William Drobyski

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Adoptively transferred gamma delta T cells indirectly regulate murine graft-versus-host reactivity following donor leukocyte infusion therapy in mice
    W R Drobyski
    Departments of Medicine and Biostatistics and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 165:1634-40. 2000
  2. ncbi request reprint Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation
    William R Drobyski
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 170:3046-53. 2003
  3. ncbi request reprint The role of allogeneic transplantation in high-risk acute myelogenous leukemia
    W R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI, USA
    Leukemia 18:1565-8. 2004
  4. ncbi request reprint Role of the passive apoptotic pathway in graft-versus-host disease
    William R Drobyski
    Department of Medicine and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 169:1626-33. 2002
  5. ncbi request reprint Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishin
    William R Drobyski
    Bone Marrow Transplant Program, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Blood 99:806-14. 2002
  6. ncbi request reprint Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene
    W R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 97:2506-13. 2001
  7. pmc Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
    Xiao Chen
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 110:3804-13. 2007
  8. pmc NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145
    Sanja Vodanovic-Jankovic
    Bone Marrow Transplant Program and the Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 107:827-34. 2006
  9. pmc Emergent autoimmunity in graft-versus-host disease
    Elizabeth Tivol
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 105:4885-91. 2005
  10. ncbi request reprint Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?
    Parameswaran Hari
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 10:743-7. 2004

Research Grants

  1. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2009
  2. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2007
  3. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2007
  4. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
  5. MODULATING GVH/GVL POST-BMT USING TK EXPRESSING T CELLS
    William Drobyski; Fiscal Year: 2004
  6. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Adoptively transferred gamma delta T cells indirectly regulate murine graft-versus-host reactivity following donor leukocyte infusion therapy in mice
    W R Drobyski
    Departments of Medicine and Biostatistics and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 165:1634-40. 2000
    ..Collectively, these data demonstrate that activated gamma delta T cells are capable of modulating the ability of MHC-incompatible nontolerant alpha beta T cells to cause GVHD after allogeneic BMT...
  2. ncbi request reprint Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation
    William R Drobyski
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 170:3046-53. 2003
    ....
  3. ncbi request reprint The role of allogeneic transplantation in high-risk acute myelogenous leukemia
    W R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI, USA
    Leukemia 18:1565-8. 2004
    ..Alternative allogeneic transplant approaches to reduce toxicity from graft-versus-host disease and enhance graft-versus-leukemia reactivity may offer therapeutic promise in this patient population...
  4. ncbi request reprint Role of the passive apoptotic pathway in graft-versus-host disease
    William R Drobyski
    Department of Medicine and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 169:1626-33. 2002
    ..Moreover, the susceptibility of donor T cells to undergo passive apoptosis is a significant factor in determining GVHD severity under noninflammatory but not inflammatory conditions...
  5. ncbi request reprint Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishin
    William R Drobyski
    Bone Marrow Transplant Program, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Blood 99:806-14. 2002
    ..There is no apparent advantage to using a mismatched unrelated versus a highly HLA-disparate family donor...
  6. ncbi request reprint Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene
    W R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 97:2506-13. 2001
    ..These studies demonstrate that administration of TK gene-modified donor T cells can be used as an approach to mitigate GVHD without compromising alloengraftment...
  7. pmc Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
    Xiao Chen
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 110:3804-13. 2007
    ....
  8. pmc NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145
    Sanja Vodanovic-Jankovic
    Bone Marrow Transplant Program and the Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 107:827-34. 2006
    ....
  9. pmc Emergent autoimmunity in graft-versus-host disease
    Elizabeth Tivol
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 105:4885-91. 2005
    ....
  10. ncbi request reprint Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?
    Parameswaran Hari
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 10:743-7. 2004
    ....
  11. pmc Gammadelta T cells do not require fully functional cytotoxic pathways or the ability to recognize recipient alloantigens to prevent graft rejection
    Sanja Vodanovic-Jankovic
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 12:1125-34. 2006
    ..The ability of these cells to promote engraftment without causing GVHD further distinguishes these cells from alphabeta T cells and may be an attribute that can be exploited in the clinical transplantation setting...
  12. ncbi request reprint Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration
    Maria Gendelman
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 105:428-31. 2005
    ....
  13. ncbi request reprint Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host disease
    Maria Gendelman
    Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 172:3328-36. 2004
    ..We conclude that host conditioning modulates the ability of exogenous IL-7 to exacerbate GVHD and that this occurs through induction of endogenous IL-7 production...
  14. ncbi request reprint Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitution
    Maria Gendelman
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Biol Blood Marrow Transplant 9:742-52. 2003
    ..Moreover, in light of previous studies demonstrating that this strategy can reduce GVHD without loss of alloengraftment and antileukemia reactivity, further examination of this approach in humans seems warranted...
  15. ncbi request reprint Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    Richard K Burt
    Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
    Exp Hematol 31:903-10. 2003
    ..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes...
  16. ncbi request reprint Regulation of alloresponses after bone marrow transplantation using donor T cells expressing a thymidine kinase suicide gene
    William R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Leuk Lymphoma 43:2011-6. 2002
    ..These studies demonstrate that specific incorporation of a suicide gene into donor T cells is a viable strategy that can be employed to reduce GVHD without compromising alloengraftment...
  17. ncbi request reprint Prospective trial of chemotherapy and donor leukocyte infusions for relapse of advanced myeloid malignancies after allogeneic stem-cell transplantation
    John E Levine
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 20:405-12. 2002
    ..A chemotherapy strategy was used to debulk disease before administration of granulocyte colony-stimulating factor (G-CSF)-primed DLIs...
  18. pmc Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial
    Eric P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 70:1546-51. 2008
    ..To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT)...
  19. pmc Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment
    Jack Gorski
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
    Blood 109:5502-10. 2007
    ..We thereby conclude that the host environment and not an intrinsic T-cell defect is primarily responsible for the lack of effective T-cell expansion and diversification of complex T-cell repertoires that occurs during GVHD...

Research Grants14

  1. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2009
    ....
  2. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2007
    ..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..
  3. Graft Versus Host Disease and Autoimmunity
    William Drobyski; Fiscal Year: 2007
    ....
  4. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  5. MODULATING GVH/GVL POST-BMT USING TK EXPRESSING T CELLS
    William Drobyski; Fiscal Year: 2004
    ..The overall goal of this project is to selectively modulate T-cell function and survival in vivo in order to augment the therapeutic index of allogeneic BMT. ..
  6. Augmentation of GVL Reactivity Without GVHD
    William Drobyski; Fiscal Year: 2009
    ..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..