M F Casanova

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Intracortical circuitry: one of psychiatry's missing assumptions
    Manuel F Casanova
    Medical College of Georgia, Department of Psychiatry, 1515 Pope St, Augusta, 30910, USA
    Eur Arch Psychiatry Clin Neurosci 254:148-51. 2004
  2. ncbi request reprint Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Anatomy and Cell Biology, Medical College of Georgia, Augusta, GA 30904 6285, USA
    Am J Geriatr Psychiatry 11:605-9. 2003
  3. ncbi request reprint Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, GA 30912, USA
    Psychiatry Res 121:59-87. 2003
  4. ncbi request reprint Rett syndrome as a minicolumnopathy
    M F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Clin Neuropathol 22:163-8. 2003
  5. ncbi request reprint Preservation of hippocampal pyramidal cells in paraphrenia
    Manuel F Casanova
    Medical College of Georgia, Downtown VA Medical Center 24, 26 Psychiatry Service, Room 3B 121, One Freedom Way, Augusta, GA 30910 6285, USA
    Schizophr Res 62:141-6. 2003
  6. ncbi request reprint Modular concepts of brain organization and the neuropathology of psychiatric conditions
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Psychiatry Res 118:101-2. 2003
  7. ncbi request reprint Clinical and macroscopic correlates of minicolumnar pathology in autism
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:692-5. 2002
  8. ncbi request reprint Neuronal density and architecture (Gray Level Index) in the brains of autistic patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:515-21. 2002
  9. ncbi request reprint Senile plaques exert no mass lesion effect on surrounding neurons
    M F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, USA
    J Neurosci Methods 110:125-33. 2001
  10. ncbi request reprint Minicolumnar pathology in autism
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA 30910, USA
    Neurology 58:428-32. 2002

Detail Information

Publications41

  1. ncbi request reprint Intracortical circuitry: one of psychiatry's missing assumptions
    Manuel F Casanova
    Medical College of Georgia, Department of Psychiatry, 1515 Pope St, Augusta, 30910, USA
    Eur Arch Psychiatry Clin Neurosci 254:148-51. 2004
    ..An appreciation of the modular framework of the brain provides a better insight as to how minicolumns contribute to the larger scope of information processing in the normal and pathological state...
  2. ncbi request reprint Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Anatomy and Cell Biology, Medical College of Georgia, Augusta, GA 30904 6285, USA
    Am J Geriatr Psychiatry 11:605-9. 2003
    ..The present article is an attempt at finding a macroscopic correlate to the described pathology...
  3. ncbi request reprint Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, GA 30912, USA
    Psychiatry Res 121:59-87. 2003
    ..The authors suggest that these metabolic abnormalities may link basal ganglia mineralization to psychotic symptomatology...
  4. ncbi request reprint Rett syndrome as a minicolumnopathy
    M F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Clin Neuropathol 22:163-8. 2003
    ..Patients with Rett syndrome are often misdiagnosed as autistic. Recent reports of minicolumnar abnormalities in the brains of autistic and Asperger's syndrome prompted us to search for similar pathology in Rett syndrome...
  5. ncbi request reprint Preservation of hippocampal pyramidal cells in paraphrenia
    Manuel F Casanova
    Medical College of Georgia, Downtown VA Medical Center 24, 26 Psychiatry Service, Room 3B 121, One Freedom Way, Augusta, GA 30910 6285, USA
    Schizophr Res 62:141-6. 2003
    ..The lack of cell loss not only distinguishes paraphrenia from Alzheimer's disease but offers, in addition, a marked similarity to a condition denoted in the medical literature as senile dementia with tangles...
  6. ncbi request reprint Modular concepts of brain organization and the neuropathology of psychiatric conditions
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA, USA
    Psychiatry Res 118:101-2. 2003
  7. ncbi request reprint Clinical and macroscopic correlates of minicolumnar pathology in autism
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:692-5. 2002
    ..This article relates different aspects of the cell minicolumn and larger-scale neuronal assemblies to potential research techniques and their application to clinical practice...
  8. ncbi request reprint Neuronal density and architecture (Gray Level Index) in the brains of autistic patients
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, Augusta, USA
    J Child Neurol 17:515-21. 2002
    ..4% in controls and 18.7% in autism (P = .724). In autism, an increased number of minicolumns, combined with fewer cells per column (or their greater dispersion), results in no global difference in neuronal density...
  9. ncbi request reprint Senile plaques exert no mass lesion effect on surrounding neurons
    M F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, USA
    J Neurosci Methods 110:125-33. 2001
    ..Contrary to earlier reports, our results noted no evidence of pyramidal cell disarray in schizophrenic patients. Our results suggest that SP's incorporate, rather than displace, their surrounding neuropil...
  10. ncbi request reprint Minicolumnar pathology in autism
    Manuel F Casanova
    Medical College of Georgia, Augusta, GA 30910, USA
    Neurology 58:428-32. 2002
    ..To determine whether differences exist in the configuration of minicolumns between the brains of autistic and control patients...
