C V Borlongan

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity
    Cesario V Borlongan
    Cellular Neurobiology Branch, NIH NIDA IRP, 5500 Nathan Shock Drive, 21224, Baltimore, MD, USA
    Brain Res 956:211-20. 2002
  2. ncbi request reprint Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, 1120 15th Street, BI 3080, Augusta, GA 30912 3200, USA
    Brain Res 1010:108-16. 2004
  3. pmc Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
    Livia S Machado
    Program in Clinical and Experimental Therapeutics, Clinical Pharmacy Department, College of Pharmacy, University of Georgia, Augusta, GA, USA
    BMC Neurosci 7:56. 2006
  4. pmc Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
    Lin Xu
    Department of Neurology, Medical College of Georgia, Augusta GA, 30912, USA
    BMC Neurol 4:7. 2004
  5. doi request reprint Cell therapy for stroke: remaining issues to address before embarking on clinical trials
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, BI 3080, Augusta, GA 30912, USA
    Stroke 40:S146-8. 2009
  6. ncbi request reprint Gene therapy, cell transplantation and stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Front Biosci 11:1090-101. 2006
  7. ncbi request reprint Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats
    Cesar V Borlongan
    Department of Neurology, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Brain Res 1048:116-22. 2005
  8. ncbi request reprint CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats
    C V Borlongan
    Department of Neurology Institute of Molecular Medicine and Genetics School of Graduate Studies, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Neuroreport 15:1543-7. 2004
  9. ncbi request reprint Acute functional effects of cyclosporine-A and methylprednisolone treatment in adult rats exposed to transient ischemic stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta VAMC, GA 30912, USA
    Life Sci 76:1503-12. 2005
  10. ncbi request reprint Methanesulfonyl fluoride, an acetylcholinesterase inhibitor, attenuates simple learning and memory deficits in ischemic rats
    Cesario V Borlongan
    National Institutes of Health, National Institute on Drug Abuse, Intramural, Research Program, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 1038:50-8. 2005

Research Grants

  1. Stem Cells for Neonatal Hypoxic-Ischemic Brain Injury
    Cesario Borlongan; Fiscal Year: 2007

Detail Information

Publications59

  1. ncbi request reprint Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity
    Cesario V Borlongan
    Cellular Neurobiology Branch, NIH NIDA IRP, 5500 Nathan Shock Drive, 21224, Baltimore, MD, USA
    Brain Res 956:211-20. 2002
    ..The safer and effective administration of lower doses of CsA combined with enhanced BBB permeability using Cereport, offers a novel way of producing protective effects in the CNS without the toxic liabilities of high-dose CsA...
  2. ncbi request reprint Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, 1120 15th Street, BI 3080, Augusta, GA 30912 3200, USA
    Brain Res 1010:108-16. 2004
    ..These data suggest that early restoration of CBF and BBB following transplantation of BMSCs could mediate the reported functional outcomes in stroke animals...
  3. pmc Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
    Livia S Machado
    Program in Clinical and Experimental Therapeutics, Clinical Pharmacy Department, College of Pharmacy, University of Georgia, Augusta, GA, USA
    BMC Neurosci 7:56. 2006
    ..Minocycline inhibits inflammation, apoptosis and extracellular matrix degradation. In this study we investigated whether delayed minocycline inhibits brain MMPs activated by ischemia in a model of temporary occlusion in Wistar rats...
  4. pmc Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
    Lin Xu
    Department of Neurology, Medical College of Georgia, Augusta GA, 30912, USA
    BMC Neurol 4:7. 2004
    ....
  5. doi request reprint Cell therapy for stroke: remaining issues to address before embarking on clinical trials
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, BI 3080, Augusta, GA 30912, USA
    Stroke 40:S146-8. 2009
    ..In addressing this issue, I borrow heavily from the conference proceedings of the 2007 STEPS (Stem Cell Therapeutics as an Emerging Paradigm in Stroke)...
  6. ncbi request reprint Gene therapy, cell transplantation and stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Front Biosci 11:1090-101. 2006
    ..This chapter will also highlight some of the most recent findings regarding NT2N cells...
