JOSEPH J CARROLL

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Invest Ophthalmol Vis Sci 53:8006-15. 2012
  2. ncbi Estimates of L:M cone ratio from ERG flicker photometry and genetics
    Joseph Carroll
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
    J Vis 2:531-42. 2002
  3. ncbi Focus on molecules: the cone opsins
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street, Milwaukee, WI 53226, USA
    Exp Eye Res 86:865-6. 2008
  4. ncbi Deletion of the X-linked opsin gene array locus control region (LCR) results in disruption of the cone mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Vision Res 50:1989-99. 2010
  5. ncbi In vivo imaging of the photoreceptor mosaic of a rod monochromat
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, The Eye Institute, 925 North 87th Street, Milwaukee, WI 53226, USA
    Vision Res 48:2564-8. 2008
  6. ncbi Adaptive optics retinal imaging: applications for studying retinal degeneration
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, 925 N 87th St, Milwaukee, WI 53226, USA
    Arch Ophthalmol 126:857-8. 2008
  7. ncbi Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 106:20948-53. 2009
  8. ncbi Variety of genotypes in males diagnosed as dichromatic on a conventional clinical anomaloscope
    Maureen Neitz
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226 4812, USA
    Vis Neurosci 21:205-16. 2004
  9. ncbi Variable optical activation of human cone photoreceptors visualized using a short coherence light source
    Jungtae Rha
    Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street, Milwaukee, Wisconsin 53226, USA
    Opt Lett 34:3782-4. 2009
  10. ncbi Color perception is mediated by a plastic neural mechanism that is adjustable in adults
    Jay Neitz
    Department of Cell Biology, Neurobiology, and Anatomy, Milwaukee, WI 53226, USA
    Neuron 35:783-92. 2002

Research Grants

  1. Organization of the Trichromatic Cone Mosaic
    Joseph Carroll; Fiscal Year: 2005
  2. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2009
  3. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2009
  4. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. ncbi The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Invest Ophthalmol Vis Sci 53:8006-15. 2012
    ..To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations...
  2. ncbi Estimates of L:M cone ratio from ERG flicker photometry and genetics
    Joseph Carroll
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
    J Vis 2:531-42. 2002
    ..Consistent with this possibility, extreme cone contribution ratios were found to be associated with atypical L-pigment amino acid combinations...
  3. ncbi Focus on molecules: the cone opsins
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street, Milwaukee, WI 53226, USA
    Exp Eye Res 86:865-6. 2008
  4. ncbi Deletion of the X-linked opsin gene array locus control region (LCR) results in disruption of the cone mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Vision Res 50:1989-99. 2010
    ..This suggests that the absence of opsin in a subset of cones results in their early degeneration, with X-inactivation the likely mechanism underlying phenotypic variability in BCM carriers...
  5. ncbi In vivo imaging of the photoreceptor mosaic of a rod monochromat
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, The Eye Institute, 925 North 87th Street, Milwaukee, WI 53226, USA
    Vision Res 48:2564-8. 2008
    ....
  6. ncbi Adaptive optics retinal imaging: applications for studying retinal degeneration
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, 925 N 87th St, Milwaukee, WI 53226, USA
    Arch Ophthalmol 126:857-8. 2008
  7. ncbi Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 106:20948-53. 2009
    ..Comparison of these mosaics provides insight into the timing and degree of cone disruption and has implications for the prospects for restoration of vision loss associated with various cone opsin mutations...
  8. ncbi Variety of genotypes in males diagnosed as dichromatic on a conventional clinical anomaloscope
    Maureen Neitz
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226 4812, USA
    Vis Neurosci 21:205-16. 2004
    ....
  9. ncbi Variable optical activation of human cone photoreceptors visualized using a short coherence light source
    Jungtae Rha
    Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street, Milwaukee, Wisconsin 53226, USA
    Opt Lett 34:3782-4. 2009
    ..The application of light-evoked signal detection techniques for in vivo retinal imaging may prove useful for assessing the functional status of cones in normal and diseased retinae...
  10. ncbi Color perception is mediated by a plastic neural mechanism that is adjustable in adults
    Jay Neitz
    Department of Cell Biology, Neurobiology, and Anatomy, Milwaukee, WI 53226, USA
    Neuron 35:783-92. 2002
    ..Thus, a neural normalization mechanism for color perception, determined by visual experience, operates to compensate for large genetic differences in retinal architecture and for changes in chromatic environment...
  11. ncbi The L:M cone ratio in males of African descent with normal color vision
    Carrie McMahon
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
    J Vis 8:5.1-9. 2008
    ..How these observations might be reconciled is discussed...
  12. ncbi Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss
    Kimberly E Stepien
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Trans Am Ophthalmol Soc 107:28-33. 2009
    ..To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity...
  13. ncbi Normality of colour vision in a compound heterozygous female carrying protan and deutan defects
    Diane M Tait
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clin Exp Optom 92:356-61. 2009
    ..These women are referred to as compound heterozygotes, though very few have been reported. Questions remain about whether the colour vision capacity of these women is comparable to that of 'normal' trichromats...
  14. ncbi Retinal imaging using commercial broadband optical coherence tomography
    Hitesh Tanna
    Department of Biomedical Engineering, Medical College of Wisconsin, Marquette University, Milwaukee, Wisconsin 53226, USA
    Br J Ophthalmol 94:372-6. 2010
    ..To examine the practical improvement in image quality afforded by a broadband light source in a clinical setting and to define image quality metrics for future use in evaluating spectral domain optical coherence tomography (SD-OCT) images...

Research Grants5

  1. Organization of the Trichromatic Cone Mosaic
    Joseph Carroll; Fiscal Year: 2005
    ..This will be done in subjects for whom we also have a representation of their cone mosaic, to be able to selectively stimulate cones from a particular class. ..
  2. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2009
    ..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..
  3. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2009
    ..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..
  4. Assessing Photoreceptor Structure and Function in Normal and Diseased Retina
    Joseph Carroll; Fiscal Year: 2010
    ..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..