Research Topics
Genomes and Genes
| Yanbin DongSummaryAffiliation: Medical College of Georgia Country: USA Publications
Research Grants
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Detail Information
Publications
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youthGaifen Liu
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
BMC Med Genet 11:57. 2010..This study aimed to assess the influence of FTO variant rs9939609 on adiposity, insulin resistance, energy intake and physical activity in European - (EA) and African-American (AA) youth...
A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffnessYanbin Dong
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Clin Endocrinol Metab 95:4584-91. 2010..Vitamin D insufficiency/deficiency is commonly observed in black youth...- Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitnessYanbin Dong
Medical College of Georgia, Department of Pediatrics, Georgia Prevention Institute, 1120 15th St, HS 1640, Augusta, GA 30912, USA
Pediatrics 125:1104-11. 2010..The objectives were to characterize the vitamin D status of black and white adolescents residing in the southeastern United States (latitude: approximately 33 degrees N) and to investigate relationships with adiposity... - Stress-induced sodium excretion: a new intermediate phenotype to study the early genetic etiology of hypertension?Dongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Hypertension 53:262-9. 2009..36 in whites and 0.39 in blacks. In summary, this study establishes Delta U(Na)V and stress U(Na)V as heritable phenotypes that may be used to study the genetic etiology of early hypertension development... 
The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twinsHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Building HS 1640, Augusta, GA 30912 3715, USA
Am J Hypertens 19:61-6. 2006..The present study evaluated the impact of the GRK4 gene variants on BP levels in normotensive adolescents and young adults...- Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youthHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3710, USA
Pharmacogenet Genomics 15:669-75. 2005..To evaluate the impact of the endothelial nitric oxide synthase (eNOS) gene on longitudinal development of blood pressure (BP) and left ventricular mass (LVM) from childhood into early adulthood... - Cardiovascular characteristics in American youth with prehypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Hypertens 20:1051-7. 2007..Cardiovascular structure and function in youth with prehypertension have been incompletely investigated... - Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youthsHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Pediatrics 121:115-22. 2008..This study aimed to evaluate comprehensively the cardiovascular phenotypes of cardiovascular disease-free youths at risk of overweight, in comparison with healthy weight and overweight... - Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youthXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, 30912, USA
Twin Res Hum Genet 9:393-402. 2006..A protective AGTR1 haplotype for LVM was also identified... - Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activityHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3715, USA
J Pediatr 158:215-20. 2011..To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents... - Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjectsDongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912 3715, USA
Hypertension 49:107-12. 2007..We proposed a viable approach to test for the multiple genetic contributions to BP and hypertension... - The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetesDongliang Ge
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
Twin Res Hum Genet 9:965-70. 2006.... - Prostasin: a possible candidate gene for human hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 21:1028-33. 2008..This study aimed to evaluate whether the human prostasin gene is a novel candidate gene underlying blood pressure (BP) elevation... - Adhesion molecule polymorphisms and pulse wave velocity in American youthHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Building HS 1640, Augusta, GA 30912 3715, United States of America
Twin Res Hum Genet 11:517-23. 2008..This article aimed at uncovering the genetic contributions of adhesion molecules, key members in the inflammatory process, to PWV in these young individuals... - The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescentsHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3715, USA
Pediatr Res 60:440-2. 2006..The 65L allele of the GRK4 gene is associated with stress-induced U(Na)V reduction, suggesting impaired sodium handling in affected black youth... - Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adultsRyan A Harris
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, USA
Am J Hypertens 24:557-62. 2011..This study sought to test the hypothesis that 16 weeks of 60,000 IU monthly supplementation of oral vitamin D(3) would improve flow-mediated dilation (FMD) in African Americans, whereas no change would be observed in the placebo group... - Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youthYanbin Dong
