Research Topics
| William DrobyskiSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Adoptively transferred gamma delta T cells indirectly regulate murine graft-versus-host reactivity following donor leukocyte infusion therapy in miceW R Drobyski
Departments of Medicine and Biostatistics and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 165:1634-40. 2000..Collectively, these data demonstrate that activated gamma delta T cells are capable of modulating the ability of MHC-incompatible nontolerant alpha beta T cells to cause GVHD after allogeneic BMT...- Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantationWilliam R Drobyski
Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 170:3046-53. 2003.... - The role of allogeneic transplantation in high-risk acute myelogenous leukemiaW R Drobyski
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI, USA
Leukemia 18:1565-8. 2004..Alternative allogeneic transplant approaches to reduce toxicity from graft-versus-host disease and enhance graft-versus-leukemia reactivity may offer therapeutic promise in this patient population... - Role of the passive apoptotic pathway in graft-versus-host diseaseWilliam R Drobyski
Department of Medicine and Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 169:1626-33. 2002..Moreover, the susceptibility of donor T cells to undergo passive apoptosis is a significant factor in determining GVHD severity under noninflammatory but not inflammatory conditions... - Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishinWilliam R Drobyski
Bone Marrow Transplant Program, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
Blood 99:806-14. 2002..There is no apparent advantage to using a mismatched unrelated versus a highly HLA-disparate family donor... - Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide geneW R Drobyski
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Blood 97:2506-13. 2001..These studies demonstrate that administration of TK gene-modified donor T cells can be used as an approach to mitigate GVHD without compromising alloengraftment... 
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host diseaseXiao Chen
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Blood 110:3804-13. 2007....- NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145Sanja Vodanovic-Jankovic
Bone Marrow Transplant Program and the Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Blood 107:827-34. 2006.... - Emergent autoimmunity in graft-versus-host diseaseElizabeth Tivol
Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Blood 105:4885-91. 2005.... - Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?Parameswaran Hari
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Biol Blood Marrow Transplant 10:743-7. 2004.... - Gammadelta T cells do not require fully functional cytotoxic pathways or the ability to recognize recipient alloantigens to prevent graft rejectionSanja Vodanovic-Jankovic
Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Biol Blood Marrow Transplant 12:1125-34. 2006..The ability of these cells to promote engraftment without causing GVHD further distinguishes these cells from alphabeta T cells and may be an attribute that can be exploited in the clinical transplantation setting... - Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administrationMaria Gendelman
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Blood 105:428-31. 2005.... - Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host diseaseMaria Gendelman
Bone Marrow Transplant Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 172:3328-36. 2004..We conclude that host conditioning modulates the ability of exogenous IL-7 to exacerbate GVHD and that this occurs through induction of endogenous IL-7 production... - Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitutionMaria Gendelman
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Biol Blood Marrow Transplant 9:742-52. 2003..Moreover, in light of previous studies demonstrating that this strategy can reduce GVHD without loss of alloengraftment and antileukemia reactivity, further examination of this approach in humans seems warranted... - Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusionsRichard K Burt
Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
Exp Hematol 31:903-10. 2003..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes... - Regulation of alloresponses after bone marrow transplantation using donor T cells expressing a thymidine kinase suicide geneWilliam R Drobyski
Bone Marrow Transplant Program, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Leuk Lymphoma 43:2011-6. 2002..These studies demonstrate that specific incorporation of a suicide gene into donor T cells is a viable strategy that can be employed to reduce GVHD without compromising alloengraftment... - Prospective trial of chemotherapy and donor leukocyte infusions for relapse of advanced myeloid malignancies after allogeneic stem-cell transplantationJohn E Levine
University of Michigan, Ann Arbor, MI, USA
J Clin Oncol 20:405-12. 2002..A chemotherapy strategy was used to debulk disease before administration of granulocyte colony-stimulating factor (G-CSF)-primed DLIs... - Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trialEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Int J Radiat Oncol Biol Phys 70:1546-51. 2008..To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT)... - Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environmentJack Gorski
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
Blood 109:5502-10. 2007..We thereby conclude that the host environment and not an intrinsic T-cell defect is primarily responsible for the lack of effective T-cell expansion and diversification of complex T-cell repertoires that occurs during GVHD...
Research Grants
- Graft Versus Host Disease and AutoimmunityWilliam Drobyski; Fiscal Year: 2009....
- Augmentation of GVL Reactivity Without GVHDWilliam Drobyski; Fiscal Year: 2007..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..
- Graft Versus Host Disease and AutoimmunityWilliam Drobyski; Fiscal Year: 2007....
- Regulation of Engraftment & Immunity by GD T CellsWilliam Drobyski; Fiscal Year: 2005....
- MODULATING GVH/GVL POST-BMT USING TK EXPRESSING T CELLSWilliam Drobyski; Fiscal Year: 2004..The overall goal of this project is to selectively modulate T-cell function and survival in vivo in order to augment the therapeutic index of allogeneic BMT. ..
- Augmentation of GVL Reactivity Without GVHDWilliam Drobyski; Fiscal Year: 2009..Better understanding of how to reduce this complication while at the same time preserving the beneficial effects that result from the transplant will lead to new therapies and better outcomes for patients. ..