C Lindsay Devane

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Differential pharmacology of newer antidepressants
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425 0742, USA
    J Clin Psychiatry 59:85-93. 1998
  2. ncbi request reprint Psychoactive drug interactions with pharmacotherapy for diabetes
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, 67 President Street, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacol Bull 36:40-52. 2002
  3. ncbi request reprint Charleston Antidepressant Drug Interactions Surveillance Program (CADISP)
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Psychopharmacol Bull 35:50-61. 2001
  4. ncbi request reprint Clinical pharmacokinetics of sertraline
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Clin Pharmacokinet 41:1247-66. 2002
  5. ncbi request reprint Clinical significance of drug binding, protein binding, and binding displacement drug interactions
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina in Charleston, Charleston, South Carolina, USA
    Psychopharmacol Bull 36:5-21. 2002
  6. ncbi request reprint Antidepressant-drug interactions are potentially but rarely clinically significant
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 31:1594-604; discussion 1614-5. 2006
  7. ncbi request reprint Pharmacokinetics, drug interactions, and tolerability of valproate
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, 67 President Street, Suite 246 North, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:25-42. 2003
  8. ncbi request reprint Immediate-release versus controlled-release formulations: pharmacokinetics of newer antidepressants in relation to nausea
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Suite 246 North, Charleston, SC 29425, USA
    J Clin Psychiatry 64:14-9. 2003
  9. ncbi request reprint Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers
    C Lindsay Devane
    Department of Psychiatry, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    J Clin Psychopharmacol 24:4-10. 2004
  10. doi request reprint Exposing fetal drug exposure
    L DeVane
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, USA
    Clin Pharmacol Ther 89:786-8. 2011

Research Grants

Detail Information

Publications65

  1. ncbi request reprint Differential pharmacology of newer antidepressants
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425 0742, USA
    J Clin Psychiatry 59:85-93. 1998
    ..This review summarizes some of the major pharmacokinetic and pharmacodynamic similarities and differences among these drugs...
  2. ncbi request reprint Psychoactive drug interactions with pharmacotherapy for diabetes
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, 67 President Street, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacol Bull 36:40-52. 2002
    ..The newer drugs for treatment of type 2 diabetes are discussed, and considerations are given for avoiding or minimizing drug interactions when prescribing psychoactive drugs to patients with diabetes...
  3. ncbi request reprint Charleston Antidepressant Drug Interactions Surveillance Program (CADISP)
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Psychopharmacol Bull 35:50-61. 2001
    ..These data do not eliminate the need for caution when prescribing antidepressants with the potential for causing metabolic interactions, but do help allay the fear that such interactions are highly prevalent and routinely hazardous...
  4. ncbi request reprint Clinical pharmacokinetics of sertraline
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Clin Pharmacokinet 41:1247-66. 2002
    ..Like other selective serotonin reuptake inhibitors, sertraline is well tolerated in therapeutic dosages and relatively safe in overdosage...
  5. ncbi request reprint Clinical significance of drug binding, protein binding, and binding displacement drug interactions
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina in Charleston, Charleston, South Carolina, USA
    Psychopharmacol Bull 36:5-21. 2002
    ..Psychopharmacology Bulletin...
  6. ncbi request reprint Antidepressant-drug interactions are potentially but rarely clinically significant
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 31:1594-604; discussion 1614-5. 2006
    ..The conclusion is drawn that drug interactions from CYP inhibition caused by the newer antidepressants are potentially, but rarely, clinically significant...
  7. ncbi request reprint Pharmacokinetics, drug interactions, and tolerability of valproate
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, 67 President Street, Suite 246 North, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:25-42. 2003
    ..Valproate has an extensive record of use across the lifespan and a good record of tolerability. Some precautions are warranted in its use, but valproate is generally safe whether administered alone or in combination with other therapies...
  8. ncbi request reprint Immediate-release versus controlled-release formulations: pharmacokinetics of newer antidepressants in relation to nausea
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Suite 246 North, Charleston, SC 29425, USA
    J Clin Psychiatry 64:14-9. 2003
    ..Although the connection has not been proven, more stable pharmacokinetic profiles might be the cause for the low occurrence of nausea with some controlled-release newer antidepressants...
