LISA CUNNINGHAMSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell deathLisa L Cunningham
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Box 250908, Charleston, SC 29425, USA
J Assoc Res Otolaryngol 7:299-307. 2006..These data indicate that heat shock can inhibit ototoxic drug-induced hair cell death, and that the utricle preparation can be used to examine the molecular mechanism(s) underlying this protective effect...- The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell deathLisa L Cunningham
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, PO Box 250908, Charleston, SC 29425, USA
Brain Res 1091:277-81. 2006..In addition, this preparation allows for examination of the effects of specific gene products through the use of transgenic and knockout mouse models... - Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell deathMona Taleb
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Cell Stress Chaperones 14:427-37. 2009..These data indicate that Hsp70 is protective against aminoglycoside-induced ototoxicity in vivo... - Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shockMona Taleb
Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
J Assoc Res Otolaryngol 9:277-89. 2008..Furthermore, overexpression of Hsp70 alone significantly inhibits aminoglycoside-induced hair cell death... 
Caspase activation in hair cells of the mouse utricle exposed to neomycinLisa L Cunningham
Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington 98195-7293, USA
J Neurosci 22:8532-40. 2002..These data indicate that caspase-9 is the primary upstream caspase mediating neomycin-induced hair cell death in this preparation...- Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio)Setsuko L Murakami
Graduate Program in Audiology, University of Washington, Seattle, WA 98195, USA
Hear Res 186:47-56. 2003..Thus zebrafish hair cells show developmental differences in sensitivity to aminoglycoside-induced death similar to those reported for inner ear hair cells of birds and mammals... - Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitroLisa L Cunningham
Washington U, St Louis, MO
J Neurobiol 60:89-100. 2004..These results suggest that the expression level of Bcl-2 has important effects on the pathway(s) important for the regulation of aminoglycoside-induced hair cell death... - Round window gentamicin application: an inner ear hair cell damage protocol for the mouseJennifer L Heydt
Department of Otolaryngology-Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195-7923, USA
Hear Res 192:65-74. 2004..In addition, this protocol produces no systemic toxicity and preserves the contralateral ear as a control... - Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)Julie A Harris
Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
J Assoc Res Otolaryngol 4:219-34. 2003..The results presented here provide a standardized preparation for studying and identifying genes that influence vertebrate hair cell death, survival, and regeneration following ototoxic insults... - JNK signaling in neomycin-induced vestibular hair cell deathKazuma Sugahara
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA 98195-7923, USA
Hear Res 221:128-35. 2006..In addition, inhibition of JNK inhibited the activation of caspase-9 in hair cells. These results indicate that JNK plays an important role in neomycin-induced vestibular hair cell death and caspase-9 activation... - Using the zebrafish lateral line to screen for ototoxicityLynn L Chiu
Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195, USA
J Assoc Res Otolaryngol 9:178-90. 2008..This study represents an important step in validating the use of the zebrafish lateral line as a screening tool for the identification of potentially ototoxic drugs... - Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activationAlan G Cheng
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195, USA
J Assoc Res Otolaryngol 4:91-105. 2003..Specifically, the upstream caspases, caspase-8 and caspase-9, and the downstream caspase-3 are activated in aminoglycoside-damaged hair cells... - Mechanisms of hair cell death and protectionAlan G Cheng
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
Curr Opin Otolaryngol Head Neck Surg 13:343-8. 2005..Current knowledge of these cell death mechanisms and potential therapeutic targets are discussed in this review...
Research Grants
- MECHANISMS OF SENSORY HAIR CELL DEATHLISA CUNNINGHAM; Fiscal Year: 2003..abstract_text> ..
- Mechanisms of Sensory Hair Cell Death and SurvivalLISA CUNNINGHAM; Fiscal Year: 2009..4). To investigate the interactions between HSPs and apoptotic proteins in hair cells exposed to ototoxic drugs. ..
- Mechanisms of Sensory Hair Cell Death and SurvivalLisa L Cunningham; Fiscal Year: 2010..Understanding these mechanisms will guide the development of therapies aimed at preventing hearing loss caused by ototoxic drugs. ..