Allen Cowley

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Progression of glomerular filtration rate reduction determined in conscious Dahl salt-sensitive hypertensive rats
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 62:85-90. 2013
  2. pmc Medullary thick ascending limb buffer vasoconstriction of renal outer-medullary vasa recta in salt-resistant but not salt-sensitive rats
    Paul M O'Connor
    Section of Experimental Medicine, Georgia Health Sciences University, Augusta, GA, USA
    Hypertension 60:965-72. 2012
  3. pmc Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans
    Srividya Kidambi
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Med Genet 13:27. 2012
  4. ncbi request reprint Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 37:456-61. 2001
  5. ncbi request reprint Role of renal NO production in the regulation of medullary blood flow
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1355-69. 2003
  6. ncbi request reprint The emergence of physiological genomics
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisc, USA
    J Vasc Res 36:83-90. 1999
  7. ncbi request reprint The genetic dissection of essential hypertension
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Genet 7:829-40. 2006
  8. pmc Application of chromosomal substitution techniques in gene-function discovery
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:46-55. 2004
  9. pmc Renal medullary oxidative stress, pressure-natriuresis, and hypertension
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:777-86. 2008
  10. pmc Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb
    Yusuke Ohsaki
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 302:F95-F102. 2012

Detail Information

Publications90

  1. pmc Progression of glomerular filtration rate reduction determined in conscious Dahl salt-sensitive hypertensive rats
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 62:85-90. 2013
    ....
  2. pmc Medullary thick ascending limb buffer vasoconstriction of renal outer-medullary vasa recta in salt-resistant but not salt-sensitive rats
    Paul M O'Connor
    Section of Experimental Medicine, Georgia Health Sciences University, Augusta, GA, USA
    Hypertension 60:965-72. 2012
    ..13BN rats in vivo. We conclude that paracrine signaling from mTAL buffers angiotensin II vasoconstriction in Dahl salt-resistant SS.13BN rats but not SS rats...
  3. pmc Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans
    Srividya Kidambi
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Med Genet 13:27. 2012
    ..We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives...
  4. ncbi request reprint Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 37:456-61. 2001
    ..BN13 rats. These results reveal a powerful gene, or set of genes, within chromosome 13 of BN/Mcw rats that confers protection from the detrimental effects of high salt to the SS/Mcw rats...
  5. ncbi request reprint Role of renal NO production in the regulation of medullary blood flow
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1355-69. 2003
    ..It is concluded that NO production in the renal medulla plays a very important role in sodium and water homeostasis and the long-term control of arterial pressure...
  6. ncbi request reprint The emergence of physiological genomics
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisc, USA
    J Vasc Res 36:83-90. 1999
    ....
  7. ncbi request reprint The genetic dissection of essential hypertension
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Genet 7:829-40. 2006
    ..Together with the computational reconstruction of regulatory networks, these methods provide opportunities to significantly advance our understanding of the underlying aetiology of hypertension...
  8. pmc Application of chromosomal substitution techniques in gene-function discovery
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:46-55. 2004
    ..Consomic rat strains are proving to be a unique scientific resource that greatly extends our understanding of genes and complex normal and pathological function...
  9. pmc Renal medullary oxidative stress, pressure-natriuresis, and hypertension
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:777-86. 2008
  10. pmc Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb
    Yusuke Ohsaki
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 302:F95-F102. 2012
    ..The mitochondrial production of H(2)O(2) may represent an important target for development of more effective antioxidant therapies...
  11. ncbi request reprint Physiology and genomics: toward systems biology
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Sheng Li Xue Bao 58:1-4. 2006
    ....
  12. ncbi request reprint Evidence that reduced renal medullary nitric oxide synthase activity of dahl s rats enables small elevations of arginine vasopressin to produce sustained hypertension
    B Yuan
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 37:524-8. 2001
    ....
  13. ncbi request reprint Production and actions of superoxide in the renal medulla
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Hypertension 37:547-53. 2001
    ..is primarily produced in the renal OM; (2) both NADH oxidase and mitochondrial enzymes are responsible for the O(2)(-.)production in this kidney region; and (3) O(2)(-. )exerts a tonic regulatory action on renal MBF...
  14. ncbi request reprint Arginine vasopressin-mediated stimulation of nitric oxide within the rat renal medulla
    F Park
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 32:896-901. 1998
    ..3 microg/kg per minute). This study demonstrates that AVP increases renal medullary interstitial [NO] through vasopressin V2 receptor stimulation, which in turn elevates blood flow to the renal medulla...