  7. ncbi request reprint Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats
    Cesar V Borlongan
    Department of Neurology, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Brain Res 1048:116-22. 2005
    ..Reduction of cerebral infarct (25%) was only noted in intracerebral transplantation. Intravenous transplantation requires optimization for improved therapeutic outcome of CD133+ cell grafts in stroke...
  8. ncbi request reprint CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats
    C V Borlongan
    Department of Neurology Institute of Molecular Medicine and Genetics School of Graduate Studies, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Neuroreport 15:1543-7. 2004
    ..This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke...
  9. ncbi request reprint Acute functional effects of cyclosporine-A and methylprednisolone treatment in adult rats exposed to transient ischemic stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta VAMC, GA 30912, USA
    Life Sci 76:1503-12. 2005
    ..These observations suggest that despite overt cerebral damage, alterations in simple, but not complex, cognitive tasks produced by MCAo could be ameliorated by low dose CsA when combined with MP...
  10. ncbi request reprint Methanesulfonyl fluoride, an acetylcholinesterase inhibitor, attenuates simple learning and memory deficits in ischemic rats
    Cesario V Borlongan
    National Institutes of Health, National Institute on Drug Abuse, Intramural, Research Program, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 1038:50-8. 2005
    ..These results show that MSF, possibly by preserving a functional cholinergic system, attenuated stroke-induced deficits in a simple learning and memory task...
  11. ncbi request reprint Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke
    Cesar V Borlongan
    Department of Neurology, School of Medicine, and the Institute of Molecular Medicine and Genetics, School of Graduate Studies, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Stroke 35:2206-10. 2004
    ..Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and in vivo neuroprotective studies...
  12. ncbi request reprint Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Stroke 35:2385-9. 2004
    ..Here, we examined whether neuroprotection by systemically delivered human umbilical cord blood (HUCB) cells was dependent on their entry into the central nervous system in a rodent model of acute stroke...
  13. ncbi request reprint Delta opioid peptide (D-Ala 2, D-Leu 5) enkephalin: linking hibernation and neuroprotection
    Cesario V Borlongan
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta GA 30912 3200, USA
    Front Biosci 9:3392-8. 2004
    ..These results taken together suggest that DADLE stands as a novel therapeutic agent. In this review paper, we present laboratory evidence supporting the use of DADLE for protection of peripheral and central nervous system...
  14. ncbi request reprint Cell transplantation: stem cells in the spotlight
    Cesar V Borlongan
    Neurology, Institute of Molecular Medicine and Genetics, School of Graduate Studies, Medical College of Georgia, Augusta 30912 3200, USA
    Cell Transplant 14:519-26. 2005
  15. ncbi request reprint Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease
    Cesario V Borlongan
    Neurology Department, Institute of Mol Med and Genetics and School of Graduate Studies, Medical College, 1120 15th Street, Augusta, GA 30912 3200, USA
    Neuroreport 15:2521-5. 2004
    ..These data are the first to demonstrate that transplanted choroid plexus cells can protect striatal neurons from excitotoxic damage and that this strategy may ultimately prove relevant for the treatment of Huntington's disease...
  16. doi request reprint Dietary supplementation exerts neuroprotective effects in ischemic stroke model
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Rejuvenation Res 11:201-14. 2008
    ..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential...
  17. ncbi request reprint Transplants of encapsulated rat choroid plexus cells exert neuroprotection in a rodent model of Huntington's disease
    Cesario V Borlongan
    Neurology Institute of Molecular Medicine and Genetics School of Graduate Studies, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Cell Transplant 16:987-92. 2008
    ..These data demonstrate that transplanted CP cells can be used to protect striatal neurons from excitotoxic damage and that the pattern of neuroprotection varies across specific neuronal populations...
  18. ncbi request reprint Stroke, with or with no ice? Observations on amphetamine for the management of acute stroke
    C V Borlongan
    Department of Neurology, Medical College of Georgia and Medical Research Service, VA Medical Center, Augusta, GA 30912, USA
    J Hum Hypertens 21:594-7. 2007
  19. ncbi request reprint Nanotechnology as an adjunct tool for transplanting engineered cells and tissues
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Curr Mol Med 7:609-18. 2007
    ..This review article discusses recent progress in the field of nanotechnology as a tool for tissue engineering, gene therapy, cell immunoisolation, and cell imaging, highlighting its direct applications in cell transplantation therapy...
  20. pmc New hope for stroke patients: mobilization of endogenous stem cells
    Cesar V Borlongan
    Medical College of Georgia Department of Neurology Cell Transplantation, Medical College of Georgia, Augusta, GA 30912 3200, USA
    CMAJ 174:954-5. 2006
  21. ncbi request reprint Intracerebral xenotransplantation of GFP mouse bone marrow stromal cells in intact and stroke rat brain: graft survival and immunologic response
    H Irons
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Transplant 13:283-94. 2004
    ....
  22. doi request reprint Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    J Cell Mol Med 14:914-21. 2010
    ..These findings extend the utility of blood-brain barrier permeabilization in facilitating cell therapy for treating neonatal HI injury...
  23. ncbi request reprint Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA USA
    Neuroscience 149:182-91. 2007
    ..The use of the HS model in conjunction with CNS disease models should further elucidate the role of exercise in neurogenesis and neurotrophic factors in neurologic disorders...
  24. ncbi request reprint Delta opioid peptide augments functional effects and intrastriatal graft survival of rat fetal ventral mesencephalic cells
    C V Borlongan
    Cellular Neurobiology, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Transplant 10:53-8. 2001
    ..These results suggest that DADLE should be considered as an adjunctive agent for neural transplantation therapy in Parkinson's disease...
  25. ncbi request reprint Cyclosporine A-induced hyperactivity in rats: is it mediated by immunosuppression, neurotrophism, or both?
    C V Borlongan
    National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology, Baltimore, MD 21224, USA
    Cell Transplant 8:153-9. 1999
    ..These results support the utility of CsA as a therapeutic agent for PD and other movement disorders...
  26. ncbi request reprint Trophic factor secreting kidney cell lines: in vitro characterization and functional effects following transplantation in ischemic rats
    R E Johnston
    Development and Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 900:268-76. 2001
    ..Reduction of infarct volume was likely achieved by the action of GDNF and/or other growth factors produced by the cells...
  27. ncbi request reprint Involvement of GDNF in neuronal protection against 6-OHDA-induced parkinsonism following intracerebral transplantation of fetal kidney tissues in adult rats
    C V Borlongan
    Cellular Neurobiology Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Neurobiol Dis 8:636-46. 2001
    ....
  28. ncbi request reprint Chronic cyclosporine-A injection in rats with damaged blood-brain barrier does not impair retention of passive avoidance
    C V Borlongan
    Department of Cellular Neurophysiology, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neurosci Res 32:195-200. 1998
    ....
  29. ncbi request reprint Transplantation therapy for Parkinson's disease
    C V Borlongan
    Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Expert Opin Investig Drugs 9:2319-30. 2000
    ....
  30. ncbi request reprint T155g-immortalized kidney cells produce growth factors and reduce sequelae of cerebral ischemia
    Ora Dillon-Carter
    Cellular Neurobiology Branch, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA
    Cell Transplant 11:251-9. 2002
    ..These cell lines may be useful for intracerebral transplantation in animal models of brain injury, stroke, or Parkinson's disease...
  31. ncbi request reprint Combined cyclosporine-A and methylprednisolone treatment exerts partial and transient neuroprotection against ischemic stroke
    Guolong Yu
    Research and Affiliations Service Line, VAMC Augusta, GA 30912, USA
    Brain Res 1018:32-7. 2004
    ..This study is the first report to demonstrate partial and transient neuroprotection against stroke by low dose CsA when combined with MP...
  32. ncbi request reprint Eleventh Annual Conference of the American Society for Neural Transplantation and Repair
    Cesario V Borlongan
    Department of Neurology Institute of Molecular Medicine and Genetics School of Graduate Studies, Medical College, Georgia, USA
    Expert Opin Biol Ther 4:1351-5. 2004
    ....
