KATHLEEN THERESA BRADY

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Cognitive enhancers in the treatment of substance use disorders: clinical evidence
    Kathleen T Brady
    Medical University of South Carolina, Department of Psychiatry, 67 President Street, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 99:285-94. 2011
  2. pmc Practical considerations for estimating clinical trial accrual periods: application to a multi-center effectiveness study
    Rickey E Carter
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    BMC Med Res Methodol 5:11. 2005
  3. ncbi request reprint Difficulties in diagnosis and management of bipolar disorder: three case presentations
    K T Brady
    Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychiatry 61:32-7. 2000
  4. pmc Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Clinical Neurosciences Division, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Arch Gen Psychiatry 66:422-30. 2009
  5. ncbi request reprint Assessing abuse liability in clinical trials
    Kathleen T Brady
    Department of Psychiatry, Ralph H Johnson Medical Center, Medical University of South Carolina MUSC CTN, 109 Bee Street, Charleston, SC 29401, USA
    Drug Alcohol Depend 70:S87-95. 2003
  6. ncbi request reprint Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder
    Kathleen T Brady
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:938-46. 2006
  7. ncbi request reprint The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response
    Kathleen T Brady
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, South Carolina 29425, USA
    J Stud Alcohol 67:700-6. 2006
  8. ncbi request reprint Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress
    Kathleen T Brady
    Clinical Neuroscience Division, Institute of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 69 President St, Charleston, SC 29425, USA
    Am J Psychiatry 162:1483-93. 2005
  9. ncbi request reprint Alcohol use and anxiety: diagnostic and management issues
    Kathleen T Brady
    Medical University of South Carolina, Department of Psychiatry, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Am J Psychiatry 164:217-21; quiz 372. 2007
  10. ncbi request reprint Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
    Exp Clin Psychopharmacol 10:276-85. 2002

Research Grants

Detail Information

Publications81

  1. pmc Cognitive enhancers in the treatment of substance use disorders: clinical evidence
    Kathleen T Brady
    Medical University of South Carolina, Department of Psychiatry, 67 President Street, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 99:285-94. 2011
    ..Agents that have shown promise in cognitive enhancement in other disorders, and have a theoretical or mechanistic rationale for application to substance use disorders are also highlighted...
  2. pmc Practical considerations for estimating clinical trial accrual periods: application to a multi-center effectiveness study
    Rickey E Carter
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    BMC Med Res Methodol 5:11. 2005
    ..Adequate participant recruitment is vital to the conduct of a clinical trial. Projected recruitment rates are often over-estimated, and the time to recruit the target population (accrual period) is often under-estimated...
  3. ncbi request reprint Difficulties in diagnosis and management of bipolar disorder: three case presentations
    K T Brady
    Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychiatry 61:32-7. 2000
    ..Special attention is given to the relationship between bipolar disorder and substance use disorders...
  4. pmc Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Clinical Neurosciences Division, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Arch Gen Psychiatry 66:422-30. 2009
    ..Little is known about the response of cocaine-dependent individuals to CRH administration...
  5. ncbi request reprint Assessing abuse liability in clinical trials
    Kathleen T Brady
    Department of Psychiatry, Ralph H Johnson Medical Center, Medical University of South Carolina MUSC CTN, 109 Bee Street, Charleston, SC 29401, USA
    Drug Alcohol Depend 70:S87-95. 2003
    ..In cases where there are reasons to suspect that a drug under development has abuse potential, systematic exploration with a series of studies specifically designed to assess abuse potential must be conducted...
  6. ncbi request reprint Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder
    Kathleen T Brady
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:938-46. 2006
    ..This study investigated the relationship between subjective and neuroendocrine stress reactivity to the cold pressor task (CPT) and prospective alcohol use among individuals with alcohol dependence, with and without comorbid PTSD...
  7. ncbi request reprint The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response
    Kathleen T Brady
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, South Carolina 29425, USA
    J Stud Alcohol 67:700-6. 2006
    ..The objective of this study was to investigate HPA axis reactivity to the cold pressor task (CPT) among individuals with alcohol dependence, PTSD, and comorbid alcohol dependence and PTSD...
