Ahmed Chahdi

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases
    Wahn Soo Choi
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1760, USA
    Ann N Y Acad Sci 968:198-212. 2002
  2. ncbi request reprint The Rac/Cdc42 guanine nucleotide exchange factor beta1Pix enhances mastoparan-activated Gi-dependent pathway in mast cells
    Ahmed Chahdi
    Division of Nephrology and the Cardiovascular Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 317:384-9. 2004
  3. pmc Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2
    Tengis S Pavlov
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 21:833-43. 2010
  4. pmc Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt
    Ahmed Chahdi
    Kidney Disease Center, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Biol Cell 19:2609-19. 2008
  5. pmc Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding
    Ahmed Chahdi
    Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Cell Biol 28:1679-87. 2008
  6. ncbi request reprint Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway
    Ahmed Chahdi
    Division of Nephrology, Department of Medicine, Kidney Disease Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Exp Biol Med (Maywood) 231:761-5. 2006
  7. pmc Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction
    Ahmed Chahdi
    Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, 53226, United States
    Cell Signal 22:325-9. 2010
  8. pmc The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits
    Ahmed Chahdi
    Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Biochem Biophys Res Commun 391:1330-5. 2010
  9. ncbi request reprint Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway
    Ahmed Chahdi
    Department of Medicine, Division of Nephrology, Kidney Disease Center and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:578-84. 2005
  10. pmc Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr
    Wahn Soo Choi
    Laboratory of Molecular Immunology, National, Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:6980-92. 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases
    Wahn Soo Choi
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1760, USA
    Ann N Y Acad Sci 968:198-212. 2002
    ..The pathological/physiological implications of the regulation of PLD by PKA require further evaluation in other cell systems...
  2. ncbi request reprint The Rac/Cdc42 guanine nucleotide exchange factor beta1Pix enhances mastoparan-activated Gi-dependent pathway in mast cells
    Ahmed Chahdi
    Division of Nephrology and the Cardiovascular Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 317:384-9. 2004
    ..Taken together, these findings implicate beta1Pix in regulating hexoasaminidase secretion and IP3 production in early stage upon mastoparan stimulation...
  3. pmc Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2
    Tengis S Pavlov
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 21:833-43. 2010
    ..Taken together, these results suggest that the inhibitory effects of chronic ET-1 on ENaC result from betaPix interacting with the 14-3-3/Nedd4-2 pathway...
  4. pmc Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt
    Ahmed Chahdi
    Kidney Disease Center, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Biol Cell 19:2609-19. 2008
    ..Our results identify p66Shc and FOXO3a as novel partners of beta(1)Pix and represent the first direct evidence of beta(1)Pix in cell proliferation via Erk/p66Shc-dependent and Akt-independent mechanisms...
  5. pmc Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding
    Ahmed Chahdi
    Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Cell Biol 28:1679-87. 2008
    ..These results indicate that 14-3-3beta negatively affects the GEF activity of dimeric beta(1)Pix only. Altogether, these results provide a mechanistic insight into the role of 14-3-3beta in modulating beta(1)Pix-GEF activity...
  6. ncbi request reprint Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway
    Ahmed Chahdi
    Division of Nephrology, Department of Medicine, Kidney Disease Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Exp Biol Med (Maywood) 231:761-5. 2006
    ..These results demonstrate that beta1Pix, along with PKA, plays a crucial role in the regulation of Cdc42 activation by ET-1...
  7. pmc Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction
    Ahmed Chahdi
    Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, 53226, United States
    Cell Signal 22:325-9. 2010
    ..Inhibition of Erk1/2 blocked p66Shc activation induced by ET-1. Altogether, our results indicate that ET-1 activates p66Shc through EGF receptor transactivation, leading to the activation of Galpha(i3), beta(1)Pix and Erk1/2...
  8. pmc The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits
    Ahmed Chahdi
    Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Biochem Biophys Res Commun 391:1330-5. 2010
    ....
  9. ncbi request reprint Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway
    Ahmed Chahdi
    Department of Medicine, Division of Nephrology, Kidney Disease Center and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:578-84. 2005
    ..Our results have provided evidence that stimulation of PKA pathway by ET-1 or cAMP analog results in beta(1)Pix phosphorylation, which in turn controls beta(1)Pix translocation to focal complexes and Cdc42 activation...
  10. pmc Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr
    Wahn Soo Choi
    Laboratory of Molecular Immunology, National, Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:6980-92. 2004
    ..The findings provide the first description of a mechanism for activation of PLD2 in a physiological setting and of a role for Fgr in Fc epsilon RI-mediated signaling...
  11. ncbi request reprint Mastoparan selectively activates phospholipase D2 in cell membranes
    Ahmed Chahdi
    Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1760, USA
    J Biol Chem 278:12039-45. 2003
    ..Therefore, mastoparan may be useful for investigating the regulation of PLD2, particularly in view of the well studied molecular interactions of mastoparan with certain other strategic signaling proteins...
  12. ncbi request reprint Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells
    Ahmed Chahdi
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892 1760, USA
    Mol Immunol 38:1269-76. 2002
    ..As the expressed PLD1 was associated with secretory granules and PLD2 with the plasma membrane, the two isoforms may serve distinct but complementary functions in secretion...