LISA CUNNINGHAM

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death
    Lisa L Cunningham
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Box 250908, Charleston, SC 29425, USA
    J Assoc Res Otolaryngol 7:299-307. 2006
  2. pmc The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death
    Lisa L Cunningham
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, PO Box 250908, Charleston, SC 29425, USA
    Brain Res 1091:277-81. 2006
  3. pmc Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death
    Mona Taleb
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Stress Chaperones 14:427-37. 2009
  4. pmc Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock
    Mona Taleb
    Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    J Assoc Res Otolaryngol 9:277-89. 2008
  5. ncbi request reprint Caspase activation in hair cells of the mouse utricle exposed to neomycin
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7293, USA
    J Neurosci 22:8532-40. 2002
  6. ncbi request reprint Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio)
    Setsuko L Murakami
    Graduate Program in Audiology, University of Washington, Seattle, WA 98195, USA
    Hear Res 186:47-56. 2003
  7. ncbi request reprint Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, 98195 7293, USA
    J Neurobiol 60:89-100. 2004
  8. ncbi request reprint Round window gentamicin application: an inner ear hair cell damage protocol for the mouse
    Jennifer L Heydt
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195 7923, USA
    Hear Res 192:65-74. 2004
  9. pmc Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)
    Julie A Harris
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 4:219-34. 2003
  10. pmc JNK signaling in neomycin-induced vestibular hair cell death
    Kazuma Sugahara
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Hear Res 221:128-35. 2006

Research Grants

  1. MECHANISMS OF SENSORY HAIR CELL DEATH
    LISA CUNNINGHAM; Fiscal Year: 2003
  2. Mechanisms of Sensory Hair Cell Death and Survival
    LISA CUNNINGHAM; Fiscal Year: 2009
  3. Mechanisms of Sensory Hair Cell Death and Survival
    Lisa L Cunningham; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. pmc Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death
    Lisa L Cunningham
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Box 250908, Charleston, SC 29425, USA
    J Assoc Res Otolaryngol 7:299-307. 2006
    ..These data indicate that heat shock can inhibit ototoxic drug-induced hair cell death, and that the utricle preparation can be used to examine the molecular mechanism(s) underlying this protective effect...
  2. pmc The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death
    Lisa L Cunningham
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, PO Box 250908, Charleston, SC 29425, USA
    Brain Res 1091:277-81. 2006
    ..In addition, this preparation allows for examination of the effects of specific gene products through the use of transgenic and knockout mouse models...
  3. pmc Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death
    Mona Taleb
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Stress Chaperones 14:427-37. 2009
    ..These data indicate that Hsp70 is protective against aminoglycoside-induced ototoxicity in vivo...
  4. pmc Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock
    Mona Taleb
    Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    J Assoc Res Otolaryngol 9:277-89. 2008
    ..Furthermore, overexpression of Hsp70 alone significantly inhibits aminoglycoside-induced hair cell death...
  5. ncbi request reprint Caspase activation in hair cells of the mouse utricle exposed to neomycin
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7293, USA
    J Neurosci 22:8532-40. 2002
    ..These data indicate that caspase-9 is the primary upstream caspase mediating neomycin-induced hair cell death in this preparation...
  6. ncbi request reprint Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio)
    Setsuko L Murakami
    Graduate Program in Audiology, University of Washington, Seattle, WA 98195, USA
    Hear Res 186:47-56. 2003
    ..Thus zebrafish hair cells show developmental differences in sensitivity to aminoglycoside-induced death similar to those reported for inner ear hair cells of birds and mammals...
  7. ncbi request reprint Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, 98195 7293, USA
    J Neurobiol 60:89-100. 2004
    ..These results suggest that the expression level of Bcl-2 has important effects on the pathway(s) important for the regulation of aminoglycoside-induced hair cell death...
  8. ncbi request reprint Round window gentamicin application: an inner ear hair cell damage protocol for the mouse
    Jennifer L Heydt
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195 7923, USA
    Hear Res 192:65-74. 2004
    ..In addition, this protocol produces no systemic toxicity and preserves the contralateral ear as a control...
  9. pmc Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)
    Julie A Harris
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 4:219-34. 2003
    ..The results presented here provide a standardized preparation for studying and identifying genes that influence vertebrate hair cell death, survival, and regeneration following ototoxic insults...
  10. pmc JNK signaling in neomycin-induced vestibular hair cell death
    Kazuma Sugahara
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Hear Res 221:128-35. 2006
    ..In addition, inhibition of JNK inhibited the activation of caspase-9 in hair cells. These results indicate that JNK plays an important role in neomycin-induced vestibular hair cell death and caspase-9 activation...
  11. pmc Using the zebrafish lateral line to screen for ototoxicity
    Lynn L Chiu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 9:178-90. 2008
    ..This study represents an important step in validating the use of the zebrafish lateral line as a screening tool for the identification of potentially ototoxic drugs...
  12. pmc Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195, USA
    J Assoc Res Otolaryngol 4:91-105. 2003
    ..Specifically, the upstream caspases, caspase-8 and caspase-9, and the downstream caspase-3 are activated in aminoglycoside-damaged hair cells...
  13. ncbi request reprint Mechanisms of hair cell death and protection
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Opin Otolaryngol Head Neck Surg 13:343-8. 2005
    ..Current knowledge of these cell death mechanisms and potential therapeutic targets are discussed in this review...

Research Grants9

  1. MECHANISMS OF SENSORY HAIR CELL DEATH
    LISA CUNNINGHAM; Fiscal Year: 2003
    ..abstract_text> ..
  2. Mechanisms of Sensory Hair Cell Death and Survival
    LISA CUNNINGHAM; Fiscal Year: 2009
    ..4). To investigate the interactions between HSPs and apoptotic proteins in hair cells exposed to ototoxic drugs. ..
  3. Mechanisms of Sensory Hair Cell Death and Survival
    Lisa L Cunningham; Fiscal Year: 2010
    ..Understanding these mechanisms will guide the development of therapies aimed at preventing hearing loss caused by ototoxic drugs. ..