S L Britton
Affiliation: Medical College of Ohio
- Is there an answer? How did the idea of breeding rats for intrinsic aerobic running capacity come about?S L Britton
IUBMB Life 55:429-30. 2003
- Animal genetic models for complex traits of physical capacityS L Britton
Functional Genomics Laboratory, Department of Physiology and Molecular Medicine, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
Exerc Sport Sci Rev 29:7-14. 2001..Genes that cause natural trait variation can ultimately be determined from animal models via genetic linkage...
- Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacityL G Koch
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
Physiol Genomics 1:63-9. 1999..63 +/- 0.08 vs. 2.85 +/- 0.07 g/kg). All five of these intermediate phenotypes could participate as variables causative of the difference in treadmill running capacity between the DA and COP strains of rats...
- Cardiac performance in inbred rat genetic models of low and high running capacityJ Chen
Functional Genomics Laboratory, Medical College of Ohio, Toledo, OH 43614-5804, USA
J Physiol 535:611-7. 2001..Understanding the genetic basis of aerobic capacity will help define the continuum between health and disease...
- Cardiac function in rats selectively bred for low- and high-capacity runningS O Hussain
Functional Genomics Laboratory, Medical College of Ohio, 3035 Arlington Ave, Toledo, OH 43614-5804, USA
Am J Physiol Regul Integr Comp Physiol 281:R1787-91. 2001....
- Artificial selection for intrinsic aerobic endurance running capacity in ratsL G Koch
Functional Genomics Laboratory, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
Physiol Genomics 5:45-52. 2001..Selection for running capacity produced changes in body weight as a correlated trait. By generation 6, the low-line females were 20% heavier than the high-line females, and the low-line males were 16% heavier than the high-line males...
- A self-powered constant infusion device for use in unrestrained ratsP H Brand
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614 5804, USA
Am J Physiol Heart Circ Physiol 278:H2157-62. 2000..The device has been used successfully to measure arterial and central venous blood pressures in two studies using rats...
- Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacityMorten A Høydal
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, St Olavs Hospital, Trondheim, Norway
Eur J Cardiovasc Prev Rehabil 14:319-25. 2007..Our working hypothesis was that NOS-1 modulates cardiomyocyte contractility more markedly in rat lines with low versus high congenital aerobic fitness...
- Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 deliveryNorberto C Gonzalez
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Appl Physiol 101:1288-96. 2006..These results indicate that continuing divergence in VO2max between lines occurs largely as a consequence of changes in the capacity to deliver O2 to the exercising muscle...
- Cardiovascular risk factors emerge after artificial selection for low aerobic capacityUlrik Wisløff
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 3, 7489 Trondheim, Norway
Science 307:418-20. 2005..Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease...
- Genetic component of sensorimotor capacity in ratsLauren Gerard Koch
Functional Genomics Laboratory, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
Physiol Genomics 13:241-7. 2003..39 in females and 0.48 in males. These results demonstrate a heritable component to sensorimotor capacity sufficient for success in developing contrasting genetic models by divergent artificial selection in rats...
- Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running enduranceRichard A Howlett
University of California San Diego, La Jolla, California 92093, USA
J Appl Physiol 94:1682-8. 2003....
- Determinants of maximal O(2) uptake in rats selectively bred for endurance running capacityKyle K Henderson
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7401, USA
J Appl Physiol 93:1265-74. 2002..kg(-1). Torr(-1) in LCR, P < 0.01) were significantly higher in HCR. The data indicate that selective breeding for exercise endurance resulted in higher VO(2 max) mostly associated with a higher transfer of O(2) at the tissue level...
- Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistanceRobert C Noland
Department of Physiology, East Carolina University, Greenville, North Carolina 27834, USA
Am J Physiol Endocrinol Metab 293:E31-41. 2007..Elevated basal skeletal muscle oxidative capacity and the ability to preserve liver oxidative capacity may protect HCR rats from HFD-induced obesity and insulin resistance...
- Aerobic metabolism underlies complexity and capacityLauren G Koch
Functional Genomics Laboratory, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109 2200, USA
J Physiol 586:83-95. 2008..Here we provide arguments from thermodynamics, evolution, metabolic network analysis, clinical observations and animal models that are in accord with the centrality of oxygen in biology...
- Evolution, atmospheric oxygen, and complex diseaseLauren Gerard Koch
Functional Genomics Laboratory, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA
Physiol Genomics 30:205-8. 2007....
- Initial signaling response to acute exercise bout is similar in hearts of rats bred for divergent exercise capacitiesCraig J Hunter
Division of Kinesiology, Laboratory of Molecular Kinesiology, The University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI 48109 2214, USA
Front Biosci 13:347-55. 2008....
- Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacityFiona J Spargo
Exercise Metabolism Group, School of Medical Sciences, Australia
Am J Physiol Endocrinol Metab 292:E1631-6. 2007..In conclusion, rats with low intrinsic aerobic capacity demonstrate abnormalities in lipid-handling capacity. These disruptions may, in part, be responsible for the increased risk of metabolic disorders observed in this phenotype...
- Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigueTeresa E Foley
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Behav Brain Res 174:132-42. 2006..These data suggest that central serotonergic and dopaminergic systems may be involved in the mechanisms by which HCR have delayed onset of exercise-induced fatigue compared to LCR...
- Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacityHeidi L Lujan
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Am J Physiol Heart Circ Physiol 291:H2933-41. 2006..The HCR and LCR represent a unique substrate for evaluation of the mechanisms underlying ischemia-mediated cardiac arrhythmogenesis...
- Test of the principle of initial value in rat genetic models of exercise capacityLauren Gerard Koch
Functional Genomics Laboratory, Department of Physical Medicine and Rehabilitation University of Michigan Medical Center, Ann Arbor, MI 48109 0549, USA
Am J Physiol Regul Integr Comp Physiol 288:R466-72. 2005..Our data demonstrate that genetic factors causative of high response to exercise are not uniquely associated with genetic factors for low intrinsic capacity and thus are not in accord with the principle of initial value...
- Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the ratAnumeet Priyadarshi
Department of Medicine, Medical College of Ohio, Toledo, Ohio 43699 0008, USA
Kidney Int 61:542-6. 2002..However, it is not clear why this response is blunted. Oxygen tension is an important regulator of erythropoietin production and release, but the effect of reduced renal mass on renal tissue oxygen tensions is currently unknown...
- Aerobic capacity-dependent differences in cardiac gene expressionAnja Bye
Department of Circulation, Norwegian University of Science and Technology, Trondheim, Norway
Physiol Genomics 33:100-9. 2008..In conclusion, inborn high vs. low aerobic capacity was associated with differences in cardiac energy substrate, growth signaling, and cellular stress...