A Y Deng

Summary

Affiliation: Medical College of Ohio
Country: USA

Publications

  1. ncbi Linkage analysis for blood pressure with rat chromosome 15 markers
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614 5804, USA
    Folia Biol (Praha) 44:45-8. 1998
  2. ncbi Is the nitric oxide system involved in genetic hypertension in Dahl rats?
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, USA
    Kidney Int 53:1501-11. 1998
  3. ncbi Mapping of selective rat chromosome regions using mouse microsatellite markers
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Folia Biol (Praha) 43:183-93. 1997
  4. ncbi Molecular analysis of the rat inducible nitric oxide synthase genes
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Clin Exp Hypertens 20:53-65. 1998
  5. ncbi Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Hypertension 30:199-202. 1997
  6. ncbi Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in Dahl rats
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Hypertension 29:49-52. 1997
  7. ncbi Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats
    M R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 5804 USA
    Genome Res 8:711-23. 1998
  8. pmc Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1
    L Gu
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 97:777-88. 1996
  9. ncbi Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Mamm Genome 8:731-5. 1997
  10. pmc Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 95:2170-7. 1995

Collaborators

Detail Information

Publications20

  1. ncbi Linkage analysis for blood pressure with rat chromosome 15 markers
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614 5804, USA
    Folia Biol (Praha) 44:45-8. 1998
    ..15, which possesses a strong effect on blood pressure in the S rat. The Chr. 15 map will be useful for mapping genes and searching for QTL of other biological traits...
  2. ncbi Is the nitric oxide system involved in genetic hypertension in Dahl rats?
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, USA
    Kidney Int 53:1501-11. 1998
    ..Nevertheless, the nitric oxide system appears to be involved secondarily in the regulation of blood pressure in the S rat, as evidenced by physiological data...
  3. ncbi Mapping of selective rat chromosome regions using mouse microsatellite markers
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Folia Biol (Praha) 43:183-93. 1997
    ..Fourteen of these polymorphic markers have been mapped to the homologous chromosome regions of the rat, and have further been utilized to localize quantitative trait loci (QTL) for blood pressure in the S rat...
  4. ncbi Molecular analysis of the rat inducible nitric oxide synthase genes
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Clin Exp Hypertens 20:53-65. 1998
    ..It contained a series of simple sequence repeats which were polymorphic among eight rat strains tested. The polymorphic feature makes the Nos2 gene a useful chromosome marker...
  5. ncbi Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Hypertension 30:199-202. 1997
    ..001) lower ratio of heart weight to body weight in the congenic strains compared with Dahl S rats. The data from two congenic strains combined unequivocally establish the existence of a blood pressure QTL on rat chromosome 2...
  6. ncbi Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in Dahl rats
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Hypertension 29:49-52. 1997
    ..The Nos3 alleles did not cosegregate with blood pressure in these populations. Therefore, Nos3 is an improbable, if not impossible, candidate gene for causing hypertension in the Dahl salt-sensitive rat...
  7. ncbi Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats
    M R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 5804 USA
    Genome Res 8:711-23. 1998
    ..Interactions between each QTL and every other locus in the genome scan yielded significant interactions between chromosomes 10 and 4, and between chromosomes 2 and 3...
  8. pmc Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1
    L Gu
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 97:777-88. 1996
    ....
  9. ncbi Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Mamm Genome 8:731-5. 1997
    ..Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker per 1.1 cM...
  10. pmc Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 95:2170-7. 1995
    ..In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure...
  11. ncbi Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10
    O I Dukhanina
    Department of Physiology and Molecular Medicine, Medical College of Ohio, P O Box 10008, Toledo, Ohio 43669, USA
    Mamm Genome 8:229-35. 1997
    ..The region does not include the locus for inducible nitric oxide synthase (Nos2), which had been considered to be a candidate locus for the QTL...
  12. pmc Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10
    J P Rapp
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
    J Clin Invest 101:1591-5. 1998
    ..0001). The interaction accounted for 24 mmHg of BP and 79 mg of heart weight. Thus, the discovery and proof of epistatic interactions are clearly critical to understanding the genetics of blood pressure...
  13. ncbi Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains
    M R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, USA
    Hypertension 38:779-85. 2001
    ....
  14. ncbi Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13
    Q Y Zhang
    Department of Physiology and Molecular Medicine, Medical College of Ohio, P O Box 10008, Toledo, Ohio 43699 0008, USA
    Mamm Genome 8:636-41. 1997
    ..This segment does not include the renin locus, which is thus excluded from being the gene on rat Chr 13 responsible for genetic differences in blood pressure detected by linkage analysis...
  15. ncbi Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension
    J P Rapp
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    Hypertension 25:1121-8. 1995
    ....
  16. pmc Mapping of a quantitative trait locus for blood pressure on rat chromosome 2
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699
    J Clin Invest 94:431-6. 1994
    ..The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance...
  17. ncbi Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699
    J Hypertens 12:1001-6. 1994
    ..significant nucleotide differences between the coding regions of the AT1B gene of the inbred Dahl salt-sensitive (SS/Jr) strain and various control strains, or between the Lyon hypertensive (LH) strain the Lyon normotensive (LN) strain?..
  18. ncbi Linkage mapping of the endothelin-converting enzyme gene (Ednce) to rat chromosome 5
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008, USA
    Mamm Genome 6:759-60. 1995
  19. ncbi Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699 0008
    Mamm Genome 5:712-6. 1994
    ..The ornithine decarboxylase (Odc) gene and ornithine decarboxylase pseudogene (Odcp) were localized to Chrs 6 and 11 respectively...
  20. ncbi In search of hypertension genes in Dahl salt-sensitive rats
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614 5804, USA
    J Hypertens 16:1707-17. 1998
    ..Work in the rat may also facilitate genetic mapping of quantitative trait loci in humans...