Georgia Prevention Institute Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
Hypertension 44:884-90. 2004..In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth... - Effects of dopamine receptor type 1 and Gs protein alpha subunit gene polymorphisms on blood pressure at rest and in response to stressYanhui Lu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Hypertens 19:832-6. 2006..Therefore, we investigated whether the A-48G polymorphism of the DRD1 gene and the T393C polymorphism of the Gs protein alpha subunit (GNAS) gene influenced BP levels at rest and in response to stress... - Update on G-protein polymorphisms in hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, 1120 15th Street, HS 1640, Augusta, GA 30912 3715, USA
Curr Hypertens Rep 8:23-9. 2006..In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension... - Urinary prostasin: a possible biomarker for renal pressure natriuresis in black adolescentsHaidong Zhu
Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30907, USA
Pediatr Res 65:443-6. 2009..43, p = 0.0001), even after being normalized by urinary creatinine. Our data suggest that urinary prostasin could be a novel biomarker and/or mechanism for renal pressure natriuresis in normotensive black adolescents... - Sex dimorphisms in inflammatory markers and adiposity in African-American youthKaren H Petty
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
Int J Pediatr Obes 5:327-33. 2010..Our aim was to determine sex differences in inflammatory markers and in the association between adiposity and inflammation in a sample of African-American adolescents... - Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or raceVanessa Bundy
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
J Pediatr Endocrinol Metab 24:119-24. 2011..To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships... - Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescentsNorman K Pollock
Department of Pediatrics, Georgia Health Sciences University, Augusta, GA, USA
J Nutr 142:251-7. 2012..05). In adolescents, higher fructose consumption is associated with multiple markers of cardiometabolic risk, but it appears that these relationships are mediated by visceral obesity... - Stress-induced sodium retention and hypertension: a review and hypothesisGregory A Harshfield
Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 4534, USA
Curr Hypertens Rep 11:29-34. 2009..Furthermore, research using this technique indicates the effectiveness of renin-angiotensin-aldosterone system blockers in correcting impaired sodium regulation and consequent hypertension in these individuals... - Adolescent obesity, bone mass, and cardiometabolic risk factorsNorman K Pollock
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
J Pediatr 158:727-34. 2011..To compare bone mass between overweight adolescents with and without cardiometabolic risk factors (CMR). Associations of bone mass with CMR and adiposity were also determined... - The association of race and sex to the pressure natriuresis response to stressGregory A Harshfield
Georgia Prevention Institute, Medical College of Georgia, MCG Annex H S 1640, Augusta, GA 30912 4534, USA
Ethn Dis 17:498-502. 2007..The purpose of this study was to examine the influence of race and sex on the pressure natriuresis response to prolonged behavioral stress in youth... - Effects of NOS3 Glu298Asp polymorphism on hemodynamic reactivity to stress: influences of ethnicity and obesitySurender Malhotra
Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3710, USA
Hypertension 44:866-71. 2004..Results indicate the importance of examining impact of BP control-related genetic polymorphisms within the context of moderating factors such as adiposity and ethnicity... - Obesity related methylation changes in DNA of peripheral blood leukocytesXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA
BMC Med 8:87. 2010..Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes... - Sympathetic nervous system, genes and human essential hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, 30912-3715, USA
Curr Neurovasc Res 2:303-17. 2005.... - A genome-wide methylation study on essential hypertension in young African American malesXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University, Augusta, Georgia, United States of America
PLoS ONE 8:e53938. 2013..Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension... - Adolescent fiber consumption is associated with visceral fat and inflammatory markersSamip Parikh
Department of Pediatrics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Clin Endocrinol Metab 97:E1451-7. 2012..The link between adolescent fiber consumption, inflammation, and body fat distribution has not been investigated... - Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertensionHaidong Zhu
Georgia Prevention Institute, Medical College of Georgia, Augusta, USA
J Hypertens 22:1269-75. 2004..The objectives of this study were to identify polymorphic variants within the gene coding for the sodium/hydrogen exchanger type 3 (NHE3) and to examine their relationship with hypertension and biochemical indices of sodium balance... - Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twinsYanbin Dong