  11. ncbi request reprint Disentangling the pathology of schizophrenia and paraphrenia
    Manuel F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, Downtown VA Medical Center, 1 Freedom Way, 26 Psychiatry Service, 3B 121, Augusta, GA 30910, USA
    Acta Neuropathol 103:313-20. 2002
    ....
  12. ncbi request reprint Asperger's syndrome and cortical neuropathology
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, USA
    J Child Neurol 17:142-5. 2002
    ..The minicolumnar changes provide a possible link to receptive field abnormalities and a useful clinicopathologic correlate to Asperger's syndrome...
  13. ncbi request reprint Hippocampal pathology in two mentally ill paraphiliacs
    Manuel F Casanova
    Medical College of Georgia, 3B 121, Downtown VA Medical Center 24, Augusta, GA 30910, USA
    Psychiatry Res 115:79-89. 2002
    ..The accompanying astrocytosis indicates a reactive, ongoing process. The findings suggest new therapeutic interventions in the treatment of paraphilia...
  14. ncbi request reprint Quantitative analysis of cell columns in the cerebral cortex
    D P Buxhoeveden
    Downtown VA Medical Center, 116 A, Psychiatry Service, 3B 121, Augusta, GA 30904, USA
    J Neurosci Methods 97:7-17. 2000
    ..On this basis several algorithms describe the distribution of cells from the center line and in relation to the available surrounding space. Other algorithms use cluster analyses to determine the spatial orientation of every column...
  15. ncbi request reprint Morphological differences between minicolumns in human and nonhuman primate cortex
    D P Buxhoeveden
    Department of Psychiatry, Medical College of Georgia, Augusta, Georgia 30904, USA
    Am J Phys Anthropol 115:361-71. 2001
    ..Because the minicolumn is a basic anatomical and functional unit of the cortex, this strong evidence showed reorganization in this area of the human brain. The relationship between the minicolumn and cortical volume is also discussed...
  16. ncbi request reprint Lateralization of minicolumns in human planum temporale is absent in nonhuman primate cortex
    D P Buxhoeveden
    Medical College of Georgia, Downtown VA Medical Center, Psychiatry Service, Augusta, GA 30904, USA
    Brain Behav Evol 57:349-58. 2001
    ..Only human brain tissue revealed robust asymmetry in two aspects of minicolumn morphology: wider columns and more neuropil space on the left side. This asymmetry was absent in chimpanzee and rhesus monkey brains...
  17. ncbi request reprint [Schizophrenia as a neurological condition caused by a failure in the lateralisation of the brain: macro and microscopic observations]
    M F Casanova
    University of Louisville, Department of Psychiatry, Louisville, KY 40202, USA
    Rev Neurol 49:136-42. 2009
    ..Some of its salient symptomatology refers to language abnormalities that resemble an aphasic disorder. Recent studies suggest that brain structures that define language functions may be abnormally lateralized in schizophrenic patients...
  18. ncbi request reprint Minicolumnar abnormalities in autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    Acta Neuropathol 112:287-303. 2006
    ..A reduction in both somatic and nucleolar cross sections could reflect a bias towards shorter connecting fibers, which favors local computation at the expense of inter-areal and callosal connectivity...
  19. ncbi request reprint Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing
    Steven A Chance
    Department of Neuropathology, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK
    Acta Neuropathol 111:459-64. 2006
    ..Since old age is the greatest risk factor for dementia, the transition to dementia may involve an extension of normal ageing processes...
  20. ncbi request reprint A comparison study of the vertical bias of pyramidal cells in the hippocampus and neocortex
    Manuel F Casanova
    Department of Psychiatry, University of Louisville, Louisville, KY 40292, USA
    Dev Neurosci 29:193-200. 2007
    ..Pyramidal cell arrays within allocortical areas and the neocortex constitute different modular arrangements. This morphological variability may be the expression of evolutionary differences in cortical development...
  21. ncbi request reprint Schizophrenia seen as a deficit in the modulation of cortical minicolumns by monoaminergic systems
    Manuel F Casanova
    Department of Psychiatry, Neurology, and Anatomy, Medical College of Georgia, USA
    Int Rev Psychiatry 19:361-72. 2007
    ..This ontogenetic deficit propitiates a cascade of neurochemical changes resulting in varying abnormalities relating information processing to behavioural states...
  22. ncbi request reprint The neuropathology of autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Brain Pathol 17:422-33. 2007
    ..The significance of future controlled studies should be judged based on their explanatory powers; that is, how well do they relate to brain growth abnormalities and/or provide useful clinicopathological correlates...
  23. ncbi request reprint The minicolumn hypothesis in neuroscience
    Daniel P Buxhoeveden
    Department of Psychiatry, Medical College of Georgia, Augusta, GA, USA
    Brain 125:935-51. 2002
    ....
  24. ncbi request reprint Encephalization, emergent properties, and psychiatry: a minicolumnar perspective
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Neuroscientist 14:101-18. 2008
    ..In addition to reframing the evolution of mind, this perspective provides a conceptual framework for a better understanding of the origin and maladaptive nature of certain psychiatric conditions...
