Affiliation: Medical College of Wisconsin
- Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brainJohan Bylund
Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Biochem Biophys Res Commun 296:677-84. 2002..The catalytic properties and physiological function of CYP4X1 are currently under investigation...
- Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6Johan Bylund
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Arch Biochem Biophys 412:34-41. 2003..CYP4F5 and CYP4F6, due to their capacities to metabolize LTB(4), may play important roles in modulating inflammatory response in these organs...
- Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytesDebebe Gebremedhin
Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
J Neurosci 23:1678-87. 2003....
- IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cellsDonald J Davidson
Child and Family Research Institute and Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
J Immunol 177:8202-11. 2006....
- On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferensKatarina Stark
Department of Pharmaceutical Biosciences, Division of Biochemical Pharmacology, Uppsala University, Uppsala Biomedical Center, P O Box 591, SE 75124 Uppsala, Sweden
Prostaglandins Other Lipid Mediat 75:47-64. 2005..Recombinant CYP4F8 was also found to catalyze n-2 hydroxylation of PGI2 and carbaprostacyclin (Km to approximately 40 microM), and n-2 and n-3 hydroxylation of carbocyclic TXA2...
- Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophilsJohan Bylund
Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
BMC Cell Biol 5:21. 2004..The receptor uncoupling results in respiratory burst activity when signals generated by reactivated formyl peptide receptors trigger the NADPH-oxidase to produce superoxide anions...
- Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapyHuamei Fu
The Phagocyte Research Laboratory, Department for Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
Antimicrob Agents Chemother 47:2545-50. 2003..These findings could be potentially used as a new approach to antibacterial chemotherapy...
- Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calciumJohan Bylund
Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
J Biol Chem 278:30578-86. 2003..Further, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, and MEK all participated in the generation of second messengers from the reactivated receptors...
- NADPH-oxidase activation in murine neutrophils via formyl peptide receptorsJohan Bylund
Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
Exp Cell Res 282:70-7. 2003..Finally, we show that a synthetic hexapeptide, WKYMVM, is a more potent stimulus than fMLF for murine neutrophils and that these two agonists probably act via nonidentical high-affinity receptors...
- Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1Lena Björkman
Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Leukoc Biol 83:245-53. 2008..Future identification and characterization of the SAA receptor could lead to development of novel, therapeutic targets for treatment of RA...