  8. ncbi request reprint Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress
    Kathleen T Brady
    Clinical Neuroscience Division, Institute of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 69 President St, Charleston, SC 29425, USA
    Am J Psychiatry 162:1483-93. 2005
    ..Better understanding of the connection between substance use disorders and psychiatric disorders could have a profound effect on prevention and treatment...
  9. ncbi request reprint Alcohol use and anxiety: diagnostic and management issues
    Kathleen T Brady
    Medical University of South Carolina, Department of Psychiatry, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Am J Psychiatry 164:217-21; quiz 372. 2007
  10. ncbi request reprint Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
    Exp Clin Psychopharmacol 10:276-85. 2002
    ..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders...
  11. ncbi request reprint The use of divalproex in alcohol relapse prevention: a pilot study
    Kathleen T Brady
    Institute of Psychiatry and Behavioral Science, Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 67:323-30. 2002
    ..This is consistent with the findings of other investigators exploring the use of DVPX in schizophrenia, personality disorder and a number of other psychiatric disorders...
  12. ncbi request reprint Treatment of patients comorbid for addiction and other psychiatric disorders
    Kathleen T Brady
    Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Curr Psychiatry Rep 9:374-80. 2007
    ..Current treatment options and implications for future research are highlighted...
  13. ncbi request reprint Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder
    Kathleen T Brady
    The Medical University of South Carolina, Department of Psychiatry, Charleston, SC 29425, USA
    Alcohol Clin Exp Res 29:395-401. 2005
    ..Posttraumatic stress disorder (PTSD) frequently co-occurs with alcohol use disorders. This study investigated the use of sertraline, a serotonin reuptake inhibitor, in treating co-occurring symptoms of alcohol dependence and PTSD...
  14. ncbi request reprint Pharmacotherapy of comorbid mood, anxiety, and substance use disorders
    Kathleen T Brady
    Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Subst Use Misuse 40:2021-41, 2043-8. 2005
    ..Some of the barriers to the use of pharmacotherapy in individuals with substance use disorders are discussed...
  15. pmc Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Affect Disord 110:167-73. 2008
    ..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
  16. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
    ..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
  17. ncbi request reprint Symptom improvement in co-occurring PTSD and alcohol dependence
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry, Charleston, South Carolina 29425, USA
    J Nerv Ment Dis 194:690-6. 2006
    ....
  18. ncbi request reprint Trauma and substance cue reactivity in individuals with comorbid posttraumatic stress disorder and cocaine or alcohol dependence
    Scott F Coffey
    Department of Psychiatry, State University of New York at Buffalo, Buffalo General Hospital, 80 Goodrich Street, Buffalo, NY 14203, USA
    Drug Alcohol Depend 65:115-27. 2002
    ....
  19. ncbi request reprint PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma
    Elizabeth J Santa Ana
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Psychoneuroendocrinology 31:501-9. 2006
    ..The findings reveal differences in the neuroendocrine response to the CPT in individuals with PTSD compared to control subjects, and differences in PTSD subjects when examined by age of index trauma...
  20. ncbi request reprint Assessment of club drug use in a treatment-seeking sample of individuals with marijuana dependence
    Marcia L Verduin
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    Am J Addict 16:484-7. 2007
    ..This appears to be the first study to report on club drug use in treatment-seeking marijuana-dependent individuals. Clinical implications and directions for future research are discussed...
  21. ncbi request reprint Gender differences in individuals with comorbid alcohol dependence and post-traumatic stress disorder
    Susan C Sonne
    Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, USA
    Am J Addict 12:412-23. 2003
    ..PTSD more often preceded alcohol dependence in women than in men. The results illustrate a number of gender differences that may shed light on etiologic models of comorbid alcohol dependence and PTSD...
  22. ncbi request reprint Affective and anxiety comorbidity in post-traumatic stress disorder treatment trials of sertraline
    Kathleen T Brady
    Medical University of South Carolina, Charleston 29425, USA
    Compr Psychiatry 44:360-9. 2003
    ..5 weeks to 5.5 weeks. We conclude that sertraline (50 to 200 mg/d) is effective and well tolerated in the treatment of PTSD for patients suffering from a current, comorbid depressive or anxiety disorders...
