C R Chitambar

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes
    Christopher R Chitambar
    Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Antioxid Redox Signal 18:956-72. 2013
  2. ncbi request reprint Gallium nitrate for the treatment of non-Hodgkin's lymphoma
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Expert Opin Investig Drugs 13:531-41. 2004
  3. ncbi request reprint Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67Ga
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Nucl Med 44:943-6. 2003
  4. ncbi request reprint Gallium compounds as antineoplastic agents
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Curr Opin Oncol 16:547-52. 2004
  5. ncbi request reprint Apoptotic mechanisms of gallium nitrate: basic and clinical investigations
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Oncology (Williston Park) 18:39-44. 2004
  6. ncbi request reprint Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cancer 119:2200-4. 2006
  7. ncbi request reprint Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibition
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226
    Mol Cancer Ther 5:2834-43. 2006
  8. ncbi request reprint Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrate
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 322:1228-36. 2007
  9. pmc A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, WI, USA
    Leuk Res 34:950-3. 2010
  10. pmc Medical applications and toxicities of gallium compounds
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Environ Res Public Health 7:2337-61. 2010

Research Grants

  1. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2005
  2. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2006
  3. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. pmc Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes
    Christopher R Chitambar
    Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Antioxid Redox Signal 18:956-72. 2013
    ..Despite advances made in the treatment of cancer, a significant number of patients succumb to this disease every year. Hence, there is a great need to develop new anticancer agents...
  2. ncbi request reprint Gallium nitrate for the treatment of non-Hodgkin's lymphoma
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Expert Opin Investig Drugs 13:531-41. 2004
    ..Multi-institutional Phase II clinical trials are in progress to evaluate gallium nitrate as a single agent or in combination. These studies will help define its role in the current treatment of NHL...
  3. ncbi request reprint Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67Ga
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Nucl Med 44:943-6. 2003
    ..Because of similarities in the transport of gallium and iron and the use of (67)Ga scanning in lymphoid malignancies, we examined the effect of HFE expression on (67)Ga uptake...
  4. ncbi request reprint Gallium compounds as antineoplastic agents
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Curr Opin Oncol 16:547-52. 2004
    ..Gallium nitrate has recently become commercially available, thus reopening the door for clinical trials evaluating it as an antineoplastic agent...
  5. ncbi request reprint Apoptotic mechanisms of gallium nitrate: basic and clinical investigations
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Oncology (Williston Park) 18:39-44. 2004
    ..Gallium nitrate is not myelosuppressive and may be used in patients with neutropenia or thrombocytopenia. A multicenter trial to evaluate the use of gallium nitrate in patients with relapsed non-Hodgkin's lymphoma is currently ongoing...
  6. ncbi request reprint Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cancer 119:2200-4. 2006
    ..Further investigation is warranted to determine whether HFE expression in tumor cells impacts on the clinical efficacy of doxorubicin...
  7. ncbi request reprint Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibition
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226
    Mol Cancer Ther 5:2834-43. 2006
    ..Our studies also suggest that the antineoplastic activity of combination gallium nitrate and bortezomib warrants further investigation...
  8. ncbi request reprint Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrate
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 322:1228-36. 2007
    ..Further studies to evaluate its antineoplastic activity in vivo are warranted...
  9. pmc A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, WI, USA
    Leuk Res 34:950-3. 2010
    ..Our results show for the first time that the proteasome may be a target for gallium maltolate and suggest that the therapeutic potential of combination bortezomib and gallium maltolate warrants further investigation...
  10. pmc Medical applications and toxicities of gallium compounds
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Environ Res Public Health 7:2337-61. 2010
    ..This review will discuss the medical applications of gallium and its mechanisms of action, the newer gallium compounds and future directions for development, and the toxicities of gallium compounds in current use...
  11. ncbi request reprint Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutation
    C R Chitambar
    Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 97:2734-40. 2001
    ..The role of HFE in iron uptake by B cells may extend beyond its known interaction with the TfR...
  12. pmc Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase
    C R Chitambar
    Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Ave, WI 53226, Milwaukee, USA
    Biochem J 345:681-5. 2000
    ..Furthermore, our studies suggest a regulatory link between ribonucleotide reductase activity and iron transport into these cells...
  13. ncbi request reprint Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin production
    C R Chitambar
    Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 272:12151-7. 1997
    ..Furthermore, since gallium has divergent effects on iron uptake and ferritin synthesis, its action may also include a direct effect on ferritin mRNA induction and IRP-1 activity...
  14. ncbi request reprint Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase
    D A Green
    Division of Hematology/Oncology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA
    Clin Cancer Res 7:3574-9. 2001
    ..Furthermore, the ESR studies suggest that inhibition of the R2 subunit of ribonucleotide reductase is at least one mechanism by which 311 blocks cell proliferation...
  15. ncbi request reprint Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrate
    Meiying Yang
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Mol Cancer Ther 6:633-43. 2007
    ..Furthermore, the endogenous level of metallothionein in lymphoma may be an important determinant of clinical response to gallium nitrate...
  16. ncbi request reprint Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis
    Srigiridhar Kotamraju
    Biophysics Department, Medical College of Wisconsin, Milwaukee 53226, USA
    Methods Enzymol 378:362-82. 2004
  17. ncbi request reprint Case reports: efalizumab-associated lymphoproliferative disease
    Satya Bommakanti
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Drugs Dermatol 6:646-8. 2007
    ..Thus, physicians need to have a high index of suspicion for malignancy in patients on immunosuppressive medications like efalizumab...
  18. pmc Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells
    Meiying Yang
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Free Radic Biol Med 45:763-72. 2008
    ..We conclude that gallium nitrate induces cellular oxidative stress as an early event which then triggers the expression of HO-1 and MT2A through different pathways...
  19. ncbi request reprint Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis
    Yoshiko Tampo
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 92:56-63. 2003
    ....
  20. ncbi request reprint Gallium nitrate revisited
    Christopher R Chitambar
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Semin Oncol 30:1-4. 2003
    ....
  21. ncbi request reprint Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis
    Srigiridhar Kotamraju
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 277:17179-87. 2002
    ..The implications of TfR-dependent iron transport in oxidant-induced apoptosis in endothelial cells are discussed...
  22. ncbi request reprint CD5+ T-cell/histiocyte-rich large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 15:1051-7. 2002
    ..This will lead to identifying more cases to understand the clinical and biologic characteristics of this variant...
  23. ncbi request reprint Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?
    Srigiridhar Kotamraju
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, USA
    Arch Biochem Biophys 423:74-80. 2004
    ..The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications...
  24. ncbi request reprint Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemma
    Bal Kampalath
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Leuk Lymphoma 45:409-14. 2004
    ..In such cases an optimum treatment strategy should be adopted to cover both malignancies with minimal toxic effect...
  25. ncbi request reprint Cellular iron metabolism: mitochondria in the spotlight
    Christopher R Chitambar
    Medical College of Wisconsin, WI, USA
    Blood 105:1844-5. 2005
    ....
  26. pmc Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway
    Srigiridhar Kotamraju
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:10653-8. 2003
    ..The relevance of biological nitration on redox signaling is discussed...
  27. ncbi request reprint Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia
    Chung Che Chang
    Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 100:4671-5. 2002
    ..Our results suggest that B-CLL with expression of MUM1/IRF4, indicative of postgerminal center origin, has a more favorable clinical course and that MUM1/IRF4 is an important prognostic marker in B-CLL...
  28. ncbi request reprint Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, P O Box 4380, 55033, Mainz, Germany
    Blood Cells Mol Dis 29:1-13. 2002
    ..Furthermore, methotrexate-resistant cell lines clustered together. Our future efforts will be directed toward those imbalances which implicate still unknown candidate drug resistance genes...
  29. ncbi request reprint Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates
    Neil P Davies
    Children s Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, Randwick, Sydney, New South Wales
    J Pharmacol Exp Ther 317:153-62. 2006
    ..In contrast to the general view that (67)Ga and (59)Fe use the same or similar uptake pathways, we show that their distribution and trafficking is markedly different in R and S cells...
  30. ncbi request reprint Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, D 55126 Mainz, Germany
    Int J Oncol 23:509-17. 2003
    ..Homo- or heterozygosity did not correlate to survival of patients in the Kaplan-Meier analysis. In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients...
  31. pmc Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine
    Jill M Kolesar
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin Madison, 600 Highland Avenue, Room K4 554, Madison, WI 53792, USA
    J Inorg Biochem 102:693-8. 2008
    ..A potential source for the increase in the heme signal is cytochrome c released from the mitochondria. These results provide valuable insight into the in vivo mechanism of action of Triapine...

Research Grants4

  1. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2005
    ..Our studies will provide new information regarding: a) the impact of HFE mutations on the response of lymphoma to gallium, and, b) the mechanism of action of gallium at the mitochondrial level. ..
  2. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2006
    ..Our studies will provide new information regarding: a) the impact of HFE mutations on the response of lymphoma to gallium, and, b) the mechanism of action of gallium at the mitochondrial level. ..
  3. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2007
    ..Our studies will provide new information regarding: a) the impact of HFE mutations on the response of lymphoma to gallium, and, b) the mechanism of action of gallium at the mitochondrial level. ..