  25. pmc Recursive trace line method for detecting myelinated bundles: a comparison study with pyramidal cell arrays
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Building 55 A, Suite 217, Louisville, KY 40292, United States
    J Neurosci Methods 168:367-72. 2008
    ..The close correspondence of derived values for myelinated axon bundles and pyramidal cell arrays suggests their participation and interaction within the same modular arrangement of the isocortex...
  26. doi request reprint Neuronal distribution in the neocortex of schizophrenic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Psychiatry Res 158:267-77. 2008
    ..The findings suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicolumn...
  27. ncbi request reprint A temporal continuity to the vertical organization of the human neocortex
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Cereb Cortex 17:130-7. 2007
    ..Neuropil development follows a prenatal phase of cubic volumetric growth with a postnatal phase of linear volumetric growth. The data suggest the continuity of columnar structures from early in gestation through postnatal maturation...
  28. ncbi request reprint Disruption in the inhibitory architecture of the cell minicolumn: implications for autism
    Manuel F Casanova
    Department of Psychiatry, Medical College of Georgia, USA
    Neuroscientist 9:496-507. 2003
    ..The authors conclude that GABAergic interneurons are vital to proper minicolumnar differentiation and signal processing (e.g., filtering capacity of the neocortex), thus providing a putative correlate to autistic symptomatology...
  29. ncbi request reprint Mean cell spacing abnormalities in the neocortex of patients with schizophrenia
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, A Building, Room 217, Louisville, KY 40292, USA
    Psychiatry Res 133:1-12. 2005
    ..The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn...
  30. ncbi request reprint Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia
    Manuel F Casanova
    Medical College of Georgia, Downtown VA Medical Center, One Freedom Way, 26 Psychiatry Service, 3B 121, Augusta, GA 30904 6285, USA
    Schizophr Res 55:19-24. 2002
    ..0183). The findings were attributed to a bias accrued to referencing measurements in schizophrenics to the distorted circumventricular surface of the temporal horn...
  31. ncbi request reprint The minicolumn and evolution of the brain
    Daniel P Buxhoeveden
    Medical College of Georgia, Augusta, GA, USA
    Brain Behav Evol 60:125-51. 2002
    ..However, recent advances in methodology enable standardized, quantified comparisons of minicolumn morphology...
  32. ncbi request reprint Minicolumnar pathology in dyslexia
    Manuel F Casanova
    Department of Psychiatry and Neurology, Medical College of Georgia, Augusta, USA
    Ann Neurol 52:108-10. 2002
    ..We report minicolumnar abnormalities in the brain of a dyslexic patient. The corresponding developmental disturbance (ie, large minicolumns) could account for the perceptual errors observed in dyslexia...
  33. ncbi request reprint Autism diagnostics by 3D texture analysis of cerebral white matter gyrifications
    Ayman El-Baz
    Bioengineering Department, University of Louisville, Louisville, KY, USA
    Med Image Comput Comput Assist Interv 10:882-90. 2007
    ..Initial experimental results suggest that the proposed 3D texture analysis is a promising supplement to the current techniques for diagnosing autism...
  34. ncbi request reprint Comparative minicolumnar morphometry of three distinguished scientists
    Manuel F Casanova
    University of Louisville, Department of Psychiatry and Behavioral Sciences, KY 40292, USA
    Autism 11:557-69. 2007
    ..A minicolumnar phenotype that provides for discrimination and/or focused attention may help explain the savant abilities observed in some autistic people and the intellectually gifted...
  35. ncbi request reprint Magnetic resonance imaging study of brain asymmetries in dyslexic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, KY 40292, USA
    J Child Neurol 20:842-7. 2005
    ..This stream of temporal analysis is of importance in motor movements. Reading might have evolved as an exaptation to motor movements requiring the sequential analysis of information...
  36. ncbi request reprint White matter volume increase and minicolumns in autism
    Manuel F Casanova
    Ann Neurol 56:453; author reply 454. 2004
  37. pmc The minicolumnopathy of autism: A link between migraine and gastrointestinal symptoms
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, 500 South Preston Street, Building 55A, Room 217, Louisville, KY 40292, United States
    Med Hypotheses 70:73-80. 2008
    ..Abdominal migraine therefore stands as a falsifiable hypothesis with added importance accrued to potential therapeutic interventions...
  38. ncbi request reprint Accelerated maturation in brains of patients with Down syndrome
    Daniel Buxhoeveden
    J Intellect Disabil Res 48:704-5. 2004
  39. ncbi request reprint Reduced temporal lobe volume in early onset conduct disorder
    Markus J P Kruesi
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Psychiatry Res 132:1-11. 2004
    ..Further investigation of both the temporal and frontal localizations of the pathophysiology of early onset conduct disorder is warranted in larger samples...
  40. ncbi request reprint Regulatory mechanisms of cortical laminar development
    Manuel F Casanova
    University of Louisville, Department of Psychiatry, 500 S Preston St, Bldg 55A Ste 210, Louisville, KY 40292, USA
    Brain Res Rev 51:72-84. 2006
    ....
  41. ncbi request reprint Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences University of Louisville, 500 South Preston Street, Louisville, KY, USA
    Neuroscientist 12:435-41. 2006
    ..This article summarizes possible links between minicolumns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism...