Research Topics
Species | Krishnan DhandapaniSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Basic fibroblast growth factor induces TGF-beta release in an isoform and glioma-specific mannerKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Neurobiology Program, and Department of Neurology, 1120 15th Street, Medical College of Georgia, Augusta, GA 30912, USA
Neuroreport 13:239-41. 2002..The bFGF effect on TGF-beta1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes...- Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathwayKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
J Biol Chem 278:43329-39. 2003..Taken together, these studies suggest that astrocytes can protect neurons from serum deprivation-induced cell death, at least in part, by release of TGF-beta and activation of a c-Jun/AP-1 protective pathway... - Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaBKrishnan M Dhandapani
Department of Neurology and Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurochem 95:9-19. 2005..SCF represents a novel therapeutic target in the treatment of neurodegenerative disease... - Role of astrocytes in estrogen-mediated neuroprotectionKrishnan M Dhandapani
Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
Exp Gerontol 42:70-5. 2007..A possible indirect pathway involving astrocytes may act in concert with the proposed direct pathway to achieve a widespread, global protection of both ER positive and negative neurons... - Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factorsKrishnan M Dhandapani
Department of Neurosurgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurochem 102:522-38. 2007..These findings support a role for curcumin as an adjunct to traditional chemotherapy and radiation in the treatment of brain cancer... - Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activationKrishnan M Dhandapani
Department of Neurosurgery, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
J Neurosci Res 85:1033-45. 2007..Functionally, bFGF-induced proliferation of glioma cells was attenuated by MEK/ERK inhibition or immunoneutralization of TGF-beta1, suggesting that this pathway may have important implications for brain tumor progression... 
Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implicationsDarrell W Brann
Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, United States
Steroids 72:381-405. 2007..Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field...- Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathwaysKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Program in Developmental Neurobiology, 1120 15th Street, Medical College of Georgia, Augusta, Georgia 30912, USA
Endocrinology 146:2749-59. 2005.... - Protective effects of estrogen and selective estrogen receptor modulators in the brainKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
Biol Reprod 67:1379-85. 2002..The role of other potential mediatory factors such as growth factors and the possibility of an astrocyte role in neuroprotection is also discussed... - Non-uniform gradient prescription for precise angular measurements using DTINathan Yanasak
Department of Radiology, Medical College of Georgia, USA
Med Image Comput Comput Assist Interv 11:866-73. 2008..Sensitivity to the a priori angular range of the principle eigenvector can be adjusted with the width of the band. Simulations and phantom data are in agreement; a preliminary validation is presented... - Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNFAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30904, USA
Neuropsychopharmacology 33:1942-51. 2008..01). These findings may have significant implications for the development of neuroprotective strategies to improve clinical outcomes when antipsychotic drugs are used chronically... 
Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cellsJohn R Vender
Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia 30912, USA
Neurosurgery 62:1122-7; discussion 1027-8. 2008..Thus, there is a need to identify novel cellular and molecular targets for pituitary tumors. We investigated the possible role of the NFkappaB transcription factor in pituitary tumor cell growth...- Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortexAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service, Augusta, Georgia 30904, USA
J Neurochem 107:941-51. 2008..The findings from the present study may be helpful for the development of novel neuroprotective strategies to improve the treatment outcome of schizophrenia... - Suberoylanilide hydroxamic acid (SAHA) induces growth arrest and apoptosis in pituitary adenoma cellsS R Sangeetha
Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30809, USA
Endocrine 35:389-96. 2009..Together, these findings support a possible utility for SAHA alone or in combination with radiation for the treatment of pituitary adenoma... - Leptin and reproductionDarrell W Brann
Neurobiology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Steroids 67:95-104. 2002..This review presents both pro and con findings, thereby demarking controversial areas that undoubtedly will be fertile ground for future investigation... - Role of astrocytes in reproduction and neuroprotectionVirendra B Mahesh
Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Mol Cell Endocrinol 246:1-9. 2006..These studies suggest that astrocytes can protect neurons, at least in part, by the release of TGF-beta and activation of a c-Jun/AP-1 protective pathway... - Estrogen-astrocyte interactions: implications for neuroprotectionKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Neurobiology Program and Department of Neurology, 1120 15th Street, Medical College of Georgia, Augusta, GA 30912, USA
BMC Neurosci 3:6. 2002..These findings suggest that while direct protection may occur in some instances, an alternative or parallel pathway for protection may exist which could involve another cell type in the brain... - Hemin-induced necroptosis involves glutathione depletion in mouse astrocytesMelissa D Laird
Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
Free Radic Biol Med 45:1103-14. 2008..Together, these studies suggest a novel role for GSH depletion in necroptotic astrocyte injury after a hemorrhagic injury and indicate that therapeutic targeting of GSH may exert a beneficial effect after ICH... - Transforming growth factor-beta: a neuroprotective factor in cerebral ischemiaKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Department of Neurology, Program in Neurobiology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Cell Biochem Biophys 39:13-22. 2003.... - Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neuronsMohammad M Khan
Institute of Neuroscience, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, 30912, USA
Endocrinology 146:5215-27. 2005.... - Neuroprotective effects of estrogen and tamoxifen in vitro: a facilitative role for glia?Krishnan Dhandapani
Institute of Molecular Medicine and Genetics, Department of Neurology, Program in Developmental Neurobiology, School of Medicine, Medical College of Georgia, Augusta 30912, USA
Endocrine 21:59-66. 2003..Together, these findings support a role for astrocytes in neuroprotection and raise the intriguing possibility that astrocytes may help mediate the neuroprotective effect of 17beta-E2 and tamoxifen... - Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?Melissa D Laird
Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia, USA
J Neurochem 113:637-48. 2010..As a whole, these data suggest clinically achievable concentrations of curcumin reduce glial activation and cerebral edema following neurotrauma, a finding which warrants further investigation... - Opposing roles for reactive astrocytes following traumatic brain injuryMelissa D Laird
Department of Neurosurgery, Medical College of Georgia, Augusta, GA 30912, USA
Neurosignals 16:154-64. 2008..As such, a primary focus of this review is to summarize the emerging evidence suggesting reactive astrocytes influence the response of the brain to TBI... - Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in miceChandramohan Wakade
Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia 30912, USA
Antioxid Redox Signal 11:35-45. 2009..Together, these data indicate a novel role for curcumin as a possible adjunct therapy after SAH, both to prevent the development of cerebral vasospasm and to reduce oxidative brain injury after secondary infarction... - Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female ratShyamal H Mehta
Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
Neuroendocrinology 77:44-50. 2003..These studies suggest that clinically important SERMs may have an additional unrecognized beneficial effect of protection of the female brain... - Orphanin FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neuronsKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Neurobiology Program, and Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
Neuroreport 13:1247-9. 2002..Together, these findings are the first to suggest a role for orphanin FQ in the regulation of gonadotropin releasing hormone secretion... - Astrocytes and brain function: implications for reproductionKrishnan M Dhandapani
Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
Exp Biol Med (Maywood) 228:253-60. 2003..As a whole, these studies provide new insights into the diversity of astrocytes and their potential role in reproductive neuroendocrine function...
Research Grants
- HMGB1 and Traumatic Brain InjuryKrishnan M Dhandapani; Fiscal Year: 2010..The present application will assess the potential role of neuronal necrosis, secondary to glutamate excitotoxicity, as a causative factor in the development of cellular edema following TBI. ..