  15. ncbi request reprint Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats
    V Gross
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol 274:R1317-23. 1998
    ..The elevated blood flow to the renal cortex may enhance sodium excretion and contribute to long-term sodium homeostasis...
  16. ncbi request reprint Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 2:107-15. 2000
    ..Given the unlikely chance of these different blood pressure traits mapping to the same region, we believe these data provide evidence that this region of rat chromosome 18 plays an important role in salt-induced hypertension...
  17. ncbi request reprint Role of renal medullary adenosine in the control of blood flow and sodium excretion
    A P Zou
    Departments of Physiology and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 276:R790-8. 1999
    ....
  18. ncbi request reprint Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains
    M R Dwinell
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Appl Physiol 98:1630-8. 2005
    ..Several chromosomal substitutions slightly altered the ventilatory responses to hypoxia and exercise. However, genes on chromosomes 6 and Y of those studied are of primary importance in aspects of ventilatory control currently studied...
  19. ncbi request reprint alpha(2)-adrenergic receptor-mediated increase in NO production buffers renal medullary vasoconstriction
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 279:R769-77. 2000
    ....
  20. ncbi request reprint Protective effect of angiotensin II-induced increase in nitric oxide in the renal medullary circulation
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 31:271-6. 1998
    ....
  21. ncbi request reprint Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 275:R1420-4. 1998
    ..The present data are consistent with the idea that chronic stimulation of V2 receptors by AVP offsets the vasoconstrictor and hypertension actions of AVP-induced stimulation of medullary V1 receptors...
  22. ncbi request reprint Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment
    M Szentivanyi
    Clinical Research Deptartment, 2nd Institute of Physiology, Semmelweis University of Medicine, Budapest, Hungary
    Hypertension 33:440-5. 1999
    ..The results provide novel insights of how the organism attempts to protect itself from the hypertensive effects of Ang II...
  23. ncbi request reprint Chronic pressure-natriuresis relationship in dogs with inherited essential hypertension
    P E Papanek
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226
    Am J Hypertens 6:960-7. 1993
    ..Plasma hormone levels in both groups of PHD studied responded in a manner similar to normal mongrel dogs with reductions of PRA, ALDO, elevations of ANP, and no change in AVP.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint A genomic-systems biology map for cardiovascular function
    M Stoll
    Department of Physiology, Bioinformatics Research Center, and, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Science 294:1723-6. 2001
    ....
  25. ncbi request reprint Expression and actions of heme oxygenase in the renal medulla of rats
    A P Zou
    Department of Physiology, Medical College of Wisconsin, MI 53226, USA
    Hypertension 35:342-7. 2000
    ....
  26. ncbi request reprint Effect of chronic salt loading on adenosine metabolism and receptor expression in renal cortex and medulla in rats
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 33:511-6. 1999
    ..The data show that stimulation of adenosine production and downregulation of A1 receptors with salt loading may play an important role in adaptation in the kidney to promote sodium excretion...
  27. ncbi request reprint Control of the renal medullary circulation by vasopressin V1 and V2 receptors in the rat
    A W Cowley
    Department Physiology, Medical College of Wisconsin, Milwaukee, USA
    Exp Physiol 85:223S-231S. 2000
    ..These changes are essential to provide a constancy of blood flow to the renal medulla and buffer against the hypertensive actions of this potent vasoconstrictor peptide...
  28. ncbi request reprint Chronic intravenous administration of V1 arginine vasopressin agonist results in sustained hypertension
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226
    Am J Physiol 267:H751-6. 1994
    ..Body weight increased throughout the study but was unrelated to the changes of MAP. We conclude that chronic stimulation of V1 receptors results in sustained hypertension in rats...
  29. ncbi request reprint Role of nitric oxide in the control of the renal medullary circulation
    D L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Clin Exp Pharmacol Physiol 24:587-90. 1997
    ..5. The data reviewed indicate that NO in the renal medulla has a powerful influence on fluid and electrolyte homeostasis and the control of blood pressure...
  30. ncbi request reprint Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney
    N Miyata
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 277:F437-46. 1999
    ..Evidence for AT2R mRNA was also found in all but two of the vascular and tubular segments, the MTAL, and the glomeruli. These results are consistent with the whole tissue immunohistochemically localized receptors...
  31. ncbi request reprint Reactive oxygen species and molecular regulation of renal oxygenation
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Acta Physiol Scand 179:233-41. 2003
    ..It is concluded that HIF-1-mediated molecular adaptation to low PO2 is of importance in the regulation of renal medullary function and that ROS may target this HIF-1-mediated medullary adaptation to damage renal function...
  32. pmc New target regions for human hypertension via comparative genomics
    M Stoll
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 10:473-82. 2000
    ....
  33. pmc Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload
    T C Herzig
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 94:7543-8. 1997
    ....
  34. ncbi request reprint Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla
    F Park
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol 273:R1742-8. 1997
    ....
  35. pmc Renal injury in angiotensin II+L-NAME-induced hypertensive rats is independent of elevated blood pressure
    Aaron J Polichnowski
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 300:F1008-16. 2011
    ....
  36. ncbi request reprint Consomic rat model systems for physiological genomics
    A W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Acta Physiol Scand 181:585-92. 2004
    ..Consomic rat strains are proving to be a unique scientific resource that can greatly extend our understanding of genes and their role in the regulation of complex function and disease...
  37. ncbi request reprint Consomic rats for the identification of genes and pathways underlying cardiovascular disease
    R J Roman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53005, USA
    Cold Spring Harb Symp Quant Biol 67:309-15. 2002
  38. pmc Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive rats
    Aaron J Polichnowski
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 55:1425-30. 2010
    ..In summary, this study demonstrates that elevated RPP is directly responsible for the excess albuminuria in Ang II-infused rats, whereas both elevated RPP and Ang II directly contribute to the observed renal oxidative stress...
  39. ncbi request reprint Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla
    Takefumi Mori
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Japan
    J Pharmacol Sci 100:2-8. 2006
    ..We conclude that oxidative stress within the renal medulla can induce hypertension and also make the kidney functionally more vulnerable to the effects of Ang II...
  40. ncbi request reprint NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterin
    Norman E Taylor
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 48:1066-71. 2006
    ..Based on the shift of BH(4) to BH(2) and the observation of l-NAME inhibitable superoxide production, we conclude that NOS uncoupling occurs in the renal medulla of hypertensive SS rats fed a high-salt diet...
  41. ncbi request reprint Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat
    Mary Pat Kunert
    University of Wisconsin Milwaukee, College of Nursing, Milwaukee, Wisconsin 53211, USA
    Physiol Genomics 26:218-25. 2006
    ..Because the BN chromosome is removed from its native background and the SS rat loses a native chromosome, it is also necessary to consider the contribution of changes in gene-to-gene interaction...
  42. ncbi request reprint Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb
    Michiaki Abe
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 291:F350-7. 2006
    ..This may lead to reduction in medullary blood flow and promote hypoxia and tubular necrosis within the renal medulla during in hypertension...
  43. ncbi request reprint NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats
    Norman E Taylor
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 47:692-8. 2006
    ..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide...
  44. ncbi request reprint BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat
    Anne E Kwitek
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 25:303-13. 2006
    ..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research...
  45. ncbi request reprint Efficient transgenic rat production by a lentiviral vector
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H881-94. 2007
    ..Thus lentiviral transgenesis provides a powerful tool for the production of transgenic inbred rats and will enhance the usefulness of this species in gene discovery and target validation studies...
  46. pmc Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 295:F837-42. 2008
    ..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats...
  47. pmc Enhanced amiloride-sensitive superoxide production in renal medullary thick ascending limb of Dahl salt-sensitive rats
    Paul M O'Connor
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53202, USA
    Am J Physiol Renal Physiol 295:F726-33. 2008
    ..Amiloride-sensitive O(2)(-) production is likely to contribute to augmented outer medullary O(2)(-) production observed in SS rats during both normal and high NaCl diets...
  48. doi request reprint Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 34:54-64. 2008
    ....
  49. pmc High perfusion pressure accelerates renal injury in salt-sensitive hypertension
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 19:1472-82. 2008
    ..We conclude that elevations of RPP contribute significantly to the fibrosis and epithelial-to-mesenchymal transition found in the early phases of hypertension in the salt-sensitive rat...
  50. ncbi request reprint Transcriptome analysis and kidney research: toward systems biology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 67:2114-22. 2005
    ....
  51. doi request reprint Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians
    Ondrej Seda
    Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
    Hypertension 51:1156-62. 2008
    ..Many of these would have been missed in a traditional, sex-adjusted setting...
  52. ncbi request reprint Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
    David L Mattson
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F1905-14. 2007
    ..The present data indicate that genes that can modify l-NAME-induced hypertension and proteinuria are on chromosomes 1, 15, 16, 18, and 20...
  53. ncbi request reprint Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53266, USA
    Physiol Genomics 31:228-35. 2007
    ..We conclude from these studies that there are four regions within chromosome 13 containing genes that interact epistatically and influence arterial pressure...