  23. ncbi request reprint Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?
    Lawrence A Labbate
    Mental Health Service, VA Medical Center, and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    Compr Psychiatry 45:304-10. 2004
    ..Hence, contrary to our hypothesis, having additional anxiety or mood disorder comorbidity did not decrease treatment response in individuals with comorbid PTSD and an alcohol use disorder...
  24. ncbi request reprint Cocaine dependence and PTSD: a pilot study of symptom interplay and treatment preferences
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Division of Clinical Neuroscience, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Addict Behav 31:351-4. 2006
    ..The findings highlight the functional relationship between these two disorders and have direct implications for treatment interventions...
  25. ncbi request reprint Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder
    Barbara O Rothbaum
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Clin Psychiatry 69:520-5. 2008
    ..The primary objective of this study was to examine risperidone augmentation in civilians with PTSD currently receiving sertraline without an optimal response...
  26. ncbi request reprint Comparative profiles of women with PTSD and comorbid cocaine or alcohol dependence
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Charleston, South Carolina, USA
    Am J Drug Alcohol Abuse 29:169-89. 2003
    ..The current findings enhance our understanding of the substance-specific profiles of women with PTSD and comorbid substance use disorders and may have important implications for the design of dual-diagnosis interventions...
  27. pmc Community-dwelling cocaine-dependent men and women respond differently to social stressors versus cocaine cues
    Angela E Waldrop
    Medical University of South Carolina, 67 President St, Charleston, SC 29403, United States
    Psychoneuroendocrinology 35:798-806. 2010
    ..11]). No gender differences were found in ACTH responses to the CUE. The results are reviewed in the context of the existing literature on gender differences in cocaine dependence and potential implications for treatment are discussed...
  28. pmc Mood disorders and substance use disorder: a complex comorbidity
    Susan B Quello
    Medical University of South Carolina, Charleston, SC 29425, USA
    Sci Pract Perspect 3:13-21. 2005
    ..Expanded communication and collaboration between substance abuse and mental health providers is crucial to improving outcomes for patients with these complex, difficult co-occurring disorders...
  29. pmc Extinction of drug cue reactivity in methamphetamine-dependent individuals
    Kimber L Price
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, 29425, USA
    Behav Res Ther 48:860-5. 2010
    ..These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies...
  30. pmc Improving the transition from residential to outpatient addiction treatment: gender differences in response to supportive telephone calls
    Rickey E Carter
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 34:47-59. 2008
    ..The findings revealed that women were more likely than men to attend aftercare. This "gender effect" persisted after adjustment for a number of potential mediators...
  31. pmc Influence of cocaine dependence and early life stress on pituitary-adrenal axis responses to CRH and the Trier social stressor
    Megan M Moran-Santa Maria
    Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, United States
    Psychoneuroendocrinology 35:1492-500. 2010
    ....
  32. pmc Reactivity to laboratory stress provocation predicts relapse to cocaine
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, MSC861, Charleston, SC 29425, United States
    Drug Alcohol Depend 106:21-7. 2010
    ..Elevated levels of stress have been associated with relapse to cocaine; however, the nature of this association is not well understood...
  33. pmc Gender and prescription opioids: findings from the National Survey on Drug Use and Health
    Sudie E Back
    Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Medical University of South Carolina, 125 Doughty St, PO Box 250861, Charleston, SC 29425, United States
    Addict Behav 35:1001-7. 2010
    ..This study compared correlates, sources and predictors of prescription opioid non-medical use, as well as abuse or dependence among men and women in a nationally-representative sample...
  34. pmc Sleep disturbances associated with posttraumatic stress disorder and alcohol dependence
    Angela E Waldrop
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Addict Behav 33:328-35. 2008
    ..These findings suggest a need for thorough assessment of sleep symptoms in patients presenting with PTSD or alcohol dependence...
  35. ncbi request reprint Cognitive-behavioral stress management for individuals with substance use disorders: a pilot study
    Sudie E Back
    Division of Clinical Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Nerv Ment Dis 195:662-8. 2007
    ..Although preliminary, the findings suggest that systematic investigation of interventions specifically targeting stress management in individuals with substance use disorders should be undertaken...