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Pharmacogenetics 14:419-27. 2004.... - Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cellsKe Li
Georgia Prevention Institute, Dept of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Physiol Regul Integr Comp Physiol 299:R590-5. 2010..6 +/- 0.2 to 4.9 +/- 0.2 muA/cm(2) (P < 0.01). This study has identified a novel function of IL-6, namely, IL-6 may activate ENaC. Therefore, renal inflammation mediated by IL-6 likely contributes to impaired pressure natriuresis... - Cardiometabolic biomarkers in young black girls: relations to body fatness and aerobic fitness, and effects of a randomized physical activity trialBernard Gutin
Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University Formerly the Medical College of Georgia, Augusta, GA 30912, USA
Int J Pediatr 2011:219268. 2011..More research is needed to clarify what types of interventions can enhance the cardiometabolic health of youths... - Single-strand conformational polymorphism analysis: basic principles and routine practiceYanbin Dong
Georgia Prevention Institute, Medical College of Georgia, Augusta, USA
Methods Mol Med 108:149-57. 2005..g., Liddle's syndrome) and polygenic disorders (e.g., essential hypertension)... - Beta2-adrenergic receptor gene and resting hemodynamics in European and African American youthHarold Snieder
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Building HS 1640, Augusta, GA 30912, USA
Am J Hypertens 15:973-9. 2002..The purpose of this study was to investigate the relationship between these polymorphisms and resting hemodynamic function in African American (AA) and European American (EA) youths... - Can novel Apo A-I polymorphisms be responsible for low HDL in South Asian immigrants?Sunita Dodani
Medical College of Georgia, Augusta, GA, USA
Indian J Hum Genet 14:9-15. 2008..Further larger studies are required to explore and uncover these associations that could be responsible for excess CAD risk in South Asians... - Circulating soluble E-selectin levels and the Ser 128Arg polymorphism in individuals from different ethnic groupsMichelle A Miller
Department of Community Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
Nutr Metab Cardiovasc Dis 15:65-70. 2005..The aim of this study was to investigate whether the Ser128 Arg polymorphism of the E-selectin gene is associated with soluble E-selectin levels in individuals from a multiethnic population... - Amiloride, a specific drug for hypertension in black people with T594M variant?Emma H Baker
Department of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
Hypertension 40:13-7. 2002..Our study supports the concept that the T594M polymorphism contributes to the elevation of blood pressure and suggests that consideration should be given to the use of amiloride in affected individuals... - Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South LondonMichelle A Miller
Department of Community Health Sciences, St George s Hospital Medical School, London, UK
Thromb Haemost 92:1060-5. 2004..Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare... - Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whitesHaidong Zhu
Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
J Hypertens 21:87-95. 2003..The possibility of impaired aldosterone production for the development of hypertension is of particular relevance in black Afro-Caribbeans exposed to a high dietary sodium intake... - Regulation of the epithelial sodium channel by accessory proteinsKelly Gormley
Division of Neurosciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Biochem J 371:1-14. 2003.... - Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosisYanbin Dong
Department of Clinical Neurosciences, St George s Hospital Medical School, London, United Kingdom
Stroke 34:203-5. 2003..Atypical phenotypes have been recognized, and the disease is probably underdiagnosed in the wider stroke population. Therefore, we determined the yield of screening for Notch3 mutations in lacunar stroke with or without leukoaraiosis... - A gene-environment interaction model of stress-induced hypertensionIkhide G Imumorin
Department of Biology, Spelman College, Atlanta, GA 30314, USA
Cardiovasc Toxicol 5:109-32. 2005.... - Genetics in psychosomatic medicine: research designs and statistical approachesJeanne M McCaffery
Weight Control and Diabetes Research Center, Brown Medical School and The Miriam Hospital, Providence, RI, USA
Psychosom Med 69:206-16. 2007..We hope this overview of twin and genetic association designs will support and stimulate thoughtful applications of genetic approaches within psychosomatic medicine...
Research Grants
- Genetics and cardiovascular reactivity in young twinsYanbin Dong; Fiscal Year: 2005....
- Genetics of Stress Induced Hypertension in Black YouthYanbin Dong; Fiscal Year: 2007..Understanding the connections between salt, stress and genetics will provide a fresh approach into evaluating risk factors for high blood pressure. ..
- Genetics of Stress Induced Hypertension in Black YouthYanbin Dong; Fiscal Year: 2009..Understanding the connections between salt, stress and genetics will provide a fresh approach into evaluating risk factors for high blood pressure. ..