J J Buccafusco

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Mol Neurosci 24:85-91. 2004
  2. ncbi request reprint A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline
    J J Buccafusco
    Veterans Administration Medical Center, Augusta, GA 30904, USA
    Neuroscience 149:487-98. 2007
  3. ncbi request reprint Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Pharmacol 74:1202-11. 2007
  4. ncbi request reprint The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Psychopharmacology (Berl) 199:481-94. 2008
  5. ncbi request reprint MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurochem Res 32:1224-37. 2007
  6. ncbi request reprint Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, United States
    Neurosci Lett 413:68-71. 2007
  7. ncbi request reprint Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Pharmacol Sci 26:352-60. 2005
  8. ncbi request reprint Neuronal nicotinic receptor subtypes: defining therapeutic targets
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, 1120 15 Street, Augusta, Georgia 30912 2300, USA
    Mol Interv 4:285-95. 2004
  9. ncbi request reprint Novel analogs of choline as potential neuroprotective agents
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Alzheimers Dis 6:S85-92. 2004
  10. ncbi request reprint The importance of brainstem cholinergic neurons in the pressor response to cocaine
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, 1120 15th St, Augusta, GA 30912 2300, USA
    J Pharmacol Exp Ther 312:179-91. 2005

Detail Information

Publications65

  1. ncbi request reprint Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Mol Neurosci 24:85-91. 2004
    ..Yet at doses that were effective in all subjects, there was no relationship between age and the improvement in task accuracy. Likewise, there was no association between baseline task proficiency and improvement in task accuracy...
  2. ncbi request reprint A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline
    J J Buccafusco
    Veterans Administration Medical Center, Augusta, GA 30904, USA
    Neuroscience 149:487-98. 2007
    ..The results of this study support the role of cholinergic systems in self-administration behavior and context-induced post-withdrawal drug seeking...
  3. ncbi request reprint Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Pharmacol 74:1202-11. 2007
    ....
  4. ncbi request reprint The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Psychopharmacology (Berl) 199:481-94. 2008
    ..The cognitive impairment associated with scopolamine is similar to that in AD. The scopolamine model is not simply a cholinergic model, as it can be reversed by drugs that are noncholinergic cognition-enhancing agents...
  5. ncbi request reprint MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurochem Res 32:1224-37. 2007
    ..The results of this study are consistent with the potential use of MHP-133 in the treatment of neurodegenerative disorders such as Alzheimer's disease...
  6. ncbi request reprint Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, United States
    Neurosci Lett 413:68-71. 2007
    ....
  7. ncbi request reprint Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Pharmacol Sci 26:352-60. 2005
    ..A better understanding of this phenomenon might shed new light on the role of nAChR systems in memory formation and retrieval...
  8. ncbi request reprint Neuronal nicotinic receptor subtypes: defining therapeutic targets
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, 1120 15 Street, Augusta, Georgia 30912 2300, USA
    Mol Interv 4:285-95. 2004
    ..For both families of cholinergic receptors, widespread exploitation in terms of therapeutics has been limited by significant side effect profiles associated with available cholinergic drugs...
  9. ncbi request reprint Novel analogs of choline as potential neuroprotective agents
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Alzheimers Dis 6:S85-92. 2004
    ....
  10. ncbi request reprint The importance of brainstem cholinergic neurons in the pressor response to cocaine
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, 1120 15th St, Augusta, GA 30912 2300, USA
    J Pharmacol Exp Ther 312:179-91. 2005
    ....
  11. doi request reprint Protracted cognitive effects produced by clonidine in Macaca nemestrina performing a delayed matching task
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Psychopharmacology (Berl) 202:477-85. 2009
    ..The alpha(2)-adrenergic receptor agonist clonidine was examined for its ability to improve working memory in monkeys...
  12. pmc Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, Georgia 30912 2300, USA
    J Pharmacol Exp Ther 328:364-70. 2009
    ..Because these "silent desensitizers" are probably acting allosterically, an additional degree of subtype specificity could be attained...
