Research Topics
| C R ChitambarSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexesChristopher R Chitambar
1 Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
Antioxid Redox Signal 18:956-72. 2013..This will help direct gallium-based therapy to cancer patients who are most likely to benefit from it. Antioxid. Redox Signal. 00, 000-000...
Gallium nitrate for the treatment of non-Hodgkin's lymphomaChristopher R Chitambar
Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Expert Opin Investig Drugs 13:531-41. 2004..Multi-institutional Phase II clinical trials are in progress to evaluate gallium nitrate as a single agent or in combination. These studies will help define its role in the current treatment of NHL...- Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67GaChristopher R Chitambar
Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Nucl Med 44:943-6. 2003..Because of similarities in the transport of gallium and iron and the use of (67)Ga scanning in lymphoid malignancies, we examined the effect of HFE expression on (67)Ga uptake... - Gallium compounds as antineoplastic agentsChristopher R Chitambar
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Curr Opin Oncol 16:547-52. 2004..Gallium nitrate has recently become commercially available, thus reopening the door for clinical trials evaluating it as an antineoplastic agent... - Apoptotic mechanisms of gallium nitrate: basic and clinical investigationsChristopher R Chitambar
Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Oncology (Williston Park) 18:39-44. 2004..Gallium nitrate is not myelosuppressive and may be used in patients with neutropenia or thrombocytopenia. A multicenter trial to evaluate the use of gallium nitrate in patients with relapsed non-Hodgkin's lymphoma is currently ongoing... - Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cellsChristopher R Chitambar
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Int J Cancer 119:2200-4. 2006..Further investigation is warranted to determine whether HFE expression in tumor cells impacts on the clinical efficacy of doxorubicin... - Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibitionChristopher R Chitambar
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226
Mol Cancer Ther 5:2834-43. 2006..Our studies also suggest that the antineoplastic activity of combination gallium nitrate and bortezomib warrants further investigation... - Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrateChristopher R Chitambar
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 322:1228-36. 2007..Further studies to evaluate its antineoplastic activity in vivo are warranted... - A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cellsChristopher R Chitambar
Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, WI, USA
Leuk Res 34:950-3. 2010..Our results show for the first time that the proteasome may be a target for gallium maltolate and suggest that the therapeutic potential of combination bortezomib and gallium maltolate warrants further investigation... - Medical applications and toxicities of gallium compoundsChristopher R Chitambar
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Int J Environ Res Public Health 7:2337-61. 2010..This review will discuss the medical applications of gallium and its mechanisms of action, the newer gallium compounds and future directions for development, and the toxicities of gallium compounds in current use... - Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutationC R Chitambar
Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
Blood 97:2734-40. 2001..The role of HFE in iron uptake by B cells may extend beyond its known interaction with the TfR... - Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductaseC R Chitambar
Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Ave, WI 53226, Milwaukee, USA
Biochem J 345:681-5. 2000..Furthermore, our studies suggest a regulatory link between ribonucleotide reductase activity and iron transport into these cells... - Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin productionC R Chitambar
Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 272:12151-7. 1997..Furthermore, since gallium has divergent effects on iron uptake and ferritin synthesis, its action may also include a direct effect on ferritin mRNA induction and IRP-1 activity... - Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductaseD A Green
Division of Hematology/Oncology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA
Clin Cancer Res 7:3574-9. 2001..Furthermore, the ESR studies suggest that inhibition of the R2 subunit of ribonucleotide reductase is at least one mechanism by which 311 blocks cell proliferation... - Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrateMeiying Yang
Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Mol Cancer Ther 6:633-43. 2007..Furthermore, the endogenous level of metallothionein in lymphoma may be an important determinant of clinical response to gallium nitrate... - Oxidant-induced iron signaling in Doxorubicin-mediated apoptosisSrigiridhar Kotamraju
Biophysics Department, Medical College of Wisconsin, Milwaukee 53226, USA
Methods Enzymol 378:362-82. 2004 - Case reports: efalizumab-associated lymphoproliferative diseaseSatya Bommakanti
Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Drugs Dermatol 6:646-8. 2007..Thus, physicians need to have a high index of suspicion for malignancy in patients on immunosuppressive medications like efalizumab... - Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cellsMeiying Yang
Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Free Radic Biol Med 45:763-72. 2008..We conclude that gallium nitrate induces cellular oxidative stress as an early event which then triggers the expression of HO-1 and MT2A through different pathways... - Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosisYoshiko Tampo
Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
Circ Res 92:56-63. 2003.... - Gallium nitrate revisitedChristopher R Chitambar
Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Semin Oncol 30:1-4. 2003.... - Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosisSrigiridhar Kotamraju
Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 277:17179-87. 2002..The implications of TfR-dependent iron transport in oxidant-induced apoptosis in endothelial cells are discussed... - CD5+ T-cell/histiocyte-rich large B-cell lymphomaChung Che Chang
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Mod Pathol 15:1051-7. 2002..This will lead to identifying more cases to understand the clinical and biologic characteristics of this variant... - Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?Srigiridhar Kotamraju
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, USA
Arch Biochem Biophys 423:74-80. 2004..The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications... - Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemmaBal Kampalath
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Leuk Lymphoma 45:409-14. 2004..In such cases an optimum treatment strategy should be adopted to cover both malignancies with minimal toxic effect... - Cellular iron metabolism: mitochondria in the spotlightChristopher R Chitambar
Medical College of Wisconsin, WI, USA
Blood 105:1844-5. 2005.... - Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathwaySrigiridhar Kotamraju
Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 100:10653-8. 2003..The relevance of biological nitration on redox signaling is discussed... - Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemiaChung Che Chang
Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
Blood 100:4671-5. 2002..Our results suggest that B-CLL with expression of MUM1/IRF4, indicative of postgerminal center origin, has a more favorable clinical course and that MUM1/IRF4 is an important prognostic marker in B-CLL... - Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell linesThomas Efferth
Virtual Campus Rhineland Palatinate, P O Box 4380, 55033, Mainz, Germany
Blood Cells Mol Dis 29:1-13. 2002..Furthermore, methotrexate-resistant cell lines clustered together. Our future efforts will be directed toward those imbalances which implicate still unknown candidate drug resistance genes... - Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediatesNeil P Davies
Children's Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, Randwick, Sydney, New South Wales
J Pharmacol Exp Ther 317:153-62. 2006..In contrast to the general view that (67)Ga and (59)Fe use the same or similar uptake pathways, we show that their distribution and trafficking is markedly different in R and S cells... - Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemiaThomas Efferth
Virtual Campus Rhineland Palatinate, D 55126 Mainz, Germany
Int J Oncol 23:509-17. 2003..Homo- or heterozygosity did not correlate to survival of patients in the Kaplan-Meier analysis. In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients... - Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with TriapineJill M Kolesar
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin Madison, 600 Highland Avenue, Room K4 554, Madison, WI 53792, USA
J Inorg Biochem 102:693-8. 2008..A potential source for the increase in the heme signal is cytochrome c released from the mitochondria. These results provide valuable insight into the in vivo mechanism of action of Triapine...
Research Grants
- Cellular Targets for Gallium Compounds in LymphomaChristopher Chitambar; Fiscal Year: 2007..Our studies will provide new information regarding: a) the impact of HFE mutations on the response of lymphoma to gallium, and, b) the mechanism of action of gallium at the mitochondrial level. ..