  54. ncbi request reprint Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway
    Paul M O'Connor
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F526-32. 2007
    ..We conclude that AVP-induced NO production in IMCD is dependent on V2R activation of the phosphoinositide pathway and the mobilization of Ca(2+) from both intracellular and extracellular pools...
  55. ncbi request reprint Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 49:1336-41. 2007
    ..Diffusion of O(2)(*-) from mTAL to surrounding tissue could contribute to reduced bioavailability of NO, reductions of medullary blood flow, and interstitial fibrosis in the outer medulla of SS/Mcwi rats...
  56. doi request reprint Renal regional proteomes in young Dahl salt-sensitive rats
    Zhongmin Tian
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 51:899-904. 2008
    ....
  57. ncbi request reprint Effect of renal medullary H2O2 on salt-induced hypertension and renal injury
    Norman E Taylor
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1573-9. 2005
    ..These data show that medullary production of H2O2 may contribute to salt-induced hypertension in SS rats and that chromosome 13 of the Brown Norway contains gene(s) that protect against renal medullary oxidant stress...
  58. ncbi request reprint Genomics and homeostasis
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R611-27. 2003
    ..The previously unimaginable goal of connecting approximately 36,000 genes to the complex functions of mammalian systems is indeed well underway...
  59. ncbi request reprint Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 16:194-203. 2004
    ..These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat...
  60. ncbi request reprint Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Physiol Genomics 15:243-57. 2003
    ..The development of a female rat systems biology map of cardiovascular function represents the first attempt to prioritize those regions of the genome important for development of hypertension and end organ damage in female rats...
  61. ncbi request reprint Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medulla
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 42:588-93. 2003
    ..We conclude that AngII stimulates O2*- production in mTAL via the NAD(P)H oxidase pathway and that interactions of O2*- and NO ultimately determine the effectiveness of in situ free-radical cross-talk between the mTAL and the VR...
  62. ncbi request reprint Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction
    Jeffrey G Dickhout
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 91:487-93. 2002
    ..We conclude that Ang II increases [Ca2+]i in pericytes of the descending vasa recta as part of its constrictor action and that this vasoconstriction is buffered by the NO from the surrounding tubular elements, such as mTALs...
  63. ncbi request reprint Identification of hypertension-related QTLs in African American sib pairs
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 40:634-9. 2002
    ..Focusing on hypertension-related phenotypes is a promising approach for identifying the genetic determinants of hypertension...
  64. ncbi request reprint Quantitative assessment of the importance of dye switching and biological replication in cDNA microarray studies
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 14:199-207. 2003
    ..Recommendations regarding the use of these procedures were proposed...
  65. ncbi request reprint Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 12:229-37. 2003
    ....
  66. ncbi request reprint Increased H(2)O(2) counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medulla
    Ya Fei Chen
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 285:R827-33. 2003
    ..This counteracting effect of H2O2 may limit the use of tempol as an antihypertensive agent under exaggerated oxidative stress in the kidney...
  67. ncbi request reprint Increased renal medullary H2O2 leads to hypertension
    Ayako Makino
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 42:25-30. 2003
    ....
  68. ncbi request reprint Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II
    Baozhi Yuan
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1219-30. 2003
    ....
  69. ncbi request reprint Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II
    Mátyás Szentiványi
    Clinical Research Department, 2nd Institute of Physiology, Semmelweis University of Medicine, H 1088 Budapest, Hungary
    Am J Physiol Regul Integr Comp Physiol 283:R266-72. 2002
    ..These results indicate that an impaired NO counterregulatory system in the outer medulla of Dahl S rats makes them more susceptible to the hypertensive actions of small elevations of ANG II...
  70. pmc High throughput gene expression profiling: a molecular approach to integrative physiology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:22-30. 2004
    ..With a keen sense of homeostasis, global regulation, and quantitative analysis, integrative physiologists are uniquely positioned to apply these techniques to enhance the understanding of complex physiological functions...
  71. ncbi request reprint Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 8:139-49. 2002
    ..These results should provide an informative source for designing future functional studies in salt-sensitive hypertension...
  72. ncbi request reprint Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53326, USA
    Hypertension 39:465-9. 2002
    ..We conclude that AVP mobilizes Ca(2+) to produce NO in IMCDs...
  73. ncbi request reprint Hyperaldosteronism and hypertension: ethnic differences
    Clarence E Grim
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:766-72. 2005
    ..These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks...
  74. ncbi request reprint Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II
    Magdalena Alonso-Galicia
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 59226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R60-8. 2002
    ....