  13. ncbi request reprint Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    J Alzheimers Dis 15:709-20. 2008
    ..Examples are provided that underscore the possible idiosyncrasies of drug action in the pharmacology of cognition--which could be of critical importance in the design of clinical trials...
  14. doi request reprint Multifunctional receptor-directed drugs for disorders of the central nervous system
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, Georgia 30912 and Charlie Norwood VA Medical Center, Augusta, Georgia 30904, USA
    Neurotherapeutics 6:4-13. 2009
    ..The author takes the liberty to include examples of the situations just mentioned from studies in his laboratory in the following discussion...
  15. doi request reprint Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA, USA
    Pain 148:446-53. 2010
    ..It is currently unclear whether the ability of acute administration of gabapentin to modestly improve working memory occurs by a mechanism that could be related to its anti-allodynic mechanism of action...
  16. doi request reprint Emerging cognitive enhancing drugs
    Jerry J Buccafusco
    Regents Professor of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Department of Pharmacology and Toxicology, Augusta, Georgia 30912 2300, USA
    Expert Opin Emerg Drugs 14:577-89. 2009
    ....
  17. ncbi request reprint Deficits in spatial learning and nicotinic-acetylcholine receptors in older, spontaneously hypertensive rats
    A V Terry
    University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 101:357-68. 2000
    ....
  18. ncbi request reprint Cocaine-induced expression differences in PSD-95/SAP-90-associated protein 4 and in Ca2+/calmodulin-dependent protein kinase subunits in amygdalae of taste aversion-prone and taste aversion-resistant rats
    R L Elkins
    Department Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann N Y Acad Sci 1003:386-90. 2003
  19. ncbi request reprint Prevention of precipitated withdrawal symptoms by activating central cholinergic systems during a dependence-producing schedule of morphine in rats
    J J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912 2300, USA
    Brain Res 852:76-83. 2000
    ....
  20. ncbi request reprint Potential cognitive actions of (n-propargly-(3r)-aminoindan-5-yl)-ethyl, methyl carbamate (tv3326), a novel neuroprotective agent, as assessed in old rhesus monkeys in their performance of versions of a delayed matching task
    J J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, 30912 2300, Augusta, GA, USA
    Neuroscience 119:669-78. 2003
    ..TV3326 was not associated with any obvious side effect or untoward reaction of the animals to the drug. Thus, TV3326 may be expected to offer a significant positive cognitive outcome in addition to its reported neuroprotective action...
  21. ncbi request reprint Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists
    R R Jonnala
    Alzheimer's Research Center, Medical College of Georgia, Augusta, Georgia 30912-2300, USA
    J Neurosci Res 66:565-72. 2001
    ..Thus the induced upregulation of the alpha7 subtype of nicotinic receptors during chronic exposure to nicotine may be responsible for the drug's neuroprotective action...
  22. ncbi request reprint Dahl salt-sensitive and salt-resistant rats: examination of learning and memory performance, blood pressure, and the expression of central nicotinic acetylcholine receptors
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, CJ 1020, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 103:351-63. 2001
    ....
  23. ncbi request reprint Differential improvement in memory-related task performance with nicotine by aged male and female rhesus monkeys
    J J Buccafusco
    Department of Pharmacology and Toxicology, Medical College of Georgia, The Veterans Affairs Medical Center, Augusta 30912 2300, USA
    Behav Pharmacol 10:681-90. 1999
    ..Therefore, aged female subjects may require a greater level of individualized treatment and perhaps higher doses of nicotinic agonists to achieve the maximal mnemonic benefit...
  24. ncbi request reprint Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo
    Xinyu D Li
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA, USA
    J Mol Neurosci 27:325-36. 2005
    ..Therefore, physiologically relevant concentrations of Abeta1-42 can prevent nicotine-induced TrkA receptor expression in brain regions containing cholinergic neurons susceptible to the neurotoxicity associated with Alzheimer's disease...
  25. ncbi request reprint The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys
    Ajay Sood
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuropharmacology 53:588-600. 2007
    ..Its cytoprotective action might also work to slow the progression of Alzheimer's disease...
  26. doi request reprint Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats
    Brandon J Hall
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Neurosci Lett 474:84-7. 2010
    ..These results provide proof of concept for the development and use of cholinergic compounds in the treatment of substance abuse...
  27. pmc Repeated, intermittent exposures to diisopropylfluorophosphate in rats: protracted effects on cholinergic markers, nerve growth factor-related proteins, and cognitive function
    A V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 176:237-53. 2011
    ....
  28. ncbi request reprint Sex dimorphisms in the cognitive-enhancing action of the Alzheimer's drug donepezil in aged Rhesus monkeys
    J J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, and the Veterans Administration Medical Center, Augusta, GA 30912, USA
    Neuropharmacology 44:381-9. 2003
    ..These findings support the concept that aged males and females respond differently to this class of agents, perhaps representing fundamental sex-related differences in memory processing, or in the manner that age affects these processes...
  29. ncbi request reprint Spinal muscarinic cholinergic and nitric oxide systems in cardiovascular regulation
    D S Feldman
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912 2300, USA
    Eur J Pharmacol 313:211-20. 1996
    ....
  30. doi request reprint Effect of administration of the nicotinic acetylcholine receptor antagonist BTMPS, during nicotine self-administration, on lever responding induced by context long after withdrawal
    Brandon J Hall
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Neuropharmacology 58:429-35. 2010
    ..Since BTMPS does not evoke anti-nicotinic effects under normal physiological conditions, these data support a proof of concept for the safe use of such compounds in the treatment of tobacco abuse...
  31. pmc A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Pharmacol 78:852-62. 2009
    ..The model could provide a means of late stage preclinical evaluation of new compounds that address the cognitive impairment associated with major psychotic disease...
  32. ncbi request reprint Inhibition of nerve growth factor signaling by peroxynitrite
    R R Jonnala
    Alzheimer Research Center, Department of Pharmacology and Toxicology, Department of Veterans Affairs Medical Center, Medical College of Georgia, Augusta, Georgia 30912-2300, USA
    J Neurosci Res 63:27-34. 2001
    ..The inactivation of TrkA receptors may contribute to the initial insult that eventually leads to neuronal cell death...
  33. pmc Repeated exposures to low-level chlorpyrifos results in impairments in sustained attention and increased impulsivity in rats
    M L Middlemore-Risher
    Program of Clinical and Experimental Therapeutics, University of Georgia, College of Pharmacy, Augusta, GA, 30912, United States
    Neurotoxicol Teratol 32:415-24. 2010
    ..These results indicate that repeated exposures to relatively low levels of chlorpyrifos lead to protracted impairments of sustained attention and an increase in impulsive behaviors in rats...
  34. ncbi request reprint Multiple central nervous system targets for eliciting beneficial effects on memory and cognition
    J J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Augusta, Georgia, USA
    J Pharmacol Exp Ther 295:438-46. 2000
    ..Thus, certain memory-enhancing agents may prove more useful when implemented early in the course of a disease such as AD, and they also may enjoy a wide application for the treatment of the memory decline associated with normal aging...
  35. ncbi request reprint The induction of surface beta-amyloid binding proteins and enhanced cytotoxicity in cultured PC-12 and IMR-32 cells by advanced glycation end products
    S Mruthinti
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Neuroscience 142:463-73. 2006
    ..These results are consistent with the ability of AGEs to enhance the cell surface expression of diverse Abeta42 binding sites, a factor that can lead to the enhanced binding of amyloid and subsequent cell death...
  36. ncbi request reprint Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy Augusta Campus, Medical College of Georgia, Augusta, GA 30912 2300, USA
    CNS Drug Rev 11:229-52. 2005
    ..Based on its relative safety in man, cotinine should prove useful in the treatment of diseases of impaired cognition and behavior without exhibiting the toxicity usually attributed to nicotine...
  37. ncbi request reprint Repeated exposures to subthreshold doses of chlorpyrifos in rats: hippocampal damage, impaired axonal transport, and deficits in spatial learning
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy Augusta Campus, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 305:375-84. 2003
    ..Some of these symptoms may be attributed to effects of the OP on axonal transport...