  36. pmc Treatment challenges associated with comorbid substance use and posttraumatic stress disorder: clinicians' perspectives
    Sudie E Back
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 18:15-20. 2009
    ..The findings increase understanding of SUD/PTSD treatment challenges, and may be useful for enhancing therapist training programs, supervision effectiveness, and designing optimal SUD/PTSD interventions...
  37. pmc Gender differences in the effect of early life trauma on hypothalamic-pituitary-adrenal axis functioning
    Stacia M DeSantis
    Department of Medicine, Division of Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Charleston, SC 29425, USA
    Depress Anxiety 28:383-92. 2011
    ..Individuals with major depressive disorder, posttraumatic stress disorder, bipolar disorder, or psychotic or eating disorders were excluded...
  38. pmc Relationship between child abuse and adult smoking
    Eve G Spratt
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Psychiatry Med 39:417-26. 2009
    ..In this study, the relationship between severe childhood abuse and smoking were examined in a group of adults without significant psychopathology...
  39. pmc Prescription opioid aberrant behaviors: a pilot study of sex differences
    Sudie E Back
    Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin J Pain 25:477-84. 2009
    ..Little is known about the sex differences in specific types of aberrant behaviors or sex-specific predictors of such behaviors. The current study is aimed to begin addressing this gap in the literature...
  40. pmc Early life trauma and sensitivity to current life stressors in individuals with and without cocaine dependence
    Sudie E Back
    Division of Clinical Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 34:389-96. 2008
    ..Adverse childhood events may lead to an altered view of the environment that contributes to increased irritability with daily life events among cocaine-dependent individuals...
  41. pmc A placebo-controlled trial of buspirone for the treatment of marijuana dependence
    Aimee L McRae-Clark
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 105:132-8. 2009
    ..054). Further study with buspirone in this population may be warranted; however, strategies to enhance study retention and improve outcome measurement should be considered in future trials...
  42. pmc Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders
    Albert J Arias
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Addict Behav 33:1199-207. 2008
    ..We examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD)...
  43. pmc Non-treatment laboratory stress- and cue-reactivity studies are associated with decreased substance use among drug-dependent individuals
    Stacia M DeSantis
    Department of Biostatistics, Bioinformatics, and Epidemiology, 135 Cannon Street Suite 303, Charleston, SC 29425, USA
    Drug Alcohol Depend 105:227-33. 2009
    ..This study examines whether participation in such studies alters drug-seeking behavior and which patient attributes contribute to increased use...
  44. ncbi request reprint Psychiatric disorders and cigarette smoking among child and adolescent psychiatry inpatients
    Himanshu P Upadhyaya
    Departments of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Addict 12:144-52. 2003
    ..56,older age=1.3, depressive disorders=4.02, conduct disorder (CD)=12.96, cannabis abuse/dependence=24.6. Hence, cigarette smoking is highly prevalent but underdiagnosed in this population...
  45. pmc D-cycloserine and cocaine cue reactivity: preliminary findings
    Kimber L Price
    Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, Charleston, SC 29425, USA
    Am J Drug Alcohol Abuse 35:434-8. 2009
    ..D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders...
  46. doi request reprint Determinants of cue-elicited craving and physiologic reactivity in methamphetamine-dependent subjects in the laboratory
    Bryan K Tolliver
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 36:106-13. 2010
    ..In this study, clinical and demographic correlates of methamphetamine craving and the optimal conditions for its measurement in the laboratory are explored...
  47. ncbi request reprint Differences in early onset alcohol use and heavy drinking among persons with childhood and adulthood trauma
    Angela E Waldrop
    Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Am J Addict 16:439-42. 2007
    ....
  48. ncbi request reprint Comparison of self-report versus agency records of service utilization in a community sample of individuals with alcohol use disorders
    Therese K Killeen
    Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street 4 North, P O Box 250861, Charleston, SC 29425 0742, USA
    Drug Alcohol Depend 73:141-7. 2004
    ..There was less agreement in emergency room visits and arrests. Factors related to discrepancies between self-report and records were explored...