  9. ncbi request reprint Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers
    C Lindsay Devane
    Department of Psychiatry, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    J Clin Psychopharmacol 24:4-10. 2004
    ..These results demonstrate in vivo that, unlike nefazodone, venlafaxine, sertraline, and fluoxetine do not possess significant metabolic inductive or inhibitory effects on CYP3A4...
  10. doi request reprint Exposing fetal drug exposure
    L DeVane
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, USA
    Clin Pharmacol Ther 89:786-8. 2011
    ..Important assumptions in reproductive medicine are that fetal exposure to any medication can present risks in pregnancy--because not all risks are known, as little exposure as possible is desirable...
  11. ncbi request reprint Risperidone in the management of psychiatric and neurodegenerative disease in the elderly: an update
    C Lindsay Devane
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:116-32. 2003
    ..There is a substantial published database supporting safe and effective use of risperidone for treatment of psychosis, agitation, and aggression in elderly patients...
  12. ncbi request reprint Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychopharmacol 20:347-9. 2000
    ..These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration...
  13. ncbi request reprint Disposition of morphine in tissues of the pregnant rat and foetus following single and continuous intraperitoneal administration to the mother
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Pharm Pharmacol 51:1283-7. 1999
    ..These results document why the rat foetus is particularly susceptible to the pharmacodynamic effects of morphine following maternal administration...
  14. ncbi request reprint An evaluation of risperidone drug interactions
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425 0742, USA
    J Clin Psychopharmacol 21:408-16. 2001
    ..Adherence to a few guidelines for the design of dosage regimens should limit the effect of drug-drug interactions on patient status and contribute to optimal pharmacotherapy with risperidone...
  15. ncbi request reprint Clinical pharmacokinetics of quetiapine: an atypical antipsychotic
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Clin Pharmacokinet 40:509-22. 2001
    ..Subsequent clinical studies of the plasma concentration versus effect relationships for quetiapine may help to further define guidelines for dosage regimen design...
  16. ncbi request reprint Substance P: a new era, a new role
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    Pharmacotherapy 21:1061-9. 2001
    ....
  17. ncbi request reprint Pharmacology of antidepressants: focus on nefazodone
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychiatry 63:10-7. 2002
    ..Relevant pharmacologic and pharmacodynamic effects are summarized that support nefazodone as an attractive choice for both the short- and long-term treatment of depression...
  18. ncbi request reprint Pharmacologic characteristics of ideal antidepressants in the 21st century
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychiatry 61:4-8. 2000
    ..Unfortunately, the ideal antidepressant is yet to be formulated. Pharmacologic characteristics for desirable improvements are discussed relative to the currently available drugs...
  19. pmc Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, USA
    Eur J Pharmacol 578:148-58. 2008
    ..Furthermore, P-glycoprotein may play a minor role in the transport of d-methylphenidate, d-modafinil, and l-modafinil...
  20. ncbi request reprint Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Drug Metab Dispos 32:906-8. 2004
    ..3 +/- 1.8 microM 2 h after DGT treatment. Our results indicate that DGT is unlikely to alter the disposition of medications primarily dependent on the CYP2D6 or CYP3A4 pathways of metabolism...
  21. ncbi request reprint Effects of St John's wort (Hypericum perforatum L.) extract on plasma androgen concentrations in healthy men and women: a pilot study
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, North Charleston, SC 29425, USA
    Phytother Res 19:901-6. 2005
    ....
  22. ncbi request reprint Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers
    John S Markowitz
    Medical University of South Carolina, Institute of Psychiatry, RM 246 North, Laboratory of Drug Disposition and Pharmacogenetics, 67 President St, Charleston, SC 29425, USA
    Clin Pharmacol Ther 74:536-42. 2003
    ..These conclusions must be weighed in the context of the study's limited assessments and regarded as only the initial investigation into the drug interaction potential of saw palmetto...
  23. ncbi request reprint Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 187:415-23. 2006
    ..The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux transport of several antipsychotics in the blood-brain barrier (BBB)...