  38. ncbi request reprint Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential
    John N Bain
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Psychopharmacology (Berl) 169:150-60. 2003
    ..Dopaminergic pathways in the frontal and limbic cortex also may be targets for these agents, where pharmacological effects could result in heightened attention and/or support self-administration behavior...
  39. ncbi request reprint Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo
    Ramamohana R Jonnala
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912, USA
    Life Sci 70:1543-54. 2002
    ....
  40. ncbi request reprint Role of alpha7 nicotinic acetylcholine receptors in the pressor response to intracerebroventricular injection of choline: blockade by amyloid peptide Abeta1-42
    Xinyu D Li
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    J Pharmacol Exp Ther 309:1206-12. 2004
    ..c.v. route significantly inhibited the choline-induced blood pressure increase as well as the choline-induced decrease in heart rate...
  41. ncbi request reprint Relationship between the induction of RAGE cell-surface antigen and the expression of amyloid binding sites
    Shyamala Mruthinti
    lzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    J Mol Neurosci 20:223-32. 2003
    ..Thus, the time-dependent formation of AGEs might play a role within the context of the immune system in the expression of binding sites for amyloid peptides, possibly resulting in enhancing cellular toxicity...
  42. ncbi request reprint Relative levels of cytoprotection produced by analogs of choline and the role of alpha7-nicotinic acetylcholine receptors
    Ramamohana R Jonnala
    Alzheimer s Research Center, Medical College of Georgia, Augusta, Georgia 30912 2300l, USA
    Synapse 47:262-9. 2003
    ....
  43. ncbi request reprint The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA 30912 2450, USA
    J Pharmacol Exp Ther 306:821-7. 2003
    ..Therefore, cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia...
  44. ncbi request reprint A computer-assisted cognitive test battery for aged monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta 30912, USA
    J Mol Neurosci 19:179-85. 2002
    ..08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging...
  45. doi request reprint Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets
    Alvin V Terry
    Department of Pharmacology and Toxicology, Graduate Program in Neuroscience, and Small Animal Behavior Core, CB 3618, The Medical College of Georgia, Augusta, GA 30912 2300, USA
    Behav Brain Res 195:30-8. 2008
    ..The purpose of this review is to provide a brief overview of these therapeutic targets within the 5-HT system and the pharmacologic approaches (including the most recently developed compounds) designed to enhance memory function...
  46. ncbi request reprint The potential role of cotinine in the cognitive and neuroprotective actions of nicotine
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Life Sci 72:2931-42. 2003
    ....
  47. ncbi request reprint Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing
    Alvin V Terry
    Department of Pharmacology and Toxicology, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2300, USA
    J Pharmacol Exp Ther 322:1117-28. 2007
    ..Such neurochemical changes may lead to deficits in information processing and cognitive function...
  48. ncbi request reprint Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility
    Debra A Gearhart
    Department of Pharmacology and Toxicology, 1120 Fifteenth Street, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Toxicol Appl Pharmacol 218:20-9. 2007
    ..We postulate that disruption of kinesin-dependent intracellular transport could account for some of the long-term effects of organophosphates on the peripheral and central nervous system...
  49. ncbi request reprint Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides
    Shyamala Mruthinti
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neurobiol Aging 25:1023-32. 2004
    ..The close relationship between titers for Abeta and RAGE IgGs suggests the possibility that the antibodies are being produced in response to a common mechanism or protein complex (with the respective epitopes) linked to the disease...
  50. ncbi request reprint Autoimmunity in Alzheimer's disease as evidenced by plasma immunoreactivity against RAGE and Abeta42: complication of diabetes
    Shyamala Mruthinti
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of GA, Augusta, Georgia 30912, USA
    Curr Alzheimer Res 3:229-35. 2006
    ..For both diseases one underlying contributing factor to cytotoxicity could be the development of an autoimmune response triggered by the presence of AGEs and amyloid peptides...
  51. ncbi request reprint The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neuropharmacology 46:10-22. 2004
    ..They also indicate that the drug is associated with long-term effects that could limit dosing regimens to one dose every two or three days. The nature of the protracted mnemonic effects produced by the compound remains to be elucidated...