  49. ncbi request reprint Gender differences in stress reactivity among cocaine-dependent individuals
    Sudie E Back
    Division of Clinical Neuroscience, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 180:169-76. 2005
    ..Important gender differences, such as reasons for using substances, have been well documented, and it is likely that men and women also differ in their stress response...
  50. ncbi request reprint Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Depress Anxiety 19:190-6. 2004
    ..This study did not find significant differences in the effectiveness of nefazodone and sertraline for the treatment of PTSD. Larger trials are warranted...
  51. ncbi request reprint Alcohol dependence and posttraumatic stress disorder: differences in clinical presentation and response to cognitive-behavioral therapy by order of onset
    Sudie E Back
    Department of Psychology, University of Georgia, Athens, GA 30606, USA
    J Subst Abuse Treat 29:29-37. 2005
    ..These findings increase awareness of the importance of considering the order of onset and may ultimately lead to treatment improvements for this population...
  52. ncbi request reprint Attention-deficit/hyperactivity disorder, medication treatment, and substance use patterns among adolescents and young adults
    Himanshu P Upadhyaya
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    J Child Adolesc Psychopharmacol 15:799-809. 2005
    ..The aim of this study was to examine the relationship between current active attention-deficit/hyperactivity disorder (ADHD) symptoms, medication treatment, and substance use patterns among college students...
  53. ncbi request reprint The use of divalproex in the treatment of addictive disorders
    Hugh Myrick
    Institute of Psychiatry 4N, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:89-97. 2003
    ..This article will review the literature regarding the use of valproate in treating alcohol withdrawal symptoms and in reducing the use of alcohol and cocaine...
  54. ncbi request reprint A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependent individuals
    Aimee L McRae
    Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 61 President Street, Charleston, SC 29425, USA
    Am J Addict 13:53-63. 2004
    ..Buspirone treatment did not significantly reduce anxiety symptoms in opioid-dependent patients. However, buspirone treatment was associated with trends toward reduction in depression scale scores and a slower return to substance use...
  55. ncbi request reprint A preliminary report on the use of virtual reality technology to elicit craving and cue reactivity in cocaine dependent individuals
    Michael E Saladin
    College of Health Professions and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Addict Behav 31:1881-94. 2006
    ..Such technology has potential utility in the development and refinement of exposure-based behavioral and pharmacological interventions for substance use disorders...
  56. ncbi request reprint Advances in diagnosis of adolescent substance abuse
    Kevin M Gray
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, 29425, USA
    Adolesc Med Clin 17:411-25. 2006
    ..The authors provide a synopsis of recent advances and important issues in this area and propose a stepwise, evidence-based approach to evaluation of substance abuse in adolescents...
  57. ncbi request reprint Triggers for cocaine and alcohol use in the presence and absence of posttraumatic stress disorder
    Angela E Waldrop
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, SC 29425, USA
    Addict Behav 32:634-9. 2007
    ..The findings highlight the importance of addressing individual-specific high-risk situations in relapse prevention...
  58. ncbi request reprint Stress reactivity: biological and subjective responses to the cold pressor and Trier Social stressors
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Psychopharmacol 21:377-85. 2006
    ..The results suggest that the TSST results in a greater HPA response than the CPT; however, the CPT may have utility in diagnostically heterogeneous patients...
  59. ncbi request reprint Neuroendocrine and behavioral responses to dopaminergic agonists in adolescents with alcohol abuse
    Himanshu P Upadhyaya
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Psychopharmacology (Berl) 166:95-101. 2003
    ..Dopaminergic systems are involved in the pathophysiology of alcohol use disorders, but there is little research investigating the role of these systems in adolescents...
  60. ncbi request reprint Treatment of marijuana dependence: a review of the literature
    Aimee L McRae
    Ralph H Johnson VAMC, 109 Bee Street, MUSC CTN, 29401, Charleston, SC, USA
    J Subst Abuse Treat 24:369-76. 2003
    ....
  61. ncbi request reprint Menstrual cycle phase effects on nicotine withdrawal and cigarette craving: a review
    Matthew J Carpenter
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Nicotine Tob Res 8:627-38. 2006
    ..Further research is necessary to replicate these findings, but they may suggest the need for focused cessation treatment during the luteal phase or quit attempts that are well timed relative to specific menstrual phases...
