Ulrich Broeckel

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
  2. pmc Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham AL 35294 0022, USA
    BMC Med Genet 10:43. 2009
  3. ncbi request reprint A locus on chromosome 10 influences C-reactive protein levels in two independent populations
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hum Genet 122:95-102. 2007
  4. ncbi request reprint Functional genomics and its implications for molecular medicine
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:807-16, vii. 2006
  5. doi request reprint The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation
    Ulrich Broeckel
    Section of Genomic Pediatrics, Children s Hospital of Wisconsin, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Curr Opin Nephrol Hypertens 20:118-24. 2011
  6. pmc Identifying genes and genetic variation underlying human diseases and complex phenotypes via recombination mapping
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:40-5. 2004
  7. ncbi request reprint DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease
    Vincent Biank
    Department of Pediatrics, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 102:391-8. 2007
  8. ncbi request reprint Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease
    Umesh Babusukumar
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 101:1354-61. 2006
  9. ncbi request reprint Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction
    Marcus Fischer
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 111:855-62. 2005
  10. ncbi request reprint Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 11:631-8. 2005

Collaborators

Detail Information

Publications29

  1. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  2. pmc Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham AL 35294 0022, USA
    BMC Med Genet 10:43. 2009
    ..Eleven of 12 promising (Q < 0.8) single-nucleotide polymorphisms (SNPs) from the genome-wide study were successfully genotyped using quantitative real time PCR in a validation study...
  3. ncbi request reprint A locus on chromosome 10 influences C-reactive protein levels in two independent populations
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hum Genet 122:95-102. 2007
    ..This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke...
  4. ncbi request reprint Functional genomics and its implications for molecular medicine
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:807-16, vii. 2006
    ..Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come...
  5. doi request reprint The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation
    Ulrich Broeckel
    Section of Genomic Pediatrics, Children s Hospital of Wisconsin, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Curr Opin Nephrol Hypertens 20:118-24. 2011
    ....
  6. pmc Identifying genes and genetic variation underlying human diseases and complex phenotypes via recombination mapping
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:40-5. 2004
    ..This review describes the motivation behind, and problems associated with, recombination mapping, in terms of both linkage mapping and linkage disequilibrium mapping...
  7. ncbi request reprint DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease
    Vincent Biank
    Department of Pediatrics, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 102:391-8. 2007
    ..Pediatric onset CD features a significantly lower incidence for female children compared with male children. We, therefore, studied the influence of gender on R30Q susceptibility in an exclusively pediatric onset IBD cohort...
  8. ncbi request reprint Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease
    Umesh Babusukumar
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 101:1354-61. 2006
    ..We performed a comprehensive analysis of OCTN variants in an independent, exclusively pediatric onset CD cohort and examined the genotype/phenotype correlations...
  9. ncbi request reprint Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction
    Marcus Fischer
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 111:855-62. 2005
    ....
  10. ncbi request reprint Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 11:631-8. 2005
    ..The first identified CD susceptibility gene, CARD15, seems to be present in up to 40% of white children with CD. However, the frequency of this gene among patients with CD of other racial/ethnic groups in the United States is not known...
  11. ncbi request reprint Identification of hypertension-related QTLs in African American sib pairs
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 40:634-9. 2002
    ..Focusing on hypertension-related phenotypes is a promising approach for identifying the genetic determinants of hypertension...
  12. ncbi request reprint Linkage analysis for complex diseases using variance component analysis: SOLAR
    Ulrich Broeckel
    Department of Medicine, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA
    Methods Mol Med 128:91-100. 2006
    ..In this chapter, we present as an introduction the statistical background of variance component analysis as implemented in the genetic analysis package SOLAR...
  13. ncbi request reprint Pediatric inflammatory bowel disease: clinical and molecular genetics
    Vincent Biank
    Department of Pediatrics, Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 13:1430-8. 2007
    ..Finally, the future directions of genetic investigations in pediatric IBD are discussed...
  14. pmc Human gene copy number spectra analysis in congenital heart malformations
    Aoy Tomita-Mitchell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Physiol Genomics 44:518-41. 2012
    ..3% had likely causal (significantly enriched), large, rare CNVs. CNV frequency spectra combined with precision phenotyping may lead to increased molecular understanding of etiologic pathways...
  15. ncbi request reprint A comprehensive linkage analysis for myocardial infarction and its related risk factors
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Genet 30:210-4. 2002
    ..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
  16. pmc A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inf
    Yi Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Med Genomics 6:14. 2013
    ..We previously performed microsatellite linkage analyses using adiponectin as a surrogate marker and revealed two QTLs on chr5 (5p14) and chr14 (14q13)...
  17. doi request reprint Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans
    Karen Maresso
    Department of Pediatrics, Children s Hospital of Wisconsin, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Adv Genet 60:107-39. 2008
    ....
  18. ncbi request reprint Genetic determinants of hypertension: an update
    Michael Harrison
    Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Hypertens Rep 10:488-95. 2008
    ..In this review, the authors summarize and evaluate the most recent findings related to hypertension gene identification...
  19. doi request reprint Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease
    Elizabeth A Worthey
    Human and Molecular Genetics Center, The Medical College of Wisconsin, Milwaukee 53226, USA
    Genet Med 13:255-62. 2011
    ..The age and severity of the presentation suggested an underlying immune defect; however, despite comprehensive clinical evaluation, we were unable to arrive at a definitive diagnosis, thereby restricting clinical management...
  20. ncbi request reprint CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Clin Gastroenterol Hepatol 2:1003-9. 2004
    ..We investigated the effect of CARD15 mutations on disease manifestation, disease progression, and the risk for early surgery in childhood-onset CD...
  21. doi request reprint The role of genomics in the neonatal ICU
    Karen Maresso
    Section of Genomic Pediatrics, Children s Research Institute, Medical College of Wisconsin, TBRC CRI, 2nd Floor, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Clin Perinatol 36:189-204. 2009
    ..Future recommendations for genomic association studies in neonatal ICU populations are also provided...
  22. pmc SORCS1 contributes to the development of renal disease in rats and humans
    Jozef Lazar
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Physiol Genomics 45:720-8. 2013
    ..The experimental data from the rat combined with association results from different ethnic groups indicates a role for SORCS1 in maintaining proper renal function. ..
  23. pmc Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease
    Aoy Tomita-Mitchell
    Division of Cardiovascular Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 42:52-60. 2010
    ..The MQPCR assay is a rapid, inexpensive, sensitive, and specific assay that can be used to screen for 22q11.2 deletion syndrome. The assay is readily adaptable to high throughput...
  24. ncbi request reprint Toward the etiologies of congenital heart diseases
    Andrew N Pelech
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, PO Box 26509, 8701 Watertown Plank Road, Milwaukee, WI 53266 0509, USA
    Clin Perinatol 32:825-44, vii. 2005
    ..Epidemiologic investigations continue to be necessary to assess the influence of the environment on genetics. We are on the threshold of influencing the occurrence of congenital heart diseases...
  25. ncbi request reprint Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men
    Frauke Friedrichs
    Leibniz Institute for Arteriosclerosis Research, Domagkstr 3, 48149, Muenster, Germany
    Hum Genet 119:305-11. 2006
    ....
  26. ncbi request reprint Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 13:1509-15. 2007
    ..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon...
  27. ncbi request reprint Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations
    Kamil Sedlacek
    Klinik und Poliklinik fur Innere Medizin II, Universitatsklinikum Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    J Mol Med (Berl) 85:997-1004. 2007
    ..These variants are unlikely to play a significant role in populations of European origin...
  28. ncbi request reprint Genes for left ventricular hypertrophy
    Donna K Arnett
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Curr Hypertens Rep 6:36-41. 2004
    ..An overview of the pathophysiology of LV hypertrophy and dysfunction is provided, in addition to evidence of the genetic basis for LV hypertrophy in humans and animal models...
  29. pmc Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
    Maren Luchtefeld
    Abteilung fur Kardiologie und Angiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Exp Med 204:1935-44. 2007
    ..Thus, the acute phase reaction should be considered an important target for future drug development in the management of CAD...

