Krishnan Dhandapani

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Basic fibroblast growth factor induces TGF-beta release in an isoform and glioma-specific manner
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Neurobiology Program, and Department of Neurology, 1120 15th Street, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroreport 13:239-41. 2002
  2. ncbi request reprint Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 278:43329-39. 2003
  3. ncbi request reprint Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB
    Krishnan M Dhandapani
    Department of Neurology and Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurochem 95:9-19. 2005
  4. ncbi request reprint Role of astrocytes in estrogen-mediated neuroprotection
    Krishnan M Dhandapani
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Gerontol 42:70-5. 2007
  5. ncbi request reprint Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors
    Krishnan M Dhandapani
    Department of Neurosurgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurochem 102:522-38. 2007
  6. ncbi request reprint Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
    Krishnan M Dhandapani
    Department of Neurosurgery, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Neurosci Res 85:1033-45. 2007
  7. pmc Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
    Darrell W Brann
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, United States
    Steroids 72:381-405. 2007
  8. ncbi request reprint Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Developmental Neurobiology, 1120 15th Street, Medical College of Georgia, Augusta, Georgia 30912, USA
    Endocrinology 146:2749-59. 2005
  9. ncbi request reprint Protective effects of estrogen and selective estrogen receptor modulators in the brain
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biol Reprod 67:1379-85. 2002
  10. ncbi request reprint Non-uniform gradient prescription for precise angular measurements using DTI
    Nathan Yanasak
    Department of Radiology, Medical College of Georgia, USA
    Med Image Comput Comput Assist Interv 11:866-73. 2008