  62. pmc Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trials
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Addict Behav 32:1433-40. 2007
    ..Past and current other drug use was similar between the two groups. These results highlight the significant impairments associated with marijuana and cocaine dependence...
  63. ncbi request reprint PTSD symptom severity as a predictor of cue-elicited drug craving in victims of violent crime
    Michael E Saladin
    College of Health Professions, Medical University of South Carolina, 77 President Street, Suite 117, PO Box 250700, Charleston, SC 29425, USA
    Addict Behav 28:1611-29. 2003
    ..The results are discussed in the context of current research, theory, and clinical practice...
  64. ncbi request reprint Effectiveness of naltrexone in a community treatment program
    Therese K Killeen
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Alcohol Clin Exp Res 28:1710-7. 2004
    ..Whether this efficacy can be generalized to individuals who have alcohol use disorders and present for treatment at front-line community treatment programs has not been well established...
  65. pmc Training physician-scientists: a model for integrating research into psychiatric residency
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, in Charleston, South Carolina 29425, USA
    Acad Psychiatry 35:40-5. 2011
    ..Physicians with in-depth experience and formal training in research design, development, implementation, statistical analysis, and interpretation of scientific information are rare...
  66. ncbi request reprint Clinical characteristics of under-reporters on urine drug screens in a cocaine treatment study
    Hugh Myrick
    Medical University of South Carolina, Department of Psychiatry, Center for Drug and Alcohol Programs, 67 President Street, Charleston, SC 29425, USA
    Am J Addict 11:255-61. 2002
    ..Significant differences were found in cocaine use patterns and the prevalence of Axis I and Axis II disorders. This information may be important in guiding the judicious use of UDS in clinical and research settings...
  67. ncbi request reprint Health service use among persons with comorbid bipolar and substance use disorders
    Marcia L Verduin
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, South Carolina 29425, USA
    Psychiatr Serv 56:475-80. 2005
    ..This study tested the hypothesis that patients with comorbid bipolar and substance use disorders use health services to a greater extent than patients with either bipolar or substance use disorder alone...
  68. pmc Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation
    Sudie E Back
    Department of Psychiatry, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC, USA
    Psychoneuroendocrinology 33:560-8. 2008
    ..In addition, there is some evidence for a more robust neuroendocrine and physiologic response to acute laboratory stress in women as compared to men...
  69. pmc A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder
    Aimee L McRae-Clark
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 19:481-9. 2010
    ..These results suggest that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population. ..
  70. ncbi request reprint Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals
    Scott F Coffey
    Department of Psychiatry, University at Buffalo, State University of New York, Buffalo General Hosptial, 14203, USA
    Exp Clin Psychopharmacol 11:18-25. 2003
    ..Moreover, scores on self-report measures indicated greater impulsivity in the CD group when compared with the MC group...
  71. ncbi request reprint Cigarette smoking and psychiatric comorbidity in children and adolescents
    Himanshu P Upadhyaya
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Am Acad Child Adolesc Psychiatry 41:1294-305. 2002
    ..To review the current state of knowledge of psychiatric comorbidity in adolescent cigarette smokers...
  72. ncbi request reprint Gabapentin in comorbid anxiety and substance use
    Marcia L Verduin
    Am J Addict 16:142-3. 2007
  73. ncbi request reprint Bupropion SR in adolescents with comorbid ADHD and nicotine dependence: a pilot study
    Himanshu P Upadhyaya
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Am Acad Child Adolesc Psychiatry 43:199-205. 2004
    ..This open-label pilot study was designed to examine the feasibility and preliminary tolerability of bupropion SR in adolescents with nicotine dependence...
  74. ncbi request reprint Trauma history screening in a community mental health center
    Karen J Cusack
    South Carolina Department of Mental Health, Charleston, South Carolina 29403, USA
    Psychiatr Serv 55:157-62. 2004
    ....