Research Grants8

  1. Genetics of CRP in families with myocardial infarction
    Ulrich Broeckel; Fiscal Year: 2003
    ..As we have clinical follow up data available on both of our study populations, we will test to what extent CRP contributes to an increased risk for cardiovascular events in the framework of our family analysis. ..
  2. Genetics of CRP in families with myocardial infarction
    Ulrich Broeckel; Fiscal Year: 2004
    ..As we have clinical follow up data available on both of our study populations, we will test to what extent CRP contributes to an increased risk for cardiovascular events in the framework of our family analysis. ..
  3. Genetics of CRP in families with myocardial infarction
    Ulrich Broeckel; Fiscal Year: 2005
    ..As we have clinical follow up data available on both of our study populations, we will test to what extent CRP contributes to an increased risk for cardiovascular events in the framework of our family analysis. ..
  4. Genetics of CRP in families with myocardial infarction
    Ulrich Broeckel; Fiscal Year: 2006
    ..As we have clinical follow up data available on both of our study populations, we will test to what extent CRP contributes to an increased risk for cardiovascular events in the framework of our family analysis. ..
  5. Genetics of CRP in families with myocardial infarction
    Ulrich Broeckel; Fiscal Year: 2007
    ..As we have clinical follow up data available on both of our study populations, we will test to what extent CRP contributes to an increased risk for cardiovascular events in the framework of our family analysis. ..
  6. Genome Wide Association of Coronary Artery Disease and Related Risk Factors
    Ulrich Broeckel; Fiscal Year: 2009
    ..This study will improve our understanding of the interplay of genetic and traditional risk factors. ..
  7. Genome Wide Association of Coronary Artery Disease and Related Risk Factors
    Ulrich Broeckel; Fiscal Year: 2010
    ..This study will improve our understanding of the interplay of genetic and traditional risk factors. ..