  24. ncbi request reprint Risperidone and paliperidone inhibit p-glycoprotein activity in vitro
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 32:757-64. 2007
    ..In particular, RSP may interact with its own active metabolite PALI by promoting its brain concentration through inhibiting P-gp-mediated efflux of PALI across endothelial cells of the BBB...
  25. ncbi request reprint Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 32:1333-6. 2004
    ....
  26. ncbi request reprint Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Institute of Psychiatry, Charleston 29425, USA
    JAMA 290:1500-4. 2003
    ..St John's wort is a popular herbal product used to treat depression but it has been implicated in drug interactions...
  27. ncbi request reprint Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 183:490-9. 2006
    ..Accumulating evidence indicates that modulation of the activity of cytochrome P450 (CYP) enzymes and the multidrug resistance transporter P-glycoprotein (P-gp) is responsible for many drug-drug interactions...
  28. ncbi request reprint Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, USA
    J Clin Pharmacol 46:164-71. 2006
    ..The homozygous TT genotype for P-gp resulted in an increased AUC of OLZ for SOT administration but not for either condition where sublingual absorption could occur...
  29. ncbi request reprint The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine
    Hao Jie Zhu
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Dispos 34:1116-21. 2006
    ..In addition, d-MPH is a relatively weak P-gp substrate, and its entry into the brain may be limited by P-gp. Furthermore, the mechanism by which d-MPH-induced locomotor activity was attenuated in P-gp KO mice remains to be elucidated...
  30. ncbi request reprint The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Pharmacol Ther 71:30-8. 2002
    ..We hypothesized that olanzapine disposition would be altered as a result of decreased glucuronidation, whereas risperidone disposition would be relatively unaffected...
  31. ncbi request reprint Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers
    John S Markowitz
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Pharmacol Ther 74:170-7. 2003
    ..7 +/- 4.4 h versus 14.5 +/- 4.3 h). Our results indicate that garlic extracts are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathway of metabolism...
  32. pmc Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Hum Genet 82:1241-8. 2008
    ..Asp260fs, respectively, compared to the wild-type enzyme. These findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates...
  33. ncbi request reprint Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 173:132-8. 2004
    ..Therefore, the function of P-gp in blood-brain barrier (BBB) may affect the concentration of methadone at its site(s) of action in the central nervous system, thereby contributing to its therapeutic efficacy and/or adverse events...
  34. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
    ..The objectives of the current study were to quantify placental permeability to antipsychotic medications and to document obstetrical outcomes for women taking these agents proximate to delivery...
  35. ncbi request reprint Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    J Psychopharmacol 20:54-9. 2006
    ....
  36. ncbi request reprint Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteers
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina MUSC, Charleston, South Carolina, USA
    Clin Pharmacokinet 44:753-65. 2005
    ..To determine if modafinil, a putative treatment for cocaine dependence, influences the pharmacokinetics of intravenous cocaine in otherwise healthy cocaine-dependent volunteers...
  37. ncbi request reprint The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 7:415-9. 2004
    ..These results indicate that P-gp in the blood-brain barrier significantly influences the brain concentrations of risperidone and 9-OH-risperidone by limiting their CNS access...
  38. ncbi request reprint Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F(2 alpha), a biomarker for in-vivo lipid peroxidation
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharm Pharmacol 57:1365-9. 2005
    ..There were no significant differences in the excretion of urinary 8-epi-PGF(2 alpha) after treatment with green tea. We conclude that 14 days of green tea supplementation did not significantly alter in-vivo lipid peroxidation...
  39. ncbi request reprint Antidepressants in amniotic fluid: another route of fetal exposure
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 163:145-7. 2006
    ..The authors' goal was to determine the concentration of antidepressants in amniotic fluid during maternal treatment of depression...
  40. ncbi request reprint The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
    Jun Sheng Wang
    Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Rev 39:723-46. 2007
    ..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology...
  41. pmc Antipsychotic drugs inhibit the function of breast cancer resistance protein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Basic Clin Pharmacol Toxicol 103:336-41. 2008
    ..The present results suggest that a potential source of pharmacokinetic interactions exists between BCRP substrates and several antipsychotics...