  52. ncbi request reprint Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, CJ 1020 The Medical College of Georgia, University of Georgia College of Pharmacy Augusta Campus, Augusta, GA 30912, USA
    Psychopharmacology (Berl) 179:725-32. 2005
    ....
  53. pmc The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models
    Alvin V Terry
    Department of Pharmacology and Toxicolog, Medical College of Georgia, Augusta, Georgia, USA
    J Pharmacol Exp Ther 336:751-66. 2011
    ..Thus, JWS (potentially via effects at several drug targets) improves information processing, attention, and memory in animal models and could potentially treat the cognitive and behavioral symptoms of some neuropsychiatric illnesses...
  54. ncbi request reprint Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, GA 30910, USA
    Psychopharmacology (Berl) 162:292-300. 2002
    ..Muscarinic-acetylcholine receptor agonists are yet to be used clinically for the treatment of Alzheimer's disease (AD) even though laboratory evidence continues to support the potential for such an approach...
  55. ncbi request reprint Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition
    J J Buccafusco
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912
    Res Commun Chem Pathol Pharmacol 75:85-98. 1992
    ....
  56. ncbi request reprint Functional central nicotinic acetylcholine receptor antagonism by systemic administration of Tinuvin 770 (BTMPS)
    John H Graham
    Medical College of Georgia, Alzheimer s Research Center, Augusta, GA 30912 2300, USA
    Curr Alzheimer Res 2:141-7. 2005
    ..Therefore, BTMPS can be considered as an alternative to or as a confirmatory drug for mecamylamine when inhibition of central nicotinic receptors is required...
  57. ncbi request reprint Effect of beta-amyloid peptide 1-42 on the cytoprotective action mediated by alpha7 nicotinic acetylcholine receptors in growth factor-deprived differentiated PC-12 cells
    Xinyu D Li
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, USA
    J Pharmacol Exp Ther 307:670-5. 2003
    ....
  58. ncbi request reprint Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Georgia 309 12, USA
    J Pharmacol Exp Ther 301:284-92. 2002
    ..Collectively, the present data suggest that in specific conditions SIB-1553A may improve certain aspects of attentional function in young adult rats and nonhuman primates without adverse side effects...
  59. ncbi request reprint Cocaine-induced expression differences in glutamate receptor subunits and transporters in amygdalae of taste aversion-prone and taste aversion-resistant rats
    R L Elkins
    Department Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann N Y Acad Sci 1003:381-5. 2003
  60. ncbi request reprint Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: a pilot study
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res Bull 74:164-71. 2007
    ..Additional studies are warranted to reveal behavioral deficits associated with this ischemia model...
  61. pmc Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques
    Koichi Hara
    Department Neurology and Inst Mol Med and Genetics, Medical College Georgia, Augusta, GA, USA
    Brain Res 1286:185-91. 2009
    ....
  62. pmc Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder
    Paul Abrams
    Bristol Urological Institute, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB
    Br J Pharmacol 148:565-78. 2006
    ..Further research is needed to show whether the M3 selective receptor antagonists have any advantage over less selective drugs, in leading to fewer adverse events...
  63. ncbi request reprint Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
    Moussa B H Youdim
    Eve Topf and US National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research, Technion Rappaport Faculty of Medicine and Department of Pharmacology, Haifa 31096, Israel
    Trends Pharmacol Sci 26:27-35. 2005
    ..These bi- or multi-functional compounds might provide greater symptomatic efficacy, and better utility as potential neuroprotective disease-modifying drugs...
  64. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
  65. ncbi request reprint The electromyographic signal as a presymptomatic indicator of organophosphates in the body
    Carlo J De Luca
    Delsys, Inc, P O Box 15734, Boston, Massachusetts, USA
    Muscle Nerve 33:369-76. 2006
    ..These findings can lead to the development of noninvasive technology for indicating the presence of OP compounds in muscle tissue prior to clinical abnormalities...

Research Grants1

  1. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Jerry Buccafusco; Fiscal Year: 2007
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..