  33. ncbi request reprint Melatonin-secreting pineal gland: a novel tissue source for neural transplantation therapy in stroke
    C V Borlongan
    Neurology Institute of Molecular Medicine and Genetics School of Graduate Studies, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Cell Transplant 12:225-34. 2003
    ..We conclude that intracerebral transplantation of pineal gland, in the presence of host intact pineal gland, protected against stroke, possibly through secretion of melatonin...
  34. doi request reprint Stem cells and neurological diseases
    D C Hess
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Prolif 41:94-114. 2008
    ..The most immediate impact on patients will be achieved by making use of the trophic support capability of cell therapy and not by a cell replacement mechanism...
  35. ncbi request reprint Motor activity-mediated partial recovery in ischemic rats
    C V Borlongan
    Development and Plasticity Section, Cellular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Neuroreport 11:4063-7. 2000
    ..e., increased use of the ischemia-affected limbs and body parts) may contribute to partial recovery of motor deficits following an experimental stroke, even in the absence of pharmacological therapeutic intervention...
  36. ncbi request reprint Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Brain Res 1009:26-33. 2004
    ..These observations suggest that restoration of CBF and BBB permeability accompanies the reported functional outcomes associated with intracerebral transplantation of BMSCs...
  37. ncbi request reprint Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats
    N Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1160:113-23. 2007
    ..These data support the use of the subtherapeutic dose of ropinirole in a chronic model of PD...
  38. ncbi request reprint Neural transplantation for treatment of Parkinson's disease
    Cesario V Borlongan
    Department of Neurobiology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    Drug Discov Today 7:674-82. 2002
    ..This article will review recent studies demonstrating the potential of these alternative cell graft sources and novel drugs for treating Parkinson's disease...
  39. ncbi request reprint Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: a pilot study
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res Bull 74:164-71. 2007
    ..Additional studies are warranted to reveal behavioral deficits associated with this ischemia model...
  40. ncbi request reprint Viral vector strategy for glial cell line-derived neurotrophic factor therapy for stroke
    Yun Wang
    Neural Protection and Regeneration, NIDA, NIH, DHHS, Baltimore, MD 21224, USA
    Front Biosci 11:1101-7. 2006
    ..Gene therapy and the use of viral vectors offer a technique for longevity of GDNF expression within the brain. In this review, we consider the risks and benefits of GDNF gene therapy as it relates to the treatment of stroke...
  41. ncbi request reprint Neurorescue effects of VEGF on a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Brain Res 1053:10-8. 2005
    ..Our results suggest that VEGF is a highly potent neurorescue molecule for Parkinson's disease therapy...
  42. ncbi request reprint Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 26:12497-511. 2006
    ..These results suggest that HB1.F3 cell transplantation exerts neuroprotective effects against dopaminergic depletion in vitro and in vivo because of trophic factor secretion and neuronal differentiation...
  43. ncbi request reprint Cyclosporine-A enhances choline acetyltransferase immunoreactivity in the septal region of adult rats
    C V Borlongan
    National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology, Baltimore, MD 21224, USA
    Neurosci Lett 279:73-6. 2000
    ..The observed enhancement of septal ChAT immunoreactivity suggests potential therapeutic utility of CsA for brain disorders characterized by alterations of the cholinergic system...
  44. ncbi request reprint Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport
    C V Borlongan
    Department of Neurology, Medical College of Georgia, BI 3080, 1120 15th Street, Augusta, GA 30912 3200, USA
    Brain Res Bull 60:297-306. 2003
    ..Because many potential drugs for CNS disorders normally do not cross the BBB, Cereport-induced transient permeation of BBB stands as an efficacious strategy for enhancing pharmacotherapy...
  45. ncbi request reprint Neural transplantation in the new millenium
    Cesario V Borlongan
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Veterans Administration Medical Center, Augusta 30912 3200, USA
    Cell Transplant 11:615-8. 2002
  46. pmc Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques
    Koichi Hara
    Department Neurology and Inst Mol Med and Genetics, Medical College Georgia, Augusta, GA, USA
    Brain Res 1286:185-91. 2009
    ....