  42. doi request reprint Aripiprazole brain concentration is altered in P-glycoprotein deficient mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Schizophr Res 110:90-4. 2009
    ..Thus, factors influencing P-gp activity within the blood brain barrier in humans may have implications for the therapeutic effects and tolerability of aripiprazole...
  43. ncbi request reprint Modafinil and cocaine interactions
    Robert Malcolm
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 32:577-87. 2006
    ..Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted...
  44. ncbi request reprint Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Clin Pharmacokinet 42:393-401. 2003
    ..To compare the rate and extent of absorption of DL-threo-methylphenidate (MPH) from two modified-release MPH formulations at their respective recommended starting doses in healthy adult volunteers...
  45. ncbi request reprint Differential time course of cytochrome P450 2D6 enzyme inhibition by fluoxetine, sertraline, and paroxetine in healthy volunteers
    Heidi L Liston
    Department of Psychiatry, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Psychopharmacol 22:169-73. 2002
    ..These data define the time course of a persistent effect that fluoxetine, sertraline, and paroxetine have on CYP2D6 following drug discontinuation and should be considered when initiating therapy with a CYP2D6 substrate...
  46. ncbi request reprint Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 317:850-7. 2006
    ..These findings indicate that CBD significantly inhibits P-gp-mediated drug transport, suggesting CBD could potentially influence the absorption and disposition of other coadministered compounds that are P-gp substrates...
  47. pmc A novel HPLC fluorescence method for the quantification of methylphenidate in human plasma
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:91-5. 2007
    ..This method is the first HPLC assay with non-MS detection providing sufficient reliability and sensitivity for both pre-clinical and clinical studies of MPH...
  48. ncbi request reprint Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 31:519-22. 2003
    ....
  49. ncbi request reprint A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Child Adolesc Psychopharmacol 16:687-98. 2006
    ..However, the present exploratory studies reflect receptor binding affinities only. The specific pharmacological activities (i.e., agonism vs. antagonism) of these compounds await further exploration...
  50. ncbi request reprint In vitro P-glycoprotein affinity for atypical and conventional antipsychotics
    David W Boulton
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Life Sci 71:163-9. 2002
    ..These results suggest that P-gp is likely to influence the access to the brain of all of the atypical antipsychotics studied to various degrees. In vivo studies are needed to confirm these findings...
  51. ncbi request reprint Sensitive quantification of atomoxetine in human plasma by HPLC with fluorescence detection using 4-(4,5-diphenyl-1H-imidazole-2-yl) benzoyl chloride derivatization
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 846:351-4. 2007
    ..3 ng/mL. The relative standard deviations of intra-day and inter-day variations were < or =8.30% and 7.47%, respectively. This method is rapid, sensitive, and suitable for both basic and clinical studies of atomoxetine...
  52. pmc Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping
    Natalie L LeVasseur
    Department of Chemistry and Biochemistry, College of Charleston, Charleston, SC, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 862:140-9. 2008
    ..Clinical implications concerning rational drug selection for an identified or suspected MPH PM are discussed...
  53. ncbi request reprint Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Institute of Psychiatry, Medical University of South Carolina, 67 President St, Suite 246 North, Charleston, SC 29425, USA
    Drug Metab Dispos 31:742-7. 2003
    ..These data suggest that coadministration of inhibitors of CYP3A4 and CYP2C8 may produce clinically significant drug-drug interactions with methadone...
  54. ncbi request reprint Effect of Ginkgo biloba extract on plasma steroid concentrations in healthy volunteers: a pilot study
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Children s Research Institute, Charleston, South Carolina 29425, USA
    Pharmacotherapy 25:1337-40. 2005
    ..To determine if a standardized ginkgo supplement significantly alters concentrations of circulating androgenic steroids in humans...
  55. ncbi request reprint Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, 67 President St suite 246 N, Charleston, SC 29425, USA
    Food Chem Toxicol 41:1199-201. 2003
    ..05). We conclude that quinine as consumed in tonic water does not inhibit CYP2D6 activity in vivo. Thus, quinine should not alter the metabolism of CYP2D6 substrates taken concomitantly with tonic water...