  75. ncbi request reprint Exposure therapy for substance abusers with PTSD: translating research to practice
    Scott F Coffey
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Behav Modif 29:10-38. 2005
    ..This article describes one of the treatments and discusses treatment modifications that have been incorporated when translating this research-based therapy to practice in an inner-city community mental health center...
  76. doi request reprint Atomoxetine treatment of adults with ADHD and comorbid alcohol use disorders
    Timothy E Wilens
    Massachusetts General Hospital, 55 Fruit Street, YAW 6900, Boston, MA 02114, USA
    Drug Alcohol Depend 96:145-54. 2008
    ..The study aim was to determine if atomoxetine was superior to placebo in improving ADHD and alcohol use in recently abstinent adults with ADHD and comorbid alcohol use disorder...
  77. ncbi request reprint Buspirone for treatment of marijuana dependence: a pilot study
    Aimee L McRae
    Am J Addict 15:404. 2006
  78. pmc Changes in PTSD symptomatology during acute and protracted alcohol and cocaine abstinence
    Scott F Coffey
    Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Drug Alcohol Depend 87:241-8. 2007
    ..Moreover, while trauma symptoms for the PTSD participants were more severe than those reported by the non-PTSD participants, trauma symptoms declined across the study period at the same rate irrespective of PTSD status...
  79. pmc Daily stressor sensitivity, abuse effects, and cocaine use in cocaine dependence
    Angela E Waldrop
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, SC 29425, USA
    Addict Behav 32:3015-25. 2007
    ..Reactivity to cocaine cues was related to daily hassle sensitivity among women only. Limitations and implications of the findings are discussed...
  80. ncbi request reprint Medical treatment of opiate dependence: expanding treatment options
    Kathleen T Brady
    Am J Psychiatry 164:702-4. 2007
  81. ncbi request reprint Overview of psychiatric disorders and the role of newer antidepressants
    Dennis S Charney
    Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 63:3-9. 2002

Research Grants28

  1. D-Cycloserine Facilitation of Cocaine-Cue Extinction
    Kathleen Brady; Fiscal Year: 2009
    ..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..
  2. D-Cycloserine Facilitation of Cocaine-Cue Extinction
    Kathleen Brady; Fiscal Year: 2009
    ..Knowledge of the brain circuitry involved in craving may be important for developing treatments for cocaine dependence. ..
  3. South Carolina Consortium of the Clinical Trials Network
    Kathleen Brady; Fiscal Year: 2007
    ..The SC Node is enthusiastic about continuing its active role in the CTN over the next five years. ..
  4. EFFECTIVENESS OF NALTREXONE IN A COMMUNITY SETTING
    Kathleen Brady; Fiscal Year: 2001
    ....
  5. Planning Grant for CTSA at MUSC
    Kathleen Brady; Fiscal Year: 2006
    ..The development and subsequent implementation of the strategic plan has the potential to transform the research enterprise of MUSC and the state. ..
  6. Drug Abuse Research Training (DART) Program
    Kathleen Brady; Fiscal Year: 2007
    ..The research education plan is consistent with recent recommendations of national consensus panels and builds on the experience of well-established research workforce development programs in the U.S. ..
  7. CLINICAL INVESTIGATION OF DRUG ABUSE DISORDERS
    Kathleen Brady; Fiscal Year: 2007
    ..The candidate would also use the time and funding provided through this award to continue to expand her activities in mentoring fellows and junior faculty. ..
  8. South Carolina Consortium of the Clinical Trials Network
    Kathleen Brady; Fiscal Year: 2007
    ..The SC Node is enthusiastic about continuing its active role in the CTN over the next five years. ..
  9. ORWH: SCOR on Sex and Gender Factors Affecting Women's Health
    Kathleen Brady; Fiscal Year: 2007
    ..Our SCOR, with a truly interdisciplinary focus on gender issues in substance use disorders, is a ready resource for inter-ORWH Center collaborations and, as such, is an asset to the ORWH program. ..
  10. Interdisciplinary Women's Health Research at MUSC
    Kathleen Brady; Fiscal Year: 2007
    ....
  11. D-Cycloserine Facilitation of Cocaine-Cue Extinction
    KATHLEEN THERESA BRADY; Fiscal Year: 2010
    ..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..