  47. ncbi request reprint Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats
    Takao Yasuhara
    Movement Disorders Program, Department of Neurology, Medical College of Georgia, 1429 Harper Street, HF 1121, Augusta, GA 30912, USA
    Brain Res 1133:49-52. 2007
    ..The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD...
  48. ncbi request reprint Transplantation of bone marrow-derived stem cells: a promising therapy for stroke
    Yamei Tang
    Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
    Cell Transplant 16:159-69. 2007
    ..The phenotypic features of MSCs and MAPCs, as well as their application in stroke, are described...
  49. ncbi request reprint Transplantation of fetal kidney cells: neuroprotection and neuroregeneration
    Yung Hsiao Chiang
    Tri Service General Hospital, National Defense Medical Center, Taiwan
    Cell Transplant 14:1-9. 2005
    ..In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models...
  50. ncbi request reprint Toxicity of semaphorin3A for dopaminergic neurons
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 382:61-5. 2005
    ..Optimizing the dosage and infusion location (i.e., nigra) and timing (more than 1 week post-transplantation) might further reveal the contribution of Sema3A to the pathogenesis of Parkinson's disease...
  51. doi request reprint Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: behavioral and histological analyses
    Takashi Agari
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan, 700 8558
    Brain Res 1203:189-96. 2008
    ..The results indicate that the blockade of amphetamine-induced rotations might be at least partially mediated by group I mGluR activation. This study advances the use of selective group I mGluRs directed toward the GP for PD treatment...
  52. ncbi request reprint Ex vivo gene therapy: transplantation of neurotrophic factor-secreting cells for cerebral ischemia
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Front Biosci 11:760-75. 2006
    ..Neurotrophic factor delivery, combined with ex vivo method, poses as novel treatment for stroke, although additional safety and efficacy studies remain to be examined...
  53. ncbi request reprint A role of the choroid plexus in transplantation therapy
    Dwaine F Emerich
    LCT BioPharma Inc, Providence, RI, USA
    Cell Transplant 14:715-25. 2005
    ..Here we describe the wide-ranging functions of the CP, alterations of these functions in aging and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma...
  54. ncbi request reprint Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys
    Dwaine F Emerich
    LCT BioPharma, Providence, RI 02906, USA
    Neurobiol Dis 23:471-80. 2006
    ..43% in controls) and striatum volume (10% decrease vs. 40% in controls). These data indicate that CP transplants might be useful for preventing the degeneration of neurons in HD...
  55. ncbi request reprint Behavioral, hormonal and histological stress markers of anxiety-separation in postnatal rats are reduced by prepro-thyrotropin-releasing hormone 178-199
    Christine E Stahl
    Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Neurosci Lett 321:85-9. 2002
    ..PPTRH 178-199 treatment can help to reduce behavioral and hormonal disturbances associated with anxiety-separation situations...
  56. ncbi request reprint The choroid plexus: function, pathology and therapeutic potential of its transplantation
    Dwaine F Emerich
    LCT BioPharma, 766 Laten Knight Rd, Cranston, RI 02921, USA
    Expert Opin Biol Ther 4:1191-201. 2004
    ..This review describes some of the anatomical and functional changes of CP in ageing and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma...
  57. ncbi request reprint Novel cell therapy approaches for brain repair
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, MDC 78, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Brain Res 157:207-22. 2006
    ..These protective effects may prove essential to maintaining restored tissue integrity over the course of various diseases or injuries...
  58. ncbi request reprint Differential expression of HCNP-related antigens in hippocampus in senescence-accelerated mice
    Kentaro Yamada
    Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Aichi, Japan
    Brain Res 1158:169-75. 2007
    ....
  59. ncbi request reprint The choroid plexus in the rise, fall and repair of the brain
    Dwaine F Emerich
    LCT BioPharma Inc, Providence, RI 02921, USA
    Bioessays 27:262-74. 2005
    ....

Research Grants1

  1. Stem Cells for Neonatal Hypoxic-Ischemic Brain Injury
    Cesario Borlongan; Fiscal Year: 2007
    ....