  75. ncbi request reprint Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 288:F1015-22. 2005
    ..Qualitatively similar results were obtained from female FHH, FHH-1BN, and BN rats. The present results indicate that genes contributing to l-NAME-induced hypertension and renal disease are found on chromosome 1 of the FHH rat...
  76. ncbi request reprint Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  77. ncbi request reprint Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:752-9. 2004
    ..We conclude that the preferential juxtamedullary injury found in Ang II hypertension is largely induced by pressure and is probably mediated through the TGF-beta and NF-kappaB pathway...
  78. ncbi request reprint Increased renal medullary oxidative stress produces hypertension
    Ayako Makino
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 39:667-72. 2002
    ..The present experiments indicate that an increase in superoxide concentration within the renal medulla selectively reduces medullary blood flow resulting in chronic hypertension...
  79. ncbi request reprint A genealogical study of essential hypertension with and without obesity in French Canadians
    Zdenka Pausova
    University of Montreal Health Centre, Canada
    Obes Res 10:463-70. 2002
    ....
  80. ncbi request reprint Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:341-6. 2004
    ..We conclude that elevations of extracellular NaCl, D-glucose, or T3 levels can activate both the Na+/K+-ATPase pump and Na+/H+ exchanger in mTAL, which, in turn, is associated with increased intracellular concentrations of superoxide...
  81. ncbi request reprint Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus
    Albert Sarkis
    Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Am J Physiol Renal Physiol 289:F1333-40. 2005
    ....
  82. doi request reprint Harnessing "omic" tools and computational hypothesis-driven approaches to understand biocomplexity: the future of Physiological Genomics
    Allen W Cowley
    Physiol Genomics 33:1-2. 2008
  83. ncbi request reprint In memoriam. Arthur C. Guyton (1919-2003)
    John E Hall
    University of Mississippi, USA
    Physiologist 46:126-8. 2003
  84. ncbi request reprint Physiological Genomics: the next three years
    Allen W Cowley
    Physiol Genomics 14:169-70. 2003
  85. ncbi request reprint Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery
    David D Gutterman
    Am J Physiol Heart Circ Physiol 291:H2555-6. 2006
  86. ncbi request reprint IUPS--a retrospective
    Allen W Cowley
    IUPS, USA
    Physiologist 49:171-3. 2006
  87. ncbi request reprint The elusive field of systems biology
    Allen W Cowley
    Physiol Genomics 16:285-6. 2004
  88. ncbi request reprint Genome-wide scan for linkage to obesity-associated hypertension in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, United Kingdom
    Hypertension 46:1280-5. 2005
    ..These results suggest that investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, may facilitate the search for genes of this complex disorder...
  89. pmc Physiological genomics: tools and concepts
    Allen W Cowley
    J Physiol 554:3. 2004
  90. ncbi request reprint Genomics and proteomics of lung disease: conference summary
    J Usha Raj
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007

Research Grants15

  1. Mechanisms of Hypertension-induced Renal Injury
    Allen W Cowley; Fiscal Year: 2010
    ..An understanding of these mechanisms could lead to new therapeutic approaches for the prevention of kidney disease in hypertension. ..
  2. Joint and Muscle Dysfunction of Temporomandibular Joint
    Allen Cowley; Fiscal Year: 2002
    ....
  3. Mechanisms of Hypertension-induced Renal Injury
    Allen Cowley; Fiscal Year: 2009
    ..An understanding of these mechanisms could lead to new therapeutic approaches for the prevention of kidney disease in hypertension. ..
  4. Genetic & Physiological Basis of Salt-induced Hypertension
    Allen Cowley; Fiscal Year: 2007
    ..The four Cores that will provide support for the PPG include: A) Administrative Core; B) Genomics Core; C) Transgenics Core; D) Research Services Core. ..
  5. Hypertension and Vascular Biology Training Grant
    Allen Cowley; Fiscal Year: 2007
    ..We are encouraged by the success of the training program thus far and the number of high quality applicants in our pools, so we are therefore requesting that the number of slots be increased from five to nine. ..
  6. A Systems Approach to the Understanding of TMJ as a Complex Disease
    Allen Cowley; Fiscal Year: 2006
    ..To develop a compelling set of recommendations for research initiatives in TMJDs that would synergize the work of multiple Institutes and Centers of the National Institutes of Health and that of academic health centers. ..
  7. Advancing Diagnostic Approaches for TMJ Disorders
    Allen Cowley; Fiscal Year: 2004
    ..abstract_text> ..