Research Grants

  1. HMGB1 and Traumatic Brain Injury
    Krishnan M Dhandapani; Fiscal Year: 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Basic fibroblast growth factor induces TGF-beta release in an isoform and glioma-specific manner
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Neurobiology Program, and Department of Neurology, 1120 15th Street, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroreport 13:239-41. 2002
    ..The bFGF effect on TGF-beta1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes...
  2. ncbi request reprint Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 278:43329-39. 2003
    ..Taken together, these studies suggest that astrocytes can protect neurons from serum deprivation-induced cell death, at least in part, by release of TGF-beta and activation of a c-Jun/AP-1 protective pathway...
  3. ncbi request reprint Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB
    Krishnan M Dhandapani
    Department of Neurology and Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurochem 95:9-19. 2005
    ..SCF represents a novel therapeutic target in the treatment of neurodegenerative disease...
  4. ncbi request reprint Role of astrocytes in estrogen-mediated neuroprotection
    Krishnan M Dhandapani
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Gerontol 42:70-5. 2007
    ..A possible indirect pathway involving astrocytes may act in concert with the proposed direct pathway to achieve a widespread, global protection of both ER positive and negative neurons...
  5. ncbi request reprint Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors
    Krishnan M Dhandapani
    Department of Neurosurgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurochem 102:522-38. 2007
    ..These findings support a role for curcumin as an adjunct to traditional chemotherapy and radiation in the treatment of brain cancer...
  6. ncbi request reprint Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
    Krishnan M Dhandapani
    Department of Neurosurgery, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Neurosci Res 85:1033-45. 2007
    ..Functionally, bFGF-induced proliferation of glioma cells was attenuated by MEK/ERK inhibition or immunoneutralization of TGF-beta1, suggesting that this pathway may have important implications for brain tumor progression...
  7. pmc Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
    Darrell W Brann
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, United States
    Steroids 72:381-405. 2007
    ..Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field...
  8. ncbi request reprint Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Developmental Neurobiology, 1120 15th Street, Medical College of Georgia, Augusta, Georgia 30912, USA
    Endocrinology 146:2749-59. 2005
    ....
  9. ncbi request reprint Protective effects of estrogen and selective estrogen receptor modulators in the brain
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biol Reprod 67:1379-85. 2002
    ..The role of other potential mediatory factors such as growth factors and the possibility of an astrocyte role in neuroprotection is also discussed...
  10. ncbi request reprint Non-uniform gradient prescription for precise angular measurements using DTI
    Nathan Yanasak
    Department of Radiology, Medical College of Georgia, USA
    Med Image Comput Comput Assist Interv 11:866-73. 2008
    ..Sensitivity to the a priori angular range of the principle eigenvector can be adjusted with the width of the band. Simulations and phantom data are in agreement; a preliminary validation is presented...
  11. ncbi request reprint Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30904, USA
    Neuropsychopharmacology 33:1942-51. 2008
    ..01). These findings may have significant implications for the development of neuroprotective strategies to improve clinical outcomes when antipsychotic drugs are used chronically...
  12. doi request reprint Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells
    John R Vender
    Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia 30912, USA
    Neurosurgery 62:1122-7; discussion 1027-8. 2008
    ..Thus, there is a need to identify novel cellular and molecular targets for pituitary tumors. We investigated the possible role of the NFkappaB transcription factor in pituitary tumor cell growth...
  13. doi request reprint Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortex
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service, Augusta, Georgia 30904, USA
    J Neurochem 107:941-51. 2008
    ..The findings from the present study may be helpful for the development of novel neuroprotective strategies to improve the treatment outcome of schizophrenia...
  14. doi request reprint Suberoylanilide hydroxamic acid (SAHA) induces growth arrest and apoptosis in pituitary adenoma cells
    S R Sangeetha
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30809, USA
    Endocrine 35:389-96. 2009
    ..Together, these findings support a possible utility for SAHA alone or in combination with radiation for the treatment of pituitary adenoma...
  15. ncbi request reprint Leptin and reproduction
    Darrell W Brann
    Neurobiology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Steroids 67:95-104. 2002
    ..This review presents both pro and con findings, thereby demarking controversial areas that undoubtedly will be fertile ground for future investigation...
  16. ncbi request reprint Role of astrocytes in reproduction and neuroprotection
    Virendra B Mahesh
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Cell Endocrinol 246:1-9. 2006
    ..These studies suggest that astrocytes can protect neurons, at least in part, by the release of TGF-beta and activation of a c-Jun/AP-1 protective pathway...
  17. pmc Estrogen-astrocyte interactions: implications for neuroprotection
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Neurobiology Program and Department of Neurology, 1120 15th Street, Medical College of Georgia, Augusta, GA 30912, USA
    BMC Neurosci 3:6. 2002
    ..These findings suggest that while direct protection may occur in some instances, an alternative or parallel pathway for protection may exist which could involve another cell type in the brain...
  18. doi request reprint Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes
    Melissa D Laird
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 45:1103-14. 2008
    ..Together, these studies suggest a novel role for GSH depletion in necroptotic astrocyte injury after a hemorrhagic injury and indicate that therapeutic targeting of GSH may exert a beneficial effect after ICH...
  19. ncbi request reprint Transforming growth factor-beta: a neuroprotective factor in cerebral ischemia
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Department of Neurology, Program in Neurobiology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Biochem Biophys 39:13-22. 2003
    ....
  20. ncbi request reprint Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons
    Mohammad M Khan
    Institute of Neuroscience, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, 30912, USA
    Endocrinology 146:5215-27. 2005
    ....
  21. ncbi request reprint Neuroprotective effects of estrogen and tamoxifen in vitro: a facilitative role for glia?
    Krishnan Dhandapani
    Institute of Molecular Medicine and Genetics, Department of Neurology, Program in Developmental Neurobiology, School of Medicine, Medical College of Georgia, Augusta 30912, USA
    Endocrine 21:59-66. 2003
    ..Together, these findings support a role for astrocytes in neuroprotection and raise the intriguing possibility that astrocytes may help mediate the neuroprotective effect of 17beta-E2 and tamoxifen...
  22. pmc Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
    Melissa D Laird
    Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia, USA
    J Neurochem 113:637-48. 2010
    ..As a whole, these data suggest clinically achievable concentrations of curcumin reduce glial activation and cerebral edema following neurotrauma, a finding which warrants further investigation...
  23. doi request reprint Opposing roles for reactive astrocytes following traumatic brain injury
    Melissa D Laird
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 16:154-64. 2008
    ..As such, a primary focus of this review is to summarize the emerging evidence suggesting reactive astrocytes influence the response of the brain to TBI...
  24. doi request reprint Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice
    Chandramohan Wakade
    Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia 30912, USA
    Antioxid Redox Signal 11:35-45. 2009
    ..Together, these data indicate a novel role for curcumin as a possible adjunct therapy after SAH, both to prevent the development of cerebral vasospasm and to reduce oxidative brain injury after secondary infarction...
  25. ncbi request reprint Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat
    Shyamal H Mehta
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroendocrinology 77:44-50. 2003
    ..These studies suggest that clinically important SERMs may have an additional unrecognized beneficial effect of protection of the female brain...
  26. ncbi request reprint Orphanin FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Neurobiology Program, and Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Neuroreport 13:1247-9. 2002
    ..Together, these findings are the first to suggest a role for orphanin FQ in the regulation of gonadotropin releasing hormone secretion...
  27. ncbi request reprint Astrocytes and brain function: implications for reproduction
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Exp Biol Med (Maywood) 228:253-60. 2003
    ..As a whole, these studies provide new insights into the diversity of astrocytes and their potential role in reproductive neuroendocrine function...

Research Grants2

  1. HMGB1 and Traumatic Brain Injury
    Krishnan M Dhandapani; Fiscal Year: 2010
    ..The present application will assess the potential role of neuronal necrosis, secondary to glutamate excitotoxicity, as a causative factor in the development of cellular edema following TBI. ..