomics 7:4. 2013
    ..The application increases the information content of diagram pages while expediting publication...
  17. pmc Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain
    Mary Pat Kunert
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Physiol Genomics 42:244-58. 2010
    ....
  18. doi request reprint Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase
    Andreas M Beyer
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Am J Physiol Heart Circ Physiol 306:H339-47. 2014
    ....
  19. pmc The Rat Genome Database pathway portal
    Victoria Petri
    Human and Molecular Genetics Center, Medical College of Wisconsin, WI, 53226 3548, USA
    Database (Oxford) 2011:bar010. 2011
    ..The Pathway Portal resources at RGD are presented, and future directions are discussed. Database URL: http://rgd.mcw.edu...
  20. ncbi request reprint Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat
    Mary Pat Kunert
    University of Wisconsin Milwaukee, College of Nursing, Milwaukee, Wisconsin 53211, USA
    Physiol Genomics 26:218-25. 2006
    ..Because the BN chromosome is removed from its native background and the SS rat loses a native chromosome, it is also necessary to consider the contribution of changes in gene-to-gene interaction...
  21. pmc The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data
    Stanley J F Laulederkind
    Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 3548, USA
    Database (Oxford) 2011:bar002. 2011
    ..The user interfaces have been adapted to the work routines of the curators, creating a suite of tools that is intuitive and powerful. Database URL: http://rgd.mcw.edu...
  22. ncbi request reprint BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat
    Anne E Kwitek
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 25:303-13. 2006
    ..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research...
  23. ncbi request reprint Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing?
    H V Forster
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, and Zablocki VA Medical Center, Milwaukee, WI 53226, USA
    Respir Physiol Neurobiol 135:247-61. 2003
    ....
  24. pmc Gene targeting in the rat: advances and opportunities
    Howard J Jacob
    Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Trends Genet 26:510-8. 2010
    ..Here, we provide a high-level description and the potential uses of these new technologies for investigators using the rat for biomedical research...
  25. ncbi request reprint Ventilatory phenotypes among four strains of adult rats
    Matthew R Hodges
    Department of Physiology, Medical College of Wisconsin, Wisconsin 53226, USA
    J Appl Physiol (1985) 93:974-83. 2002
    ..Finally, the data establish a foundation for physiological genomic studies aimed at elucidating the genetics of these ventilatory control mechanisms...
  26. pmc Three ontologies to define phenotype measurement data
    Mary Shimoyama
    Human and Molecular Genetics Center, Medical College of Wisconsin Milwaukee, WI, USA
    Front Genet 3:87. 2012
    ....
  27. doi request reprint FMRI and fcMRI phenotypes map the genomic effect of chromosome 13 in Brown Norway and Dahl salt-sensitive rats
    Zhixin Li
    Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Neuroimage 90:403-12. 2014
    ..These findings prove the concept of neuroimaging-based phenotypes as a novel approach to visualize and fine-map the genetic effects onto brain biology at a systems level. ..

Research Grants1