  56. ncbi request reprint Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ther Drug Monit 25:197-202. 2003
    ..The validation data support the use of this method for human pharmacokinetic studies of modafinil in patients with known or suspected use of common antidepressants, psychostimulants, and drugs of abuse...
  57. ncbi request reprint P-glycoprotein does not actively transport nicotine and cotinine
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina 49425, USA
    Addict Biol 10:127-9. 2005
    ..The observed carrier-mediated nicotine transport in various cell lines may be mediated by other transporter proteins but not P-gp...
  58. doi request reprint P-glycoprotein inhibition potentiates the behavioural and neurochemical actions of risperidone in rats
    Alejandra M Pacchioni
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 13:1067-77. 2010
    ..These results provide functional evidence concordant with prior data for increased brain levels of risperidone following PSC 833 treatment...
  59. ncbi request reprint Pharmacokinetics, drug interactions, and tolerability of paroxetine and paroxetine CR
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Psychopharmacol Bull 37:29-41. 2003
    ..Paroxetine controlled-release is an enteric-coated formulation with release features that may enhance clinical outcome by modifying absorption-related pharmacokinetics, improving tolerability, and maintaining therapeutic benefits..
  60. ncbi request reprint Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder
    S Craig Risch
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Int J Neuropsychopharmacol 9:603-5. 2006
    ..Thus, in this study, donepezil did not induce or worsen depressive symptoms in schizophrenic and schizoaffective disorder patients...
  61. ncbi request reprint Anxiety disorders in the 21st century: status, challenges, opportunities, and comorbidity with depression
    C Lindsay Devane
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, P O Box 250861, Room PH246, Charleston, SC 29425, USA
    Am J Manag Care 11:S344-53. 2005
    ....
  62. ncbi request reprint Hypotension and bradycardia in a healthy volunteer following a single 5 mg dose of olanzapine
    John S Markowitz
    Institute of Psychiatry, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Pharmacol 42:104-6. 2002
    ..This case suggests that atypical antipsychotics, although generally better tolerated than conventional agents, may still result in untoward reactions that may be partially due to individual differences in drug absorption and metabolism...
  63. doi request reprint Pro-inflammatory biomakers in depression: treatment with venlafaxine
    John E Piletz
    Department of Psychiatry, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    World J Biol Psychiatry 10:313-23. 2009
    ..09), and MCP-1 (P=0.02), suggesting that these biomarkers may have become selectively lowered in the serotonergic dose range of venlafaxine. This is the first report of venlafaxine's possible effect on pro-inflammatory biomarkers...
  64. ncbi request reprint Open-label steady-state pharmacokinetic drug interaction study on co-administered quetiapine fumarate and divalproex sodium in patients with schizophrenia, schizoaffective disorder, or bipolar disorder
    Helen R Winter
    AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA
    Hum Psychopharmacol 22:469-76. 2007
    ..To determine whether there is a pharmacokinetic drug interaction between quetiapine fumarate and divalproex sodium...
  65. ncbi request reprint Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study
    S Craig Risch
    Langley Porter Psychiatric Institute, University of California San Francisco 94143 0984, USA
    Schizophr Res 93:131-5. 2007
    ..018, n=13). These results are discussed with respect to other studies using cholinesterase inhibitors as an augmentation strategy in schizophrenia...

Research Grants8

  1. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2001
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  2. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2002
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  3. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  4. PGP Regulation of Antipsychotic Exposure and Effects
    C Devane; Fiscal Year: 2005
    ..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
  5. PGP Regulation of Antipsychotic Exposure and Effects
    C Devane; Fiscal Year: 2006
    ..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
  6. PGP Regulation of Antipsychotic Exposure and Effects
    C Devane; Fiscal Year: 2007
    ..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
  7. Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART)
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2010
    ..PROJECT NARRATIVE: Autism occurs in approximately 1 in 150 children. The investigators propose a multi-center clinical trial to provide evidence-based guidance in the selection and monitoring of durg treatment of autism. ..